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Protein

Zinc finger protein 524

Gene

ZNF524

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi51 – 63A.T hookAdd BLAST13
Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171443-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 524
Gene namesi
Name:ZNF524
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:28322. ZNF524.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171443.
PharmGKBiPA134981576.

Polymorphism and mutation databases

BioMutaiZNF524.
DMDMi74760750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002345791 – 264Zinc finger protein 524Add BLAST264

Proteomic databases

MaxQBiQ96C55.
PaxDbiQ96C55.
PeptideAtlasiQ96C55.
PRIDEiQ96C55.

PTM databases

iPTMnetiQ96C55.
PhosphoSitePlusiQ96C55.

Expressioni

Gene expression databases

BgeeiENSG00000171443.
CleanExiHS_ZNF524.
ExpressionAtlasiQ96C55. baseline and differential.
GenevisibleiQ96C55. HS.

Organism-specific databases

HPAiHPA050981.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ZC4H2Q9NQZ63EBI-10283126,EBI-747993

Protein-protein interaction databases

BioGridi127090. 9 interactors.
IntActiQ96C55. 10 interactors.
STRINGi9606.ENSP00000301073.

Structurei

3D structure databases

ProteinModelPortaliQ96C55.
SMRiQ96C55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 A.T hook DNA-binding domain.Curated
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri114 – 136C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri142 – 164C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri170 – 192C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri198 – 221C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ96C55.
OMAiPKSGQEP.
OrthoDBiEOG091G0MXV.
PhylomeDBiQ96C55.
TreeFamiTF338348.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPSPDPLP SPLPGEEEKP LALSPPVPRG RRGRRPGGAT SSNRTLKASL
60 70 80 90 100
PRKRGRPPKS GQEPPLVQVQ GVTAPVGSSG GSDLLLIDDQ GVPYTVSEGS
110 120 130 140 150
AAGPEGSGPR KAPHFCPVCL RAFPYLSDLE RHSISHSELK PHQCKVCGKT
160 170 180 190 200
FKRSSHLRRH CNIHAGLRPF RCPLCPRRFR EAGELAHHHR VHSGERPYQC
210 220 230 240 250
PICRLRFTEA NTLRRHAKRK HPEAMGVPLC APDPGSEPPW DEEGIPATAG
260
AEEEEETEGK GEPA
Length:264
Mass (Da):28,709
Last modified:December 1, 2001 - v1
Checksum:iB248388F26BBB487
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51P → H in AAH67748 (PubMed:15489334).Curated1
Sequence conflicti176P → T in AAH67748 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007396 mRNA. Translation: AAH07396.2.
BC014666 mRNA. Translation: AAH14666.1.
BC067748 mRNA. Translation: AAH67748.1.
CCDSiCCDS12929.1.
RefSeqiNP_694951.1. NM_153219.3.
UniGeneiHs.440291.

Genome annotation databases

EnsembliENST00000301073; ENSP00000301073; ENSG00000171443.
ENST00000591046; ENSP00000466907; ENSG00000171443.
GeneIDi147807.
KEGGihsa:147807.
UCSCiuc002qlk.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC007396 mRNA. Translation: AAH07396.2.
BC014666 mRNA. Translation: AAH14666.1.
BC067748 mRNA. Translation: AAH67748.1.
CCDSiCCDS12929.1.
RefSeqiNP_694951.1. NM_153219.3.
UniGeneiHs.440291.

3D structure databases

ProteinModelPortaliQ96C55.
SMRiQ96C55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127090. 9 interactors.
IntActiQ96C55. 10 interactors.
STRINGi9606.ENSP00000301073.

PTM databases

iPTMnetiQ96C55.
PhosphoSitePlusiQ96C55.

Polymorphism and mutation databases

BioMutaiZNF524.
DMDMi74760750.

Proteomic databases

MaxQBiQ96C55.
PaxDbiQ96C55.
PeptideAtlasiQ96C55.
PRIDEiQ96C55.

Protocols and materials databases

DNASUi147807.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301073; ENSP00000301073; ENSG00000171443.
ENST00000591046; ENSP00000466907; ENSG00000171443.
GeneIDi147807.
KEGGihsa:147807.
UCSCiuc002qlk.2. human.

Organism-specific databases

CTDi147807.
GeneCardsiZNF524.
HGNCiHGNC:28322. ZNF524.
HPAiHPA050981.
neXtProtiNX_Q96C55.
OpenTargetsiENSG00000171443.
PharmGKBiPA134981576.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129799.
HOGENOMiHOG000059663.
HOVERGENiHBG079385.
InParanoidiQ96C55.
OMAiPKSGQEP.
OrthoDBiEOG091G0MXV.
PhylomeDBiQ96C55.
TreeFamiTF338348.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171443-MONOMER.

Miscellaneous databases

GenomeRNAii147807.
PROiQ96C55.

Gene expression databases

BgeeiENSG00000171443.
CleanExiHS_ZNF524.
ExpressionAtlasiQ96C55. baseline and differential.
GenevisibleiQ96C55. HS.

Family and domain databases

Gene3Di3.30.160.60. 4 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN524_HUMAN
AccessioniPrimary (citable) accession number: Q96C55
Secondary accession number(s): Q6NW31, Q96IL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.