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Protein

Ropporin-1-like protein

Gene

ROPN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA-dependent signaling processes required for spermatozoa capacitation.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1-like protein
Short name:
ROPN1-like protein
Alternative name(s):
AKAP-associated sperm protein
Gene namesi
Name:ROPN1L
Synonyms:ASP, RSPH111 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000145491.11
HGNCiHGNC:24060 ROPN1L
MIMi611756 gene
neXtProtiNX_Q96C74

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium, Flagellum

Pathology & Biotechi

Organism-specific databases

DisGeNETi83853
OpenTargetsiENSG00000145491
PharmGKBiPA134956127

Polymorphism and mutation databases

BioMutaiROPN1L
DMDMi296452880

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073981 – 230Ropporin-1-like proteinAdd BLAST230

Post-translational modificationi

Sumoylated, sumoylation decreases upon spermatozoa capacitation conditions.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ96C74
MaxQBiQ96C74
PaxDbiQ96C74
PeptideAtlasiQ96C74
PRIDEiQ96C74

PTM databases

PhosphoSitePlusiQ96C74

Expressioni

Gene expression databases

BgeeiENSG00000145491
CleanExiHS_ROPN1L
GenevisibleiQ96C74 HS

Organism-specific databases

HPAiHPA039193
HPA041830

Interactioni

Subunit structurei

May interact with AKAP3 (PubMed:11278869). Interacts with FSCB; the interaction increases upon spermatozoa capacitation conditions (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RSPH3Q86UC25EBI-9033237,EBI-6873025

Protein-protein interaction databases

BioGridi123769, 6 interactors
IntActiQ96C74, 4 interactors
STRINGi9606.ENSP00000274134

Structurei

3D structure databases

ProteinModelPortaliQ96C74
SMRiQ96C74
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 46RIIaAdd BLAST30

Sequence similaritiesi

Belongs to the ropporin family.Curated

Phylogenomic databases

eggNOGiENOG410IRZH Eukaryota
ENOG410Y08Y LUCA
GeneTreeiENSGT00390000012731
HOGENOMiHOG000006862
HOVERGENiHBG060390
InParanoidiQ96C74
OMAiKDRMEMP
OrthoDBiEOG091G0LKF
PhylomeDBiQ96C74
TreeFamiTF105421

Sequencei

Sequence statusi: Complete.

Q96C74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLR WSAGYFSALS
60 70 80 90 100
RGDPLPVKDR MEMPTATQKT DTGLTQGLLK VLHKQCHHKR YVELTDLEQK
110 120 130 140 150
WKNLCLPKEK FKALLQLDPC ENKIKWINFL ALGCSMLGGS LNTALKHLCE
160 170 180 190 200
ILTDDPEGGP ARIPFKTFSY VYRYLARLDS DVSPLETESY LASLKENIDA
210 220 230
RKNGMIGLSD FFFPKRKLLE SIENSEDVGH
Length:230
Mass (Da):26,107
Last modified:May 18, 2010 - v2
Checksum:i5692E967769E8D45
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035442103N → K. Corresponds to variant dbSNP:rs35573613Ensembl.1
Natural variantiVAR_057789113A → V. Corresponds to variant dbSNP:rs2303986Ensembl.1
Natural variantiVAR_035443156P → R1 PublicationCorresponds to variant dbSNP:rs17851209Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239723 mRNA Translation: AAG59587.1
AC092336 Genomic DNA No translation available.
CH471102 Genomic DNA Translation: EAX08063.1
CH471102 Genomic DNA Translation: EAX08064.1
BC014607 mRNA Translation: AAH14607.1
CCDSiCCDS3879.1
RefSeqiNP_001188395.1, NM_001201466.1
NP_114122.2, NM_031916.4
UniGeneiHs.381089

Genome annotation databases

EnsembliENST00000274134; ENSP00000274134; ENSG00000145491
ENST00000503804; ENSP00000421405; ENSG00000145491
GeneIDi83853
KEGGihsa:83853
UCSCiuc003jex.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiROP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96C74
Secondary accession number(s): D3DTC9, Q9BZX0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: May 23, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health