Q96C00 (ZBTB9_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 9

Gene names

Name:

ZBTB9

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Potential.
Sequence similarities	Contains 1 BTB (POZ) domain. Contains 2 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrion Inferred from direct assay. Source: HPA nucleolus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Zinc finger and BTB domain-containing protein 9		PRO_0000047723
Regions
	Domain	48 – 112	65	BTB
	Zinc finger	411 – 433	23	C2H2-type 1
	Zinc finger	438 – 460	23	C2H2-type 2; atypical
	Compositional bias	235 – 280	46	Pro-rich
	Compositional bias	298 – 389	92	Gly-rich
Amino acid modifications
	Modified residue	376	1	Phosphothreonine Ref.2
Natural variations
	Natural variant	274	1	A → G. Corresponds to variant rs9469425 [ dbSNP | Ensembl ].		VAR_061981

Sequences

	Sequence		Length	Mass (Da)
	Q96C00 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 2BC8041790090FD9	FASTA	473	50,602
	10 20 30 40 50 60 METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV SLLVQGRELR 70 80 90 100 110 120 AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL QLIYSGRLRL PLDALPAHLL 130 140 150 160 170 180 VASGLQMWQV VDQCSEILRE LETSGGGISA RGGNSYHALL STTSSTGGWC IRSSPFQTPV 190 200 210 220 230 240 QSSASTESPA STESPVGGEG SELGEVLQIQ VEEEEEEEED DDDEDQGSAT LSQTPQPQRV 250 260 270 280 290 300 SGVFPRPHGP HPLPMTATPR KLPEGESAPL ELPAPPALPP KIFYIKQEPF EPKEEISGSG 310 320 330 340 350 360 TQPGGAKEET KVFSGGDTEG NGELGFLLPS GPGPTSGGGG PSWKPVDLHG NEILSGGGGP 370 380 390 400 410 420 GGAGQAVHGP VKLGGTPPAD GKRFGCLCGK RFAVKPKRDR HIMLTFSLRP FGCGICNKRF 430 440 450 460 470 KLKHHLTEHM KTHAGALHAC PHCGRRFRVH ACFLRHRDLC KGQGWATAHW TYK

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Eye.
[2]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-376, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC014978 mRNA. Translation: AAH14978.1.
IPI	IPI00060141.
RefSeq	NP_689948.1. NM_152735.3.
UniGene	Hs.591805.
3D structure databases
ProteinModelPortal	Q96C00.
SMR	Q96C00. Positions 21-132, 332-470.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96C00. 2 interactions.
PTM databases
PhosphoSite	Q96C00.
Polymorphism databases
DMDM	46577533.
Proteomic databases
PRIDE	Q96C00.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000395064; ENSP00000378503; ENSG00000213588. ENST00000414934; ENSP00000413557; ENSG00000236515.
GeneID	221504.
KEGG	hsa:221504.
UCSC	uc003oeq.1. human.
Organism-specific databases
CTD	221504.
GeneCards	GC06P033496.
HGNC	HGNC:28323. ZBTB9.
HPA	HPA036767.
neXtProt	NX_Q96C00.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00580000081322.
HOGENOM	HBG282552.
HOVERGEN	HBG101113.
InParanoid	Q96C00.
OMA	IFYIKQE.
OrthoDB	EOG447FTD.
PhylomeDB	Q96C00.
Gene expression databases
Bgee	Q96C00.
CleanEx	HS_ZBTB9.
Genevestigator	Q96C00.
GermOnline	ENSG00000197283. Homo sapiens.
Family and domain databases
InterPro	IPR000210. BTB/POZ-like. IPR011333. BTB/POZ_fold. IPR013069. BTB_POZ. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.710.10. BTB/POZ_fold. 1 hit. G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
KO	K10496.
Pfam	PF00651. BTB. 1 hit. [Graphical view]
SMART	SM00225. BTB. 1 hit. SM00355. ZnF_C2H2. 2 hits. [Graphical view]
SUPFAM	SSF54695. BTB/POZ_fold. 1 hit.
PROSITE	PS50097. BTB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 1 hit. PS50157. ZINC_FINGER_C2H2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	91383.

Entry information

Entry name

ZBTB9_HUMAN

Accession

Primary (citable) accession number: Q96C00

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.