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Q96C24

- SYTL4_HUMAN

UniProt

Q96C24 - SYTL4_HUMAN

Protein

Synaptotagmin-like protein 4

Gene

SYTL4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 2 (11 Jan 2011)
      Previous versions | rss
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    Functioni

    Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri63 – 10543FYVE-typeAdd
    BLAST

    GO - Molecular functioni

    1. neurexin family protein binding Source: UniProtKB
    2. phospholipid binding Source: UniProtKB
    3. transporter activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. exocytosis Source: Ensembl
    2. intracellular protein transport Source: InterPro
    3. multivesicular body sorting pathway Source: UniProtKB
    4. negative regulation of insulin secretion Source: Ensembl
    5. positive regulation of exocytosis Source: UniProtKB
    6. positive regulation of protein secretion Source: UniProtKB

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptotagmin-like protein 4
    Alternative name(s):
    Exophilin-2
    Granuphilin
    Gene namesi
    Name:SYTL4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:15588. SYTL4.

    Subcellular locationi

    Membrane By similarity; Peripheral membrane protein By similarity. Cell membrane By similarity; Peripheral membrane protein By similarity. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity
    Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles By similarity.By similarity

    GO - Cellular componenti

    1. centrosome Source: HPA
    2. cytoplasm Source: HPA
    3. endosome Source: UniProtKB
    4. extrinsic component of membrane Source: UniProtKB
    5. nucleus Source: HPA
    6. plasma membrane Source: UniProtKB-SubCell
    7. secretory granule Source: Ensembl
    8. synaptic vesicle Source: InterPro
    9. transport vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37987.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 671671Synaptotagmin-like protein 4PRO_0000190216Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei204 – 2041Phosphoserine1 Publication
    Modified residuei217 – 2171Phosphoserine1 Publication
    Modified residuei289 – 2891Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96C24.
    PaxDbiQ96C24.
    PRIDEiQ96C24.

    PTM databases

    PhosphoSiteiQ96C24.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96C24.
    BgeeiQ96C24.
    CleanExiHS_SYTL4.
    GenevestigatoriQ96C24.

    Organism-specific databases

    HPAiHPA001475.
    HPA001589.

    Interactioni

    Subunit structurei

    Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A By similarity.By similarity

    Protein-protein interaction databases

    BioGridi125120. 10 interactions.
    IntActiQ96C24. 3 interactions.
    STRINGi9606.ENSP00000263033.

    Structurei

    Secondary structure

    1
    671
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi64 – 663
    Beta strandi71 – 733
    Turni75 – 773
    Beta strandi78 – 803
    Turni81 – 844
    Beta strandi91 – 944
    Beta strandi100 – 1023
    Beta strandi359 – 3679
    Turni368 – 3714
    Beta strandi372 – 38211
    Turni388 – 3914
    Beta strandi395 – 4028
    Helixi407 – 4093
    Beta strandi410 – 4123
    Beta strandi423 – 4319
    Helixi437 – 4393
    Beta strandi441 – 4499
    Helixi451 – 4533
    Beta strandi455 – 46410
    Helixi465 – 4684
    Turni469 – 4713
    Beta strandi474 – 4796

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CSZNMR-A43-105[»]
    3FDWX-ray2.20A/B352-488[»]
    ProteinModelPortaliQ96C24.
    SMRiQ96C24. Positions 10-120, 354-652.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ96C24.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 122119RabBDPROSITE-ProRule annotationAdd
    BLAST
    Domaini358 – 462105C2 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini513 – 617105C2 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi305 – 3117Poly-Glu

    Sequence similaritiesi

    Contains 2 C2 domains.PROSITE-ProRule annotation
    Contains 1 FYVE-type zinc finger.Curated
    Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri63 – 10543FYVE-typeAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG293068.
    HOVERGENiHBG054255.
    InParanoidiQ96C24.
    KOiK17598.
    OrthoDBiEOG7JMGDC.
    PhylomeDBiQ96C24.
    TreeFamiTF341184.

    Family and domain databases

    Gene3Di2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProiIPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028694. SYTL4.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PANTHERiPTHR10024:SF9. PTHR10024:SF9. 1 hit.
    PfamiPF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    [Graphical view]
    PRINTSiPR00399. SYNAPTOTAGMN.
    SMARTiSM00239. C2. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49562. SSF49562. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEiPS50004. C2. 2 hits.
    PS50916. RABBD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG    50
    AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW 100
    RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE 150
    TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE 200
    SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF 250
    VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL 300
    NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD 350
    FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY 400
    LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG 450
    RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV 500
    VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF 550
    VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT 600
    VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP 650
    GSWAEGTLQL RSSMAKQKLG L 671
    Length:671
    Mass (Da):76,024
    Last modified:January 11, 2011 - v2
    Checksum:i04152119330EAB84
    GO
    Isoform 2 (identifier: Q96C24-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         336-657: Missing.
         658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

    Note: May be due to an intron retention. No experimental confirmation available.

    Show »
    Length:349
    Mass (Da):39,813
    Checksum:i815C9B7DC933119E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti44 – 441L → P in CAI46126. (PubMed:17974005)Curated
    Sequence conflicti160 – 1601T → A in BAC04287. (PubMed:14702039)Curated
    Sequence conflicti251 – 2511V → A in CAI46126. (PubMed:17974005)Curated
    Sequence conflicti287 – 2871S → G in BAC04287. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti420 – 4201I → V.3 Publications
    Corresponds to variant rs2022039 [ dbSNP | Ensembl ].
    VAR_016076

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei336 – 657322Missing in isoform 2. 1 PublicationVSP_015237Add
    BLAST
    Alternative sequencei658 – 67114LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2. 1 PublicationVSP_015238Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094110 mRNA. Translation: BAC04287.1.
    BX537410 mRNA. Translation: CAD97652.1.
    AL832596 mRNA. Translation: CAI46126.1.
    BC014913 mRNA. Translation: AAH14913.1.
    Z73900, AL391688 Genomic DNA. Translation: CAI42004.1.
    Z73900, AL391688 Genomic DNA. Translation: CAI42005.1.
    CCDSiCCDS14472.1. [Q96C24-1]
    RefSeqiNP_001123368.1. NM_001129896.2. [Q96C24-1]
    NP_001167539.1. NM_001174068.1. [Q96C24-1]
    NP_542775.2. NM_080737.2. [Q96C24-1]
    XP_005262283.1. XM_005262226.1. [Q96C24-1]
    XP_005262286.1. XM_005262229.1. [Q96C24-1]
    XP_006724780.1. XM_006724717.1. [Q96C24-1]
    XP_006724781.1. XM_006724718.1. [Q96C24-1]
    UniGeneiHs.592224.

    Genome annotation databases

    EnsembliENST00000263033; ENSP00000263033; ENSG00000102362. [Q96C24-1]
    ENST00000276141; ENSP00000276141; ENSG00000102362. [Q96C24-1]
    ENST00000372981; ENSP00000362072; ENSG00000102362. [Q96C24-2]
    ENST00000372989; ENSP00000362080; ENSG00000102362. [Q96C24-1]
    GeneIDi94121.
    KEGGihsa:94121.
    UCSCiuc004egd.4. human. [Q96C24-1]
    uc004egg.4. human. [Q96C24-2]

    Polymorphism databases

    DMDMi317373281.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK094110 mRNA. Translation: BAC04287.1 .
    BX537410 mRNA. Translation: CAD97652.1 .
    AL832596 mRNA. Translation: CAI46126.1 .
    BC014913 mRNA. Translation: AAH14913.1 .
    Z73900 , AL391688 Genomic DNA. Translation: CAI42004.1 .
    Z73900 , AL391688 Genomic DNA. Translation: CAI42005.1 .
    CCDSi CCDS14472.1. [Q96C24-1 ]
    RefSeqi NP_001123368.1. NM_001129896.2. [Q96C24-1 ]
    NP_001167539.1. NM_001174068.1. [Q96C24-1 ]
    NP_542775.2. NM_080737.2. [Q96C24-1 ]
    XP_005262283.1. XM_005262226.1. [Q96C24-1 ]
    XP_005262286.1. XM_005262229.1. [Q96C24-1 ]
    XP_006724780.1. XM_006724717.1. [Q96C24-1 ]
    XP_006724781.1. XM_006724718.1. [Q96C24-1 ]
    UniGenei Hs.592224.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CSZ NMR - A 43-105 [» ]
    3FDW X-ray 2.20 A/B 352-488 [» ]
    ProteinModelPortali Q96C24.
    SMRi Q96C24. Positions 10-120, 354-652.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 125120. 10 interactions.
    IntActi Q96C24. 3 interactions.
    STRINGi 9606.ENSP00000263033.

    Chemistry

    DrugBanki DB00047. Insulin Glargine recombinant.
    DB00046. Insulin Lyspro recombinant.
    DB00030. Insulin recombinant.
    DB00071. Insulin, porcine.

    PTM databases

    PhosphoSitei Q96C24.

    Polymorphism databases

    DMDMi 317373281.

    Proteomic databases

    MaxQBi Q96C24.
    PaxDbi Q96C24.
    PRIDEi Q96C24.

    Protocols and materials databases

    DNASUi 94121.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000263033 ; ENSP00000263033 ; ENSG00000102362 . [Q96C24-1 ]
    ENST00000276141 ; ENSP00000276141 ; ENSG00000102362 . [Q96C24-1 ]
    ENST00000372981 ; ENSP00000362072 ; ENSG00000102362 . [Q96C24-2 ]
    ENST00000372989 ; ENSP00000362080 ; ENSG00000102362 . [Q96C24-1 ]
    GeneIDi 94121.
    KEGGi hsa:94121.
    UCSCi uc004egd.4. human. [Q96C24-1 ]
    uc004egg.4. human. [Q96C24-2 ]

    Organism-specific databases

    CTDi 94121.
    GeneCardsi GC0XM099929.
    H-InvDB HIX0016918.
    HGNCi HGNC:15588. SYTL4.
    HPAi HPA001475.
    HPA001589.
    MIMi 300723. gene.
    neXtProti NX_Q96C24.
    PharmGKBi PA37987.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293068.
    HOVERGENi HBG054255.
    InParanoidi Q96C24.
    KOi K17598.
    OrthoDBi EOG7JMGDC.
    PhylomeDBi Q96C24.
    TreeFami TF341184.

    Miscellaneous databases

    ChiTaRSi SYTL4. human.
    EvolutionaryTracei Q96C24.
    GeneWikii SYTL4.
    GenomeRNAii 94121.
    NextBioi 78402.
    PROi Q96C24.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96C24.
    Bgeei Q96C24.
    CleanExi HS_SYTL4.
    Genevestigatori Q96C24.

    Family and domain databases

    Gene3Di 2.60.40.150. 2 hits.
    3.30.40.10. 1 hit.
    InterProi IPR000008. C2_dom.
    IPR001565. Synaptotagmin.
    IPR028694. SYTL4.
    IPR010911. Znf_FYVE-typ.
    IPR011011. Znf_FYVE_PHD.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    PANTHERi PTHR10024:SF9. PTHR10024:SF9. 1 hit.
    Pfami PF00168. C2. 2 hits.
    PF02318. FYVE_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00399. SYNAPTOTAGMN.
    SMARTi SM00239. C2. 2 hits.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49562. SSF49562. 2 hits.
    SSF57903. SSF57903. 1 hit.
    PROSITEi PS50004. C2. 2 hits.
    PS50916. RABBD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-420.
      Tissue: Adrenal gland.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-420.
      Tissue: Endometrium and Spinal cord.
    3. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-420.
      Tissue: Uterus.
    5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Platelet.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204; SER-217 AND SER-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Solution structure of the RING domain of the synaptotagmin-like protein 4."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 43-105.
    9. "Crystal structure of a C2 domain from human synaptotagmin-like protein 4."
      New York structural genomix research consortium (NYSGXRC)
      Submitted (DEC-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 352-488.

    Entry informationi

    Entry nameiSYTL4_HUMAN
    AccessioniPrimary (citable) accession number: Q96C24
    Secondary accession number(s): Q5H9J3
    , Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 25, 2003
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3