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Q96C24

- SYTL4_HUMAN

UniProt

Q96C24 - SYTL4_HUMAN

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Protein
Synaptotagmin-like protein 4
Gene
SYTL4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-type
Add
BLAST

GO - Molecular functioni

  1. neurexin family protein binding Source: UniProtKB
  2. phospholipid binding Source: UniProtKB
  3. transporter activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. exocytosis Source: Ensembl
  2. intracellular protein transport Source: InterPro
  3. multivesicular body sorting pathway Source: UniProtKB
  4. negative regulation of insulin secretion Source: Ensembl
  5. positive regulation of exocytosis Source: UniProtKB
  6. positive regulation of protein secretion Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 4
Alternative name(s):
Exophilin-2
Granuphilin
Gene namesi
Name:SYTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:15588. SYTL4.

Subcellular locationi

Membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle membrane; Peripheral membrane protein By similarity
Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles By similarity.

GO - Cellular componenti

  1. centrosome Source: HPA
  2. cytoplasm Source: HPA
  3. endosome Source: UniProtKB
  4. extrinsic component of membrane Source: UniProtKB
  5. nucleus Source: HPA
  6. plasma membrane Source: UniProtKB-SubCell
  7. secretory granule Source: Ensembl
  8. synaptic vesicle Source: InterPro
  9. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37987.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Synaptotagmin-like protein 4
PRO_0000190216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei289 – 2891Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96C24.
PaxDbiQ96C24.
PRIDEiQ96C24.

PTM databases

PhosphoSiteiQ96C24.

Expressioni

Gene expression databases

ArrayExpressiQ96C24.
BgeeiQ96C24.
CleanExiHS_SYTL4.
GenevestigatoriQ96C24.

Organism-specific databases

HPAiHPA001475.
HPA001589.

Interactioni

Subunit structurei

Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A By similarity.

Protein-protein interaction databases

BioGridi125120. 10 interactions.
IntActiQ96C24. 3 interactions.
STRINGi9606.ENSP00000263033.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi64 – 663
Beta strandi71 – 733
Turni75 – 773
Beta strandi78 – 803
Turni81 – 844
Beta strandi91 – 944
Beta strandi100 – 1023
Beta strandi359 – 3679
Turni368 – 3714
Beta strandi372 – 38211
Turni388 – 3914
Beta strandi395 – 4028
Helixi407 – 4093
Beta strandi410 – 4123
Beta strandi423 – 4319
Helixi437 – 4393
Beta strandi441 – 4499
Helixi451 – 4533
Beta strandi455 – 46410
Helixi465 – 4684
Turni469 – 4713
Beta strandi474 – 4796

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSZNMR-A43-105[»]
3FDWX-ray2.20A/B352-488[»]
ProteinModelPortaliQ96C24.
SMRiQ96C24. Positions 10-120, 354-652.

Miscellaneous databases

EvolutionaryTraceiQ96C24.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 122119RabBD
Add
BLAST
Domaini358 – 462105C2 1
Add
BLAST
Domaini513 – 617105C2 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi305 – 3117Poly-Glu

Sequence similaritiesi

Contains 2 C2 domains.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293068.
HOVERGENiHBG054255.
InParanoidiQ96C24.
KOiK17598.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ96C24.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028694. SYTL4.
IPR010911. Znf_FYVE-typ.
IPR011011. Znf_FYVE_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF9. PTHR10024:SF9. 1 hit.
PfamiPF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG    50
AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW 100
RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE 150
TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE 200
SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF 250
VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL 300
NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD 350
FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY 400
LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG 450
RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV 500
VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF 550
VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT 600
VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP 650
GSWAEGTLQL RSSMAKQKLG L 671
Length:671
Mass (Da):76,024
Last modified:January 11, 2011 - v2
Checksum:i04152119330EAB84
GO
Isoform 2 (identifier: Q96C24-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-657: Missing.
     658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:349
Mass (Da):39,813
Checksum:i815C9B7DC933119E
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti420 – 4201I → V.3 Publications
Corresponds to variant rs2022039 [ dbSNP | Ensembl ].
VAR_016076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei336 – 657322Missing in isoform 2.
VSP_015237Add
BLAST
Alternative sequencei658 – 67114LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2.
VSP_015238Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441L → P in CAI46126. 1 Publication
Sequence conflicti160 – 1601T → A in BAC04287. 1 Publication
Sequence conflicti251 – 2511V → A in CAI46126. 1 Publication
Sequence conflicti287 – 2871S → G in BAC04287. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094110 mRNA. Translation: BAC04287.1.
BX537410 mRNA. Translation: CAD97652.1.
AL832596 mRNA. Translation: CAI46126.1.
BC014913 mRNA. Translation: AAH14913.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42004.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42005.1.
CCDSiCCDS14472.1. [Q96C24-1]
RefSeqiNP_001123368.1. NM_001129896.2. [Q96C24-1]
NP_001167539.1. NM_001174068.1. [Q96C24-1]
NP_542775.2. NM_080737.2. [Q96C24-1]
XP_005262283.1. XM_005262226.1. [Q96C24-1]
XP_005262286.1. XM_005262229.1. [Q96C24-1]
XP_006724780.1. XM_006724717.1. [Q96C24-1]
XP_006724781.1. XM_006724718.1. [Q96C24-1]
UniGeneiHs.592224.

Genome annotation databases

EnsembliENST00000263033; ENSP00000263033; ENSG00000102362. [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362. [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362. [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362. [Q96C24-1]
ENST00000455616; ENSP00000390252; ENSG00000102362. [Q96C24-1]
GeneIDi94121.
KEGGihsa:94121.
UCSCiuc004egd.4. human. [Q96C24-1]
uc004egg.4. human. [Q96C24-2]

Polymorphism databases

DMDMi317373281.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK094110 mRNA. Translation: BAC04287.1 .
BX537410 mRNA. Translation: CAD97652.1 .
AL832596 mRNA. Translation: CAI46126.1 .
BC014913 mRNA. Translation: AAH14913.1 .
Z73900 , AL391688 Genomic DNA. Translation: CAI42004.1 .
Z73900 , AL391688 Genomic DNA. Translation: CAI42005.1 .
CCDSi CCDS14472.1. [Q96C24-1 ]
RefSeqi NP_001123368.1. NM_001129896.2. [Q96C24-1 ]
NP_001167539.1. NM_001174068.1. [Q96C24-1 ]
NP_542775.2. NM_080737.2. [Q96C24-1 ]
XP_005262283.1. XM_005262226.1. [Q96C24-1 ]
XP_005262286.1. XM_005262229.1. [Q96C24-1 ]
XP_006724780.1. XM_006724717.1. [Q96C24-1 ]
XP_006724781.1. XM_006724718.1. [Q96C24-1 ]
UniGenei Hs.592224.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CSZ NMR - A 43-105 [» ]
3FDW X-ray 2.20 A/B 352-488 [» ]
ProteinModelPortali Q96C24.
SMRi Q96C24. Positions 10-120, 354-652.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 125120. 10 interactions.
IntActi Q96C24. 3 interactions.
STRINGi 9606.ENSP00000263033.

Chemistry

DrugBanki DB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

PTM databases

PhosphoSitei Q96C24.

Polymorphism databases

DMDMi 317373281.

Proteomic databases

MaxQBi Q96C24.
PaxDbi Q96C24.
PRIDEi Q96C24.

Protocols and materials databases

DNASUi 94121.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000263033 ; ENSP00000263033 ; ENSG00000102362 . [Q96C24-1 ]
ENST00000276141 ; ENSP00000276141 ; ENSG00000102362 . [Q96C24-1 ]
ENST00000372981 ; ENSP00000362072 ; ENSG00000102362 . [Q96C24-2 ]
ENST00000372989 ; ENSP00000362080 ; ENSG00000102362 . [Q96C24-1 ]
ENST00000455616 ; ENSP00000390252 ; ENSG00000102362 . [Q96C24-1 ]
GeneIDi 94121.
KEGGi hsa:94121.
UCSCi uc004egd.4. human. [Q96C24-1 ]
uc004egg.4. human. [Q96C24-2 ]

Organism-specific databases

CTDi 94121.
GeneCardsi GC0XM099929.
H-InvDB HIX0016918.
HGNCi HGNC:15588. SYTL4.
HPAi HPA001475.
HPA001589.
MIMi 300723. gene.
neXtProti NX_Q96C24.
PharmGKBi PA37987.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293068.
HOVERGENi HBG054255.
InParanoidi Q96C24.
KOi K17598.
OrthoDBi EOG7JMGDC.
PhylomeDBi Q96C24.
TreeFami TF341184.

Miscellaneous databases

ChiTaRSi SYTL4. human.
EvolutionaryTracei Q96C24.
GeneWikii SYTL4.
GenomeRNAii 94121.
NextBioi 78402.
PROi Q96C24.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96C24.
Bgeei Q96C24.
CleanExi HS_SYTL4.
Genevestigatori Q96C24.

Family and domain databases

Gene3Di 2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProi IPR000008. C2_dom.
IPR001565. Synaptotagmin.
IPR028694. SYTL4.
IPR010911. Znf_FYVE-typ.
IPR011011. Znf_FYVE_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
PANTHERi PTHR10024:SF9. PTHR10024:SF9. 1 hit.
Pfami PF00168. C2. 2 hits.
PF02318. FYVE_2. 1 hit.
[Graphical view ]
PRINTSi PR00399. SYNAPTOTAGMN.
SMARTi SM00239. C2. 2 hits.
SM00184. RING. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEi PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-420.
    Tissue: Adrenal gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-420.
    Tissue: Endometrium and Spinal cord.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-420.
    Tissue: Uterus.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204; SER-217 AND SER-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Solution structure of the RING domain of the synaptotagmin-like protein 4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 43-105.
  9. "Crystal structure of a C2 domain from human synaptotagmin-like protein 4."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (DEC-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 352-488.

Entry informationi

Entry nameiSYTL4_HUMAN
AccessioniPrimary (citable) accession number: Q96C24
Secondary accession number(s): Q5H9J3
, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: July 9, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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