Q96C74 (ROP1L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ropporin-1-like protein
Short name=ROPN1-like protein

Alternative name(s):
AKAP-associated sperm protein

Gene names

Name:	ROPN1L
Synonyms:	ASP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	May interact with AKAP3.
Sequence similarities	Belongs to the ropporin family. Contains 1 RIIa domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ciliary or flagellar motility Inferred from direct assay. Source: BHF-UCL signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from direct assay. Source: BHF-UCL motile cilium Inferred from direct assay. Source: BHF-UCL
Molecular function	cAMP-dependent protein kinase regulator activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: BHF-UCL
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Ropporin-1-like protein		PRO_0000307398
Regions
	Domain	17 – 46	30	RIIa
Natural variations
	Natural variant	103	1	N → K. Corresponds to variant rs35573613 [ dbSNP | Ensembl ].		VAR_035442
	Natural variant	113	1	A → V. Corresponds to variant rs2303986 [ dbSNP | Ensembl ].		VAR_057789
	Natural variant	156	1	P → R. Ref.4 Corresponds to variant rs17851209 [ dbSNP | Ensembl ].		VAR_035443

Sequences

	Sequence		Length	Mass (Da)
	Q96C74 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 5692E967769E8D45	FASTA	230	26,107
	10 20 30 40 50 60 MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLR WSAGYFSALS RGDPLPVKDR 70 80 90 100 110 120 MEMPTATQKT DTGLTQGLLK VLHKQCHHKR YVELTDLEQK WKNLCLPKEK FKALLQLDPC 130 140 150 160 170 180 ENKIKWINFL ALGCSMLGGS LNTALKHLCE ILTDDPEGGP ARIPFKTFSY VYRYLARLDS 190 200 210 220 230 DVSPLETESY LASLKENIDA RKNGMIGLSD FFFPKRKLLE SIENSEDVGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA." Carr D.W., Fujita A., Stentz C.L., Liberty G.A., Olson G.E., Narumiya S. J. Biol. Chem. 276:17332-17338(2001) [PubMed: 11278869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE INTERACTION WITH AKAP3. Tissue: Testis.
[2]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed: 15372022] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-156. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF239723 mRNA. Translation: AAG59587.1. AC092336 Genomic DNA. No translation available. CH471102 Genomic DNA. Translation: EAX08063.1. CH471102 Genomic DNA. Translation: EAX08064.1. BC014607 mRNA. Translation: AAH14607.1.
IPI	IPI00303831.
RefSeq	NP_001188395.1. NM_001201466.1. NP_114122.2. NM_031916.4.
UniGene	Hs.381089.
3D structure databases
ProteinModelPortal	Q96C74.
SMR	Q96C74. Positions 13-52.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96C74.
Polymorphism databases
DMDM	296452880.
Proteomic databases
PRIDE	Q96C74.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000274134; ENSP00000274134; ENSG00000145491.
GeneID	83853.
KEGG	hsa:83853.
UCSC	uc003jex.2. human.
Organism-specific databases
CTD	83853.
GeneCards	GC05P010441.
HGNC	HGNC:24060. ROPN1L.
HPA	HPA039193.
MIM	611756. gene.
neXtProt	NX_Q96C74.
PharmGKB	PA134956127.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14316.
GeneTree	ENSGT00390000012731.
HOGENOM	HBG715724.
HOVERGEN	HBG060390.
InParanoid	Q96C74.
OMA	FSYVYRY.
OrthoDB	EOG4N04FR.
PhylomeDB	Q96C74.
Gene expression databases
ArrayExpress	Q96C74.
Bgee	Q96C74.
CleanEx	HS_ROPN1L.
Genevestigator	Q96C74.
Family and domain databases
InterPro	IPR003117. cAMP_dep_PK_reg_su_I/II_a/b. [Graphical view]
SUPFAM	SSF47391. cAMP-dep_prot_kin_reg_I/II_a/b. 1 hit.
ProtoNet	Search...
Other
NextBio	72835.
SOURCE	Search...

Entry information

Entry name

ROP1L_HUMAN

Accession

Primary (citable) accession number: Q96C74
Secondary accession number(s): D3DTC9, Q9BZX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	May 18, 2010
Last modified:	December 14, 2011
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.