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Q96C90

- PP14B_HUMAN

UniProt

Q96C90 - PP14B_HUMAN

Protein

Protein phosphatase 1 regulatory subunit 14B

Gene

PPP1R14B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated By similarity.By similarity

    GO - Molecular functioni

    1. protein phosphatase inhibitor activity Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of phosphorylation Source: InterPro

    Keywords - Molecular functioni

    Protein phosphatase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14B
    Alternative name(s):
    Phospholipase C-beta-3 neighbouring gene protein
    Gene namesi
    Name:PPP1R14B
    Synonyms:PLCB3N, PNG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9057. PPP1R14B.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33624.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 147146Protein phosphatase 1 regulatory subunit 14BPRO_0000071490Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications
    Modified residuei32 – 321Phosphoserine3 Publications
    Modified residuei57 – 571PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96C90.
    PaxDbiQ96C90.
    PRIDEiQ96C90.

    PTM databases

    PhosphoSiteiQ96C90.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed at low levels.1 Publication

    Gene expression databases

    BgeeiQ96C90.
    CleanExiHS_PPP1R14B.
    GenevestigatoriQ96C90.

    Interactioni

    Protein-protein interaction databases

    BioGridi117696. 4 interactions.
    IntActiQ96C90. 2 interactions.
    MINTiMINT-3051633.
    STRINGi9606.ENSP00000310117.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96C90.
    SMRiQ96C90. Positions 55-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili61 – 10343Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP1 inhibitor family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG124396.
    HOGENOMiHOG000231993.
    HOVERGENiHBG054419.
    InParanoidiQ96C90.
    KOiK17555.
    OMAiNLEEWII.
    PhylomeDBiQ96C90.
    TreeFamiTF105546.

    Family and domain databases

    Gene3Di1.10.150.220. 1 hit.
    InterProiIPR008025. PP1_inhibitor.
    [Graphical view]
    PANTHERiPTHR16188. PTHR16188. 1 hit.
    PfamiPF05361. PP1_inhibitor. 1 hit.
    [Graphical view]
    SUPFAMiSSF81790. SSF81790. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96C90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV    50
    RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL 100
    LDMESDDARA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK 147
    Length:147
    Mass (Da):15,911
    Last modified:November 9, 2004 - v3
    Checksum:i2932A4EA9F312451
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT009914 mRNA. Translation: AAP88916.1.
    BC014522 mRNA. Translation: AAH14522.3.
    BC094817 mRNA. Translation: AAH94817.1.
    CCDSiCCDS31596.1.
    RefSeqiNP_619634.1. NM_138689.2.
    UniGeneiHs.523760.
    Hs.596713.

    Genome annotation databases

    EnsembliENST00000309318; ENSP00000310117; ENSG00000173457.
    GeneIDi26472.
    KEGGihsa:26472.
    UCSCiuc001nza.3. human.

    Polymorphism databases

    DMDMi55583975.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BT009914 mRNA. Translation: AAP88916.1 .
    BC014522 mRNA. Translation: AAH14522.3 .
    BC094817 mRNA. Translation: AAH94817.1 .
    CCDSi CCDS31596.1.
    RefSeqi NP_619634.1. NM_138689.2.
    UniGenei Hs.523760.
    Hs.596713.

    3D structure databases

    ProteinModelPortali Q96C90.
    SMRi Q96C90. Positions 55-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117696. 4 interactions.
    IntActi Q96C90. 2 interactions.
    MINTi MINT-3051633.
    STRINGi 9606.ENSP00000310117.

    PTM databases

    PhosphoSitei Q96C90.

    Polymorphism databases

    DMDMi 55583975.

    Proteomic databases

    MaxQBi Q96C90.
    PaxDbi Q96C90.
    PRIDEi Q96C90.

    Protocols and materials databases

    DNASUi 26472.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309318 ; ENSP00000310117 ; ENSG00000173457 .
    GeneIDi 26472.
    KEGGi hsa:26472.
    UCSCi uc001nza.3. human.

    Organism-specific databases

    CTDi 26472.
    GeneCardsi GC11M064011.
    HGNCi HGNC:9057. PPP1R14B.
    MIMi 601140. gene.
    neXtProti NX_Q96C90.
    PharmGKBi PA33624.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG124396.
    HOGENOMi HOG000231993.
    HOVERGENi HBG054419.
    InParanoidi Q96C90.
    KOi K17555.
    OMAi NLEEWII.
    PhylomeDBi Q96C90.
    TreeFami TF105546.

    Miscellaneous databases

    GeneWikii PPP1R14B.
    GenomeRNAii 26472.
    NextBioi 48728.
    PROi Q96C90.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96C90.
    CleanExi HS_PPP1R14B.
    Genevestigatori Q96C90.

    Family and domain databases

    Gene3Di 1.10.150.220. 1 hit.
    InterProi IPR008025. PP1_inhibitor.
    [Graphical view ]
    PANTHERi PTHR16188. PTHR16188. 1 hit.
    Pfami PF05361. PP1_inhibitor. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81790. SSF81790. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    3. "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13."
      Lagercrantz J., Carson E., Larsson C., Nordenskjoeld M., Weber G.
      Genomics 31:380-384(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPP14B_HUMAN
    AccessioniPrimary (citable) accession number: Q96C90
    Secondary accession number(s): Q504S7, Q7KZD7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 9, 2004
    Last sequence update: November 9, 2004
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3