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Protein

Uncharacterized protein C12orf43

Gene

C12orf43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157895-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C12orf43
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:25719. C12orf43.

Pathology & Biotechi

Organism-specific databases

DisGeNETi64897.
OpenTargetsiENSG00000157895.
PharmGKBiPA143485373.

Polymorphism and mutation databases

BioMutaiC12orf43.
DMDMi125863775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002768501 – 262Uncharacterized protein C12orf43Add BLAST262

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61PhosphoserineCombined sources1
Modified residuei79PhosphothreonineCombined sources1
Modified residuei138PhosphoserineCombined sources1
Modified residuei182PhosphothreonineCombined sources1
Modified residuei211PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96C57.
MaxQBiQ96C57.
PaxDbiQ96C57.
PeptideAtlasiQ96C57.
PRIDEiQ96C57.

PTM databases

iPTMnetiQ96C57.
PhosphoSitePlusiQ96C57.

Expressioni

Gene expression databases

BgeeiENSG00000157895.
CleanExiHS_C12orf43.
ExpressionAtlasiQ96C57. baseline and differential.
GenevisibleiQ96C57. HS.

Organism-specific databases

HPAiHPA046148.
HPA061739.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF1P542742EBI-11305571,EBI-710997

Protein-protein interaction databases

BioGridi122339. 16 interactors.
IntActiQ96C57. 2 interactors.
MINTiMINT-5009328.
STRINGi9606.ENSP00000288757.

Structurei

3D structure databases

ProteinModelPortaliQ96C57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi148 – 152Poly-Ser5
Compositional biasi186 – 244Lys-richAdd BLAST59

Phylogenomic databases

eggNOGiENOG410IYW6. Eukaryota.
ENOG410YR2K. LUCA.
GeneTreeiENSGT00390000010771.
HOGENOMiHOG000111759.
HOVERGENiHBG081238.
InParanoidiQ96C57.
PhylomeDBiQ96C57.
TreeFamiTF336221.

Family and domain databases

InterProiIPR026694. UPF_C12orf43.
[Graphical view]
PANTHERiPTHR14482. PTHR14482. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96C57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPSGTVSD SESSNSSSDA EELERCREAA MPAWGLEQRP HVAGKPRAGA
60 70 80 90 100
ANSQLSTSQP SLRHKVNEHE QDGNELQTTP EFRAHVAKKL GALLDSFITI
110 120 130 140 150
SEAAKEPAKA KVQKVALEDD GFRLFFTSVP GGREKEESPQ PRRKRQPSSS
160 170 180 190 200
SEDSDEEWRR CREAAVSASD ILQESAIHSP GTVEKEAKKK RKLKKKAKKV
210 220 230 240 250
ASVDSAVAAT TPTSMATVQK QKSGELNGDQ VSLGTKKKKK AKKASETSPF
260
PPAKSATAIP AN
Length:262
Mass (Da):28,171
Last modified:February 6, 2007 - v2
Checksum:i443F91BC023F0DC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → A in BAD96350 (Ref. 2) Curated1
Sequence conflicti151S → SS in AAH14661 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03049144G → R.Corresponds to variant rs11537857dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022510 mRNA. Translation: BAB14068.1.
AK222630 mRNA. Translation: BAD96350.1.
BC014661 mRNA. Translation: AAH14661.1.
CCDSiCCDS9210.1.
RefSeqiNP_001273120.1. NM_001286191.1.
NP_001273121.1. NM_001286192.1.
NP_001273124.1. NM_001286195.1.
NP_001273125.1. NM_001286196.1.
NP_001273126.1. NM_001286197.1.
NP_001273127.1. NM_001286198.1.
NP_075046.1. NM_022895.2.
UniGeneiHs.528671.

Genome annotation databases

EnsembliENST00000288757; ENSP00000288757; ENSG00000157895.
GeneIDi64897.
KEGGihsa:64897.
UCSCiuc001tzh.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022510 mRNA. Translation: BAB14068.1.
AK222630 mRNA. Translation: BAD96350.1.
BC014661 mRNA. Translation: AAH14661.1.
CCDSiCCDS9210.1.
RefSeqiNP_001273120.1. NM_001286191.1.
NP_001273121.1. NM_001286192.1.
NP_001273124.1. NM_001286195.1.
NP_001273125.1. NM_001286196.1.
NP_001273126.1. NM_001286197.1.
NP_001273127.1. NM_001286198.1.
NP_075046.1. NM_022895.2.
UniGeneiHs.528671.

3D structure databases

ProteinModelPortaliQ96C57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122339. 16 interactors.
IntActiQ96C57. 2 interactors.
MINTiMINT-5009328.
STRINGi9606.ENSP00000288757.

PTM databases

iPTMnetiQ96C57.
PhosphoSitePlusiQ96C57.

Polymorphism and mutation databases

BioMutaiC12orf43.
DMDMi125863775.

Proteomic databases

EPDiQ96C57.
MaxQBiQ96C57.
PaxDbiQ96C57.
PeptideAtlasiQ96C57.
PRIDEiQ96C57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000288757; ENSP00000288757; ENSG00000157895.
GeneIDi64897.
KEGGihsa:64897.
UCSCiuc001tzh.3. human.

Organism-specific databases

CTDi64897.
DisGeNETi64897.
GeneCardsiC12orf43.
H-InvDBHIX0011076.
HGNCiHGNC:25719. C12orf43.
HPAiHPA046148.
HPA061739.
neXtProtiNX_Q96C57.
OpenTargetsiENSG00000157895.
PharmGKBiPA143485373.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYW6. Eukaryota.
ENOG410YR2K. LUCA.
GeneTreeiENSGT00390000010771.
HOGENOMiHOG000111759.
HOVERGENiHBG081238.
InParanoidiQ96C57.
PhylomeDBiQ96C57.
TreeFamiTF336221.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157895-MONOMER.

Miscellaneous databases

GeneWikiiC12orf43.
GenomeRNAii64897.
PROiQ96C57.

Gene expression databases

BgeeiENSG00000157895.
CleanExiHS_C12orf43.
ExpressionAtlasiQ96C57. baseline and differential.
GenevisibleiQ96C57. HS.

Family and domain databases

InterProiIPR026694. UPF_C12orf43.
[Graphical view]
PANTHERiPTHR14482. PTHR14482. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCL043_HUMAN
AccessioniPrimary (citable) accession number: Q96C57
Secondary accession number(s): Q53HF0, Q9H9Z7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: February 6, 2007
Last modified: November 2, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.