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Protein

Serine/threonine-protein kinase ULK4

Gene

ULK4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

GO - Biological processi

  • microtubule cytoskeleton organization Source: MGI
  • regulation of JNK cascade Source: MGI
  • regulation of MAPK cascade Source: MGI
  • regulation of neuron migration Source: MGI
  • regulation of neuron projection development Source: MGI
  • regulation of p38MAPK cascade Source: MGI
  • regulation of protein kinase C signaling Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS15628-MONOMER.
SignaLinkiQ96C45.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)
Alternative name(s):
Unc-51-like kinase 4
Gene namesi
Name:ULK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:15784. ULK4.

Pathology & Biotechi

Involvement in diseasei

Various anomalies in ULK4 gene have been reported for several cases of schizophrenia, schizophrenia plus bipolar disorder and autism. ULK4 gene has been proposed to be a rare susceptibility risk factor for a range of psychiatric diseases including schizophrenia.

Organism-specific databases

DisGeNETi54986.
OpenTargetsiENSG00000168038.
PharmGKBiPA134978836.

Polymorphism and mutation databases

BioMutaiULK4.
DMDMi118574241.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002601541 – 1275Serine/threonine-protein kinase ULK4Add BLAST1275

Proteomic databases

EPDiQ96C45.
PaxDbiQ96C45.
PeptideAtlasiQ96C45.
PRIDEiQ96C45.

PTM databases

iPTMnetiQ96C45.
PhosphoSitePlusiQ96C45.

Expressioni

Tissue specificityi

Expressed in the brain, mainly in postmitotic neurons, including GABAergic neurons, but not in astrocytes (at protein level).1 Publication

Inductioni

Up-regulated during neuronal differentiation of neuroblastoma cells treated with all-trans or 9-cis retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000168038.
CleanExiHS_ULK4.
ExpressionAtlasiQ96C45. baseline and differential.
GenevisibleiQ96C45. HS.

Organism-specific databases

HPAiHPA017930.

Interactioni

Protein-protein interaction databases

BioGridi120321. 5 interactors.
IntActiQ96C45. 1 interactor.
STRINGi9606.ENSP00000301831.

Structurei

3D structure databases

ProteinModelPortaliQ96C45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 280Protein kinasePROSITE-ProRule annotationAdd BLAST277
Repeati842 – 880HEAT 1Add BLAST39
Repeati926 – 964HEAT 2Add BLAST39
Repeati1025 – 1063HEAT 3Add BLAST39
Repeati1151 – 1189HEAT 4Add BLAST39
Repeati1213 – 1253HEAT 5Add BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1147 – 1150Poly-Leu4

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
Contains 5 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0597. Eukaryota.
ENOG410XRQ6. LUCA.
GeneTreeiENSGT00860000133711.
HOGENOMiHOG000007938.
HOVERGENiHBG094135.
InParanoidiQ96C45.
KOiK17545.
OMAiAKGHKSG.
OrthoDBiEOG091G02A0.
PhylomeDBiQ96C45.
TreeFamiTF332678.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT
60 70 80 90 100
REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE
110 120 130 140 150
FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL
160 170 180 190 200
EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS
210 220 230 240 250
DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS
260 270 280 290 300
SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR
310 320 330 340 350
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL
360 370 380 390 400
EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL
410 420 430 440 450
SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV
460 470 480 490 500
DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE
510 520 530 540 550
VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV
560 570 580 590 600
VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA
610 620 630 640 650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP
660 670 680 690 700
ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA
710 720 730 740 750
SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA
760 770 780 790 800
KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS
810 820 830 840 850
KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP
860 870 880 890 900
VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS
910 920 930 940 950
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF
960 970 980 990 1000
SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE
1010 1020 1030 1040 1050
PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT
1060 1070 1080 1090 1100
MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN
1110 1120 1130 1140 1150
NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL
1160 1170 1180 1190 1200
NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV
1210 1220 1230 1240 1250
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL
1260 1270
APGSGSFADS AVAPLALEIL QAVGH
Length:1,275
Mass (Da):142,442
Last modified:November 28, 2006 - v2
Checksum:iD3DB6795CEB1DC76
GO

Sequence cautioni

The sequence BAA91270 differs from that shown. Reason: Frameshift at position 489.Curated
The sequence BAG52707 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti388K → E in BAA91270 (PubMed:14702039).Curated1
Sequence conflicti553 – 580AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794 (PubMed:15489334).CuratedAdd BLAST28
Sequence conflicti732G → V in BAA91270 (PubMed:14702039).Curated1
Sequence conflicti1024R → S in AAH40739 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04128618V → A.1 PublicationCorresponds to variant rs34538622dbSNPEnsembl.1
Natural variantiVAR_04128739K → R.1 PublicationCorresponds to variant rs2272007dbSNPEnsembl.1
Natural variantiVAR_041288139N → K.1 PublicationCorresponds to variant rs35833603dbSNPEnsembl.1
Natural variantiVAR_041289223S → N.1 PublicationCorresponds to variant rs55840267dbSNPEnsembl.1
Natural variantiVAR_051679224I → V.Corresponds to variant rs1716975dbSNPEnsembl.1
Natural variantiVAR_041290348S → G.2 PublicationsCorresponds to variant rs35263917dbSNPEnsembl.1
Natural variantiVAR_041291415T → M.1 PublicationCorresponds to variant rs371185820dbSNPEnsembl.1
Natural variantiVAR_041292417S → P.1 PublicationCorresponds to variant rs75907560dbSNPEnsembl.1
Natural variantiVAR_029005542A → T.Corresponds to variant rs1052501dbSNPEnsembl.1
Natural variantiVAR_029006569K → R.Corresponds to variant rs3774372dbSNPEnsembl.1
Natural variantiVAR_029007603L → S.Corresponds to variant rs17063572dbSNPEnsembl.1
Natural variantiVAR_029008640S → A.Corresponds to variant rs4973986dbSNPEnsembl.1
Natural variantiVAR_029009715A → T.Corresponds to variant rs17215589dbSNPEnsembl.1
Natural variantiVAR_0597721260S → N.Corresponds to variant rs12488691dbSNPEnsembl.1
Natural variantiVAR_0516801261A → V.Corresponds to variant rs6769117dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000581 mRNA. Translation: BAA91270.1. Frameshift.
AK093396 mRNA. Translation: BAG52707.1. Different initiation.
AK304341 mRNA. Translation: BAG65186.1.
AC104305 Genomic DNA. No translation available.
BC014794 mRNA. Translation: AAH14794.1.
BC040739 mRNA. Translation: AAH40739.1.
AL133104 mRNA. Translation: CAB61411.1.
CCDSiCCDS43071.1.
PIRiT42683.
RefSeqiNP_060356.2. NM_017886.3.
UniGeneiHs.656192.

Genome annotation databases

EnsembliENST00000301831; ENSP00000301831; ENSG00000168038.
GeneIDi54986.
KEGGihsa:54986.
UCSCiuc003ckv.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK000581 mRNA. Translation: BAA91270.1. Frameshift.
AK093396 mRNA. Translation: BAG52707.1. Different initiation.
AK304341 mRNA. Translation: BAG65186.1.
AC104305 Genomic DNA. No translation available.
BC014794 mRNA. Translation: AAH14794.1.
BC040739 mRNA. Translation: AAH40739.1.
AL133104 mRNA. Translation: CAB61411.1.
CCDSiCCDS43071.1.
PIRiT42683.
RefSeqiNP_060356.2. NM_017886.3.
UniGeneiHs.656192.

3D structure databases

ProteinModelPortaliQ96C45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120321. 5 interactors.
IntActiQ96C45. 1 interactor.
STRINGi9606.ENSP00000301831.

PTM databases

iPTMnetiQ96C45.
PhosphoSitePlusiQ96C45.

Polymorphism and mutation databases

BioMutaiULK4.
DMDMi118574241.

Proteomic databases

EPDiQ96C45.
PaxDbiQ96C45.
PeptideAtlasiQ96C45.
PRIDEiQ96C45.

Protocols and materials databases

DNASUi54986.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301831; ENSP00000301831; ENSG00000168038.
GeneIDi54986.
KEGGihsa:54986.
UCSCiuc003ckv.5. human.

Organism-specific databases

CTDi54986.
DisGeNETi54986.
GeneCardsiULK4.
H-InvDBHIX0021423.
HIX0038398.
HGNCiHGNC:15784. ULK4.
HPAiHPA017930.
MIMi617010. gene.
neXtProtiNX_Q96C45.
OpenTargetsiENSG00000168038.
PharmGKBiPA134978836.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0597. Eukaryota.
ENOG410XRQ6. LUCA.
GeneTreeiENSGT00860000133711.
HOGENOMiHOG000007938.
HOVERGENiHBG094135.
InParanoidiQ96C45.
KOiK17545.
OMAiAKGHKSG.
OrthoDBiEOG091G02A0.
PhylomeDBiQ96C45.
TreeFamiTF332678.

Enzyme and pathway databases

BioCyciZFISH:HS15628-MONOMER.
SignaLinkiQ96C45.

Miscellaneous databases

ChiTaRSiULK4. human.
GenomeRNAii54986.
PROiQ96C45.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168038.
CleanExiHS_ULK4.
ExpressionAtlasiQ96C45. baseline and differential.
GenevisibleiQ96C45. HS.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiULK4_HUMAN
AccessioniPrimary (citable) accession number: Q96C45
Secondary accession number(s): A6NF15
, B3KSE5, B4E2M4, Q8IW79, Q9NWV6, Q9UF96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: November 30, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.