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Protein

Protein FAM136A

Gene

FAM136A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM136A
Gene namesi
Name:FAM136A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25911. FAM136A.

Subcellular locationi

  1. Mitochondrion By similarity

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. mitochondrion Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386322.

Polymorphism and mutation databases

BioMutaiFAM136A.
DMDMi74751785.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 138137Protein FAM136APRO_0000296950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei124 – 1241PhosphothreonineBy similarity
Modified residuei126 – 1261PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96C01.
PaxDbiQ96C01.
PRIDEiQ96C01.

PTM databases

PhosphoSiteiQ96C01.

Expressioni

Gene expression databases

BgeeiQ96C01.
CleanExiHS_FAM136A.
ExpressionAtlasiQ96C01. baseline and differential.
GenevestigatoriQ96C01.

Organism-specific databases

HPAiHPA030103.
HPA030104.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM1O151161EBI-373319,EBI-347619

Protein-protein interaction databases

BioGridi124345. 7 interactions.
IntActiQ96C01. 2 interactions.
MINTiMINT-3051500.
STRINGi9606.ENSP00000037869.

Structurei

3D structure databases

ProteinModelPortaliQ96C01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM136 family.Curated

Phylogenomic databases

eggNOGiNOG330245.
GeneTreeiENSGT00390000006707.
HOGENOMiHOG000007920.
HOVERGENiHBG105585.
InParanoidiQ96C01.
OrthoDBiEOG7034JP.
PhylomeDBiQ96C01.
TreeFamiTF315119.

Family and domain databases

InterProiIPR008560. DUF842_euk.
[Graphical view]
PANTHERiPTHR21096. PTHR21096. 1 hit.
PfamiPF05811. DUF842. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96C01-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAELQQLRVQ EAVESMVKSL ERENIRKMQG LMFRCSASCC EDSQASMKQV
60 70 80 90 100
HQCIERCHVP LAQAQALVTS ELEKFQDRLA RCTMHCNDKA KDSIDAGSKE
110 120 130
LQVKQQLDSC VTKCVDDHMH LIPTMTKKMK EALLSIGK
Length:138
Mass (Da):15,641
Last modified:December 1, 2001 - v1
Checksum:i72D3CA33B937F8B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131V → M in BAB55208 (PubMed:14702039).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027574 mRNA. Translation: BAB55208.1.
AC022201 Genomic DNA. Translation: AAX93110.1.
BC014975 mRNA. Translation: AAH14975.1.
CCDSiCCDS1904.1.
RefSeqiNP_116211.2. NM_032822.2.
UniGeneiHs.516077.

Genome annotation databases

EnsembliENST00000037869; ENSP00000037869; ENSG00000035141.
GeneIDi84908.
KEGGihsa:84908.
UCSCiuc002sgq.4. human.

Polymorphism and mutation databases

BioMutaiFAM136A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027574 mRNA. Translation: BAB55208.1.
AC022201 Genomic DNA. Translation: AAX93110.1.
BC014975 mRNA. Translation: AAH14975.1.
CCDSiCCDS1904.1.
RefSeqiNP_116211.2. NM_032822.2.
UniGeneiHs.516077.

3D structure databases

ProteinModelPortaliQ96C01.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124345. 7 interactions.
IntActiQ96C01. 2 interactions.
MINTiMINT-3051500.
STRINGi9606.ENSP00000037869.

PTM databases

PhosphoSiteiQ96C01.

Polymorphism and mutation databases

BioMutaiFAM136A.
DMDMi74751785.

Proteomic databases

MaxQBiQ96C01.
PaxDbiQ96C01.
PRIDEiQ96C01.

Protocols and materials databases

DNASUi84908.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000037869; ENSP00000037869; ENSG00000035141.
GeneIDi84908.
KEGGihsa:84908.
UCSCiuc002sgq.4. human.

Organism-specific databases

CTDi84908.
GeneCardsiGC02M070523.
H-InvDBHIX0002139.
HGNCiHGNC:25911. FAM136A.
HPAiHPA030103.
HPA030104.
neXtProtiNX_Q96C01.
PharmGKBiPA162386322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG330245.
GeneTreeiENSGT00390000006707.
HOGENOMiHOG000007920.
HOVERGENiHBG105585.
InParanoidiQ96C01.
OrthoDBiEOG7034JP.
PhylomeDBiQ96C01.
TreeFamiTF315119.

Miscellaneous databases

ChiTaRSiFAM136A. human.
GeneWikiiFAM136A.
GenomeRNAii84908.
NextBioi75284.
PROiQ96C01.

Gene expression databases

BgeeiQ96C01.
CleanExiHS_FAM136A.
ExpressionAtlasiQ96C01. baseline and differential.
GenevestigatoriQ96C01.

Family and domain databases

InterProiIPR008560. DUF842_euk.
[Graphical view]
PANTHERiPTHR21096. PTHR21096. 1 hit.
PfamiPF05811. DUF842. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF136A_HUMAN
AccessioniPrimary (citable) accession number: Q96C01
Secondary accession number(s): Q96SS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: April 29, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.