Q96C24 (SYTL4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptotagmin-like protein 4

Alternative name(s):
Exophilin-2
Granuphilin

Gene names

Name:

SYTL4

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	671 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner By similarity.
Subunit structure	Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B By similarity.
Subcellular location	Membrane; Peripheral membrane protein By similarity. Cell membrane; Peripheral membrane protein By similarity. Cytoplasmic vesicle › secretory vesicle membrane; Peripheral membrane protein By similarity. Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles By similarity.
Sequence similarities	Contains 2 C2 domains. Contains 1 FYVE-type zinc finger. Contains 1 RabBD (Rab-binding) domain.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	exocytosis Inferred from electronic annotation. Source: Compara intracellular protein transport Inferred from electronic annotation. Source: InterPro multivesicular body sorting pathway Inferred from mutant phenotype PubMed 19966785. Source: UniProtKB negative regulation of insulin secretion Inferred from electronic annotation. Source: Compara positive regulation of exocytosis Inferred from mutant phenotype PubMed 19966785. Source: UniProtKB positive regulation of protein secretion Inferred from mutant phenotype PubMed 19966785. Source: UniProtKB
Cellular_component	centrosome Inferred from direct assay. Source: HPA endosome Inferred from direct assay PubMed 19966785. Source: UniProtKB extrinsic to membrane Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell secretory granule Inferred from electronic annotation. Source: Compara synaptic vesicle Inferred from electronic annotation. Source: InterPro transport vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	neurexin family protein binding Inferred from sequence or structural similarity. Source: UniProtKB phospholipid binding Inferred from sequence or structural similarity. Source: UniProtKB transporter activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96C24-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96C24-2)

The sequence of this isoform differs from the canonical sequence as follows:
     336-657: Missing.
     658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

Note: May be due to an intron retention. No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 671

671

Synaptotagmin-like protein 4

PRO_0000190216

Regions

Domain

4 – 122

119

RabBD

Domain

358 – 462

105

C2 1

Domain

513 – 617

105

C2 2

Zinc finger

63 – 105

43

FYVE-type

Compositional bias

305 – 311

7

Poly-Glu

Amino acid modifications

Modified residue

204

1

Phosphoserine Ref.7

Modified residue

217

1

Phosphoserine Ref.7

Modified residue

289

1

Phosphoserine Ref.7

Natural variations

Alternative sequence

336 – 657

322

Missing in isoform 2.

VSP_015237

Alternative sequence

658 – 671

14

LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2.

VSP_015238

Natural variant

420

1

I → V. Ref.1 Ref.2 Ref.4
Corresponds to variant rs2022039 [ dbSNP | Ensembl ].

VAR_016076

Experimental info

Sequence conflict

44

1

L → P in CAI46126. Ref.2

Sequence conflict

160

1

T → A in BAC04287. Ref.1

Sequence conflict

251

1

V → A in CAI46126. Ref.2

Sequence conflict

287

1

S → G in BAC04287. Ref.1

Secondary structure

1

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671

Helix Strand Turn

Details...

Beta strand

64 – 66

3

Beta strand

71 – 73

3

Turn

75 – 77

3

Beta strand

78 – 80

3

Turn

81 – 84

4

Beta strand

91 – 94

4

Beta strand

100 – 102

3

Beta strand

359 – 367

9

Turn

368 – 371

4

Beta strand

372 – 382

11

Turn

388 – 391

4

Beta strand

395 – 402

8

Helix

407 – 409

3

Beta strand

410 – 412

3

Beta strand

423 – 431

9

Helix

437 – 439

3

Beta strand

441 – 449

9

Helix

451 – 453

3

Beta strand

455 – 464

10

Helix

465 – 468

4

Turn

469 – 471

3

Beta strand

474 – 479

6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 2. Checksum: 04152119330EAB84	FASTA	671	76,024
	10 20 30 40 50 60 MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD 70 80 90 100 110 120 RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY 130 140 150 160 170 180 DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE TVGQSLLHQT QMGDIWPGRK IIQERQKEPS 190 200 210 220 230 240 VLFEVPKLKS GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE 250 260 270 280 290 300 TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL 310 320 330 340 350 360 NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD FGNIFVTGRI 370 380 390 400 410 420 AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY LLPDKSRQGK RKTSIKRDTI 430 440 450 460 470 480 NPLYDETLRY EIPESLLAQR TLQFSVWHHG RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL 490 500 510 520 530 540 HGKISAESPT GLPSHKGELV VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA 550 560 570 580 590 600 AKAGGTSDSF VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT 610 620 630 640 650 660 VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP GSWAEGTLQL 670 RSSMAKQKLG L
	Isoform 2 [UniParc]. Checksum: 815C9B7DC933119E	FASTA	349	39,813
	10 20 30 40 50 60 MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG AKRGSQHYSD 70 80 90 100 110 120 RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW RCKVCAKEIE LKKATGDWFY 130 140 150 160 170 180 DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE TVGQSLLHQT QMGDIWPGRK IIQERQKEPS 190 200 210 220 230 240 VLFEVPKLKS GKSALEAESE SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE 250 260 270 280 290 300 TQPGGQNVVF VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL 310 320 330 340 NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMVSSIR SVVTGMLGY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-420. Tissue: Adrenal gland.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-420. Tissue: Endometrium and Spinal cord.
[3]	"The DNA sequence of the human X chromosome." Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R. Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-420. Tissue: Uterus.
[5]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Platelet.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204; SER-217 AND SER-289, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Solution structure of the RING domain of the synaptotagmin-like protein 4." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 43-105.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AK094110 mRNA. Translation: BAC04287.1.
BX537410 mRNA. Translation: CAD97652.1.
AL832596 mRNA. Translation: CAI46126.1.
BC014913 mRNA. Translation: AAH14913.1.
AL391688, Z73900 Genomic DNA. Translation: CAI41007.1.
AL391688, Z73900 Genomic DNA. Translation: CAI41008.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42004.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42005.1.

IPI

IPI00639966.
IPI01015206.

RefSeq

NP_001123368.1. NM_001129896.2.
NP_001167539.1. NM_001174068.1.
NP_542775.2. NM_080737.2.

UniGene

Hs.592224.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CSZ	NMR	-	A	43-105	[»]
3FDW	X-ray	2.20	A/B	352-488	[»]

ProteinModelPortal

Q96C24.

SMR

Q96C24. Positions 10-120, 354-650.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q96C24. 3 interactions.

STRING

9606.ENSP00000263033.

PTM databases

PhosphoSite

Q96C24.

Polymorphism databases

DMDM

33301663.

Proteomic databases

PaxDb

Q96C24.

PRIDE

Q96C24.

Protocols and materials databases

DNASU

94121.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000263033; ENSP00000263033; ENSG00000102362.
ENST00000276141; ENSP00000276141; ENSG00000102362.
ENST00000372981; ENSP00000362072; ENSG00000102362.
ENST00000372989; ENSP00000362080; ENSG00000102362.
ENST00000455616; ENSP00000390252; ENSG00000102362.

GeneID

94121.

KEGG

hsa:94121.

UCSC

uc004egd.4. human.
uc004egg.4. human.

Organism-specific databases

CTD

94121.

GeneCards

GC0XM099929.

H-InvDB

HIX0016918.

HGNC

HGNC:15588. SYTL4.

HPA

HPA001475.
HPA001589.

MIM

300723. gene.

neXtProt

NX_Q96C24.

PharmGKB

PA37987.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG293068.

HOVERGEN

HBG054255.

InParanoid

Q96C24.

OrthoDB

EOG4Z62NS.

PhylomeDB

Q96C24.

Gene expression databases

ArrayExpress

Q96C24.

Bgee

Q96C24.

CleanEx

HS_SYTL4.

Genevestigator

Q96C24.

GermOnline

ENSG00000102362. Homo sapiens.

Family and domain databases

Gene3D

3.30.40.10. 1 hit.

InterPro

IPR000008. C2_Ca-dep.
IPR008973. C2_Ca/lipid-bd_dom_CaLB.
IPR018029. C2_membr_targeting.
IPR010911. Rab-bd_domain.
IPR001565. Synaptotagmin.
IPR011011. Znf_FYVE_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]

Pfam

PF00168. C2. 2 hits.
[Graphical view]

PRINTS

PR00399. SYNAPTOTAGMN.

SMART

SM00239. C2. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]

SUPFAM

SSF49562. C2_CaLB. 2 hits.
SSF57903. FYVE_PHD_ZnF. 1 hit.

PROSITE

PS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
PS50178. ZF_FYVE. False negative.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

SYTL4. human.

DrugBank

DB00047. Insulin Glargine recombinant.
DB00046. Insulin Lyspro recombinant.
DB00030. Insulin recombinant.
DB00071. Insulin, porcine.

EvolutionaryTrace

Q96C24.

GenomeRNAi

94121.

NextBio

78402.

SOURCE

Search...

Entry information

Entry name

SYTL4_HUMAN

Accession

Primary (citable) accession number: Q96C24
Secondary accession number(s): Q5H9J3 , Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 25, 2003
Last sequence update:	January 11, 2011
Last modified:	May 1, 2013
This is version 115 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.