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Protein

Zinc finger protein 707

Gene

ZNF707

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 707
Gene namesi
Name:ZNF707
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:27815. ZNF707.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670506.

Polymorphism and mutation databases

BioMutaiZNF707.
DMDMi296453056.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 371371Zinc finger protein 707PRO_0000233284Add
BLAST

Proteomic databases

EPDiQ96C28.
PaxDbiQ96C28.
PeptideAtlasiQ96C28.
PRIDEiQ96C28.

PTM databases

iPTMnetiQ96C28.
PhosphoSiteiQ96C28.

Expressioni

Gene expression databases

BgeeiQ96C28.
CleanExiHS_ZNF707.
ExpressionAtlasiQ96C28. baseline and differential.
GenevisibleiQ96C28. HS.

Organism-specific databases

HPAiHPA044991.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-748111,EBI-748961
KRTAP10-5P603703EBI-748111,EBI-10172150
KRTAP10-7P604093EBI-748111,EBI-10172290
RALBP1Q153113EBI-748111,EBI-749285

Protein-protein interaction databases

BioGridi130290. 59 interactions.
IntActiQ96C28. 7 interactions.
MINTiMINT-1460658.
STRINGi9606.ENSP00000351482.

Structurei

3D structure databases

ProteinModelPortaliQ96C28.
SMRiQ96C28. Positions 104-366.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 7972KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri176 – 19823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri204 – 22623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri232 – 25423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri260 – 28223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri288 – 31023C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129992.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96C28.
KOiK09228.
OMAiSFICGTC.
PhylomeDBiQ96C28.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDMAQEPVTF RDVAIYFSRE EWACLEPSQR ALYRDVMLDN FSSVAALGFC
60 70 80 90 100
SPRPDLVSRL EQWEEPWVED RERPEFQAVQ RGPRPGARKS ADPKRPCDHP
110 120 130 140 150
AWAHKKTHVR RERAREGSSF RKGFRLDTDD GQLPRAAPER TDAKPTAFPC
160 170 180 190 200
QVLTQRCGRR PGRRERRKQR AVELSFICGT CGKALSCHSR LLAHQTVHTG
210 220 230 240 250
TKAFECPECG QTFRWASNLQ RHQKNHTREK PFCCEACGQA FSLKDRLAQH
260 270 280 290 300
RKVHTEHRPY SCGDCGKAFK QKSNLLRHQL VHTGERPFYC ADCGKAFRTK
310 320 330 340 350
ENLSHHQRVH SGEKPYTCAE CGKSFRWPKG FSIHRRLHLT KRFYECGHCG
360 370
KGFRHLGFFT RHQRTHRHGE V
Length:371
Mass (Da):43,088
Last modified:May 18, 2010 - v2
Checksum:i113B680E5296FF3B
GO

Sequence cautioni

The sequence AAH14894.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAF83121.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → V in BAF83121 (PubMed:14702039).Curated
Sequence conflicti192 – 1921L → F in BAG51493 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti96 – 961P → H.2 Publications
Corresponds to variant rs6987308 [ dbSNP | Ensembl ].
VAR_033596

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290432 mRNA. Translation: BAF83121.1. Different initiation.
AK055263 mRNA. Translation: BAG51493.1.
AC105219 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82210.1.
CH471162 Genomic DNA. Translation: EAW82211.1.
CH471162 Genomic DNA. Translation: EAW82214.1.
BC014894 mRNA. Translation: AAH14894.1. Different initiation.
CCDSiCCDS47932.1.
RefSeqiNP_001094068.1. NM_001100598.1.
NP_001094069.1. NM_001100599.1.
NP_001275734.1. NM_001288805.1.
NP_001275735.1. NM_001288806.1.
NP_001275736.1. NM_001288807.1.
NP_001275737.1. NM_001288808.1.
NP_001275738.1. NM_001288809.1.
NP_776192.2. NM_173831.3.
XP_011515278.1. XM_011516976.1.
XP_011515279.1. XM_011516977.1.
XP_011544830.1. XM_011546528.1.
XP_011544831.1. XM_011546529.1.
UniGeneiHs.521922.

Genome annotation databases

EnsembliENST00000358656; ENSP00000351482; ENSG00000181135.
ENST00000418203; ENSP00000413215; ENSG00000181135.
ENST00000532158; ENSP00000436250; ENSG00000181135.
ENST00000532205; ENSP00000436212; ENSG00000181135.
ENST00000611146; ENSP00000484032; ENSG00000274352.
ENST00000611844; ENSP00000481069; ENSG00000274352.
ENST00000617261; ENSP00000484744; ENSG00000274352.
ENST00000622212; ENSP00000481033; ENSG00000274352.
GeneIDi286075.
KEGGihsa:286075.
UCSCiuc003yze.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290432 mRNA. Translation: BAF83121.1. Different initiation.
AK055263 mRNA. Translation: BAG51493.1.
AC105219 Genomic DNA. No translation available.
CH471162 Genomic DNA. Translation: EAW82210.1.
CH471162 Genomic DNA. Translation: EAW82211.1.
CH471162 Genomic DNA. Translation: EAW82214.1.
BC014894 mRNA. Translation: AAH14894.1. Different initiation.
CCDSiCCDS47932.1.
RefSeqiNP_001094068.1. NM_001100598.1.
NP_001094069.1. NM_001100599.1.
NP_001275734.1. NM_001288805.1.
NP_001275735.1. NM_001288806.1.
NP_001275736.1. NM_001288807.1.
NP_001275737.1. NM_001288808.1.
NP_001275738.1. NM_001288809.1.
NP_776192.2. NM_173831.3.
XP_011515278.1. XM_011516976.1.
XP_011515279.1. XM_011516977.1.
XP_011544830.1. XM_011546528.1.
XP_011544831.1. XM_011546529.1.
UniGeneiHs.521922.

3D structure databases

ProteinModelPortaliQ96C28.
SMRiQ96C28. Positions 104-366.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi130290. 59 interactions.
IntActiQ96C28. 7 interactions.
MINTiMINT-1460658.
STRINGi9606.ENSP00000351482.

PTM databases

iPTMnetiQ96C28.
PhosphoSiteiQ96C28.

Polymorphism and mutation databases

BioMutaiZNF707.
DMDMi296453056.

Proteomic databases

EPDiQ96C28.
PaxDbiQ96C28.
PeptideAtlasiQ96C28.
PRIDEiQ96C28.

Protocols and materials databases

DNASUi286075.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358656; ENSP00000351482; ENSG00000181135.
ENST00000418203; ENSP00000413215; ENSG00000181135.
ENST00000532158; ENSP00000436250; ENSG00000181135.
ENST00000532205; ENSP00000436212; ENSG00000181135.
ENST00000611146; ENSP00000484032; ENSG00000274352.
ENST00000611844; ENSP00000481069; ENSG00000274352.
ENST00000617261; ENSP00000484744; ENSG00000274352.
ENST00000622212; ENSP00000481033; ENSG00000274352.
GeneIDi286075.
KEGGihsa:286075.
UCSCiuc003yze.5. human.

Organism-specific databases

CTDi286075.
GeneCardsiZNF707.
HGNCiHGNC:27815. ZNF707.
HPAiHPA044991.
neXtProtiNX_Q96C28.
PharmGKBiPA142670506.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129992.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96C28.
KOiK09228.
OMAiSFICGTC.
PhylomeDBiQ96C28.
TreeFamiTF337055.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii286075.
PROiQ96C28.

Gene expression databases

BgeeiQ96C28.
CleanExiHS_ZNF707.
ExpressionAtlasiQ96C28. baseline and differential.
GenevisibleiQ96C28. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT HIS-96.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT HIS-96.
    Tissue: Uterus.

Entry informationi

Entry nameiZN707_HUMAN
AccessioniPrimary (citable) accession number: Q96C28
Secondary accession number(s): A8K317, B3KNY1, D3DWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: May 18, 2010
Last modified: July 6, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.