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Q96C45

- ULK4_HUMAN

UniProt

Q96C45 - ULK4_HUMAN

Protein

Serine/threonine-protein kinase ULK4

Gene

ULK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. cilium morphogenesis Source: Ensembl
    2. epithelial cilium movement Source: Ensembl
    3. ventricular system development Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ96C45.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)
    Alternative name(s):
    Unc-51-like kinase 4
    Gene namesi
    Name:ULK4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:15784. ULK4.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134978836.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12751275Serine/threonine-protein kinase ULK4PRO_0000260154Add
    BLAST

    Proteomic databases

    MaxQBiQ96C45.
    PaxDbiQ96C45.
    PRIDEiQ96C45.

    PTM databases

    PhosphoSiteiQ96C45.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96C45.
    BgeeiQ96C45.
    CleanExiHS_ULK4.
    GenevestigatoriQ96C45.

    Organism-specific databases

    HPAiHPA017930.

    Interactioni

    Protein-protein interaction databases

    BioGridi120321. 5 interactions.
    IntActiQ96C45. 1 interaction.
    STRINGi9606.ENSP00000301831.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96C45.
    SMRiQ96C45. Positions 1-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 280277Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Repeati842 – 88039HEAT 1Add
    BLAST
    Repeati926 – 96439HEAT 2Add
    BLAST
    Repeati1025 – 106339HEAT 3Add
    BLAST
    Repeati1151 – 118939HEAT 4Add
    BLAST
    Repeati1213 – 125341HEAT 5Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1147 – 11504Poly-Leu

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
    Contains 5 HEAT repeats.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000007938.
    HOVERGENiHBG094135.
    InParanoidiQ96C45.
    KOiK17545.
    OMAiLQHPFWK.
    OrthoDBiEOG7KWSGS.
    PhylomeDBiQ96C45.
    TreeFamiTF332678.

    Family and domain databases

    Gene3Di1.25.10.10. 3 hits.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 3 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96C45-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT     50
    REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE 100
    FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL 150
    EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS 200
    DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS 250
    SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 300
    NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL 350
    EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL 400
    SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV 450
    DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE 500
    VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV 550
    VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA 600
    VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP 650
    ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA 700
    SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA 750
    KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS 800
    KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP 850
    VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS 900
    EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF 950
    SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE 1000
    PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT 1050
    MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN 1100
    NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL 1150
    NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV 1200
    EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL 1250
    APGSGSFADS AVAPLALEIL QAVGH 1275
    Length:1,275
    Mass (Da):142,442
    Last modified:November 28, 2006 - v2
    Checksum:iD3DB6795CEB1DC76
    GO

    Sequence cautioni

    The sequence BAA91270.1 differs from that shown. Reason: Frameshift at position 489.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti388 – 3881K → E in BAA91270. (PubMed:14702039)Curated
    Sequence conflicti553 – 58028AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794. (PubMed:15489334)CuratedAdd
    BLAST
    Sequence conflicti732 – 7321G → V in BAA91270. (PubMed:14702039)Curated
    Sequence conflicti1024 – 10241R → S in AAH40739. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181V → A.1 Publication
    Corresponds to variant rs34538622 [ dbSNP | Ensembl ].
    VAR_041286
    Natural varianti39 – 391K → R.1 Publication
    Corresponds to variant rs2272007 [ dbSNP | Ensembl ].
    VAR_041287
    Natural varianti139 – 1391N → K.1 Publication
    Corresponds to variant rs35833603 [ dbSNP | Ensembl ].
    VAR_041288
    Natural varianti223 – 2231S → N.1 Publication
    Corresponds to variant rs55840267 [ dbSNP | Ensembl ].
    VAR_041289
    Natural varianti224 – 2241I → V.
    Corresponds to variant rs1716975 [ dbSNP | Ensembl ].
    VAR_051679
    Natural varianti348 – 3481S → G.2 Publications
    Corresponds to variant rs35263917 [ dbSNP | Ensembl ].
    VAR_041290
    Natural varianti415 – 4151T → M.1 Publication
    VAR_041291
    Natural varianti417 – 4171S → P.1 Publication
    VAR_041292
    Natural varianti542 – 5421A → T.
    Corresponds to variant rs1052501 [ dbSNP | Ensembl ].
    VAR_029005
    Natural varianti569 – 5691K → R.
    Corresponds to variant rs3774372 [ dbSNP | Ensembl ].
    VAR_029006
    Natural varianti603 – 6031L → S.
    Corresponds to variant rs17063572 [ dbSNP | Ensembl ].
    VAR_029007
    Natural varianti640 – 6401S → A.
    Corresponds to variant rs4973986 [ dbSNP | Ensembl ].
    VAR_029008
    Natural varianti715 – 7151A → T.
    Corresponds to variant rs17215589 [ dbSNP | Ensembl ].
    VAR_029009
    Natural varianti1260 – 12601S → N.
    Corresponds to variant rs12488691 [ dbSNP | Ensembl ].
    VAR_059772
    Natural varianti1261 – 12611A → V.
    Corresponds to variant rs6769117 [ dbSNP | Ensembl ].
    VAR_051680

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104305 Genomic DNA. No translation available.
    AK000581 mRNA. Translation: BAA91270.1. Frameshift.
    BC014794 mRNA. Translation: AAH14794.1.
    BC040739 mRNA. Translation: AAH40739.1.
    AL133104 mRNA. Translation: CAB61411.1.
    CCDSiCCDS43071.1.
    PIRiT42683.
    RefSeqiNP_060356.2. NM_017886.2.
    UniGeneiHs.656192.

    Genome annotation databases

    EnsembliENST00000301831; ENSP00000301831; ENSG00000168038.
    ENST00000420927; ENSP00000412187; ENSG00000168038.
    GeneIDi54986.
    KEGGihsa:54986.
    UCSCiuc003ckv.4. human.

    Polymorphism databases

    DMDMi118574241.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC104305 Genomic DNA. No translation available.
    AK000581 mRNA. Translation: BAA91270.1 . Frameshift.
    BC014794 mRNA. Translation: AAH14794.1 .
    BC040739 mRNA. Translation: AAH40739.1 .
    AL133104 mRNA. Translation: CAB61411.1 .
    CCDSi CCDS43071.1.
    PIRi T42683.
    RefSeqi NP_060356.2. NM_017886.2.
    UniGenei Hs.656192.

    3D structure databases

    ProteinModelPortali Q96C45.
    SMRi Q96C45. Positions 1-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120321. 5 interactions.
    IntActi Q96C45. 1 interaction.
    STRINGi 9606.ENSP00000301831.

    PTM databases

    PhosphoSitei Q96C45.

    Polymorphism databases

    DMDMi 118574241.

    Proteomic databases

    MaxQBi Q96C45.
    PaxDbi Q96C45.
    PRIDEi Q96C45.

    Protocols and materials databases

    DNASUi 54986.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000301831 ; ENSP00000301831 ; ENSG00000168038 .
    ENST00000420927 ; ENSP00000412187 ; ENSG00000168038 .
    GeneIDi 54986.
    KEGGi hsa:54986.
    UCSCi uc003ckv.4. human.

    Organism-specific databases

    CTDi 54986.
    GeneCardsi GC03M041265.
    H-InvDB HIX0021423.
    HIX0038398.
    HGNCi HGNC:15784. ULK4.
    HPAi HPA017930.
    neXtProti NX_Q96C45.
    PharmGKBi PA134978836.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000007938.
    HOVERGENi HBG094135.
    InParanoidi Q96C45.
    KOi K17545.
    OMAi LQHPFWK.
    OrthoDBi EOG7KWSGS.
    PhylomeDBi Q96C45.
    TreeFami TF332678.

    Enzyme and pathway databases

    SignaLinki Q96C45.

    Miscellaneous databases

    ChiTaRSi ULK4. human.
    GenomeRNAii 54986.
    NextBioi 58269.
    PROi Q96C45.

    Gene expression databases

    ArrayExpressi Q96C45.
    Bgeei Q96C45.
    CleanExi HS_ULK4.
    Genevestigatori Q96C45.

    Family and domain databases

    Gene3Di 1.25.10.10. 3 hits.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 3 hits.
    SSF56112. SSF56112. 2 hits.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-732, VARIANT GLY-348.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 AND 985-1275.
      Tissue: Brain and Lymph.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1275.
      Tissue: Testis.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-18; ARG-39; LYS-139; ASN-223; GLY-348; MET-415 AND PRO-417.

    Entry informationi

    Entry nameiULK4_HUMAN
    AccessioniPrimary (citable) accession number: Q96C45
    Secondary accession number(s): A6NF15
    , Q8IW79, Q9NWV6, Q9UF96
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3