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Q96C45 (ULK4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase ULK4

EC=2.7.11.1
Alternative name(s):
Unc-51-like kinase 4
Gene names
Name:ULK4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1275 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Domain

The protein kinase domain is predicted to be catalytically inactive.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.

Contains 5 HEAT repeats.

Contains 1 protein kinase domain.

Sequence caution

The sequence BAA91270.1 differs from that shown. Reason: Frameshift at position 489.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12751275Serine/threonine-protein kinase ULK4
PRO_0000260154

Regions

Domain4 – 280277Protein kinase
Repeat842 – 88039HEAT 1
Repeat926 – 96439HEAT 2
Repeat1025 – 106339HEAT 3
Repeat1151 – 118939HEAT 4
Repeat1213 – 125341HEAT 5
Compositional bias1147 – 11504Poly-Leu

Natural variations

Natural variant181V → A. Ref.6
Corresponds to variant rs34538622 [ dbSNP | Ensembl ].
VAR_041286
Natural variant391K → R. Ref.6
Corresponds to variant rs2272007 [ dbSNP | Ensembl ].
VAR_041287
Natural variant1391N → K. Ref.6
Corresponds to variant rs35833603 [ dbSNP | Ensembl ].
VAR_041288
Natural variant2231S → N. Ref.6
Corresponds to variant rs55840267 [ dbSNP | Ensembl ].
VAR_041289
Natural variant2241I → V.
Corresponds to variant rs1716975 [ dbSNP | Ensembl ].
VAR_051679
Natural variant3481S → G. Ref.2 Ref.6
Corresponds to variant rs35263917 [ dbSNP | Ensembl ].
VAR_041290
Natural variant4151T → M. Ref.6
VAR_041291
Natural variant4171S → P. Ref.6
VAR_041292
Natural variant5421A → T.
Corresponds to variant rs1052501 [ dbSNP | Ensembl ].
VAR_029005
Natural variant5691K → R.
Corresponds to variant rs3774372 [ dbSNP | Ensembl ].
VAR_029006
Natural variant6031L → S.
Corresponds to variant rs17063572 [ dbSNP | Ensembl ].
VAR_029007
Natural variant6401S → A.
Corresponds to variant rs4973986 [ dbSNP | Ensembl ].
VAR_029008
Natural variant7151A → T.
Corresponds to variant rs17215589 [ dbSNP | Ensembl ].
VAR_029009
Natural variant12601S → N.
Corresponds to variant rs12488691 [ dbSNP | Ensembl ].
VAR_059772
Natural variant12611A → V.
Corresponds to variant rs6769117 [ dbSNP | Ensembl ].
VAR_051680

Experimental info

Sequence conflict3881K → E in BAA91270. Ref.2
Sequence conflict553 – 58028AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794. Ref.3
Sequence conflict7321G → V in BAA91270. Ref.2
Sequence conflict10241R → S in AAH40739. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q96C45 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: D3DB6795CEB1DC76

FASTA1,275142,442
        10         20         30         40         50         60 
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT REIKHKNIVT 

        70         80         90        100        110        120 
FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE FGIDLISGLH HLHKLGILFC 

       130        140        150        160        170        180 
DISPRKILLE GPGTLKFSNF CLAKVEGENL EEFFALVAAE EGGGDNGENV LKKSMKSRVK 

       190        200        210        220        230        240 
GSPVYTAPEV VRGADFSISS DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI 

       250        260        270        280        290        300 
PKDSSRPKAS SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR 

       310        320        330        340        350        360 
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL EGQLNESMFL 

       370        380        390        400        410        420 
LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL SQQDLESQMR ELIYTDSDLV 

       430        440        450        460        470        480 
VTPIIDNPKI MKQPPVKFDA KILHLPTYSV DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG 

       490        500        510        520        530        540 
ASRAKLNLLC YLCVVAGHQE VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH 

       550        560        570        580        590        600 
TAELQENTPV VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA 

       610        620        630        640        650        660 
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP ILWYLFRHST 

       670        680        690        700        710        720 
ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA SAICKVQQYM LTLFAAMLSC 

       730        740        750        760        770        780 
GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA KAFLVLLYIL IYNREMLLLS CQARLVMYIE 

       790        800        810        820        830        840 
RDSRKTTPGK EQQSGNEYLS KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK 

       850        860        870        880        890        900 
QLKLCLPLMP VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS 

       910        920        930        940        950        960 
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF SLRLLSETTS 

       970        980        990       1000       1010       1020 
LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE PDPVPAYALK LLVAMTEHNP 

      1030       1040       1050       1060       1070       1080 
TFTRLVEESK LIPLIFEVTL EHQESILGNT MQSVIALLSN LVACKDSNME LLYEQGLVSH 

      1090       1100       1110       1120       1130       1140 
ICNLLTETAT LCLDVDNKNN NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED 

      1150       1160       1170       1180       1190       1200 
PQAAEDLLLL NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV 

      1210       1220       1230       1240       1250       1260 
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL APGSGSFADS 

      1270 
AVAPLALEIL QAVGH 

« Hide

References

[1]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-732, VARIANT GLY-348.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 AND 985-1275.
Tissue: Brain and Lymph.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1275.
Tissue: Testis.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-18; ARG-39; LYS-139; ASN-223; GLY-348; MET-415 AND PRO-417.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC104305 Genomic DNA. No translation available.
AK000581 mRNA. Translation: BAA91270.1. Frameshift.
BC014794 mRNA. Translation: AAH14794.1.
BC040739 mRNA. Translation: AAH40739.1.
AL133104 mRNA. Translation: CAB61411.1.
CCDSCCDS43071.1.
PIRT42683.
RefSeqNP_060356.2. NM_017886.2.
UniGeneHs.656192.

3D structure databases

ProteinModelPortalQ96C45.
SMRQ96C45. Positions 1-305.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120321. 5 interactions.
IntActQ96C45. 1 interaction.
STRING9606.ENSP00000301831.

PTM databases

PhosphoSiteQ96C45.

Polymorphism databases

DMDM118574241.

Proteomic databases

MaxQBQ96C45.
PaxDbQ96C45.
PRIDEQ96C45.

Protocols and materials databases

DNASU54986.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000301831; ENSP00000301831; ENSG00000168038.
ENST00000420927; ENSP00000412187; ENSG00000168038.
GeneID54986.
KEGGhsa:54986.
UCSCuc003ckv.4. human.

Organism-specific databases

CTD54986.
GeneCardsGC03M041265.
H-InvDBHIX0021423.
HIX0038398.
HGNCHGNC:15784. ULK4.
HPAHPA017930.
neXtProtNX_Q96C45.
PharmGKBPA134978836.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000007938.
HOVERGENHBG094135.
InParanoidQ96C45.
KOK17545.
OMALQHPFWK.
OrthoDBEOG7KWSGS.
PhylomeDBQ96C45.
TreeFamTF332678.

Enzyme and pathway databases

SignaLinkQ96C45.

Gene expression databases

ArrayExpressQ96C45.
BgeeQ96C45.
CleanExHS_ULK4.
GenevestigatorQ96C45.

Family and domain databases

Gene3D1.25.10.10. 3 hits.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 3 hits.
SSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSULK4. human.
GenomeRNAi54986.
NextBio58269.
PROQ96C45.

Entry information

Entry nameULK4_HUMAN
AccessionPrimary (citable) accession number: Q96C45
Secondary accession number(s): A6NF15 expand/collapse secondary AC list , Q8IW79, Q9NWV6, Q9UF96
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM