Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger and BTB domain-containing protein 9

Gene

ZBTB9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri411 – 433C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-31399-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 9
Gene namesi
Name:ZBTB9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:28323. ZBTB9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221504.
OpenTargetsiENSG00000213588.
ENSG00000236515.
PharmGKBiPA134895172.

Polymorphism and mutation databases

BioMutaiZBTB9.
DMDMi46577533.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477231 – 473Zinc finger and BTB domain-containing protein 9Add BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki286Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96C00.
MaxQBiQ96C00.
PaxDbiQ96C00.
PeptideAtlasiQ96C00.
PRIDEiQ96C00.

PTM databases

iPTMnetiQ96C00.
PhosphoSitePlusiQ96C00.

Expressioni

Gene expression databases

BgeeiENSG00000213588.
CleanExiHS_ZBTB9.
ExpressionAtlasiQ96C00. differential.
GenevisibleiQ96C00. HS.

Organism-specific databases

HPAiHPA036767.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAPN7Q7Z4793EBI-395708,EBI-10213454
DTNBO609413EBI-395708,EBI-740402
DYRK2Q926303EBI-395708,EBI-749432
EHHADHQ084265EBI-395708,EBI-2339219
EIF4E2O605733EBI-395708,EBI-398610
KRTAP10-7P604094EBI-395708,EBI-10172290
KRTAP10-9P604115EBI-395708,EBI-10172052
KRTAP12-2P599915EBI-395708,EBI-10176379
LASP1Q148473EBI-395708,EBI-742828
MCM6Q145663EBI-395708,EBI-374900
MDFIQ997505EBI-395708,EBI-724076
MORF4L1Q9UBU83EBI-395708,EBI-399246
PIN1Q135265EBI-395708,EBI-714158
PIN4Q9Y2373EBI-395708,EBI-714599
TSR2Q969E85EBI-395708,EBI-746981

Protein-protein interaction databases

BioGridi128736. 42 interactors.
IntActiQ96C00. 29 interactors.
STRINGi9606.ENSP00000378503.

Structurei

3D structure databases

ProteinModelPortaliQ96C00.
SMRiQ96C00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 112BTBPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi235 – 280Pro-richAdd BLAST46
Compositional biasi298 – 389Gly-richAdd BLAST92

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 2 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri411 – 433C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 2; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231208.
HOVERGENiHBG101113.
InParanoidiQ96C00.
KOiK10496.
OMAiIFYIKQE.
OrthoDBiEOG091G07XH.
PhylomeDBiQ96C00.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96C00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METPTPLPPV PASPTCNPAP RTIQIEFPQH SSSLLESLNR HRLEGKFCDV
60 70 80 90 100
SLLVQGRELR AHKAVLAAAS PYFHDKLLLG DAPRLTLPSV IEADAFEGLL
110 120 130 140 150
QLIYSGRLRL PLDALPAHLL VASGLQMWQV VDQCSEILRE LETSGGGISA
160 170 180 190 200
RGGNSYHALL STTSSTGGWC IRSSPFQTPV QSSASTESPA STESPVGGEG
210 220 230 240 250
SELGEVLQIQ VEEEEEEEED DDDEDQGSAT LSQTPQPQRV SGVFPRPHGP
260 270 280 290 300
HPLPMTATPR KLPEGESAPL ELPAPPALPP KIFYIKQEPF EPKEEISGSG
310 320 330 340 350
TQPGGAKEET KVFSGGDTEG NGELGFLLPS GPGPTSGGGG PSWKPVDLHG
360 370 380 390 400
NEILSGGGGP GGAGQAVHGP VKLGGTPPAD GKRFGCLCGK RFAVKPKRDR
410 420 430 440 450
HIMLTFSLRP FGCGICNKRF KLKHHLTEHM KTHAGALHAC PHCGRRFRVH
460 470
ACFLRHRDLC KGQGWATAHW TYK
Length:473
Mass (Da):50,602
Last modified:December 1, 2001 - v1
Checksum:i2BC8041790090FD9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061981274A → G.Corresponds to variant rs9469425dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA. Translation: BAG53637.1.
BX088650 Genomic DNA. Translation: CAM26308.1.
CH471081 Genomic DNA. Translation: EAX03739.1.
BC014978 mRNA. Translation: AAH14978.1.
CCDSiCCDS4780.1.
RefSeqiNP_689948.1. NM_152735.3.
UniGeneiHs.591805.

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588.
ENST00000414934; ENSP00000413557; ENSG00000236515.
GeneIDi221504.
KEGGihsa:221504.
UCSCiuc003oeq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122644 mRNA. Translation: BAG53637.1.
BX088650 Genomic DNA. Translation: CAM26308.1.
CH471081 Genomic DNA. Translation: EAX03739.1.
BC014978 mRNA. Translation: AAH14978.1.
CCDSiCCDS4780.1.
RefSeqiNP_689948.1. NM_152735.3.
UniGeneiHs.591805.

3D structure databases

ProteinModelPortaliQ96C00.
SMRiQ96C00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128736. 42 interactors.
IntActiQ96C00. 29 interactors.
STRINGi9606.ENSP00000378503.

PTM databases

iPTMnetiQ96C00.
PhosphoSitePlusiQ96C00.

Polymorphism and mutation databases

BioMutaiZBTB9.
DMDMi46577533.

Proteomic databases

EPDiQ96C00.
MaxQBiQ96C00.
PaxDbiQ96C00.
PeptideAtlasiQ96C00.
PRIDEiQ96C00.

Protocols and materials databases

DNASUi221504.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000395064; ENSP00000378503; ENSG00000213588.
ENST00000414934; ENSP00000413557; ENSG00000236515.
GeneIDi221504.
KEGGihsa:221504.
UCSCiuc003oeq.4. human.

Organism-specific databases

CTDi221504.
DisGeNETi221504.
GeneCardsiZBTB9.
HGNCiHGNC:28323. ZBTB9.
HPAiHPA036767.
neXtProtiNX_Q96C00.
OpenTargetsiENSG00000213588.
ENSG00000236515.
PharmGKBiPA134895172.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231208.
HOVERGENiHBG101113.
InParanoidiQ96C00.
KOiK10496.
OMAiIFYIKQE.
OrthoDBiEOG091G07XH.
PhylomeDBiQ96C00.

Enzyme and pathway databases

BioCyciZFISH:G66-31399-MONOMER.

Miscellaneous databases

GenomeRNAii221504.
PROiQ96C00.

Gene expression databases

BgeeiENSG00000213588.
CleanExiHS_ZBTB9.
ExpressionAtlasiQ96C00. differential.
GenevisibleiQ96C00. HS.

Family and domain databases

Gene3Di3.30.160.60. 1 hit.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 2 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBTB9_HUMAN
AccessioniPrimary (citable) accession number: Q96C00
Secondary accession number(s): A2AB19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.