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Protein

Synaptotagmin-like protein 4

Gene

SYTL4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca2+-independent manner (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: GO_Central
  2. calcium ion binding Source: GO_Central
  3. clathrin binding Source: GO_Central
  4. neurexin family protein binding Source: UniProtKB
  5. phospholipid binding Source: UniProtKB
  6. syntaxin binding Source: GO_Central
  7. transporter activity Source: InterPro
  8. zinc ion binding Source: InterPro

GO - Biological processi

  1. calcium ion-dependent exocytosis of neurotransmitter Source: GO_Central
  2. intracellular protein transport Source: InterPro
  3. multivesicular body sorting pathway Source: UniProtKB
  4. negative regulation of insulin secretion Source: Ensembl
  5. positive regulation of exocytosis Source: UniProtKB
  6. positive regulation of protein secretion Source: UniProtKB
  7. regulation of calcium ion-dependent exocytosis Source: GO_Central
  8. synaptic vesicle exocytosis Source: GO_Central
  9. vesicle fusion Source: GO_Central
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-like protein 4
Alternative name(s):
Exophilin-2
Granuphilin
Gene namesi
Name:SYTL4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:15588. SYTL4.

Subcellular locationi

  1. Membrane By similarity; Peripheral membrane protein By similarity
  2. Cell membrane By similarity; Peripheral membrane protein By similarity
  3. Cytoplasmic vesiclesecretory vesicle membrane By similarity; Peripheral membrane protein By similarity

  4. Note: Detected close to the plasma membrane and on secretory granules. In pancreas, interacts with insulin-containing vesicles (By similarity).By similarity

GO - Cellular componenti

  1. centrosome Source: HPA
  2. cytoplasm Source: HPA
  3. endosome Source: UniProtKB
  4. exocytic vesicle Source: GO_Central
  5. extrinsic component of membrane Source: UniProtKB
  6. nucleoplasm Source: HPA
  7. plasma membrane Source: GO_Central
  8. secretory granule Source: Ensembl
  9. synaptic vesicle Source: InterPro
  10. transport vesicle membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37987.

Chemistry

DrugBankiDB00030. Insulin Regular.

Polymorphism and mutation databases

BioMutaiSYTL4.
DMDMi317373281.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 671671Synaptotagmin-like protein 4PRO_0000190216Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei204 – 2041Phosphoserine1 Publication
Modified residuei217 – 2171Phosphoserine1 Publication
Modified residuei274 – 2741Phosphoserine1 Publication
Modified residuei289 – 2891Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96C24.
PaxDbiQ96C24.
PRIDEiQ96C24.

PTM databases

PhosphoSiteiQ96C24.

Expressioni

Gene expression databases

BgeeiQ96C24.
CleanExiHS_SYTL4.
ExpressionAtlasiQ96C24. baseline and differential.
GenevestigatoriQ96C24.

Organism-specific databases

HPAiHPA001475.
HPA001589.

Interactioni

Subunit structurei

Part of a ternary complex containing STX1A and RAB27A. Can bind both dominant negative and dominant active mutants of RAB27A. Binds STXBP1, RAB3A, RAB8A and RAB27B. Interacts with MYO5A (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP70Q8NHQ13EBI-747142,EBI-739624
FXR2P511163EBI-747142,EBI-740459
HMG20AQ9NP663EBI-747142,EBI-740641
ZBTB7BO151563EBI-747142,EBI-740434

Protein-protein interaction databases

BioGridi125120. 17 interactions.
IntActiQ96C24. 7 interactions.
STRINGi9606.ENSP00000263033.

Structurei

Secondary structure

1
671
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi64 – 663Combined sources
Beta strandi71 – 733Combined sources
Turni75 – 773Combined sources
Beta strandi78 – 803Combined sources
Turni81 – 844Combined sources
Beta strandi91 – 944Combined sources
Beta strandi100 – 1023Combined sources
Beta strandi359 – 3679Combined sources
Turni368 – 3714Combined sources
Beta strandi372 – 38211Combined sources
Turni388 – 3914Combined sources
Beta strandi395 – 4028Combined sources
Helixi407 – 4093Combined sources
Beta strandi410 – 4123Combined sources
Beta strandi423 – 4319Combined sources
Helixi437 – 4393Combined sources
Beta strandi441 – 4499Combined sources
Helixi451 – 4533Combined sources
Beta strandi455 – 46410Combined sources
Helixi465 – 4684Combined sources
Turni469 – 4713Combined sources
Beta strandi474 – 4796Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSZNMR-A43-105[»]
3FDWX-ray2.20A/B352-488[»]
ProteinModelPortaliQ96C24.
SMRiQ96C24. Positions 10-120, 354-652.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96C24.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 122119RabBDPROSITE-ProRule annotationAdd
BLAST
Domaini358 – 462105C2 1PROSITE-ProRule annotationAdd
BLAST
Domaini513 – 617105C2 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi305 – 3117Poly-Glu

Sequence similaritiesi

Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 FYVE-type zinc finger.Curated
Contains 1 RabBD (Rab-binding) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri63 – 10543FYVE-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG293068.
GeneTreeiENSGT00780000121872.
HOVERGENiHBG054255.
InParanoidiQ96C24.
KOiK17598.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ96C24.
TreeFamiTF341184.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR001565. Synaptotagmin.
IPR028694. SYTL4.
IPR011011. Znf_FYVE_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF9. PTHR10024:SF9. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96C24-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSELLDLSFL SEEEKDLILS VLQRDEEVRK ADEKRIRRLK NELLEIKRKG
60 70 80 90 100
AKRGSQHYSD RTCARCQESL GRLSPKTNTC RGCNHLVCRD CRIQESNGTW
110 120 130 140 150
RCKVCAKEIE LKKATGDWFY DQKVNRFAYR TGSEIIRMSL RHKPAVSKRE
160 170 180 190 200
TVGQSLLHQT QMGDIWPGRK IIQERQKEPS VLFEVPKLKS GKSALEAESE
210 220 230 240 250
SLDSFTADSD STSRRDSLDK SGLFPEWKKM SAPKSQVEKE TQPGGQNVVF
260 270 280 290 300
VDEGEMIFKK NTRKILRPSE YTKSVIDLRP EDVVHESGSL GDRSKSVPGL
310 320 330 340 350
NVDMEEEEEE EDIDHLVKLH RQKLARSSMQ SGSSMSTIGS MMSIYSEAGD
360 370 380 390 400
FGNIFVTGRI AFSLKYEQQT QSLVVHVKEC HQLAYADEAK KRSNPYVKTY
410 420 430 440 450
LLPDKSRQGK RKTSIKRDTI NPLYDETLRY EIPESLLAQR TLQFSVWHHG
460 470 480 490 500
RFGRNTFLGE AEIQMDSWKL DKKLDHCLPL HGKISAESPT GLPSHKGELV
510 520 530 540 550
VSLKYIPASK TPVGGDRKKS KGGEGGELQV WIKEAKNLTA AKAGGTSDSF
560 570 580 590 600
VKGYLLPMRN KASKRKTPVM KKTLNPHYNH TFVYNGVRLE DLQHMCLELT
610 620 630 640 650
VWDREPLASN DFLGGVRLGV GTGISNGEVV DWMDSTGEEV SLWQKMRQYP
660 670
GSWAEGTLQL RSSMAKQKLG L
Length:671
Mass (Da):76,024
Last modified:January 11, 2011 - v2
Checksum:i04152119330EAB84
GO
Isoform 2 (identifier: Q96C24-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     336-657: Missing.
     658-671: LQLRSSMAKQKLGL → VSSIRSVVTGMLGY

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:349
Mass (Da):39,813
Checksum:i815C9B7DC933119E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti44 – 441L → P in CAI46126 (PubMed:17974005).Curated
Sequence conflicti160 – 1601T → A in BAC04287 (PubMed:14702039).Curated
Sequence conflicti251 – 2511V → A in CAI46126 (PubMed:17974005).Curated
Sequence conflicti287 – 2871S → G in BAC04287 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti420 – 4201I → V.3 Publications
Corresponds to variant rs2022039 [ dbSNP | Ensembl ].
VAR_016076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei336 – 657322Missing in isoform 2. 1 PublicationVSP_015237Add
BLAST
Alternative sequencei658 – 67114LQLRS…QKLGL → VSSIRSVVTGMLGY in isoform 2. 1 PublicationVSP_015238Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094110 mRNA. Translation: BAC04287.1.
BX537410 mRNA. Translation: CAD97652.1.
AL832596 mRNA. Translation: CAI46126.1.
BC014913 mRNA. Translation: AAH14913.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42004.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42005.1.
CCDSiCCDS14472.1. [Q96C24-1]
RefSeqiNP_001123368.1. NM_001129896.2. [Q96C24-1]
NP_001167539.1. NM_001174068.1. [Q96C24-1]
NP_542775.2. NM_080737.2. [Q96C24-1]
XP_005262286.1. XM_005262229.1. [Q96C24-1]
XP_006724781.1. XM_006724718.2. [Q96C24-1]
UniGeneiHs.592224.

Genome annotation databases

EnsembliENST00000263033; ENSP00000263033; ENSG00000102362. [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362. [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362. [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362. [Q96C24-1]
GeneIDi94121.
KEGGihsa:94121.
UCSCiuc004egd.4. human. [Q96C24-1]
uc004egg.4. human. [Q96C24-2]

Polymorphism and mutation databases

BioMutaiSYTL4.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK094110 mRNA. Translation: BAC04287.1.
BX537410 mRNA. Translation: CAD97652.1.
AL832596 mRNA. Translation: CAI46126.1.
BC014913 mRNA. Translation: AAH14913.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42004.1.
Z73900, AL391688 Genomic DNA. Translation: CAI42005.1.
CCDSiCCDS14472.1. [Q96C24-1]
RefSeqiNP_001123368.1. NM_001129896.2. [Q96C24-1]
NP_001167539.1. NM_001174068.1. [Q96C24-1]
NP_542775.2. NM_080737.2. [Q96C24-1]
XP_005262286.1. XM_005262229.1. [Q96C24-1]
XP_006724781.1. XM_006724718.2. [Q96C24-1]
UniGeneiHs.592224.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSZNMR-A43-105[»]
3FDWX-ray2.20A/B352-488[»]
ProteinModelPortaliQ96C24.
SMRiQ96C24. Positions 10-120, 354-652.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125120. 17 interactions.
IntActiQ96C24. 7 interactions.
STRINGi9606.ENSP00000263033.

Chemistry

DrugBankiDB00030. Insulin Regular.

PTM databases

PhosphoSiteiQ96C24.

Polymorphism and mutation databases

BioMutaiSYTL4.
DMDMi317373281.

Proteomic databases

MaxQBiQ96C24.
PaxDbiQ96C24.
PRIDEiQ96C24.

Protocols and materials databases

DNASUi94121.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263033; ENSP00000263033; ENSG00000102362. [Q96C24-1]
ENST00000276141; ENSP00000276141; ENSG00000102362. [Q96C24-1]
ENST00000372981; ENSP00000362072; ENSG00000102362. [Q96C24-2]
ENST00000372989; ENSP00000362080; ENSG00000102362. [Q96C24-1]
GeneIDi94121.
KEGGihsa:94121.
UCSCiuc004egd.4. human. [Q96C24-1]
uc004egg.4. human. [Q96C24-2]

Organism-specific databases

CTDi94121.
GeneCardsiGC0XM099929.
H-InvDBHIX0016918.
HGNCiHGNC:15588. SYTL4.
HPAiHPA001475.
HPA001589.
MIMi300723. gene.
neXtProtiNX_Q96C24.
PharmGKBiPA37987.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG293068.
GeneTreeiENSGT00780000121872.
HOVERGENiHBG054255.
InParanoidiQ96C24.
KOiK17598.
OrthoDBiEOG7JMGDC.
PhylomeDBiQ96C24.
TreeFamiTF341184.

Miscellaneous databases

ChiTaRSiSYTL4. human.
EvolutionaryTraceiQ96C24.
GeneWikiiSYTL4.
GenomeRNAii94121.
NextBioi78402.
PROiQ96C24.
SOURCEiSearch...

Gene expression databases

BgeeiQ96C24.
CleanExiHS_SYTL4.
ExpressionAtlasiQ96C24. baseline and differential.
GenevestigatoriQ96C24.

Family and domain databases

Gene3Di2.60.40.150. 2 hits.
3.30.40.10. 1 hit.
InterProiIPR000008. C2_dom.
IPR010911. Rab_BD.
IPR001565. Synaptotagmin.
IPR028694. SYTL4.
IPR011011. Znf_FYVE_PHD.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PANTHERiPTHR10024:SF9. PTHR10024:SF9. 1 hit.
PfamiPF00168. C2. 2 hits.
[Graphical view]
PRINTSiPR00399. SYNAPTOTAGMN.
SMARTiSM00239. C2. 2 hits.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 2 hits.
SSF57903. SSF57903. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50916. RABBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT VAL-420.
    Tissue: Adrenal gland.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT VAL-420.
    Tissue: Endometrium and Spinal cord.
  3. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-420.
    Tissue: Uterus.
  5. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Platelet.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204; SER-217 AND SER-289, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-274, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Solution structure of the RING domain of the synaptotagmin-like protein 4."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 43-105.
  10. "Crystal structure of a C2 domain from human synaptotagmin-like protein 4."
    New York structural genomix research consortium (NYSGXRC)
    Submitted (DEC-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 352-488.

Entry informationi

Entry nameiSYTL4_HUMAN
AccessioniPrimary (citable) accession number: Q96C24
Secondary accession number(s): Q5H9J3
, Q5JPG8, Q8N9P4, Q9H4R0, Q9H4R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: January 11, 2011
Last modified: April 29, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.