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Q96C10

- DHX58_HUMAN

UniProt

Q96C10 - DHX58_HUMAN

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Protein
Probable ATP-dependent RNA helicase DHX58
Gene
DHX58, D11LGP2E, LGP2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.10 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Cofactori

Zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Zinc
Metal bindingi559 – 5591Zinc
Metal bindingi612 – 6121Zinc
Metal bindingi615 – 6151Zinc

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 318ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. double-stranded RNA binding Source: UniProtKB
  4. helicase activity Source: UniProtKB-KW
  5. protein binding Source: UniProtKB
  6. single-stranded RNA binding Source: UniProtKB
  7. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. defense response to virus Source: UniProtKB-KW
  2. innate immune response Source: UniProtKB-KW
  3. negative regulation of MDA-5 signaling pathway Source: UniProtKB
  4. negative regulation of RIG-I signaling pathway Source: UniProtKB
  5. negative regulation of innate immune response Source: UniProtKB
  6. negative regulation of type I interferon production Source: UniProtKB
  7. positive regulation of MDA-5 signaling pathway Source: UniProtKB
  8. positive regulation of RIG-I signaling pathway Source: UniProtKB
  9. positive regulation of type I interferon production Source: UniProtKB
  10. regulation of innate immune response Source: UniProtKB
  11. response to virus Source: UniProtKB
  12. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Antiviral defense, Host-virus interaction, Immunity, Innate immunity

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, RNA-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_25359. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DHX58 (EC:3.6.4.13)
Alternative name(s):
Probable ATP-dependent helicase LGP2
Protein D11Lgp2 homolog
RIG-I-like receptor 3
Short name:
RLR-3
RIG-I-like receptor LGP2
Short name:
RLR
Gene namesi
Name:DHX58
Synonyms:D11LGP2E, LGP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:29517. DHX58.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi634 – 6341K → E: Abolishes RNA binding. 2 Publications
Mutagenesisi651 – 6511K → E: Abolishes RNA binding. 1 Publication

Organism-specific databases

PharmGKBiPA162383566.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Probable ATP-dependent RNA helicase DHX58
PRO_0000102010Add
BLAST

Proteomic databases

MaxQBiQ96C10.
PaxDbiQ96C10.
PRIDEiQ96C10.

PTM databases

PhosphoSiteiQ96C10.

Expressioni

Inductioni

By interferon (IFN), virus infection, or intracellular dsRNA.

Gene expression databases

ArrayExpressiQ96C10.
BgeeiQ96C10.
CleanExiHS_DHX58.
GenevestigatoriQ96C10.

Organism-specific databases

HPAiHPA018670.
HPA019570.

Interactioni

Subunit structurei

Monomer in the absence of dsRNA. Homodimer in the presence of dsRNA. Interacts with DDX58/RIG-I (via CARD domain), MAVS/IPS1 and DDX60. Found in a complex with DDX58/RIG-I and IFIH1/MDA5. Interacts (via helicase C-terminal domain) with non-structural protein V of Human parainfluenza 2 virus, Human parainfluenza 5 virus, measles virus, mumps virus, hendra virus and nipah virus.7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AGO2Q9UKV82EBI-744193,EBI-528269
DHX30Q7L2E32EBI-744193,EBI-1211456
DICER1Q9UPY32EBI-744193,EBI-395506
EIF2AK2P195252EBI-744193,EBI-640775
EIF6P565372EBI-744193,EBI-372243
NKRFO152262EBI-744193,EBI-766011
P/VP112072EBI-744193,EBI-6148694From a different organism.
P/VP309272EBI-744193,EBI-6599165From a different organism.
P/VQ9EMA92EBI-744193,EBI-6598728From a different organism.
STAU2Q9NUL32EBI-744193,EBI-722938

Protein-protein interaction databases

BioGridi122553. 14 interactions.
DIPiDIP-60792N.
IntActiQ96C10. 18 interactions.
MINTiMINT-1460040.
STRINGi9606.ENSP00000251642.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi549 – 5513
Beta strandi553 – 5564
Turni557 – 5593
Beta strandi562 – 5654
Helixi566 – 5683
Beta strandi569 – 5724
Turni573 – 5753
Beta strandi576 – 5794
Helixi582 – 5876
Beta strandi588 – 5903
Beta strandi592 – 5943
Beta strandi597 – 5993
Beta strandi602 – 61211
Turni613 – 6153
Beta strandi618 – 6258
Beta strandi628 – 6336
Helixi635 – 6373
Beta strandi638 – 6425
Beta strandi645 – 6473
Helixi652 – 6543
Beta strandi655 – 6573
Helixi664 – 6718

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2RQANMR-A546-678[»]
2W4RX-ray2.60A/B/C/D537-678[»]
3EQTX-ray2.00A/B541-678[»]
ProteinModelPortaliQ96C10.
SMRiQ96C10. Positions 1-678.

Miscellaneous databases

EvolutionaryTraceiQ96C10.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 188178Helicase ATP-binding
Add
BLAST
Domaini350 – 514165Helicase C-terminal
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni476 – 678203Repressor domain
Add
BLAST
Regioni572 – 65584RNA-binding
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili489 – 54658 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi131 – 1344DECH box

Domaini

The repressor domain is capable of inhibiting dimerization and signaling of DDX58/RIG-I and also facilitates binding of dsRNA.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG1111.
HOGENOMiHOG000230992.
HOVERGENiHBG106019.
InParanoidiQ96C10.
KOiK12649.
OMAiENPKLEM.
PhylomeDBiQ96C10.
TreeFamiTF330258.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view]
PfamiPF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C10-1 [UniParc]FASTAAdd to Basket

« Hide

MELRSYQWEV IMPALEGKNI IIWLPTGAGK TRAAAYVAKR HLETVDGAKV    50
VVLVNRVHLV TQHGEEFRRM LDGRWTVTTL SGDMGPRAGF GHLARCHDLL 100
ICTAELLQMA LTSPEEEEHV ELTVFSLIVV DECHHTHKDT VYNVIMSQYL 150
ELKLQRAQPL PQVLGLTASP GTGGASKLDG AINHVLQLCA NLDTWCIMSP 200
QNCCPQLQEH SQQPCKQYNL CHRRSQDPFG DLLKKLMDQI HDHLEMPELS 250
RKFGTQMYEQ QVVKLSEAAA LAGLQEQRVY ALHLRRYNDA LLIHDTVRAV 300
DALAALQDFY HREHVTKTQI LCAERRLLAL FDDRKNELAH LATHGPENPK 350
LEMLEKILQR QFSSSNSPRG IIFTRTRQSA HSLLLWLQQQ QGLQTVDIRA 400
QLLIGAGNSS QSTHMTQRDQ QEVIQKFQDG TLNLLVATSV AEEGLDIPHC 450
NVVVRYGLLT NEISMVQARG RARADQSVYA FVATEGSREL KRELINEALE 500
TLMEQAVAAV QKMDQAEYQA KIRDLQQAAL TKRAAQAAQR ENQRQQFPVE 550
HVQLLCINCM VAVGHGSDLR KVEGTHHVNV NPNFSNYYNV SRDPVVINKV 600
FKDWKPGGVI SCRNCGEVWG LQMIYKSVKL PVLKVRSMLL ETPQGRIQAK 650
KWSRVPFSVP DFDFLQHCAE NLSDLSLD 678
Length:678
Mass (Da):76,613
Last modified:December 1, 2001 - v1
Checksum:i859E1749C7313D06
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti76 – 761T → A.
Corresponds to variant rs34891485 [ dbSNP | Ensembl ].
VAR_049336
Natural varianti95 – 951R → Q.
Corresponds to variant rs35118457 [ dbSNP | Ensembl ].
VAR_049337
Natural varianti425 – 4251Q → R.
Corresponds to variant rs2074158 [ dbSNP | Ensembl ].
VAR_019394
Natural varianti523 – 5231R → Q.
Corresponds to variant rs2074160 [ dbSNP | Ensembl ].
VAR_019395

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731R → W in BAB13818. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021416 mRNA. Translation: BAB13818.1.
BC014949 mRNA. Translation: AAH14949.1.
CCDSiCCDS11416.1.
RefSeqiNP_077024.2. NM_024119.2.
UniGeneiHs.55918.

Genome annotation databases

EnsembliENST00000251642; ENSP00000251642; ENSG00000108771.
ENST00000563880; ENSP00000455290; ENSG00000260178.
GeneIDi79132.
KEGGihsa:79132.
UCSCiuc002hyw.3. human.

Polymorphism databases

DMDMi50401123.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK021416 mRNA. Translation: BAB13818.1 .
BC014949 mRNA. Translation: AAH14949.1 .
CCDSi CCDS11416.1.
RefSeqi NP_077024.2. NM_024119.2.
UniGenei Hs.55918.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2RQA NMR - A 546-678 [» ]
2W4R X-ray 2.60 A/B/C/D 537-678 [» ]
3EQT X-ray 2.00 A/B 541-678 [» ]
ProteinModelPortali Q96C10.
SMRi Q96C10. Positions 1-678.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122553. 14 interactions.
DIPi DIP-60792N.
IntActi Q96C10. 18 interactions.
MINTi MINT-1460040.
STRINGi 9606.ENSP00000251642.

PTM databases

PhosphoSitei Q96C10.

Polymorphism databases

DMDMi 50401123.

Proteomic databases

MaxQBi Q96C10.
PaxDbi Q96C10.
PRIDEi Q96C10.

Protocols and materials databases

DNASUi 79132.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251642 ; ENSP00000251642 ; ENSG00000108771 .
ENST00000563880 ; ENSP00000455290 ; ENSG00000260178 .
GeneIDi 79132.
KEGGi hsa:79132.
UCSCi uc002hyw.3. human.

Organism-specific databases

CTDi 79132.
GeneCardsi GC17M040255.
HGNCi HGNC:29517. DHX58.
HPAi HPA018670.
HPA019570.
MIMi 608588. gene.
neXtProti NX_Q96C10.
PharmGKBi PA162383566.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1111.
HOGENOMi HOG000230992.
HOVERGENi HBG106019.
InParanoidi Q96C10.
KOi K12649.
OMAi ENPKLEM.
PhylomeDBi Q96C10.
TreeFami TF330258.

Enzyme and pathway databases

Reactomei REACT_25359. RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways.

Miscellaneous databases

ChiTaRSi DHX58. human.
EvolutionaryTracei Q96C10.
GeneWikii LGP2.
GenomeRNAii 79132.
NextBioi 67993.
PROi Q96C10.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96C10.
Bgeei Q96C10.
CleanExi HS_DHX58.
Genevestigatori Q96C10.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR006935. Helicase/UvrB_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR021673. RIG-I_C-RD.
[Graphical view ]
Pfami PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF11648. RIG-I_C-RD. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
PROSITEi PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. "Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity."
    Yoneyama M., Kikuchi M., Matsumoto K., Imaizumi T., Miyagishi M., Taira K., Foy E., Loo Y.-M., Gale M. Jr., Akira S., Yonehara S., Kato A., Fujita T.
    J. Immunol. 175:2851-2858(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  4. "RNA- and virus-independent inhibition of antiviral signaling by RNA helicase LGP2."
    Komuro A., Horvath C.M.
    J. Virol. 80:12332-12342(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH MAVS/IPS1 AND DDX58/RIG-I.
  5. "Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2."
    Saito T., Hirai R., Loo Y.-M., Owen D., Johnson C.L., Sinha S.C., Akira S., Fujita T., Gale M. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 104:582-587(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DDX58/RIG-I.
  6. "Regulation of interferon production by RIG-I and LGP2: a lesson in self-control."
    Vitour D., Meurs E.F.
    Sci. STKE 2007:PE20-PE20(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  7. "Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response."
    Murali A., Li X., Ranjith-Kumar C.T., Bhardwaj K., Holzenburg A., Li P., Kao C.C.
    J. Biol. Chem. 283:15825-15833(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  8. "Regulation of signal transduction by enzymatically inactive antiviral RNA helicase proteins MDA5, RIG-I, and LGP2."
    Bamming D., Horvath C.M.
    J. Biol. Chem. 284:9700-9712(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  9. "A shared interface mediates paramyxovirus interference with antiviral RNA helicases MDA5 and LGP2."
    Parisien J.P., Bamming D., Komuro A., Ramachandran A., Rodriguez J.J., Barber G., Wojahn R.D., Horvath C.M.
    J. Virol. 83:7252-7260(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARAMYXOVIRUSES NON-STRUCTURAL PROTEIN V.
  10. "Immune signaling by RIG-I-like receptors."
    Loo Y.M., Gale M. Jr.
    Immunity 34:680-692(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  11. "RIG-I/MDA5/MAVS are required to signal a protective IFN response in rotavirus-infected intestinal epithelium."
    Broquet A.H., Hirata Y., McAllister C.S., Kagnoff M.F.
    J. Immunol. 186:1618-1626(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  12. "Ambivalent role of the innate immune response in rabies virus pathogenesis."
    Chopy D., Pothlichet J., Lafage M., Megret F., Fiette L., Si-Tahar M., Lafon M.
    J. Virol. 85:6657-6668(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling."
    Miyashita M., Oshiumi H., Matsumoto M., Seya T.
    Mol. Cell. Biol. 31:3802-3819(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DDX60.
  14. "Regulation of RLR-mediated innate immune signaling--it is all about keeping the balance."
    Eisenaecher K., Krug A.
    Eur. J. Cell Biol. 91:36-47(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  15. "Sensing of viral nucleic acids by RIG-I: from translocation to translation."
    Schmidt A., Rothenfusser S., Hopfner K.P.
    Eur. J. Cell Biol. 91:78-85(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW ON FUNCTION.
  16. "The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA."
    Li X., Ranjith-Kumar C.T., Brooks M.T., Dharmaiah S., Herr A.B., Kao C., Li P.
    J. Biol. Chem. 284:13881-13891(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 541-678 IN COMPLEX WITH RNA, FUNCTION, SUBUNIT, MUTAGENESIS OF LYS-634 AND LYS-651, ZINC-BINDING SITES.
  17. "Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors."
    Takahasi K., Kumeta H., Tsuduki N., Narita R., Shigemoto T., Hirai R., Yoneyama M., Horiuchi M., Ogura K., Fujita T., Inagaki F.
    J. Biol. Chem. 284:17465-17474(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 546-678, FUNCTION, SUBCELLULAR LOCATION.
  18. "The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA."
    Pippig D.A., Hellmuth J.C., Cui S., Kirchhofer A., Lammens K., Lammens A., Schmidt A., Rothenfusser S., Hopfner K.-P.
    Nucleic Acids Res. 37:2014-2025(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 537-678, FUNCTION, SUBUNIT, MUTAGENESIS OF LYS-634, ZINC-BINDING SITES.

Entry informationi

Entry nameiDHX58_HUMAN
AccessioniPrimary (citable) accession number: Q96C10
Secondary accession number(s): Q9HAM6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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