Reviewed, UniProtKB/Swiss-Prot Q96C74 (ROP1L_HUMAN)

Names and origin

Protein names

Recommended name:
    Ropporin-1-like protein
      Short name=ROPN1-like protein
Alternative name(s):
    AKAP-associated sperm protein

Gene names

Name:	ROPN1L
Synonyms:	ASP

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	230 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	May interact with AKAP3.
Sequence similarities	Belongs to the ropporin family. Contains 1 RIIa domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Molecular function	cAMP-dependent protein kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 230	230	Ropporin-1-like protein		PRO_0000307398
Regions
	Domain	17 – 46	30	RIIa
Natural variations
	Natural variant	103	1	N → K: dbSNP rs35573613.		VAR_035442
	Natural variant	113	1	A → V: dbSNP rs2303986.		VAR_057789
	Natural variant	156	1	R → P: dbSNP rs17851209. Ref.1		VAR_035443

Sequences

	Sequence		Length	Mass (Da)
	Q96C74-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 5692EBEFFC9C05CF	FASTA	230	26,166
	10 20 30 40 50 60 MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLR WSAGYFSALS RGDPLPVKDR 70 80 90 100 110 120 MEMPTATQKT DTGLTQGLLK VLHKQCHHKR YVELTDLEQK WKNLCLPKEK FKALLQLDPC 130 140 150 160 170 180 ENKIKWINFL ALGCSMLGGS LNTALKHLCE ILTDDREGGP ARIPFKTFSY VYRYLARLDS 190 200 210 220 230 DVSPLETESY LASLKENIDA RKNGMIGLSD FFFPKRKLLE SIENSEDVGH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA." Carr D.W., Fujita A., Stentz C.L., Liberty G.A., Olson G.E., Narumiya S. J. Biol. Chem. 276:17332-17338(2001) [PubMed: 11278869] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], POSSIBLE INTERACTION WITH AKAP3, VARIANT PRO-156. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF239723 mRNA. Translation: AAG59587.1. BC014607 mRNA. Translation: AAH14607.1.
IPI	IPI00303831.
RefSeq	NP_114122.2.
UniGene	Hs.381089
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000145491. Homo sapiens. [Contig view]
GeneID	83853.
KEGG	hsa:83853.
Organism-specific databases
GeneCards	GC05P010495.
HGNC	HGNC:24060. ROPN1L.
MIM	611756. gene.
PharmGKB	PA134956127.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q96C74.
HOVERGEN	Q96C74.
Gene expression databases
ArrayExpress	Q96C74.
Bgee	Q96C74.
CleanEx	HS_ROPN1L.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	72835.
SOURCE	Search...

Entry information

Entry name

ROP1L_HUMAN

Accession

Primary (citable) accession number: Q96C74
Secondary accession number(s): Q9BZX0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 23, 2007
Last sequence update:	December 1, 2001
Last modified:	May 26, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)