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Q96C90

- PP14B_HUMAN

UniProt

Q96C90 - PP14B_HUMAN

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Protein

Protein phosphatase 1 regulatory subunit 14B

Gene
PPP1R14B, PLCB3N, PNG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated By similarity.

GO - Molecular functioni

  1. protein phosphatase inhibitor activity Source: UniProtKB-KW

GO - Biological processi

  1. regulation of phosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14B
Alternative name(s):
Phospholipase C-beta-3 neighbouring gene protein
Gene namesi
Synonyms:PLCB3N, PNG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9057. PPP1R14B.

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33624.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 147146Protein phosphatase 1 regulatory subunit 14BPRO_0000071490Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications
Modified residuei32 – 321Phosphoserine3 Publications
Modified residuei57 – 571Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) By similarity.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96C90.
PaxDbiQ96C90.
PRIDEiQ96C90.

PTM databases

PhosphoSiteiQ96C90.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at low levels.1 Publication

Gene expression databases

BgeeiQ96C90.
CleanExiHS_PPP1R14B.
GenevestigatoriQ96C90.

Interactioni

Protein-protein interaction databases

BioGridi117696. 4 interactions.
IntActiQ96C90. 2 interactions.
MINTiMINT-3051633.
STRINGi9606.ENSP00000310117.

Structurei

3D structure databases

ProteinModelPortaliQ96C90.
SMRiQ96C90. Positions 55-140.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili61 – 10343 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the PP1 inhibitor family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG124396.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ96C90.
KOiK17555.
OMAiNLEEWII.
PhylomeDBiQ96C90.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96C90-1 [UniParc]FASTAAdd to Basket

« Hide

MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV    50
RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL 100
LDMESDDARA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK 147
Length:147
Mass (Da):15,911
Last modified:November 9, 2004 - v3
Checksum:i2932A4EA9F312451
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT009914 mRNA. Translation: AAP88916.1.
BC014522 mRNA. Translation: AAH14522.3.
BC094817 mRNA. Translation: AAH94817.1.
CCDSiCCDS31596.1.
RefSeqiNP_619634.1. NM_138689.2.
UniGeneiHs.523760.
Hs.596713.

Genome annotation databases

EnsembliENST00000309318; ENSP00000310117; ENSG00000173457.
GeneIDi26472.
KEGGihsa:26472.
UCSCiuc001nza.3. human.

Polymorphism databases

DMDMi55583975.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BT009914 mRNA. Translation: AAP88916.1 .
BC014522 mRNA. Translation: AAH14522.3 .
BC094817 mRNA. Translation: AAH94817.1 .
CCDSi CCDS31596.1.
RefSeqi NP_619634.1. NM_138689.2.
UniGenei Hs.523760.
Hs.596713.

3D structure databases

ProteinModelPortali Q96C90.
SMRi Q96C90. Positions 55-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117696. 4 interactions.
IntActi Q96C90. 2 interactions.
MINTi MINT-3051633.
STRINGi 9606.ENSP00000310117.

PTM databases

PhosphoSitei Q96C90.

Polymorphism databases

DMDMi 55583975.

Proteomic databases

MaxQBi Q96C90.
PaxDbi Q96C90.
PRIDEi Q96C90.

Protocols and materials databases

DNASUi 26472.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309318 ; ENSP00000310117 ; ENSG00000173457 .
GeneIDi 26472.
KEGGi hsa:26472.
UCSCi uc001nza.3. human.

Organism-specific databases

CTDi 26472.
GeneCardsi GC11M064011.
HGNCi HGNC:9057. PPP1R14B.
MIMi 601140. gene.
neXtProti NX_Q96C90.
PharmGKBi PA33624.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG124396.
HOGENOMi HOG000231993.
HOVERGENi HBG054419.
InParanoidi Q96C90.
KOi K17555.
OMAi NLEEWII.
PhylomeDBi Q96C90.
TreeFami TF105546.

Miscellaneous databases

GeneWikii PPP1R14B.
GenomeRNAii 26472.
NextBioi 48728.
PROi Q96C90.
SOURCEi Search...

Gene expression databases

Bgeei Q96C90.
CleanExi HS_PPP1R14B.
Genevestigatori Q96C90.

Family and domain databases

Gene3Di 1.10.150.220. 1 hit.
InterProi IPR008025. PP1_inhibitor.
[Graphical view ]
PANTHERi PTHR16188. PTHR16188. 1 hit.
Pfami PF05361. PP1_inhibitor. 1 hit.
[Graphical view ]
SUPFAMi SSF81790. SSF81790. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. "Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13."
    Lagercrantz J., Carson E., Larsson C., Nordenskjoeld M., Weber G.
    Genomics 31:380-384(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-32, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPP14B_HUMAN
AccessioniPrimary (citable) accession number: Q96C90
Secondary accession number(s): Q504S7, Q7KZD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: July 9, 2014
This is version 106 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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