Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q96C45

- ULK4_HUMAN

UniProt

Q96C45 - ULK4_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Serine/threonine-protein kinase ULK4

Gene

ULK4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. cilium morphogenesis Source: Ensembl
  2. epithelial cilium movement Source: Ensembl
  3. microtubule cytoskeleton organization Source: MGI
  4. regulation of JNK cascade Source: MGI
  5. regulation of MAPK cascade Source: MGI
  6. regulation of neuron migration Source: MGI
  7. regulation of neuron projection development Source: MGI
  8. regulation of p38MAPK cascade Source: MGI
  9. regulation of protein kinase C signaling Source: MGI
  10. ventricular system development Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ96C45.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase ULK4 (EC:2.7.11.1)
Alternative name(s):
Unc-51-like kinase 4
Gene namesi
Name:ULK4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:15784. ULK4.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978836.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12751275Serine/threonine-protein kinase ULK4PRO_0000260154Add
BLAST

Proteomic databases

MaxQBiQ96C45.
PaxDbiQ96C45.
PRIDEiQ96C45.

PTM databases

PhosphoSiteiQ96C45.

Expressioni

Gene expression databases

BgeeiQ96C45.
CleanExiHS_ULK4.
ExpressionAtlasiQ96C45. baseline and differential.
GenevestigatoriQ96C45.

Organism-specific databases

HPAiHPA017930.

Interactioni

Protein-protein interaction databases

BioGridi120321. 5 interactions.
IntActiQ96C45. 1 interaction.
STRINGi9606.ENSP00000301831.

Structurei

3D structure databases

ProteinModelPortaliQ96C45.
SMRiQ96C45. Positions 1-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 280277Protein kinasePROSITE-ProRule annotationAdd
BLAST
Repeati842 – 88039HEAT 1Add
BLAST
Repeati926 – 96439HEAT 2Add
BLAST
Repeati1025 – 106339HEAT 3Add
BLAST
Repeati1151 – 118939HEAT 4Add
BLAST
Repeati1213 – 125341HEAT 5Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1147 – 11504Poly-Leu

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.PROSITE-ProRule annotation
Contains 5 HEAT repeats.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108824.
HOGENOMiHOG000007938.
HOVERGENiHBG094135.
InParanoidiQ96C45.
KOiK17545.
OMAiLQHPFWK.
OrthoDBiEOG7KWSGS.
PhylomeDBiQ96C45.
TreeFamiTF332678.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 3 hits.
SSF56112. SSF56112. 2 hits.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C45-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MENFILYEEI GRGSKTVVYK GRRKGTINFV AILCTDKCKR PEITNWVRLT
60 70 80 90 100
REIKHKNIVT FHEWYETSNH LWLVVELCTG GSLKTVIAQD ENLPEDVVRE
110 120 130 140 150
FGIDLISGLH HLHKLGILFC DISPRKILLE GPGTLKFSNF CLAKVEGENL
160 170 180 190 200
EEFFALVAAE EGGGDNGENV LKKSMKSRVK GSPVYTAPEV VRGADFSISS
210 220 230 240 250
DLWSLGCLLY EMFSGKPPFF SESISELTEK ILCEDPLPPI PKDSSRPKAS
260 270 280 290 300
SDFINLLDGL LQRDPQKRLT WTRLLQHSFW KKAFAGADQE SSVEDLSLSR
310 320 330 340 350
NTMECSGPQD SKELLQNSQS RQAKGHKSGQ PLGHSFRLEN PTEFRPKSTL
360 370 380 390 400
EGQLNESMFL LSSRPTPRTS TAVEVSPGED MTHCSPQKTS PLTKITSGHL
410 420 430 440 450
SQQDLESQMR ELIYTDSDLV VTPIIDNPKI MKQPPVKFDA KILHLPTYSV
460 470 480 490 500
DKLLFLKDQD WNDFLQQVCS QIDSTEKSMG ASRAKLNLLC YLCVVAGHQE
510 520 530 540 550
VATRLLHSPL FQLLIQHLRI APNWDIRAKV AHVIGLLASH TAELQENTPV
560 570 580 590 600
VEAIVLLTEL IRENFRNSKL KQCLLPTLGE LIYLVATQEE KKKNPRECWA
610 620 630 640 650
VPLAAYTVLM RCLREGEERV VNHMAAKIIE NVCTTFSAQS QGFITGEIGP
660 670 680 690 700
ILWYLFRHST ADSLRITAVS ALCRITRHSP TAFQNVIEKV GLNSVINSLA
710 720 730 740 750
SAICKVQQYM LTLFAAMLSC GIHLQRLIQE KGFVSTIIRL LDSPSTCIRA
760 770 780 790 800
KAFLVLLYIL IYNREMLLLS CQARLVMYIE RDSRKTTPGK EQQSGNEYLS
810 820 830 840 850
KCLDLLICHI VQELPRILGD ILNSLANVSG RKHPSTVQVK QLKLCLPLMP
860 870 880 890 900
VVLHLVTSQV FRPQVVTEEF LFSYGTILSH IKSVDSGETN IDGAIGLTAS
910 920 930 940 950
EEFIKITLSA FEAIIQYPIL LKDYRSTVVD YILPPLVSLV QSQNVEWRLF
960 970 980 990 1000
SLRLLSETTS LLVNQEFGDG KEKASVDSDS NLLALIRDVL LPQYEHILLE
1010 1020 1030 1040 1050
PDPVPAYALK LLVAMTEHNP TFTRLVEESK LIPLIFEVTL EHQESILGNT
1060 1070 1080 1090 1100
MQSVIALLSN LVACKDSNME LLYEQGLVSH ICNLLTETAT LCLDVDNKNN
1110 1120 1130 1140 1150
NEMAAPLLFS LLDILHSMLT YTSGIVRLAL QAQKSGSGED PQAAEDLLLL
1160 1170 1180 1190 1200
NRPLTDLISL LIPLLPNEDP EIFDVSSKCL SILVQLYGGE NPDSLSPENV
1210 1220 1230 1240 1250
EIFAHLLTSK EDPKEQKLLL RILRRMITSN EKHLESLKNA GSLLRALERL
1260 1270
APGSGSFADS AVAPLALEIL QAVGH
Length:1,275
Mass (Da):142,442
Last modified:November 28, 2006 - v2
Checksum:iD3DB6795CEB1DC76
GO

Sequence cautioni

The sequence BAA91270.1 differs from that shown. Reason: Frameshift at position 489.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti388 – 3881K → E in BAA91270. (PubMed:14702039)Curated
Sequence conflicti553 – 58028AIVLL…PTLGE → TTSSIGIGILNCLVQHSTPV PRQCLVYV in AAH14794. (PubMed:15489334)CuratedAdd
BLAST
Sequence conflicti732 – 7321G → V in BAA91270. (PubMed:14702039)Curated
Sequence conflicti1024 – 10241R → S in AAH40739. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181V → A.1 Publication
Corresponds to variant rs34538622 [ dbSNP | Ensembl ].
VAR_041286
Natural varianti39 – 391K → R.1 Publication
Corresponds to variant rs2272007 [ dbSNP | Ensembl ].
VAR_041287
Natural varianti139 – 1391N → K.1 Publication
Corresponds to variant rs35833603 [ dbSNP | Ensembl ].
VAR_041288
Natural varianti223 – 2231S → N.1 Publication
Corresponds to variant rs55840267 [ dbSNP | Ensembl ].
VAR_041289
Natural varianti224 – 2241I → V.
Corresponds to variant rs1716975 [ dbSNP | Ensembl ].
VAR_051679
Natural varianti348 – 3481S → G.2 Publications
Corresponds to variant rs35263917 [ dbSNP | Ensembl ].
VAR_041290
Natural varianti415 – 4151T → M.1 Publication
VAR_041291
Natural varianti417 – 4171S → P.1 Publication
VAR_041292
Natural varianti542 – 5421A → T.
Corresponds to variant rs1052501 [ dbSNP | Ensembl ].
VAR_029005
Natural varianti569 – 5691K → R.
Corresponds to variant rs3774372 [ dbSNP | Ensembl ].
VAR_029006
Natural varianti603 – 6031L → S.
Corresponds to variant rs17063572 [ dbSNP | Ensembl ].
VAR_029007
Natural varianti640 – 6401S → A.
Corresponds to variant rs4973986 [ dbSNP | Ensembl ].
VAR_029008
Natural varianti715 – 7151A → T.
Corresponds to variant rs17215589 [ dbSNP | Ensembl ].
VAR_029009
Natural varianti1260 – 12601S → N.
Corresponds to variant rs12488691 [ dbSNP | Ensembl ].
VAR_059772
Natural varianti1261 – 12611A → V.
Corresponds to variant rs6769117 [ dbSNP | Ensembl ].
VAR_051680

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104305 Genomic DNA. No translation available.
AK000581 mRNA. Translation: BAA91270.1. Frameshift.
BC014794 mRNA. Translation: AAH14794.1.
BC040739 mRNA. Translation: AAH40739.1.
AL133104 mRNA. Translation: CAB61411.1.
CCDSiCCDS43071.1.
PIRiT42683.
RefSeqiNP_060356.2. NM_017886.2.
UniGeneiHs.656192.

Genome annotation databases

EnsembliENST00000301831; ENSP00000301831; ENSG00000168038.
ENST00000420927; ENSP00000412187; ENSG00000168038.
GeneIDi54986.
KEGGihsa:54986.
UCSCiuc003ckv.4. human.

Polymorphism databases

DMDMi118574241.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC104305 Genomic DNA. No translation available.
AK000581 mRNA. Translation: BAA91270.1 . Frameshift.
BC014794 mRNA. Translation: AAH14794.1 .
BC040739 mRNA. Translation: AAH40739.1 .
AL133104 mRNA. Translation: CAB61411.1 .
CCDSi CCDS43071.1.
PIRi T42683.
RefSeqi NP_060356.2. NM_017886.2.
UniGenei Hs.656192.

3D structure databases

ProteinModelPortali Q96C45.
SMRi Q96C45. Positions 1-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120321. 5 interactions.
IntActi Q96C45. 1 interaction.
STRINGi 9606.ENSP00000301831.

PTM databases

PhosphoSitei Q96C45.

Polymorphism databases

DMDMi 118574241.

Proteomic databases

MaxQBi Q96C45.
PaxDbi Q96C45.
PRIDEi Q96C45.

Protocols and materials databases

DNASUi 54986.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000301831 ; ENSP00000301831 ; ENSG00000168038 .
ENST00000420927 ; ENSP00000412187 ; ENSG00000168038 .
GeneIDi 54986.
KEGGi hsa:54986.
UCSCi uc003ckv.4. human.

Organism-specific databases

CTDi 54986.
GeneCardsi GC03M041265.
H-InvDB HIX0021423.
HIX0038398.
HGNCi HGNC:15784. ULK4.
HPAi HPA017930.
neXtProti NX_Q96C45.
PharmGKBi PA134978836.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108824.
HOGENOMi HOG000007938.
HOVERGENi HBG094135.
InParanoidi Q96C45.
KOi K17545.
OMAi LQHPFWK.
OrthoDBi EOG7KWSGS.
PhylomeDBi Q96C45.
TreeFami TF332678.

Enzyme and pathway databases

SignaLinki Q96C45.

Miscellaneous databases

ChiTaRSi ULK4. human.
GenomeRNAii 54986.
NextBioi 58269.
PROi Q96C45.

Gene expression databases

Bgeei Q96C45.
CleanExi HS_ULK4.
ExpressionAtlasi Q96C45. baseline and differential.
Genevestigatori Q96C45.

Family and domain databases

Gene3Di 1.25.10.10. 3 hits.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 3 hits.
SSF56112. SSF56112. 2 hits.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-732, VARIANT GLY-348.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-580 AND 985-1275.
    Tissue: Brain and Lymph.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 953-1275.
    Tissue: Testis.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ALA-18; ARG-39; LYS-139; ASN-223; GLY-348; MET-415 AND PRO-417.

Entry informationi

Entry nameiULK4_HUMAN
AccessioniPrimary (citable) accession number: Q96C45
Secondary accession number(s): A6NF15
, Q8IW79, Q9NWV6, Q9UF96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3