Q96C45 (ULK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase ULK4
EC=2.7.11.1

Alternative name(s):
Unc-51-like kinase 4

Gene names

Name:

ULK4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1275 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Domain	The protein kinase domain is predicted to be catalytically inactive.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 5 HEAT repeats. Contains 1 protein kinase domain.
Sequence caution	The sequence BAA91270.1 differs from that shown. Reason: Frameshift at position 489.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cilium morphogenesis Inferred from electronic annotation. Source: Compara epithelial cilium movement Inferred from electronic annotation. Source: Compara ventricular system development Inferred from electronic annotation. Source: Compara
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1275	1275	Serine/threonine-protein kinase ULK4		PRO_0000260154
Regions
	Domain	4 – 280	277	Protein kinase
	Repeat	842 – 880	39	HEAT 1
	Repeat	926 – 964	39	HEAT 2
	Repeat	1025 – 1063	39	HEAT 3
	Repeat	1151 – 1189	39	HEAT 4
	Repeat	1213 – 1253	41	HEAT 5
	Compositional bias	1147 – 1150	4	Poly-Leu
Natural variations
	Natural variant	18	1	V → A. Ref.6 Corresponds to variant rs34538622 [ dbSNP | Ensembl ].		VAR_041286
	Natural variant	39	1	K → R. Ref.6 Corresponds to variant rs2272007 [ dbSNP | Ensembl ].		VAR_041287
	Natural variant	139	1	N → K. Ref.6 Corresponds to variant rs35833603 [ dbSNP | Ensembl ].		VAR_041288
	Natural variant	223	1	S → N. Ref.6 Corresponds to variant rs55840267 [ dbSNP | Ensembl ].		VAR_041289
	Natural variant	224	1	I → V. Corresponds to variant rs1716975 [ dbSNP | Ensembl ].		VAR_051679
	Natural variant	348	1	S → G. Ref.2 Ref.6 Corresponds to variant rs35263917 [ dbSNP | Ensembl ].		VAR_041290
	Natural variant	415	1	T → M. Ref.6		VAR_041291
	Natural variant	417	1	S → P. Ref.6		VAR_041292
	Natural variant	542	1	A → T. Corresponds to variant rs1052501 [ dbSNP | Ensembl ].		VAR_029005
	Natural variant	569	1	K → R. Corresponds to variant rs3774372 [ dbSNP | Ensembl ].		VAR_029006
	Natural variant	603	1	L → S. Corresponds to variant rs17063572 [ dbSNP | Ensembl ].		VAR_029007
	Natural variant	640	1	S → A. Corresponds to variant rs4973986 [ dbSNP | Ensembl ].		VAR_029008
	Natural variant	715	1	A → T. Corresponds to variant rs17215589 [ dbSNP | Ensembl ].		VAR_029009
	Natural variant	1260	1	S → N. Corresponds to variant rs12488691 [ dbSNP | Ensembl ].		VAR_059772
	Natural variant	1261	1	A → V. Corresponds to variant rs6769117 [ dbSNP | Ensembl ].		VAR_051680
Experimental info
	Sequence conflict	388	1	K → E in BAA91270. Ref.2
	Sequence conflict	553 – 580	28	AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794. Ref.3
	Sequence conflict	732	1	G → V in BAA91270. Ref.2
	Sequence conflict	1024	1	R → S in AAH40739. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96C45 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: D3DB6795CEB1DC76	FASTA	1,275	142,442
	10 20 30 40 50 60 MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT REIKHKNIVT 70 80 90 100 110 120 FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE FGIDLISGLH HLHKLGILFC 130 140 150 160 170 180 DISPRKILLE GPGTLKFSNF CLAKVEGENL EEFFALVAAE EGGGDNGENV LKKSMKSRVK 190 200 210 220 230 240 GSPVYTAPEV VRGADFSISS DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI 250 260 270 280 290 300 PKDSSRPKAS SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 310 320 330 340 350 360 NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL EGQLNESMFL 370 380 390 400 410 420 LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL SQQDLESQMR ELIYTDSDLV 430 440 450 460 470 480 VTPIIDNPKI MKQPPVKFDA KILHLPTYSV DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG 490 500 510 520 530 540 ASRAKLNLLC YLCVVAGHQE VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH 550 560 570 580 590 600 TAELQENTPV VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA 610 620 630 640 650 660 VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP ILWYLFRHST 670 680 690 700 710 720 ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA SAICKVQQYM LTLFAAMLSC 730 740 750 760 770 780 GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA KAFLVLLYIL IYNREMLLLS CQARLVMYIE 790 800 810 820 830 840 RDSRKTTPGK EQQSGNEYLS KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK 850 860 870 880 890 900 QLKLCLPLMP VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS 910 920 930 940 950 960 EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF SLRLLSETTS 970 980 990 1000 1010 1020 LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE PDPVPAYALK LLVAMTEHNP 1030 1040 1050 1060 1070 1080 TFTRLVEESK LIPLIFEVTL EHQESILGNT MQSVIALLSN LVACKDSNME LLYEQGLVSH 1090 1100 1110 1120 1130 1140 ICNLLTETAT LCLDVDNKNN NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED 1150 1160 1170 1180 1190 1200 PQAAEDLLLL NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV 1210 1220 1230 1240 1250 1260 EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL APGSGSFADS 1270 AVAPLALEIL QAVGH

References

[1]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-732, VARIANT GLY-348.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 AND 985-1275. Tissue: Brain and Lymph.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1275. Tissue: Testis.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Patterns of somatic mutation in human cancer genomes." Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R. Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-18; ARG-39; LYS-139; ASN-223; GLY-348; MET-415 AND PRO-417.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC104305 Genomic DNA. No translation available. AK000581 mRNA. Translation: BAA91270.1. Frameshift. BC014794 mRNA. Translation: AAH14794.1. BC040739 mRNA. Translation: AAH40739.1. AL133104 mRNA. Translation: CAB61411.1.
IPI	IPI00807602.
PIR	T42683.
RefSeq	NP_060356.2. NM_017886.2.
UniGene	Hs.656192.
3D structure databases
ProteinModelPortal	Q96C45.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96C45. 1 interaction.
STRING	9606.ENSP00000301831.
PTM databases
PhosphoSite	Q96C45.
Polymorphism databases
DMDM	118574241.
Proteomic databases
PaxDb	Q96C45.
PRIDE	Q96C45.
Protocols and materials databases
DNASU	54986.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000301831; ENSP00000301831; ENSG00000168038. ENST00000420927; ENSP00000412187; ENSG00000168038.
GeneID	54986.
KEGG	hsa:54986.
UCSC	uc003ckv.4. human.
Organism-specific databases
CTD	54986.
GeneCards	GC03M041265.
H-InvDB	HIX0021423. HIX0038398.
HGNC	HGNC:15784. ULK4.
HPA	HPA017930.
neXtProt	NX_Q96C45.
PharmGKB	PA134978836.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000007938.
HOVERGEN	HBG094135.
InParanoid	Q96C45.
OMA	PPFFSET.
OrthoDB	EOG40S0F5.
Gene expression databases
ArrayExpress	Q96C45.
Bgee	Q96C45.
CleanEx	HS_ULK4.
Genevestigator	Q96C45.
GermOnline	ENSG00000093222. Homo sapiens.
Family and domain databases
Gene3D	1.25.10.10. 3 hits.
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits. SSF56112. Kinase_like. 1 hit.
PROSITE	PS50077. HEAT_REPEAT. False negative. PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ULK4. human.
GenomeRNAi	54986.
NextBio	58269.

Entry information

Entry name

ULK4_HUMAN

Accession

Primary (citable) accession number: Q96C45
Secondary accession number(s): A6NF15 , Q8IW79, Q9NWV6, Q9UF96

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 96 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.