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Protein

Zinc finger and BTB domain-containing protein 9

Gene

ZBTB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri411 – 43323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 9
Gene namesi
Name:ZBTB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:28323. ZBTB9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895172.

Polymorphism and mutation databases

BioMutaiZBTB9.
DMDMi46577533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Zinc finger and BTB domain-containing protein 9PRO_0000047723Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki286 – 286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96C00.
MaxQBiQ96C00.
PaxDbiQ96C00.
PRIDEiQ96C00.

PTM databases

iPTMnetiQ96C00.
PhosphoSiteiQ96C00.

Expressioni

Gene expression databases

BgeeiQ96C00.
CleanExiHS_ZBTB9.
ExpressionAtlasiQ96C00. baseline.
GenevisibleiQ96C00. HS.

Organism-specific databases

HPAiHPA036767.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPN7Q7Z4793EBI-395708,EBI-10213454
DTNBO609413EBI-395708,EBI-740402
DYRK2Q926303EBI-395708,EBI-749432
EHHADHQ084263EBI-395708,EBI-2339219
EIF4E2O605733EBI-395708,EBI-398610
KRTAP10-7P604094EBI-395708,EBI-10172290
KRTAP10-9P604113EBI-395708,EBI-10172052
KRTAP12-2P599913EBI-395708,EBI-10176379
LASP1Q148473EBI-395708,EBI-742828
MCM6Q145663EBI-395708,EBI-374900
MDFIQ997503EBI-395708,EBI-724076
MORF4L1Q9UBU83EBI-395708,EBI-399246
PIN1Q135263EBI-395708,EBI-714158
PIN4Q9Y2373EBI-395708,EBI-714599
TSR2Q969E83EBI-395708,EBI-746981

Protein-protein interaction databases

BioGridi128736. 42 interactions.
IntActiQ96C00. 17 interactions.
STRINGi9606.ENSP00000378503.

Structurei

3D structure databases

ProteinModelPortaliQ96C00.
SMRiQ96C00. Positions 26-134, 374-460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 11265BTBPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi235 – 28046Pro-richAdd
BLAST
Compositional biasi298 – 38992Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri411 – 43323C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri438 – 46023C2H2-type 2; atypicalPROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231208.
HOVERGENiHBG101113.
InParanoidiQ96C00.
KOiK10496.
OMAiIFYIKQE.
OrthoDBiEOG71K640.
PhylomeDBiQ96C00.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV
60 70 80 90 100
SLLVQGRELR AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL
110 120 130 140 150
QLIYSGRLRL PLDALPAHLL VASGLQMWQV VDQCSEILRE LETSGGGISA
160 170 180 190 200
RGGNSYHALL STTSSTGGWC IRSSPFQTPV QSSASTESPA STESPVGGEG
210 220 230 240 250
SELGEVLQIQ VEEEEEEEED DDDEDQGSAT LSQTPQPQRV SGVFPRPHGP
260 270 280 290 300
HPLPMTATPR KLPEGESAPL ELPAPPALPP KIFYIKQEPF EPKEEISGSG
310 320 330 340 350
TQPGGAKEET KVFSGGDTEG NGELGFLLPS GPGPTSGGGG PSWKPVDLHG
360 370 380 390 400
NEILSGGGGP GGAGQAVHGP VKLGGTPPAD GKRFGCLCGK RFAVKPKRDR
410 420 430 440 450
HIMLTFSLRP FGCGICNKRF KLKHHLTEHM KTHAGALHAC PHCGRRFRVH
460 470
ACFLRHRDLC KGQGWATAHW TYK
Length:473
Mass (Da):50,602
Last modified:December 1, 2001 - v1
Checksum:i2BC8041790090FD9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti274 – 2741A → G.
Corresponds to variant rs9469425 [ dbSNP | Ensembl ].
VAR_061981

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA. Translation: BAG53637.1.
BX088650 Genomic DNA. Translation: CAM26308.1.
CH471081 Genomic DNA. Translation: EAX03739.1.
BC014978 mRNA. Translation: AAH14978.1.
CCDSiCCDS4780.1.
RefSeqiNP_689948.1. NM_152735.3.
UniGeneiHs.591805.

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588.
ENST00000414934; ENSP00000413557; ENSG00000236515.
GeneIDi221504.
KEGGihsa:221504.
UCSCiuc003oeq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA. Translation: BAG53637.1.
BX088650 Genomic DNA. Translation: CAM26308.1.
CH471081 Genomic DNA. Translation: EAX03739.1.
BC014978 mRNA. Translation: AAH14978.1.
CCDSiCCDS4780.1.
RefSeqiNP_689948.1. NM_152735.3.
UniGeneiHs.591805.

3D structure databases

ProteinModelPortaliQ96C00.
SMRiQ96C00. Positions 26-134, 374-460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128736. 42 interactions.
IntActiQ96C00. 17 interactions.
STRINGi9606.ENSP00000378503.

PTM databases

iPTMnetiQ96C00.
PhosphoSiteiQ96C00.

Polymorphism and mutation databases

BioMutaiZBTB9.
DMDMi46577533.

Proteomic databases

EPDiQ96C00.
MaxQBiQ96C00.
PaxDbiQ96C00.
PRIDEiQ96C00.

Protocols and materials databases

DNASUi221504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588.
ENST00000414934; ENSP00000413557; ENSG00000236515.
GeneIDi221504.
KEGGihsa:221504.
UCSCiuc003oeq.4. human.

Organism-specific databases

CTDi221504.
GeneCardsiZBTB9.
HGNCiHGNC:28323. ZBTB9.
HPAiHPA036767.
neXtProtiNX_Q96C00.
PharmGKBiPA134895172.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231208.
HOVERGENiHBG101113.
InParanoidiQ96C00.
KOiK10496.
OMAiIFYIKQE.
OrthoDBiEOG71K640.
PhylomeDBiQ96C00.

Miscellaneous databases

GenomeRNAii221504.
PROiQ96C00.

Gene expression databases

BgeeiQ96C00.
CleanExiHS_ZBTB9.
ExpressionAtlasiQ96C00. baseline.
GenevisibleiQ96C00. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Uncovering global SUMOylation signaling networks in a site-specific manner."
    Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M., Vertegaal A.C.
    Nat. Struct. Mol. Biol. 21:927-936(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "SUMO-2 orchestrates chromatin modifiers in response to DNA damage."
    Hendriks I.A., Treffers L.W., Verlaan-de Vries M., Olsen J.V., Vertegaal A.C.
    Cell Rep. 10:1778-1791(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-286, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZBTB9_HUMAN
AccessioniPrimary (citable) accession number: Q96C00
Secondary accession number(s): A2AB19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.