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Protein

Ropporin-1-like protein

Gene

ROPN1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • epithelial cilium movement Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145491-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ropporin-1-like protein
Short name:
ROPN1-like protein
Alternative name(s):
AKAP-associated sperm protein
Gene namesi
Name:ROPN1L
Synonyms:ASP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:24060. ROPN1L.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • motile cilium Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi83853.
OpenTargetsiENSG00000145491.
PharmGKBiPA134956127.

Polymorphism and mutation databases

BioMutaiROPN1L.
DMDMi296452880.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003073981 – 230Ropporin-1-like proteinAdd BLAST230

Proteomic databases

MaxQBiQ96C74.
PaxDbiQ96C74.
PeptideAtlasiQ96C74.
PRIDEiQ96C74.

PTM databases

PhosphoSitePlusiQ96C74.

Expressioni

Gene expression databases

BgeeiENSG00000145491.
CleanExiHS_ROPN1L.
GenevisibleiQ96C74. HS.

Organism-specific databases

HPAiHPA039193.
HPA041830.

Interactioni

Subunit structurei

May interact with AKAP3.

Binary interactionsi

WithEntry#Exp.IntActNotes
RSPH3Q86UC25EBI-9033237,EBI-6873025

Protein-protein interaction databases

BioGridi123769. 6 interactors.
IntActiQ96C74. 3 interactors.
STRINGi9606.ENSP00000274134.

Structurei

3D structure databases

ProteinModelPortaliQ96C74.
SMRiQ96C74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 46RIIaAdd BLAST30

Sequence similaritiesi

Belongs to the ropporin family.Curated
Contains 1 RIIa domain.Curated

Phylogenomic databases

eggNOGiENOG410IRZH. Eukaryota.
ENOG410Y08Y. LUCA.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ96C74.
OMAiKDRMEMP.
OrthoDBiEOG091G0LKF.
PhylomeDBiQ96C74.
TreeFamiTF105421.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96C74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPDTMFCA QQIHIPPELP DILKQFTKAA IRTQPADVLR WSAGYFSALS
60 70 80 90 100
RGDPLPVKDR MEMPTATQKT DTGLTQGLLK VLHKQCHHKR YVELTDLEQK
110 120 130 140 150
WKNLCLPKEK FKALLQLDPC ENKIKWINFL ALGCSMLGGS LNTALKHLCE
160 170 180 190 200
ILTDDPEGGP ARIPFKTFSY VYRYLARLDS DVSPLETESY LASLKENIDA
210 220 230
RKNGMIGLSD FFFPKRKLLE SIENSEDVGH
Length:230
Mass (Da):26,107
Last modified:May 18, 2010 - v2
Checksum:i5692E967769E8D45
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035442103N → K.Corresponds to variant rs35573613dbSNPEnsembl.1
Natural variantiVAR_057789113A → V.Corresponds to variant rs2303986dbSNPEnsembl.1
Natural variantiVAR_035443156P → R.1 PublicationCorresponds to variant rs17851209dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239723 mRNA. Translation: AAG59587.1.
AC092336 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08063.1.
CH471102 Genomic DNA. Translation: EAX08064.1.
BC014607 mRNA. Translation: AAH14607.1.
CCDSiCCDS3879.1.
RefSeqiNP_001188395.1. NM_001201466.1.
NP_114122.2. NM_031916.4.
UniGeneiHs.381089.

Genome annotation databases

EnsembliENST00000274134; ENSP00000274134; ENSG00000145491.
ENST00000503804; ENSP00000421405; ENSG00000145491.
GeneIDi83853.
KEGGihsa:83853.
UCSCiuc003jex.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF239723 mRNA. Translation: AAG59587.1.
AC092336 Genomic DNA. No translation available.
CH471102 Genomic DNA. Translation: EAX08063.1.
CH471102 Genomic DNA. Translation: EAX08064.1.
BC014607 mRNA. Translation: AAH14607.1.
CCDSiCCDS3879.1.
RefSeqiNP_001188395.1. NM_001201466.1.
NP_114122.2. NM_031916.4.
UniGeneiHs.381089.

3D structure databases

ProteinModelPortaliQ96C74.
SMRiQ96C74.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123769. 6 interactors.
IntActiQ96C74. 3 interactors.
STRINGi9606.ENSP00000274134.

PTM databases

PhosphoSitePlusiQ96C74.

Polymorphism and mutation databases

BioMutaiROPN1L.
DMDMi296452880.

Proteomic databases

MaxQBiQ96C74.
PaxDbiQ96C74.
PeptideAtlasiQ96C74.
PRIDEiQ96C74.

Protocols and materials databases

DNASUi83853.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274134; ENSP00000274134; ENSG00000145491.
ENST00000503804; ENSP00000421405; ENSG00000145491.
GeneIDi83853.
KEGGihsa:83853.
UCSCiuc003jex.5. human.

Organism-specific databases

CTDi83853.
DisGeNETi83853.
GeneCardsiROPN1L.
HGNCiHGNC:24060. ROPN1L.
HPAiHPA039193.
HPA041830.
MIMi611756. gene.
neXtProtiNX_Q96C74.
OpenTargetsiENSG00000145491.
PharmGKBiPA134956127.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IRZH. Eukaryota.
ENOG410Y08Y. LUCA.
GeneTreeiENSGT00390000012731.
HOGENOMiHOG000006862.
HOVERGENiHBG060390.
InParanoidiQ96C74.
OMAiKDRMEMP.
OrthoDBiEOG091G0LKF.
PhylomeDBiQ96C74.
TreeFamiTF105421.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000145491-MONOMER.

Miscellaneous databases

GenomeRNAii83853.
PROiQ96C74.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000145491.
CleanExiHS_ROPN1L.
GenevisibleiQ96C74. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiROP1L_HUMAN
AccessioniPrimary (citable) accession number: Q96C74
Secondary accession number(s): D3DTC9, Q9BZX0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.