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Protein

Protein phosphatase 1 regulatory subunit 14B

Gene

PPP1R14B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein phosphatase inhibitor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173457-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14B
Alternative name(s):
Phospholipase C-beta-3 neighbouring gene protein
Gene namesi
Name:PPP1R14B
Synonyms:PLCB3N, PNG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9057. PPP1R14B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi26472.
OpenTargetsiENSG00000173457.
PharmGKBiPA33624.

Polymorphism and mutation databases

BioMutaiPPP1R14B.
DMDMi55583975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000714902 – 147Protein phosphatase 1 regulatory subunit 14BAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei21PhosphoserineCombined sources1
Modified residuei29PhosphotyrosineCombined sources1
Modified residuei32PhosphoserineCombined sources1
Modified residuei57PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ96C90.
MaxQBiQ96C90.
PaxDbiQ96C90.
PeptideAtlasiQ96C90.
PRIDEiQ96C90.
TopDownProteomicsiQ96C90.

PTM databases

iPTMnetiQ96C90.
PhosphoSitePlusiQ96C90.

Expressioni

Tissue specificityi

Ubiquitous. Expressed at low levels.1 Publication

Gene expression databases

BgeeiENSG00000173457.
CleanExiHS_PPP1R14B.
ExpressionAtlasiQ96C90. baseline and differential.
GenevisibleiQ96C90. HS.

Organism-specific databases

HPAiHPA053882.

Interactioni

Protein-protein interaction databases

BioGridi117696. 8 interactors.
IntActiQ96C90. 2 interactors.
MINTiMINT-3051633.
STRINGi9606.ENSP00000310117.

Structurei

3D structure databases

ProteinModelPortaliQ96C90.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili61 – 103Sequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ96C90.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG091G122D.
PhylomeDBiQ96C90.
TreeFamiTF105546.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96C90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSGTAGGA ALAAPAPGPG SGGPGPRVYF QSPPGAAGEG PGGADDEGPV
60 70 80 90 100
RRQGKVTVKY DRKELRKRLN LEEWILEQLT RLYDCQEEEI PELEIDVDEL
110 120 130 140
LDMESDDARA ARVKELLVDC YKPTEAFISG LLDKIRGMQK LSTPQKK
Length:147
Mass (Da):15,911
Last modified:November 9, 2004 - v3
Checksum:i2932A4EA9F312451
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009914 mRNA. Translation: AAP88916.1.
BC014522 mRNA. Translation: AAH14522.3.
BC094817 mRNA. Translation: AAH94817.1.
CCDSiCCDS31596.1.
RefSeqiNP_619634.1. NM_138689.2.
UniGeneiHs.523760.
Hs.596713.

Genome annotation databases

EnsembliENST00000309318; ENSP00000310117; ENSG00000173457.
GeneIDi26472.
KEGGihsa:26472.
UCSCiuc001nza.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BT009914 mRNA. Translation: AAP88916.1.
BC014522 mRNA. Translation: AAH14522.3.
BC094817 mRNA. Translation: AAH94817.1.
CCDSiCCDS31596.1.
RefSeqiNP_619634.1. NM_138689.2.
UniGeneiHs.523760.
Hs.596713.

3D structure databases

ProteinModelPortaliQ96C90.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117696. 8 interactors.
IntActiQ96C90. 2 interactors.
MINTiMINT-3051633.
STRINGi9606.ENSP00000310117.

PTM databases

iPTMnetiQ96C90.
PhosphoSitePlusiQ96C90.

Polymorphism and mutation databases

BioMutaiPPP1R14B.
DMDMi55583975.

Proteomic databases

EPDiQ96C90.
MaxQBiQ96C90.
PaxDbiQ96C90.
PeptideAtlasiQ96C90.
PRIDEiQ96C90.
TopDownProteomicsiQ96C90.

Protocols and materials databases

DNASUi26472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309318; ENSP00000310117; ENSG00000173457.
GeneIDi26472.
KEGGihsa:26472.
UCSCiuc001nza.4. human.

Organism-specific databases

CTDi26472.
DisGeNETi26472.
GeneCardsiPPP1R14B.
HGNCiHGNC:9057. PPP1R14B.
HPAiHPA053882.
MIMi601140. gene.
neXtProtiNX_Q96C90.
OpenTargetsiENSG00000173457.
PharmGKBiPA33624.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZK. Eukaryota.
ENOG4111NI3. LUCA.
GeneTreeiENSGT00390000003608.
HOGENOMiHOG000231993.
HOVERGENiHBG054419.
InParanoidiQ96C90.
KOiK17555.
OMAiCEEEAIP.
OrthoDBiEOG091G122D.
PhylomeDBiQ96C90.
TreeFamiTF105546.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173457-MONOMER.

Miscellaneous databases

GeneWikiiPPP1R14B.
GenomeRNAii26472.
PROiQ96C90.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173457.
CleanExiHS_PPP1R14B.
ExpressionAtlasiQ96C90. baseline and differential.
GenevisibleiQ96C90. HS.

Family and domain databases

Gene3Di1.10.150.220. 1 hit.
InterProiIPR008025. PP1_inhibitor.
[Graphical view]
PANTHERiPTHR16188. PTHR16188. 1 hit.
PfamiPF05361. PP1_inhibitor. 1 hit.
[Graphical view]
SUPFAMiSSF81790. SSF81790. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPP14B_HUMAN
AccessioniPrimary (citable) accession number: Q96C90
Secondary accession number(s): Q504S7, Q7KZD7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: November 30, 2016
This is version 127 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.