Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Leukocyte receptor cluster member 1

Gene

LENG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 1
Gene namesi
Name:LENG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15502. LENG1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000275935.
ENSG00000276628.
ENSG00000276774.
ENSG00000276959.
ENSG00000277457.
ENSG00000277808.
ENSG00000278257.
ENSG00000278426.
ENSG00000278516.
PharmGKBiPA134904804.

Polymorphism and mutation databases

BioMutaiLENG1.
DMDMi74731296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546271 – 264Leukocyte receptor cluster member 1Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BZ8.
MaxQBiQ96BZ8.
PaxDbiQ96BZ8.
PeptideAtlasiQ96BZ8.
PRIDEiQ96BZ8.

PTM databases

iPTMnetiQ96BZ8.
PhosphoSitePlusiQ96BZ8.

Expressioni

Gene expression databases

BgeeiENSG00000105617.
CleanExiHS_LENG1.
GenevisibleiQ96BZ8. HS.

Organism-specific databases

HPAiHPA043541.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
BANPQ8N9N53EBI-726510,EBI-744695
CALCOCO2Q131373EBI-726510,EBI-739580
CARD9Q9H2573EBI-726510,EBI-751319
CCDC102BA1A4H13EBI-726510,EBI-10171570
CCDC136Q96JN2-23EBI-726510,EBI-10171416
CCDC155Q8N6L03EBI-726510,EBI-749265
CCDC57Q2TAC23EBI-726510,EBI-2808286
CDR2Q018505EBI-726510,EBI-1181367
CEP57L1Q8IYX8-23EBI-726510,EBI-10181988
CEP70Q8NHQ15EBI-726510,EBI-739624
FSD2A1L4K15EBI-726510,EBI-5661036
GOLGA2A0A0C4DGS54EBI-726510,EBI-11522202
GOLGA2Q083793EBI-726510,EBI-618309
KIFC3Q9BVG83EBI-726510,EBI-2125614
KRT31Q153235EBI-726510,EBI-948001
KRT40Q6A1623EBI-726510,EBI-10171697
LDOC1O957515EBI-726510,EBI-740738
MID2Q9UJV3-25EBI-726510,EBI-10172526
MTUS2Q5JR593EBI-726510,EBI-742948
NAB2Q157425EBI-726510,EBI-8641936
NECAB2H3BTW23EBI-726510,EBI-10172876
PAK7Q8TB933EBI-726510,EBI-741896
PDE4DIPQ5VU433EBI-726510,EBI-1105124
ROPN1Q9HAT05EBI-726510,EBI-1378139
SPERTQ8NA613EBI-726510,EBI-741724
STX11O755583EBI-726510,EBI-714135
TCF4P158843EBI-726510,EBI-533224
TFIP11Q9UBB93EBI-726510,EBI-1105213
TMEM239Q8WW343EBI-726510,EBI-9675724
TRIM27P143733EBI-726510,EBI-719493
TRIM54Q9BYV23EBI-726510,EBI-2130429
USHBP1Q8N6Y03EBI-726510,EBI-739895

Protein-protein interaction databases

BioGridi122582. 44 interactors.
IntActiQ96BZ8. 65 interactors.
MINTiMINT-1397585.
STRINGi9606.ENSP00000222224.

Structurei

3D structure databases

ProteinModelPortaliQ96BZ8.
SMRiQ96BZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 46Sequence analysisAdd BLAST31
Coiled coili89 – 115Sequence analysisAdd BLAST27
Coiled coili196 – 222Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0Q4. Eukaryota.
ENOG4111NQR. LUCA.
HOGENOMiHOG000006930.
HOVERGENiHBG060372.
InParanoidiQ96BZ8.
OMAiGVTRGNK.
OrthoDBiEOG091G0RX6.
PhylomeDBiQ96BZ8.
TreeFamiTF317830.

Family and domain databases

InterProiIPR019339. CIR_N_dom.
[Graphical view]
PfamiPF10197. Cir_N. 1 hit.
[Graphical view]
SMARTiSM01083. Cir_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL
60 70 80 90 100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK
110 120 130 140 150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI
160 170 180 190 200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR
210 220 230 240 250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ
260
LARRPRQQDP HLTH
Length:264
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:i25516678771B31F7
GO

Sequence cautioni

The sequence AAG01393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05109097E → K.Corresponds to variant rs35089861dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
CCDSiCCDS12881.1.
RefSeqiNP_077292.2. NM_024316.2.
UniGeneiHs.590974.

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000610998; ENSP00000481386; ENSG00000276959.
ENST00000613622; ENSP00000478485; ENSG00000278516.
ENST00000614037; ENSP00000483164; ENSG00000276774.
ENST00000616103; ENSP00000481252; ENSG00000277808.
ENST00000616816; ENSP00000480516; ENSG00000277457.
ENST00000617592; ENSP00000481079; ENSG00000278426.
ENST00000619669; ENSP00000477607; ENSG00000276628.
ENST00000621285; ENSP00000479538; ENSG00000278257.
ENST00000621927; ENSP00000481948; ENSG00000275935.
GeneIDi79165.
KEGGihsa:79165.
UCSCiuc002qdm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
CCDSiCCDS12881.1.
RefSeqiNP_077292.2. NM_024316.2.
UniGeneiHs.590974.

3D structure databases

ProteinModelPortaliQ96BZ8.
SMRiQ96BZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122582. 44 interactors.
IntActiQ96BZ8. 65 interactors.
MINTiMINT-1397585.
STRINGi9606.ENSP00000222224.

PTM databases

iPTMnetiQ96BZ8.
PhosphoSitePlusiQ96BZ8.

Polymorphism and mutation databases

BioMutaiLENG1.
DMDMi74731296.

Proteomic databases

EPDiQ96BZ8.
MaxQBiQ96BZ8.
PaxDbiQ96BZ8.
PeptideAtlasiQ96BZ8.
PRIDEiQ96BZ8.

Protocols and materials databases

DNASUi79165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000610998; ENSP00000481386; ENSG00000276959.
ENST00000613622; ENSP00000478485; ENSG00000278516.
ENST00000614037; ENSP00000483164; ENSG00000276774.
ENST00000616103; ENSP00000481252; ENSG00000277808.
ENST00000616816; ENSP00000480516; ENSG00000277457.
ENST00000617592; ENSP00000481079; ENSG00000278426.
ENST00000619669; ENSP00000477607; ENSG00000276628.
ENST00000621285; ENSP00000479538; ENSG00000278257.
ENST00000621927; ENSP00000481948; ENSG00000275935.
GeneIDi79165.
KEGGihsa:79165.
UCSCiuc002qdm.4. human.

Organism-specific databases

CTDi79165.
GeneCardsiLENG1.
HGNCiHGNC:15502. LENG1.
HPAiHPA043541.
neXtProtiNX_Q96BZ8.
OpenTargetsiENSG00000275935.
ENSG00000276628.
ENSG00000276774.
ENSG00000276959.
ENSG00000277457.
ENSG00000277808.
ENSG00000278257.
ENSG00000278426.
ENSG00000278516.
PharmGKBiPA134904804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0Q4. Eukaryota.
ENOG4111NQR. LUCA.
HOGENOMiHOG000006930.
HOVERGENiHBG060372.
InParanoidiQ96BZ8.
OMAiGVTRGNK.
OrthoDBiEOG091G0RX6.
PhylomeDBiQ96BZ8.
TreeFamiTF317830.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000105617-MONOMER.

Miscellaneous databases

GenomeRNAii79165.
PROiQ96BZ8.

Gene expression databases

BgeeiENSG00000105617.
CleanExiHS_LENG1.
GenevisibleiQ96BZ8. HS.

Family and domain databases

InterProiIPR019339. CIR_N_dom.
[Graphical view]
PfamiPF10197. Cir_N. 1 hit.
[Graphical view]
SMARTiSM01083. Cir_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLENG1_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.