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Protein

RUN domain-containing protein 1

Gene

RUNDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role as p53/TP53 inhibitor and thus may have oncogenic activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RUN domain-containing protein 1
Gene namesi
Name:RUNDC1
ORF Names:LP5161
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:25418. RUNDC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134956633.

Polymorphism and mutation databases

BioMutaiRUNDC1.
DMDMi296452974.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 613613RUN domain-containing protein 1PRO_0000284511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541PhosphothreonineCombined sources
Modified residuei71 – 711PhosphoserineCombined sources
Modified residuei75 – 751PhosphoserineCombined sources
Modified residuei497 – 4971PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96C34.
PaxDbiQ96C34.
PeptideAtlasiQ96C34.
PRIDEiQ96C34.

PTM databases

iPTMnetiQ96C34.
PhosphoSiteiQ96C34.

Expressioni

Gene expression databases

BgeeiENSG00000198863.
CleanExiHS_RUNDC1.
ExpressionAtlasiQ96C34. baseline and differential.
GenevisibleiQ96C34. HS.

Organism-specific databases

HPAiHPA023726.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127025. 5 interactions.
STRINGi9606.ENSP00000354622.

Structurei

3D structure databases

ProteinModelPortaliQ96C34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini421 – 602182RUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili160 – 23576Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi24 – 307Poly-Glu

Sequence similaritiesi

Contains 1 RUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3759. Eukaryota.
ENOG410XQKK. LUCA.
GeneTreeiENSGT00390000007311.
HOGENOMiHOG000018481.
HOVERGENiHBG063773.
InParanoidiQ96C34.
OMAiERWAPVG.
OrthoDBiEOG091G0627.
PhylomeDBiQ96C34.
TreeFamiTF105949.

Family and domain databases

InterProiIPR004012. Run_dom.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
PROSITEiPS50826. RUN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96C34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVEAAAEP VTVVAAVGPK AKDEEEEEEE PLPPCEAVRW APVGAVAEAR
60 70 80 90 100
PGATAFLEEA TAEEPGAAPG SPPDSPGRTL RRLRAERRRL DSALLALSSH
110 120 130 140 150
FAQVQFRLRQ VVRGAPAEQQ RLLRELEDFA FRGCPHVLGY EGPGDPASDE
160 170 180 190 200
GDGLPGDRPW LRGEDQSEQE KQERLETQRE KQKELILQLK TQLDDLETFA
210 220 230 240 250
YQEGSYDSLP QSVVLERQRV IIDELIKKLD MNLNEDISSL STEELRQRVD
260 270 280 290 300
AAVAQIVNPA RVKEQLVEQL KTQIRDLEMF INFIQDEVGS PLQTGGGHCE
310 320 330 340 350
CKAGGKTGNG CSRTGSSRTP PGNSKTKAED VKKVRETGLH LMRRALAVLQ
360 370 380 390 400
IFAVSQFGCA TGQIPPTLWQ RVQADRDYSP LLKRLEVSVD RVKQLALRQQ
410 420 430 440 450
PHDHVITSAN LQDLSLGGKD ELTMAVRKEL TVAVRDLLAH GLYASSPGMS
460 470 480 490 500
LVMAPIACLL PAFSSAPEAM HPWELFVKYY HAKNGRAYVE SPARKLSQSF
510 520 530 540 550
ALPVTGGTVV TPKQSLLTAI HMVLTEHDPF KRSADSELKA LVCMALNEQR
560 570 580 590 600
LVSWVNLICK SGSLIEPHYQ PWSYMAHTGF ESALNLLSRL SSLKFSLPVD
610
LAVRQLKNIK DAF
Length:613
Mass (Da):67,643
Last modified:May 18, 2010 - v3
Checksum:i27DA61C05ADFE3EE
GO
Isoform 2 (identifier: Q96C34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     286-286: Missing.

Note: No experimental confirmation available.
Show »
Length:612
Mass (Da):67,528
Checksum:i38023DF1B42D304B
GO

Sequence cautioni

The sequence AAH14873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAO86728 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti166 – 1661Q → QGL in AAO86728 (PubMed:15498874).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41V → I.1 Publication
Corresponds to variant rs17853899 [ dbSNP | Ensembl ].
VAR_031760
Natural varianti160 – 1601W → R.3 Publications
Corresponds to variant rs1708875 [ dbSNP | Ensembl ].
VAR_031761
Natural varianti397 – 3971L → M.1 Publication
Corresponds to variant rs17857183 [ dbSNP | Ensembl ].
VAR_031762
Natural varianti566 – 5661E → K.
Corresponds to variant rs3744241 [ dbSNP | Ensembl ].
VAR_051328

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei286 – 2861Missing in isoform 2. 1 PublicationVSP_024551

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA. No translation available.
BC014873 mRNA. Translation: AAH14873.1. Different initiation.
BC039247 mRNA. Translation: AAH39247.1.
AL831813 mRNA. Translation: CAD38528.1.
AY189284 mRNA. Translation: AAO86728.1. Different initiation.
CCDSiCCDS11448.1. [Q96C34-1]
RefSeqiNP_001308310.1. NM_001321381.1.
NP_775102.2. NM_173079.3.
UniGeneiHs.632255.

Genome annotation databases

EnsembliENST00000361677; ENSP00000354622; ENSG00000198863. [Q96C34-1]
GeneIDi146923.
UCSCiuc002ici.1. human. [Q96C34-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC055866 Genomic DNA. No translation available.
BC014873 mRNA. Translation: AAH14873.1. Different initiation.
BC039247 mRNA. Translation: AAH39247.1.
AL831813 mRNA. Translation: CAD38528.1.
AY189284 mRNA. Translation: AAO86728.1. Different initiation.
CCDSiCCDS11448.1. [Q96C34-1]
RefSeqiNP_001308310.1. NM_001321381.1.
NP_775102.2. NM_173079.3.
UniGeneiHs.632255.

3D structure databases

ProteinModelPortaliQ96C34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127025. 5 interactions.
STRINGi9606.ENSP00000354622.

PTM databases

iPTMnetiQ96C34.
PhosphoSiteiQ96C34.

Polymorphism and mutation databases

BioMutaiRUNDC1.
DMDMi296452974.

Proteomic databases

MaxQBiQ96C34.
PaxDbiQ96C34.
PeptideAtlasiQ96C34.
PRIDEiQ96C34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361677; ENSP00000354622; ENSG00000198863. [Q96C34-1]
GeneIDi146923.
UCSCiuc002ici.1. human. [Q96C34-1]

Organism-specific databases

GeneCardsiRUNDC1.
H-InvDBHIX0020512.
HGNCiHGNC:25418. RUNDC1.
HPAiHPA023726.
neXtProtiNX_Q96C34.
PharmGKBiPA134956633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3759. Eukaryota.
ENOG410XQKK. LUCA.
GeneTreeiENSGT00390000007311.
HOGENOMiHOG000018481.
HOVERGENiHBG063773.
InParanoidiQ96C34.
OMAiERWAPVG.
OrthoDBiEOG091G0627.
PhylomeDBiQ96C34.
TreeFamiTF105949.

Miscellaneous databases

ChiTaRSiRUNDC1. human.
GenomeRNAii146923.
PROiQ96C34.

Gene expression databases

BgeeiENSG00000198863.
CleanExiHS_RUNDC1.
ExpressionAtlasiQ96C34. baseline and differential.
GenevisibleiQ96C34. HS.

Family and domain databases

InterProiIPR004012. Run_dom.
[Graphical view]
PfamiPF02759. RUN. 1 hit.
[Graphical view]
SMARTiSM00593. RUN. 1 hit.
[Graphical view]
PROSITEiPS50826. RUN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRUND1_HUMAN
AccessioniPrimary (citable) accession number: Q96C34
Secondary accession number(s): Q6Y2K8, Q8IXT9, Q8N3W1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.