Reviewed,
UniProtKB/Swiss-Prot Q96C36 (P5CR2_HUMAN)
Last modified
February 9, 2010.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Pyrroline-5-carboxylate reductase 2 Short name=P5C reductase 2 Short name=P5CR 2 EC=1.5.1.2 | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 320 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H. |
| Pathway | |
| Subunit structure | Homodecamer; composed of 5 homodimers By similarity. |
| Sequence similarities | Belongs to the pyrroline-5-carboxylate reductase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Proline biosynthesis |
| Ligand | NADP |
| Molecular function | Oxidoreductase |
| PTM | Acetylation Phosphoprotein |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW proline biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro pyrroline-5-carboxylate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.6 | ||||||
| Chain | 2 – 320 | 319 | Pyrroline-5-carboxylate reductase 2 | PRO_0000187317 | |||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylserine Ref.6 | ||||||
| Modified residue | 303 | 1 | Phosphoserine Ref.9 | ||||||
| Modified residue | 304 | 1 | Phosphoserine Ref.9 Ref.7 | ||||||
Experimental info | |||||||||
| Sequence conflict | 13 | 1 | Y → N in AAP97169. Ref.1 | ||||||
| Sequence conflict | 23 – 24 | 2 | GI → AF in AAP97169. Ref.1 | ||||||
| Sequence conflict | 72 – 73 | 2 | PH → HI in AAP97169. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of a new human cDNA homologous to human pyrroline 5-carboxylate reductase mRNA." Yue P., Yu L., Zhao S.Y. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Cervix and Skin. |
| [6] | Bienvenut W.V., Heiserich L., Gottlieb E., Zebisch A., Kolch W. Submitted (OCT-2008) to UniProtKB Cited for: PROTEIN SEQUENCE OF 2-17, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT SER-2, MASS SPECTROMETRY. Tissue: Colon carcinoma. |
| [7] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-304, MASS SPECTROMETRY. |
| [8] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [9] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-303 AND SER-304, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF087859 mRNA. Translation: AAP97169.1. AK291913 mRNA. Translation: BAF84602.1. AL117348 Genomic DNA. Translation: CAI21802.1. CH471098 Genomic DNA. Translation: EAW69762.1. BC014868 mRNA. Translation: AAH14868.1. BC020553 mRNA. Translation: AAH20553.1. |
| IPI | IPI00470610. |
| RefSeq | NP_037460.2. |
| UniGene | Hs.654718 |
3D structure databases | |
| SMR | Q96C36. Positions 1-275. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q96C36. 3 interactions. |
| STRING | Q96C36. |
PTM databases | |
| PhosphoSite | Q96C36. |
Proteomic databases | |
| PRIDE | Q96C36. |
Genome annotation databases | |
| Ensembl | ENST00000343818; ENSP00000342502; ENSG00000143811; Homo sapiens. [Genome view] |
| GeneID | 29920. |
| KEGG | hsa:29920. |
| UCSC | uc001hpq.1. human. |
Organism-specific databases | |
| CTD | 29920. |
| GeneCards | GC01M224174. |
| H-InvDB | HIX0001639. |
| HGNC | HGNC:30262. PYCR2. |
| PharmGKB | PA134881955. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q96C36. |
| InParanoid | Q96C36. |
| OMA | NLVRVMP. |
| PhylomeDB | Q96C36. |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.2. 247. |
Gene expression databases | |
| ArrayExpress | Q96C36. |
| Bgee | Q96C36. |
| CleanEx | HS_PYCR2. |
| Genevestigator | Q96C36. |
| GermOnline | ENSG00000143811. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR016040. NAD(P)-bd_dom. IPR004455. NADP_OxRdtase_F420. IPR000304. P5CR. [Graphical view] |
| Gene3D | G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. |
| PANTHER | PTHR11645. P5CR. 1 hit. |
| Pfam | PF03807. F420_oxidored. 1 hit. [Graphical view] |
| PIRSF | PIRSF000193. Pyrrol-5-carb_rd. 1 hit. |
| TIGRFAMs | TIGR00112. proC. 1 hit. |
| PROSITE | PS00521. P5CR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| DrugBank | DB00172. L-Proline. DB00157. NADH. |
| NextBio | 52520. |
Entry information
| Entry name | P5CR2_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96C36 Secondary accession number(s): A8K798, Q7Z515, Q9Y5J4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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