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Q96BZ8

- LENG1_HUMAN

UniProt

Q96BZ8 - LENG1_HUMAN

Protein

Leukocyte receptor cluster member 1

Gene

LENG1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leukocyte receptor cluster member 1
    Gene namesi
    Name:LENG1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:15502. LENG1.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134904804.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 264264Leukocyte receptor cluster member 1PRO_0000254627Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591Phosphoserine3 Publications
    Modified residuei245 – 2451Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96BZ8.
    PaxDbiQ96BZ8.
    PRIDEiQ96BZ8.

    PTM databases

    PhosphoSiteiQ96BZ8.

    Expressioni

    Gene expression databases

    BgeeiQ96BZ8.
    CleanExiHS_LENG1.
    GenevestigatoriQ96BZ8.

    Organism-specific databases

    HPAiHPA043541.

    Interactioni

    Protein-protein interaction databases

    BioGridi122582. 6 interactions.
    IntActiQ96BZ8. 5 interactions.
    MINTiMINT-1397585.
    STRINGi9606.ENSP00000222224.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili16 – 4631Sequence AnalysisAdd
    BLAST
    Coiled coili89 – 11527Sequence AnalysisAdd
    BLAST
    Coiled coili196 – 22227Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG85993.
    HOGENOMiHOG000006930.
    HOVERGENiHBG060372.
    InParanoidiQ96BZ8.
    OMAiRRDRESW.
    OrthoDBiEOG79CZ1H.
    PhylomeDBiQ96BZ8.
    TreeFamiTF317830.

    Family and domain databases

    InterProiIPR019339. CIR_N_dom.
    [Graphical view]
    SMARTiSM01083. Cir_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96BZ8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL    50
    RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK 100
    RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI 150
    KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR 200
    AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ 250
    LARRPRQQDP HLTH 264
    Length:264
    Mass (Da):30,529
    Last modified:December 1, 2001 - v1
    Checksum:i25516678771B31F7
    GO

    Sequence cautioni

    The sequence AAG01393.1 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti97 – 971E → K.
    Corresponds to variant rs35089861 [ dbSNP | Ensembl ].
    VAR_051090

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014986 mRNA. Translation: AAH14986.1.
    AF211966 mRNA. Translation: AAG01393.1. Different initiation.
    CCDSiCCDS12881.1.
    RefSeqiNP_077292.2. NM_024316.2.
    UniGeneiHs.590974.

    Genome annotation databases

    EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
    GeneIDi79165.
    KEGGihsa:79165.
    UCSCiuc002qdm.3. human.

    Polymorphism databases

    DMDMi74731296.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC014986 mRNA. Translation: AAH14986.1 .
    AF211966 mRNA. Translation: AAG01393.1 . Different initiation.
    CCDSi CCDS12881.1.
    RefSeqi NP_077292.2. NM_024316.2.
    UniGenei Hs.590974.

    3D structure databases

    ProteinModelPortali Q96BZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122582. 6 interactions.
    IntActi Q96BZ8. 5 interactions.
    MINTi MINT-1397585.
    STRINGi 9606.ENSP00000222224.

    PTM databases

    PhosphoSitei Q96BZ8.

    Polymorphism databases

    DMDMi 74731296.

    Proteomic databases

    MaxQBi Q96BZ8.
    PaxDbi Q96BZ8.
    PRIDEi Q96BZ8.

    Protocols and materials databases

    DNASUi 79165.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222224 ; ENSP00000222224 ; ENSG00000105617 .
    GeneIDi 79165.
    KEGGi hsa:79165.
    UCSCi uc002qdm.3. human.

    Organism-specific databases

    CTDi 79165.
    GeneCardsi GC19M054658.
    HGNCi HGNC:15502. LENG1.
    HPAi HPA043541.
    neXtProti NX_Q96BZ8.
    PharmGKBi PA134904804.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85993.
    HOGENOMi HOG000006930.
    HOVERGENi HBG060372.
    InParanoidi Q96BZ8.
    OMAi RRDRESW.
    OrthoDBi EOG79CZ1H.
    PhylomeDBi Q96BZ8.
    TreeFami TF317830.

    Miscellaneous databases

    GenomeRNAii 79165.
    NextBioi 68110.
    PROi Q96BZ8.

    Gene expression databases

    Bgeei Q96BZ8.
    CleanExi HS_LENG1.
    Genevestigatori Q96BZ8.

    Family and domain databases

    InterProi IPR019339. CIR_N_dom.
    [Graphical view ]
    SMARTi SM01083. Cir_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    2. "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster."
      Wende H., Volz A., Ziegler A.
      Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-264, IDENTIFICATION IN THE LRC.
      Tissue: Thymus.
    3. Erratum
      Wende H., Volz A., Ziegler A.
      Immunogenetics 52:3-4(2001)
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiLENG1_HUMAN
    AccessioniPrimary (citable) accession number: Q96BZ8
    Secondary accession number(s): Q9HCU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations

    External Data

    Dasty 3