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Protein

Leukocyte receptor cluster member 1

Gene

LENG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 1
Gene namesi
Name:LENG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19, UP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:15502. LENG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904804.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Leukocyte receptor cluster member 1PRO_0000254627Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591Phosphoserine3 Publications
Modified residuei245 – 2451Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BZ8.
PaxDbiQ96BZ8.
PRIDEiQ96BZ8.

PTM databases

PhosphoSiteiQ96BZ8.

Expressioni

Gene expression databases

BgeeiQ96BZ8.
CleanExiHS_LENG1.
GenevestigatoriQ96BZ8.

Organism-specific databases

HPAiHPA043541.

Interactioni

Protein-protein interaction databases

BioGridi122582. 41 interactions.
IntActiQ96BZ8. 6 interactions.
MINTiMINT-1397585.
STRINGi9606.ENSP00000222224.

Structurei

3D structure databases

ProteinModelPortaliQ96BZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili16 – 4631Sequence AnalysisAdd
BLAST
Coiled coili89 – 11527Sequence AnalysisAdd
BLAST
Coiled coili196 – 22227Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85993.
HOGENOMiHOG000006930.
HOVERGENiHBG060372.
InParanoidiQ96BZ8.
OMAiRRDRESW.
OrthoDBiEOG79CZ1H.
PhylomeDBiQ96BZ8.
TreeFamiTF317830.

Family and domain databases

InterProiIPR019339. CIR_N_dom.
[Graphical view]
SMARTiSM01083. Cir_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BZ8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL
60 70 80 90 100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK
110 120 130 140 150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI
160 170 180 190 200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR
210 220 230 240 250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ
260
LARRPRQQDP HLTH
Length:264
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:i25516678771B31F7
GO

Sequence cautioni

The sequence AAG01393.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971E → K.
Corresponds to variant rs35089861 [ dbSNP | Ensembl ].
VAR_051090

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
CCDSiCCDS12881.1.
RefSeqiNP_077292.2. NM_024316.2.
UniGeneiHs.590974.

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000610998; ENSP00000481386; ENSG00000276959.
ENST00000613622; ENSP00000478485; ENSG00000278516.
ENST00000614037; ENSP00000483164; ENSG00000276774.
ENST00000616103; ENSP00000481252; ENSG00000277808.
ENST00000616816; ENSP00000480516; ENSG00000277457.
ENST00000617592; ENSP00000481079; ENSG00000278426.
ENST00000619669; ENSP00000477607; ENSG00000276628.
ENST00000621285; ENSP00000479538; ENSG00000278257.
ENST00000621927; ENSP00000481948; ENSG00000275935.
GeneIDi79165.
KEGGihsa:79165.
UCSCiuc002qdm.3. human.

Polymorphism databases

DMDMi74731296.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
CCDSiCCDS12881.1.
RefSeqiNP_077292.2. NM_024316.2.
UniGeneiHs.590974.

3D structure databases

ProteinModelPortaliQ96BZ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122582. 41 interactions.
IntActiQ96BZ8. 6 interactions.
MINTiMINT-1397585.
STRINGi9606.ENSP00000222224.

PTM databases

PhosphoSiteiQ96BZ8.

Polymorphism databases

DMDMi74731296.

Proteomic databases

MaxQBiQ96BZ8.
PaxDbiQ96BZ8.
PRIDEiQ96BZ8.

Protocols and materials databases

DNASUi79165.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000610998; ENSP00000481386; ENSG00000276959.
ENST00000613622; ENSP00000478485; ENSG00000278516.
ENST00000614037; ENSP00000483164; ENSG00000276774.
ENST00000616103; ENSP00000481252; ENSG00000277808.
ENST00000616816; ENSP00000480516; ENSG00000277457.
ENST00000617592; ENSP00000481079; ENSG00000278426.
ENST00000619669; ENSP00000477607; ENSG00000276628.
ENST00000621285; ENSP00000479538; ENSG00000278257.
ENST00000621927; ENSP00000481948; ENSG00000275935.
GeneIDi79165.
KEGGihsa:79165.
UCSCiuc002qdm.3. human.

Organism-specific databases

CTDi79165.
GeneCardsiGC19M054658.
HGNCiHGNC:15502. LENG1.
HPAiHPA043541.
neXtProtiNX_Q96BZ8.
PharmGKBiPA134904804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85993.
HOGENOMiHOG000006930.
HOVERGENiHBG060372.
InParanoidiQ96BZ8.
OMAiRRDRESW.
OrthoDBiEOG79CZ1H.
PhylomeDBiQ96BZ8.
TreeFamiTF317830.

Miscellaneous databases

GenomeRNAii79165.
NextBioi68110.
PROiQ96BZ8.

Gene expression databases

BgeeiQ96BZ8.
CleanExiHS_LENG1.
GenevestigatoriQ96BZ8.

Family and domain databases

InterProiIPR019339. CIR_N_dom.
[Graphical view]
SMARTiSM01083. Cir_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  2. "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster."
    Wende H., Volz A., Ziegler A.
    Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-264, IDENTIFICATION IN THE LRC.
    Tissue: Thymus.
  3. Erratum
    Wende H., Volz A., Ziegler A.
    Immunogenetics 52:3-4(2001)
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic kidney.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiLENG1_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: February 4, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.