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Q96C01

- F136A_HUMAN

UniProt

Q96C01 - F136A_HUMAN

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Protein

Protein FAM136A

Gene

FAM136A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM136A
Gene namesi
Name:FAM136A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:25911. FAM136A.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytoplasm Source: LIFEdb
  2. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162386322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 138137Protein FAM136APRO_0000296950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei124 – 1241PhosphothreonineBy similarity
Modified residuei126 – 1261PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ96C01.
PaxDbiQ96C01.
PRIDEiQ96C01.

PTM databases

PhosphoSiteiQ96C01.

Expressioni

Gene expression databases

BgeeiQ96C01.
CleanExiHS_FAM136A.
ExpressionAtlasiQ96C01. baseline and differential.
GenevestigatoriQ96C01.

Organism-specific databases

HPAiHPA030103.
HPA030104.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LSM1O151161EBI-373319,EBI-347619

Protein-protein interaction databases

BioGridi124345. 4 interactions.
IntActiQ96C01. 2 interactions.
MINTiMINT-3051500.
STRINGi9606.ENSP00000037869.

Structurei

3D structure databases

ProteinModelPortaliQ96C01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM136 family.Curated

Phylogenomic databases

eggNOGiNOG330245.
GeneTreeiENSGT00390000006707.
HOGENOMiHOG000007920.
HOVERGENiHBG105585.
InParanoidiQ96C01.
OrthoDBiEOG7034JP.
PhylomeDBiQ96C01.
TreeFamiTF315119.

Family and domain databases

InterProiIPR008560. DUF842_euk.
[Graphical view]
PANTHERiPTHR21096. PTHR21096. 1 hit.
PfamiPF05811. DUF842. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96C01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAELQQLRVQ EAVESMVKSL ERENIRKMQG LMFRCSASCC EDSQASMKQV
60 70 80 90 100
HQCIERCHVP LAQAQALVTS ELEKFQDRLA RCTMHCNDKA KDSIDAGSKE
110 120 130
LQVKQQLDSC VTKCVDDHMH LIPTMTKKMK EALLSIGK
Length:138
Mass (Da):15,641
Last modified:December 1, 2001 - v1
Checksum:i72D3CA33B937F8B7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131V → M in BAB55208. (PubMed:14702039)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027574 mRNA. Translation: BAB55208.1.
AC022201 Genomic DNA. Translation: AAX93110.1.
BC014975 mRNA. Translation: AAH14975.1.
CCDSiCCDS1904.1.
RefSeqiNP_116211.2. NM_032822.2.
UniGeneiHs.516077.

Genome annotation databases

EnsembliENST00000037869; ENSP00000037869; ENSG00000035141.
GeneIDi84908.
KEGGihsa:84908.
UCSCiuc002sgq.4. human.

Polymorphism databases

DMDMi74751785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027574 mRNA. Translation: BAB55208.1 .
AC022201 Genomic DNA. Translation: AAX93110.1 .
BC014975 mRNA. Translation: AAH14975.1 .
CCDSi CCDS1904.1.
RefSeqi NP_116211.2. NM_032822.2.
UniGenei Hs.516077.

3D structure databases

ProteinModelPortali Q96C01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 124345. 4 interactions.
IntActi Q96C01. 2 interactions.
MINTi MINT-3051500.
STRINGi 9606.ENSP00000037869.

PTM databases

PhosphoSitei Q96C01.

Polymorphism databases

DMDMi 74751785.

Proteomic databases

MaxQBi Q96C01.
PaxDbi Q96C01.
PRIDEi Q96C01.

Protocols and materials databases

DNASUi 84908.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000037869 ; ENSP00000037869 ; ENSG00000035141 .
GeneIDi 84908.
KEGGi hsa:84908.
UCSCi uc002sgq.4. human.

Organism-specific databases

CTDi 84908.
GeneCardsi GC02M070523.
H-InvDB HIX0002139.
HGNCi HGNC:25911. FAM136A.
HPAi HPA030103.
HPA030104.
neXtProti NX_Q96C01.
PharmGKBi PA162386322.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG330245.
GeneTreei ENSGT00390000006707.
HOGENOMi HOG000007920.
HOVERGENi HBG105585.
InParanoidi Q96C01.
OrthoDBi EOG7034JP.
PhylomeDBi Q96C01.
TreeFami TF315119.

Miscellaneous databases

ChiTaRSi FAM136A. human.
GeneWikii FAM136A.
GenomeRNAii 84908.
NextBioi 75284.
PROi Q96C01.

Gene expression databases

Bgeei Q96C01.
CleanExi HS_FAM136A.
ExpressionAtlasi Q96C01. baseline and differential.
Genevestigatori Q96C01.

Family and domain databases

InterProi IPR008560. DUF842_euk.
[Graphical view ]
PANTHERi PTHR21096. PTHR21096. 1 hit.
Pfami PF05811. DUF842. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Teratocarcinoma.
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiF136A_HUMAN
AccessioniPrimary (citable) accession number: Q96C01
Secondary accession number(s): Q96SS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3