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Q96C01

- F136A_HUMAN

UniProt

Q96C01 - F136A_HUMAN

Protein

Protein FAM136A

Gene

FAM136A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein FAM136A
    Gene namesi
    Name:FAM136A
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:25911. FAM136A.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytoplasm Source: LIFEdb
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162386322.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 138137Protein FAM136APRO_0000296950Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Modified residuei124 – 1241PhosphothreonineBy similarity
    Modified residuei126 – 1261PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ96C01.
    PaxDbiQ96C01.
    PRIDEiQ96C01.

    PTM databases

    PhosphoSiteiQ96C01.

    Expressioni

    Gene expression databases

    ArrayExpressiQ96C01.
    BgeeiQ96C01.
    CleanExiHS_FAM136A.
    GenevestigatoriQ96C01.

    Organism-specific databases

    HPAiHPA030103.
    HPA030104.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    LSM1O151161EBI-373319,EBI-347619

    Protein-protein interaction databases

    BioGridi124345. 1 interaction.
    IntActiQ96C01. 2 interactions.
    MINTiMINT-3051500.
    STRINGi9606.ENSP00000037869.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96C01.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FAM136 family.Curated

    Phylogenomic databases

    eggNOGiNOG330245.
    HOGENOMiHOG000007920.
    HOVERGENiHBG105585.
    InParanoidiQ96C01.
    OrthoDBiEOG7034JP.
    PhylomeDBiQ96C01.
    TreeFamiTF315119.

    Family and domain databases

    InterProiIPR008560. DUF842_euk.
    [Graphical view]
    PANTHERiPTHR21096. PTHR21096. 1 hit.
    PfamiPF05811. DUF842. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96C01-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAELQQLRVQ EAVESMVKSL ERENIRKMQG LMFRCSASCC EDSQASMKQV    50
    HQCIERCHVP LAQAQALVTS ELEKFQDRLA RCTMHCNDKA KDSIDAGSKE 100
    LQVKQQLDSC VTKCVDDHMH LIPTMTKKMK EALLSIGK 138
    Length:138
    Mass (Da):15,641
    Last modified:December 1, 2001 - v1
    Checksum:i72D3CA33B937F8B7
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131V → M in BAB55208. (PubMed:14702039)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027574 mRNA. Translation: BAB55208.1.
    AC022201 Genomic DNA. Translation: AAX93110.1.
    BC014975 mRNA. Translation: AAH14975.1.
    CCDSiCCDS1904.1.
    RefSeqiNP_116211.2. NM_032822.2.
    UniGeneiHs.516077.

    Genome annotation databases

    EnsembliENST00000037869; ENSP00000037869; ENSG00000035141.
    GeneIDi84908.
    KEGGihsa:84908.
    UCSCiuc002sgq.4. human.

    Polymorphism databases

    DMDMi74751785.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK027574 mRNA. Translation: BAB55208.1 .
    AC022201 Genomic DNA. Translation: AAX93110.1 .
    BC014975 mRNA. Translation: AAH14975.1 .
    CCDSi CCDS1904.1.
    RefSeqi NP_116211.2. NM_032822.2.
    UniGenei Hs.516077.

    3D structure databases

    ProteinModelPortali Q96C01.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 124345. 1 interaction.
    IntActi Q96C01. 2 interactions.
    MINTi MINT-3051500.
    STRINGi 9606.ENSP00000037869.

    PTM databases

    PhosphoSitei Q96C01.

    Polymorphism databases

    DMDMi 74751785.

    Proteomic databases

    MaxQBi Q96C01.
    PaxDbi Q96C01.
    PRIDEi Q96C01.

    Protocols and materials databases

    DNASUi 84908.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000037869 ; ENSP00000037869 ; ENSG00000035141 .
    GeneIDi 84908.
    KEGGi hsa:84908.
    UCSCi uc002sgq.4. human.

    Organism-specific databases

    CTDi 84908.
    GeneCardsi GC02M070523.
    H-InvDB HIX0002139.
    HGNCi HGNC:25911. FAM136A.
    HPAi HPA030103.
    HPA030104.
    neXtProti NX_Q96C01.
    PharmGKBi PA162386322.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG330245.
    HOGENOMi HOG000007920.
    HOVERGENi HBG105585.
    InParanoidi Q96C01.
    OrthoDBi EOG7034JP.
    PhylomeDBi Q96C01.
    TreeFami TF315119.

    Miscellaneous databases

    ChiTaRSi FAM136A. human.
    GeneWikii FAM136A.
    GenomeRNAii 84908.
    NextBioi 75284.
    PROi Q96C01.

    Gene expression databases

    ArrayExpressi Q96C01.
    Bgeei Q96C01.
    CleanExi HS_FAM136A.
    Genevestigatori Q96C01.

    Family and domain databases

    InterProi IPR008560. DUF842_euk.
    [Graphical view ]
    PANTHERi PTHR21096. PTHR21096. 1 hit.
    Pfami PF05811. DUF842. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Teratocarcinoma.
    2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiF136A_HUMAN
    AccessioniPrimary (citable) accession number: Q96C01
    Secondary accession number(s): Q96SS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3