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Q96C90 (PP14B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein phosphatase 1 regulatory subunit 14B
Alternative name(s):
Phospholipase C-beta-3 neighbouring gene protein
Gene names
Name:PPP1R14B
Synonyms:PLCB3N, PNG
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated By similarity.

Subcellular location

Cytoplasm Probable.

Tissue specificity

Ubiquitous. Expressed at low levels. Ref.3

Post-translational modification

Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) By similarity.

Sequence similarities

Belongs to the PP1 inhibitor family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
   Molecular functionProtein phosphatase inhibitor
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processregulation of phosphorylation

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein phosphatase inhibitor activity

Inferred from electronic annotation. Source: UniProtKB-KW

protein phosphatase type 1 regulator activity

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.6
Chain2 – 147146Protein phosphatase 1 regulatory subunit 14B
PRO_0000071490

Regions

Coiled coil61 – 10343 Potential

Amino acid modifications

Modified residue21N-acetylalanine Ref.6 Ref.10 Ref.11
Modified residue321Phosphoserine Ref.4 Ref.5 Ref.8
Modified residue571Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q96C90 [UniParc].

Last modified November 9, 2004. Version 3.
Checksum: 2932A4EA9F312451

FASTA14715,911
        10         20         30         40         50         60 
MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV RRQGKVTVKY 

        70         80         90        100        110        120 
DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL LDMESDDARA ARVKELLVDC 

       130        140 
YKPTEAFISG LLDKIRGMQK LSTPQKK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[3]"Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13."
Lagercrantz J., Carson E., Larsson C., Nordenskjoeld M., Weber G.
Genomics 31:380-384(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[4]"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[11]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BT009914 mRNA. Translation: AAP88916.1.
BC014522 mRNA. Translation: AAH14522.3.
BC094817 mRNA. Translation: AAH94817.1.
RefSeqNP_619634.1. NM_138689.2.
UniGeneHs.523760.
Hs.596713.

3D structure databases

ProteinModelPortalQ96C90.
SMRQ96C90. Positions 55-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117696. 4 interactions.
IntActQ96C90. 2 interactions.
MINTMINT-3051633.
STRING9606.ENSP00000310117.

PTM databases

PhosphoSiteQ96C90.

Polymorphism databases

DMDM55583975.

Proteomic databases

PaxDbQ96C90.
PRIDEQ96C90.

Protocols and materials databases

DNASU26472.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309318; ENSP00000310117; ENSG00000173457.
GeneID26472.
KEGGhsa:26472.
UCSCuc001nza.3. human.

Organism-specific databases

CTD26472.
GeneCardsGC11M064011.
HGNCHGNC:9057. PPP1R14B.
MIM601140. gene.
neXtProtNX_Q96C90.
PharmGKBPA33624.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG124396.
HOGENOMHOG000231993.
HOVERGENHBG054419.
InParanoidQ96C90.
KOK17555.
OMANLEEWII.
PhylomeDBQ96C90.
TreeFamTF105546.

Gene expression databases

BgeeQ96C90.
CleanExHS_PPP1R14B.
GenevestigatorQ96C90.

Family and domain databases

Gene3D1.10.150.220. 1 hit.
InterProIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERPTHR16188. PTHR16188. 1 hit.
PfamPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMSSF81790. SSF81790. 1 hit.
ProtoNetSearch...

Other

GeneWikiPPP1R14B.
GenomeRNAi26472.
NextBio48728.
PROQ96C90.
SOURCESearch...

Entry information

Entry namePP14B_HUMAN
AccessionPrimary (citable) accession number: Q96C90
Secondary accession number(s): Q504S7, Q7KZD7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: April 16, 2014
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM