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Q96BZ8 (LENG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leukocyte receptor cluster member 1
Gene names
Name:LENG1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length264 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Sequence caution

The sequence AAG01393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 264264Leukocyte receptor cluster member 1
PRO_0000254627

Regions

Coiled coil16 – 4631 Potential
Coiled coil89 – 11527 Potential
Coiled coil196 – 22227 Potential

Amino acid modifications

Modified residue591Phosphoserine Ref.5 Ref.6 Ref.7
Modified residue2451Phosphoserine Ref.4

Natural variations

Natural variant971E → K.
Corresponds to variant rs35089861 [ dbSNP | Ensembl ].
VAR_051090

Sequences

Sequence LengthMass (Da)Tools
Q96BZ8 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 25516678771B31F7

FASTA26430,529
        10         20         30         40         50         60 
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL RKKARHQNSL 

        70         80         90        100        110        120 
PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK RQEKERQEKA LGILTYLGQS 

       130        140        150        160        170        180 
AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI KSRLDPLREM QKHLGKKRQH GGDEGSRSRK 

       190        200        210        220        230        240 
EKEGSEKQRP KEPPSLDQLR AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR 

       250        260 
RRYNSQFNPQ LARRPRQQDP HLTH 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[2]"Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster."
Wende H., Volz A., Ziegler A.
Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-264, IDENTIFICATION IN THE LRC.
Tissue: Thymus.
[3]Erratum
Wende H., Volz A., Ziegler A.
Immunogenetics 52:3-4(2001)
[4]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic kidney.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[7]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
RefSeqNP_077292.2. NM_024316.2.
UniGeneHs.590974.

3D structure databases

ProteinModelPortalQ96BZ8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid122582. 5 interactions.
IntActQ96BZ8. 5 interactions.
MINTMINT-1397585.
STRING9606.ENSP00000222224.

PTM databases

PhosphoSiteQ96BZ8.

Polymorphism databases

DMDM74731296.

Proteomic databases

MaxQBQ96BZ8.
PaxDbQ96BZ8.
PRIDEQ96BZ8.

Protocols and materials databases

DNASU79165.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000571795; ENSP00000460529; ENSG00000272996.
ENST00000575187; ENSP00000459276; ENSG00000262168.
ENST00000575918; ENSP00000461644; ENSG00000262174.
ENST00000608153; ENSP00000477038; ENSG00000272726.
ENST00000608267; ENSP00000477447; ENSG00000273292.
ENST00000608366; ENSP00000476971; ENSG00000273128.
ENST00000608685; ENSP00000477406; ENSG00000273315.
ENST00000609965; ENSP00000476974; ENSG00000273182.
GeneID79165.
KEGGhsa:79165.
UCSCuc002qdm.3. human.

Organism-specific databases

CTD79165.
GeneCardsGC19M054658.
HGNCHGNC:15502. LENG1.
HPAHPA043541.
neXtProtNX_Q96BZ8.
PharmGKBPA134904804.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG85993.
HOGENOMHOG000006930.
HOVERGENHBG060372.
InParanoidQ96BZ8.
OMARRDRESW.
OrthoDBEOG79CZ1H.
PhylomeDBQ96BZ8.
TreeFamTF317830.

Gene expression databases

BgeeQ96BZ8.
CleanExHS_LENG1.
GenevestigatorQ96BZ8.

Family and domain databases

InterProIPR019339. CIR_N_dom.
[Graphical view]
SMARTSM01083. Cir_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi79165.
NextBio68110.
PROQ96BZ8.

Entry information

Entry nameLENG1_HUMAN
AccessionPrimary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM