Q96C11 (FGGY_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
FGGY carbohydrate kinase domain-containing protein
EC=2.7.1.-

Gene names

Name:

FGGY

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	551 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Tissue specificity	Expressed in kidney, lung and small intestine and to a lower extent in liver and detected in cerebrospinal fluid (at protein level). Ref.5
Developmental stage	Expressed in fetal brain (at protein level). Ref.5
Involvement in disease	Amyotrophic lateral sclerosis (ALS) [MIM:105400]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Sequence similarities	Belongs to the FGGY kinase family.
Sequence caution	The sequence AAH14947.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Amyotrophic lateral sclerosis Neurodegeneration
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cell death Inferred from electronic annotation. Source: UniProtKB-KW neuron homeostasis Inferred from mutant phenotype Ref.5. Source: UniProtKB
Molecular_function	kinase activity Inferred from electronic annotation. Source: UniProtKB-KW phosphotransferase activity, alcohol group as acceptor Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96C11-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96C11-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.
     359-551: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96C11-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-112: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q96C11-3)

The sequence of this isoform differs from the canonical sequence as follows:
     407-407: M → MRTTGYLYIPALAALHSPSSLLSPQ

Note: No experimental confirmation available.

Isoform 5 (identifier: Q96C11-5)

The sequence of this isoform differs from the canonical sequence as follows:
     68-155: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 551	551	FGGY carbohydrate kinase domain-containing protein		PRO_0000326452
Natural variations
	Alternative sequence	1 – 112	112	Missing in isoform 2 and isoform 3.		VSP_032658
	Alternative sequence	68 – 155	88	Missing in isoform 5.		VSP_045338
	Alternative sequence	359 – 551	193	Missing in isoform 2.		VSP_032659
	Alternative sequence	407	1	M → MRTTGYLYIPALAALHSPSS LLSPQ in isoform 4.		VSP_033424
	Natural variant	43	1	N → K. Corresponds to variant rs835409 [ dbSNP | Ensembl ].		VAR_059193
	Natural variant	134	1	L → V. Corresponds to variant rs11207463 [ dbSNP | Ensembl ].		VAR_040072
	Natural variant	246	1	L → V. Corresponds to variant rs11207463 [ dbSNP | Ensembl ].		VAR_059194

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 938946C33E6DC78F	FASTA	551	59,993
	10 20 30 40 50 60 MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH HEQSSEDIWA 70 80 90 100 110 120 ACCVVTKKVV QGIDLNQIRG LGFDATCSLV VLDKQFHPLP VNQEGDSHRN VIMWLDHRAV 130 140 150 160 170 180 SQVNRINETK HSVLQYVGGV MSVEMQAPKL LWLKENLREI CWDKAGHFFD LPDFLSWKAT 190 200 210 220 230 240 GVTARSLCSL VCKWTYSAEK GWDDSFWKMI GLEDFVADNY SKIGNQVLPP GASLGNGLTP 250 260 270 280 290 300 EAARDLGLLP GIAVAASLID AHAGGLGVIG ADVRGHGLIC EGQPVTSRLA VICGTSSCHM 310 320 330 340 350 360 GISKDPIFVP GVWGPYFSAM VPGFWLNEGG QSVTGKLIDH MVQGHAAFPE LQVKATARCQ 370 380 390 400 410 420 SIYAYLNSHL DLIKKAQPVG FLTVDLHVWP DFHGNRSPLA DLTLKGMVTG LKLSQDLDDL 430 440 450 460 470 480 AILYLATVQA IALGTRFIIE AMEAAGHSIS TLFLCGGLSK NPLFVQMHAD ITGMPVVLSQ 490 500 510 520 530 540 EVESVLVGAA VLGACASGDF ASVQEAMAKM SKVGKVVFPR LQDKKYYDKK YQVFLKLVEH 550 QKEYLAIMND D
	Isoform 2 [UniParc]. Checksum: 04D5374635B4DB01	FASTA	246	26,577
	10 20 30 40 50 60 MWLDHRAVSQ VNRINETKHS VLQYVGGVMS VEMQAPKLLW LKENLREICW DKAGHFFDLP 70 80 90 100 110 120 DFLSWKATGV TARSLCSLVC KWTYSAEKGW DDSFWKMIGL EDFVADNYSK IGNQVLPPGA 130 140 150 160 170 180 SLGNGLTPEA ARDLGLLPGI AVAASLIDAH AGGLGVIGAD VRGHGLICEG QPVTSRLAVI 190 200 210 220 230 240 CGTSSCHMGI SKDPIFVPGV WGPYFSAMVP GFWLNEGGQS VTGKLIDHMV QGHAAFPELQ VKATAR
	Isoform 3 [UniParc]. Checksum: 6DF2354474EBE3E8	FASTA	439	47,706
	10 20 30 40 50 60 MWLDHRAVSQ VNRINETKHS VLQYVGGVMS VEMQAPKLLW LKENLREICW DKAGHFFDLP 70 80 90 100 110 120 DFLSWKATGV TARSLCSLVC KWTYSAEKGW DDSFWKMIGL EDFVADNYSK IGNQVLPPGA 130 140 150 160 170 180 SLGNGLTPEA ARDLGLLPGI AVAASLIDAH AGGLGVIGAD VRGHGLICEG QPVTSRLAVI 190 200 210 220 230 240 CGTSSCHMGI SKDPIFVPGV WGPYFSAMVP GFWLNEGGQS VTGKLIDHMV QGHAAFPELQ 250 260 270 280 290 300 VKATARCQSI YAYLNSHLDL IKKAQPVGFL TVDLHVWPDF HGNRSPLADL TLKGMVTGLK 310 320 330 340 350 360 LSQDLDDLAI LYLATVQAIA LGTRFIIEAM EAAGHSISTL FLCGGLSKNP LFVQMHADIT 370 380 390 400 410 420 GMPVVLSQEV ESVLVGAAVL GACASGDFAS VQEAMAKMSK VGKVVFPRLQ DKKYYDKKYQ 430 VFLKLVEHQK EYLAIMNDD
	Isoform 4 [UniParc]. Checksum: 3F1D3C60B539B98A	FASTA	575	62,532
	10 20 30 40 50 60 MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH HEQSSEDIWA 70 80 90 100 110 120 ACCVVTKKVV QGIDLNQIRG LGFDATCSLV VLDKQFHPLP VNQEGDSHRN VIMWLDHRAV 130 140 150 160 170 180 SQVNRINETK HSVLQYVGGV MSVEMQAPKL LWLKENLREI CWDKAGHFFD LPDFLSWKAT 190 200 210 220 230 240 GVTARSLCSL VCKWTYSAEK GWDDSFWKMI GLEDFVADNY SKIGNQVLPP GASLGNGLTP 250 260 270 280 290 300 EAARDLGLLP GIAVAASLID AHAGGLGVIG ADVRGHGLIC EGQPVTSRLA VICGTSSCHM 310 320 330 340 350 360 GISKDPIFVP GVWGPYFSAM VPGFWLNEGG QSVTGKLIDH MVQGHAAFPE LQVKATARCQ 370 380 390 400 410 420 SIYAYLNSHL DLIKKAQPVG FLTVDLHVWP DFHGNRSPLA DLTLKGMRTT GYLYIPALAA 430 440 450 460 470 480 LHSPSSLLSP QVTGLKLSQD LDDLAILYLA TVQAIALGTR FIIEAMEAAG HSISTLFLCG 490 500 510 520 530 540 GLSKNPLFVQ MHADITGMPV VLSQEVESVL VGAAVLGACA SGDFASVQEA MAKMSKVGKV 550 560 570 VFPRLQDKKY YDKKYQVFLK LVEHQKEYLA IMNDD
	Isoform 5 [UniParc]. Checksum: C124C94AEBB4384A	FASTA	463	50,035
	10 20 30 40 50 60 MSGGEQKPER YYVGVDVGTG SVRAALVDQS GVLLAFADQP IKNWEPQFNH HEQSSEDIWA 70 80 90 100 110 120 ACCVVTKNLR EICWDKAGHF FDLPDFLSWK ATGVTARSLC SLVCKWTYSA EKGWDDSFWK 130 140 150 160 170 180 MIGLEDFVAD NYSKIGNQVL PPGASLGNGL TPEAARDLGL LPGIAVAASL IDAHAGGLGV 190 200 210 220 230 240 IGADVRGHGL ICEGQPVTSR LAVICGTSSC HMGISKDPIF VPGVWGPYFS AMVPGFWLNE 250 260 270 280 290 300 GGQSVTGKLI DHMVQGHAAF PELQVKATAR CQSIYAYLNS HLDLIKKAQP VGFLTVDLHV 310 320 330 340 350 360 WPDFHGNRSP LADLTLKGMV TGLKLSQDLD DLAILYLATV QAIALGTRFI IEAMEAAGHS 370 380 390 400 410 420 ISTLFLCGGL SKNPLFVQMH ADITGMPVVL SQEVESVLVG AAVLGACASG DFASVQEAMA 430 440 450 460 KMSKVGKVVF PRLQDKKYYD KKYQVFLKLV EHQKEYLAIM NDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 5). Tissue: Cerebellum, Mammary gland and Synovium.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin.
[5]	"Whole-genome analysis of sporadic amyotrophic lateral sclerosis." Dunckley T., Huentelman M.J., Craig D.W., Pearson J.V., Szelinger S., Joshipura K., Halperin R.F., Stamper C., Jensen K.R., Letizia D., Hesterlee S.E., Pestronk A., Levine T., Bertorini T., Graves M.C., Mozaffar T., Jackson C.E., Bosch P. , McVey A., Dick A., Barohn R., Lomen-Hoerth C., Rosenfeld J., O'connor D.T., Zhang K., Crook R., Ryberg H., Hutton M., Katz J., Simpson E.P., Mitsumoto H., Bowser R., Miller R.G., Appel S.H., Stephan D.A. N. Engl. J. Med. 357:775-788(2007) [PubMed] [Europe PMC] [Abstract] Cited for: INVOLVEMENT IN SPORADIC AMYOTROPHIC LATERAL SCLEROSIS, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022237 mRNA. Translation: BAB13993.1. AK054842 mRNA. Translation: BAG51432.1. AK315649 mRNA. Translation: BAG38015.1. AL954338 Genomic DNA. No translation available. AL713859 , AC093424, AL035416, AL390234, BX119322 Genomic DNA. Translation: CAH71629.1. AL390234 , AC093424, AL035416, AL713859, BX119322 Genomic DNA. Translation: CAI18949.1. BX119322 , AC093424, AL035416, AL390234, AL713859 Genomic DNA. Translation: CAI22210.1. AL035416 , AC093424, AL390234, AL713859, BX119322 Genomic DNA. Translation: CAI22776.1. AL713859 , AC093424, AL035416, AL390234, BX119322 Genomic DNA. Translation: CAH71628.1. AL390234 , AC093424, AL035416, AL713859, BX119322 Genomic DNA. Translation: CAI18948.1. BX119322 , AC093424, AL035416, AL390234, AL713859 Genomic DNA. Translation: CAI22209.1. AL035416 , AC093424, AL390234, AL713859, BX119322 Genomic DNA. Translation: CAI22775.1. AL713859 , AC093424, AL035416, AL390234, BX119322 Genomic DNA. Translation: CAH71630.1. AL390234 , AC093424, AL035416, AL713859, BX119322 Genomic DNA. Translation: CAI18947.1. BX119322 , AC093424, AL035416, AL390234, AL713859 Genomic DNA. Translation: CAI22211.1. AL035416 , AC093424, AL390234, AL713859, BX119322 Genomic DNA. Translation: CAI22777.1. CH471059 Genomic DNA. Translation: EAX06621.1. CH471059 Genomic DNA. Translation: EAX06622.1. CH471059 Genomic DNA. Translation: EAX06623.1. CH471059 Genomic DNA. Translation: EAX06624.1. BC014947 mRNA. Translation: AAH14947.1. Different initiation.
IPI	IPI00478961. IPI00479683. IPI00641302. IPI00892757.
RefSeq	NP_001106882.1. NM_001113411.1. NP_001231643.1. NM_001244714.1. NP_060761.3. NM_018291.3.
UniGene	Hs.444301.
3D structure databases
ProteinModelPortal	Q96C11.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000360262.
PTM databases
PhosphoSite	Q96C11.
Polymorphism databases
DMDM	172045850.
Proteomic databases
PaxDb	Q96C11.
PRIDE	Q96C11.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000303721; ENSP00000305922; ENSG00000172456. ENST00000371212; ENSP00000360256; ENSG00000172456. ENST00000371218; ENSP00000360262; ENSG00000172456.
GeneID	55277.
KEGG	hsa:55277.
UCSC	uc001czg.2. human. uc001czi.4. human. uc009wac.3. human.
Organism-specific databases
CTD	55277.
GeneCards	GC01P059762.
HGNC	HGNC:25610. FGGY.
HPA	HPA052442. HPA054971.
MIM	105400. phenotype. 611370. gene.
neXtProt	NX_Q96C11.
PharmGKB	PA162388453.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1069.
HOGENOM	HOG000222136.
HOVERGEN	HBG055703.
OMA	WKATGVT.
Gene expression databases
ArrayExpress	Q96C11.
Bgee	Q96C11.
CleanEx	HS_FGGY.
Genevestigator	Q96C11.
Family and domain databases
InterPro	IPR006003. Carb_kinase_FGGY-rel. IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. [Graphical view]
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01315. 5C_CHO_kinase. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	55277.
NextBio	59413.
SOURCE	Search...

Entry information

Entry name

FGGY_HUMAN

Accession

Primary (citable) accession number: Q96C11
Secondary accession number(s): B1AK92 , B1AK93, B1AK94, B2RDR8, D3DQ56, Q9HA63

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	May 1, 2013
This is version 83 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.