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Protein

Synaptotagmin-like protein 4

Gene

SYTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 105FYVE-typeAdd BLAST43

GO - Molecular functioni

GO - Biological processi

  • calcium ion-regulated exocytosis of neurotransmitter Source: GO_Central
  • intracellular protein transport Source: InterPro
  • multivesicular body sorting pathway Source: UniProtKB
  • negative regulation of insulin secretion Source: Ensembl
  • platelet degranulation Source: Reactome
  • positive regulation of exocytosis Source: UniProtKB
  • positive regulation of protein secretion Source: UniProtKB
  • regulation of calcium ion-dependent exocytosis Source: GO_Central
  • vesicle fusion Source: GO_Central

Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 4
Alternative name(s):
Exophilin-2
Granuphilin
Gene namesi
Name:SYTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102362.15
HGNCiHGNC:15588 SYTL4
MIMi300723 gene
neXtProtiNX_Q96C24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000102362
PharmGKBiPA37987

Chemistry databases

DrugBankiDB00030 Insulin Human
DB00071 Insulin Pork

Polymorphism and mutation databases

BioMutaiSYTL4
DMDMi317373281

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001902161 – 671Synaptotagmin-like protein 4Add BLAST671

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei201PhosphoserineBy similarity1
Modified residuei204PhosphoserineCombined sources1
Modified residuei217PhosphoserineCombined sources1
Modified residuei221PhosphoserineCombined sources1
Modified residuei274PhosphoserineCombined sources1
Modified residuei289PhosphoserineCombined sources1
Modified residuei488PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96C24
PaxDbiQ96C24
PeptideAtlasiQ96C24
PRIDEiQ96C24

PTM databases

iPTMnetiQ96C24
PhosphoSitePlusiQ96C24

Expressioni

Gene expression databases

BgeeiENSG00000102362
CleanExiHS_SYTL4
ExpressionAtlasiQ96C24 baseline and differential
GenevisibleiQ96C24 HS

Organism-specific databases

HPAiHPA001475
HPA001589

Interactioni

Subunit structurei

Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi125120, 21 interactors
IntActiQ96C24, 22 interactors
STRINGi9606.ENSP00000263033

Structurei

Secondary structure

1671
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi64 – 66Combined sources3
Beta strandi71 – 73Combined sources3
Turni75 – 77Combined sources3
Beta strandi78 – 80Combined sources3
Turni81 – 84Combined sources4
Beta strandi91 – 94Combined sources4
Beta strandi100 – 102Combined sources3
Turni103 – 105Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi359 – 367Combined sources9
Turni368 – 371Combined sources4
Beta strandi372 – 382Combined sources11
Turni388 – 391Combined sources4
Beta strandi395 – 402Combined sources8
Helixi407 – 409Combined sources3
Beta strandi410 – 412Combined sources3
Beta strandi423 – 431Combined sources9
Helixi437 – 439Combined sources3
Beta strandi441 – 449Combined sources9
Helixi451 – 453Combined sources3
Beta strandi455 – 464Combined sources10
Helixi465 – 468Combined sources4
Turni469 – 471Combined sources3
Beta strandi474 – 479Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CSZNMR-A43-105[»]
3FDWX-ray2.20A/B352-488[»]
5X6TNMR-A59-111[»]
ProteinModelPortaliQ96C24
SMRiQ96C24
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96C24

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 122RabBDPROSITE-ProRule annotationAdd BLAST119
Domaini358 – 462C2 1PROSITE-ProRule annotationAdd BLAST105
Domaini513 – 617C2 2PROSITE-ProRule annotationAdd BLAST105

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 311Poly-Glu7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri63 – 105FYVE-typeAdd BLAST43

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XRME LUCA
GeneTreeiENSGT00810000125376
HOVERGENiHBG054255
InParanoidiQ96C24
KOiK17598
OMAiHYNHTFV
OrthoDBiEOG091G07OO
PhylomeDBiQ96C24
TreeFamiTF341184

Family and domain databases

CDDicd04029 C2A_SLP-4_5, 1 hit
Gene3Di2.60.40.150, 2 hits
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR010911 Rab_BD
IPR037303 SLP-4/5_C2A
IPR001565 Synaptotagmin
IPR028694 SYTL4
IPR011011 Znf_FYVE_PHD
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10024:SF9 PTHR10024:SF9, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50916 RABBD, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG
60 70 80 90 100
AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW
110 120 130 140 150
RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE
160 170 180 190 200
TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE
210 220 230 240 250
SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF
260 270 280 290 300
VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL
310 320 330 340 350
NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD
360 370 380 390 400
FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY
410 420 430 440 450
LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG
460 470 480 490 500
RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV
510 520 530 540 550
VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF
560 570 580 590 600
VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT
610 620 630 640 650
VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP
660 670
GSWAEGTLQL RSSMAKQKLG L
Length:671
Mass (Da):76,024
Last modified:January 11, 2011 - v2
Checksum:i04152119330EAB84
GO
Isoform 2 (identifier: Q96C24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-657: Missing.
     658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:349
Mass (Da):39,813
Checksum:i815C9B7DC933119E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44L → P in CAI46126 (PubMed:17974005).Curated1
Sequence conflicti160T → A in BAC04287 (PubMed:14702039).Curated1
Sequence conflicti251V → A in CAI46126 (PubMed:17974005).Curated1
Sequence conflicti287S → G in BAC04287 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_016076420I → V3 PublicationsCorresponds to variant dbSNP:rs2022039Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015237336 – 657Missing in isoform 2. 1 PublicationAdd BLAST322
Alternative sequenceiVSP_015238658 – 671LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2. 1 PublicationAdd BLAST14

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094110 mRNA Translation: BAC04287.1
BX537410 mRNA Translation: CAD97652.1
AL832596 mRNA Translation: CAI46126.1
BC014913 mRNA Translation: AAH14913.1
Z73900, AL391688 Genomic DNA Translation: CAI42004.1
Z73900, AL391688 Genomic DNA Translation: CAI42005.1
CCDSiCCDS14472.1 [Q96C24-1]
RefSeqiNP_001123368.1, NM_001129896.2 [Q96C24-1]
NP_001167539.1, NM_001174068.1 [Q96C24-1]
NP_542775.2, NM_080737.2 [Q96C24-1]
XP_005262286.1, XM_005262229.2 [Q96C24-1]
XP_011529370.1, XM_011531068.2 [Q96C24-1]
XP_016885460.1, XM_017029971.1 [Q96C24-1]
UniGeneiHs.592224

Genome annotation databases

EnsembliENST00000263033; ENSP00000263033; ENSG00000102362 [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362 [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362 [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362 [Q96C24-1]
GeneIDi94121
KEGGihsa:94121
UCSCiuc004egd.6 human [Q96C24-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSYTL4_HUMAN
AccessioniPrimary (citable) accession number: Q96C24
Secondary accession number(s): Q5H9J3
, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: March 28, 2018
This is version 162 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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