Q96C12 (ARMC5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Armadillo repeat-containing protein 5

Gene names

Name:

ARMC5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	935 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities	Contains 7 ARM repeats. Contains 1 BTB (POZ) domain.
Sequence caution	The sequence BAB15720.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96C12-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: Gene prediction based on EST data.

Isoform 2 (identifier: Q96C12-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96C12-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-164: Missing.
     667-935: Missing.

Isoform 4 (identifier: Q96C12-4)

The sequence of this isoform differs from the canonical sequence as follows:
     624-725: RLLQNLTVQA...VSPAVPQAVP → FPYPPVSLPP...PGSAIGSALS
     726-935: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 935	935	Armadillo repeat-containing protein 5		PRO_0000284405
Regions
	Repeat	143 – 183	41	ARM 1
	Repeat	185 – 225	41	ARM 2
	Repeat	227 – 267	41	ARM 3
	Repeat	271 – 310	40	ARM 4
	Repeat	312 – 357	46	ARM 5
	Repeat	359 – 403	45	ARM 6
	Repeat	405 – 444	40	ARM 7
	Domain	748 – 816	69	BTB
Natural variations
	Alternative sequence	1 – 164	164	Missing in isoform 2 and isoform 3.		VSP_024505
	Alternative sequence	624 – 725	102	RLLQN…PQAVP → FPYPPVSLPPCESPSSPMAS MGPEPHLPTLSSPARPPDNL SPEWGGEQGVPVPPWAHRQS SAVSSALALGPRYPNSRCSP APRIWAGLCFFPGSAIGSAL S in isoform 4.		VSP_024506
	Alternative sequence	667 – 935	269	Missing in isoform 3.		VSP_024507
	Alternative sequence	726 – 935	210	Missing in isoform 4.		VSP_024508
	Natural variant	170	1	I → V. Ref.2 Corresponds to variant rs35923277 [ dbSNP | Ensembl ].		VAR_050674

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: EA2F94BA028C3B1C	FASTA	935	97,682
	10 20 30 40 50 60 MAAAKPTLTD SLSFCLAQLA AAAGEALGGE KDPATNETPL SRALLALRTR HIKAAGGIER 70 80 90 100 110 120 FRARGGLRPL LALLRRAAAA GSAPSQAGPG SAPSSAASGA SSPAPASGPA PSAVSSSSPT 130 140 150 160 170 180 PPVRLRKTLD LALSILADCC TEGACRTEVR RLGGILPLVT ILQCMKTDSI QNRTARALGN 190 200 210 220 230 240 LAMEPESCGD IHCAGAVPLL VESLTACQDS QCLQSVVRAL RNLADSPQHR LALAQQGAVR 250 260 270 280 290 300 PLAELLATAP DAALTLALVR ALLELSRGCS RACAEQLSLG GGLGPLVSLA SHPKRAVREG 310 320 330 340 350 360 TILILANLCA QGLIRPALGN AGGVEVLVDE LRQRRDPNGA SPTSQQPLVR AVCLLCREAI 370 380 390 400 410 420 NRARLRDAGG LDLLMGLLRD PRASAWHPRI VAALVGFLYD TGALGRLQAL GLVPLLAGQL 430 440 450 460 470 480 CGEAGEEEEE GREAASWDFP EERTPERAQG GSFRSLRSWL ISEGYATGPD DISPDWSPEQ 490 500 510 520 530 540 CPPEPMEPAS PAPTPTSLRA PRTQRTPGRS PAAAIEEPWG REGPALLLLS RFSQAPDPSG 550 560 570 580 590 600 ALVTGPALYG LLTYVTGAPG PPSPRALRIL SRLTCNPACL EAFVRSYGAA LLRAWLVLGV 610 620 630 640 650 660 APDDWPAPRA RPTLHSRHRE LGERLLQNLT VQAESPFGVG ALTHLLLSGS PEDRVACALT 670 680 690 700 710 720 LPFICRKPSL WRRLLLEQGG LRLLLAALTR PAPHPLFLFF AADSLSCLQD LVSPTVSPAV 730 740 750 760 770 780 PQAVPMDLDS PSPCLYEPLL GPAPVPAPDL HFLLDSGLQL PAQRAASATA SPFFRALLSG 790 800 810 820 830 840 SFAEAQMDLV PLRGLSPGAA WPVLHHLHGC RGCGAALGPV PPPGQPLLGS EAEEALEAAG 850 860 870 880 890 900 RFLLPGLEEE LEEAVGRIHL GPQGGPESVG EVFRLGRPRL AAHCARWTLG SEQCPRKRGL 910 920 930 ALVGLVEAAG EEAGPLTEAL LAVVMGIELG ARVPA
	Isoform 2 [UniParc]. Checksum: 98E3B052CD34191B	FASTA	771	81,369
	10 20 30 40 50 60 MKTDSIQNRT ARALGNLAME PESCGDIHCA GAVPLLVESL TACQDSQCLQ SVVRALRNLA 70 80 90 100 110 120 DSPQHRLALA QQGAVRPLAE LLATAPDAAL TLALVRALLE LSRGCSRACA EQLSLGGGLG 130 140 150 160 170 180 PLVSLASHPK RAVREGTILI LANLCAQGLI RPALGNAGGV EVLVDELRQR RDPNGASPTS 190 200 210 220 230 240 QQPLVRAVCL LCREAINRAR LRDAGGLDLL MGLLRDPRAS AWHPRIVAAL VGFLYDTGAL 250 260 270 280 290 300 GRLQALGLVP LLAGQLCGEA GEEEEEGREA ASWDFPEERT PERAQGGSFR SLRSWLISEG 310 320 330 340 350 360 YATGPDDISP DWSPEQCPPE PMEPASPAPT PTSLRAPRTQ RTPGRSPAAA IEEPWGREGP 370 380 390 400 410 420 ALLLLSRFSQ APDPSGALVT GPALYGLLTY VTGAPGPPSP RALRILSRLT CNPACLEAFV 430 440 450 460 470 480 RSYGAALLRA WLVLGVAPDD WPAPRARPTL HSRHRELGER LLQNLTVQAE SPFGVGALTH 490 500 510 520 530 540 LLLSGSPEDR VACALTLPFI CRKPSLWRRL LLEQGGLRLL LAALTRPAPH PLFLFFAADS 550 560 570 580 590 600 LSCLQDLVSP TVSPAVPQAV PMDLDSPSPC LYEPLLGPAP VPAPDLHFLL DSGLQLPAQR 610 620 630 640 650 660 AASATASPFF RALLSGSFAE AQMDLVPLRG LSPGAAWPVL HHLHGCRGCG AALGPVPPPG 670 680 690 700 710 720 QPLLGSEAEE ALEAAGRFLL PGLEEELEEA VGRIHLGPQG GPESVGEVFR LGRPRLAAHC 730 740 750 760 770 ARWTLGSEQC PRKRGLALVG LVEAAGEEAG PLTEALLAVV MGIELGARVP A
	Isoform 3 [UniParc]. Checksum: 949C53AB035CD55A	FASTA	502	53,306
	10 20 30 40 50 60 MKTDSIQNRT ARALGNLAME PESCGDIHCA GAVPLLVESL TACQDSQCLQ SVVRALRNLA 70 80 90 100 110 120 DSPQHRLALA QQGAVRPLAE LLATAPDAAL TLALVRALLE LSRGCSRACA EQLSLGGGLG 130 140 150 160 170 180 PLVSLASHPK RAVREGTILI LANLCAQGLI RPALGNAGGV EVLVDELRQR RDPNGASPTS 190 200 210 220 230 240 QQPLVRAVCL LCREAINRAR LRDAGGLDLL MGLLRDPRAS AWHPRIVAAL VGFLYDTGAL 250 260 270 280 290 300 GRLQALGLVP LLAGQLCGEA GEEEEEGREA ASWDFPEERT PERAQGGSFR SLRSWLISEG 310 320 330 340 350 360 YATGPDDISP DWSPEQCPPE PMEPASPAPT PTSLRAPRTQ RTPGRSPAAA IEEPWGREGP 370 380 390 400 410 420 ALLLLSRFSQ APDPSGALVT GPALYGLLTY VTGAPGPPSP RALRILSRLT CNPACLEAFV 430 440 450 460 470 480 RSYGAALLRA WLVLGVAPDD WPAPRARPTL HSRHRELGER LLQNLTVQAE SPFGVGALTH 490 500 LLLSGSPEDR VACALTLPFI CR
	Isoform 4 [UniParc]. Checksum: 25480699A0C50DB7	FASTA	724	75,511
	10 20 30 40 50 60 MAAAKPTLTD SLSFCLAQLA AAAGEALGGE KDPATNETPL SRALLALRTR HIKAAGGIER 70 80 90 100 110 120 FRARGGLRPL LALLRRAAAA GSAPSQAGPG SAPSSAASGA SSPAPASGPA PSAVSSSSPT 130 140 150 160 170 180 PPVRLRKTLD LALSILADCC TEGACRTEVR RLGGILPLVT ILQCMKTDSI QNRTARALGN 190 200 210 220 230 240 LAMEPESCGD IHCAGAVPLL VESLTACQDS QCLQSVVRAL RNLADSPQHR LALAQQGAVR 250 260 270 280 290 300 PLAELLATAP DAALTLALVR ALLELSRGCS RACAEQLSLG GGLGPLVSLA SHPKRAVREG 310 320 330 340 350 360 TILILANLCA QGLIRPALGN AGGVEVLVDE LRQRRDPNGA SPTSQQPLVR AVCLLCREAI 370 380 390 400 410 420 NRARLRDAGG LDLLMGLLRD PRASAWHPRI VAALVGFLYD TGALGRLQAL GLVPLLAGQL 430 440 450 460 470 480 CGEAGEEEEE GREAASWDFP EERTPERAQG GSFRSLRSWL ISEGYATGPD DISPDWSPEQ 490 500 510 520 530 540 CPPEPMEPAS PAPTPTSLRA PRTQRTPGRS PAAAIEEPWG REGPALLLLS RFSQAPDPSG 550 560 570 580 590 600 ALVTGPALYG LLTYVTGAPG PPSPRALRIL SRLTCNPACL EAFVRSYGAA LLRAWLVLGV 610 620 630 640 650 660 APDDWPAPRA RPTLHSRHRE LGEFPYPPVS LPPCESPSSP MASMGPEPHL PTLSSPARPP 670 680 690 700 710 720 DNLSPEWGGE QGVPVPPWAH RQSSAVSSAL ALGPRYPNSR CSPAPRIWAG LCFFPGSAIG SALS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Shan Y.X., Yu L., Huang C.Q. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT VAL-170. Tissue: Spleen and Teratocarcinoma.
[3]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed: 15616553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Skin.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY217348 mRNA. Translation: AAO45101.1. AK023125 mRNA. Translation: BAB14418.1. AK024430 mRNA. Translation: BAB15720.1. Different initiation. AC026471 Genomic DNA. No translation available. BC014945 mRNA. Translation: AAH14945.1.
IPI	IPI00100910. IPI00303372. IPI00843868. IPI00983741.
RefSeq	NP_001098717.1. NM_001105247.1. NP_079018.1. NM_024742.2.
UniGene	Hs.121915.
3D structure databases
ProteinModelPortal	Q96C12.
SMR	Q96C12. Positions 109-420, 642-690, 749-890.
ModBase	Search...
Polymorphism databases
DMDM	145558851.
Proteomic databases
PRIDE	Q96C12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000268314; ENSP00000268314; ENSG00000140691. ENST00000408912; ENSP00000386125; ENSG00000140691.
GeneID	79798.
KEGG	hsa:79798.
UCSC	uc002eca.2. human. uc002ecb.1. human. uc002ecc.1. human.
Organism-specific databases
CTD	79798.
GeneCards	GC16P031473.
HGNC	HGNC:25781. ARMC5.
HPA	HPA041524.
neXtProt	NX_Q96C12.
PharmGKB	PA134926941.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG12284.
GeneTree	ENSGT00390000009109.
HOVERGEN	HBG055351.
InParanoid	Q96C12.
OrthoDB	EOG4W3SMH.
Gene expression databases
ArrayExpress	Q96C12.
Bgee	Q96C12.
CleanEx	HS_ARMC5.
Genevestigator	Q96C12.
Family and domain databases
InterPro	IPR011989. ARM-like. IPR016024. ARM-type_fold. IPR000225. Armadillo. IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. [Graphical view]
Gene3D	G3DSA:1.25.10.10. ARM-like. 4 hits. G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit.
SMART	SM00185. ARM. 4 hits. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 2 hits.
PROSITE	PS50176. ARM_REPEAT. 1 hit. PS50097. BTB. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	69346.

Entry information

Entry name

ARMC5_HUMAN

Accession

Primary (citable) accession number: Q96C12
Secondary accession number(s): Q86WM9, Q9H7P8, Q9H925

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 17, 2007
Last sequence update:	April 17, 2007
Last modified:	January 25, 2012
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.