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Protein

Leukocyte receptor cluster member 1

Gene

LENG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 1
Gene namesi
Name:LENG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15502. LENG1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904804.

Polymorphism and mutation databases

BioMutaiLENG1.
DMDMi74731296.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546271 – 264Leukocyte receptor cluster member 1Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BZ8.
MaxQBiQ96BZ8.
PaxDbiQ96BZ8.
PeptideAtlasiQ96BZ8.
PRIDEiQ96BZ8.

PTM databases

iPTMnetiQ96BZ8.
PhosphoSitePlusiQ96BZ8.

Expressioni

Gene expression databases

BgeeiENSG00000105617.
CleanExiHS_LENG1.
GenevisibleiQ96BZ8. HS.

Organism-specific databases

HPAiHPA043541.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122582. 51 interactors.
IntActiQ96BZ8. 73 interactors.
MINTiMINT-1397585.
STRINGi9606.ENSP00000222224.

Structurei

3D structure databases

ProteinModelPortaliQ96BZ8.
SMRiQ96BZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 46Sequence analysisAdd BLAST31
Coiled coili89 – 115Sequence analysisAdd BLAST27
Coiled coili196 – 222Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0Q4. Eukaryota.
ENOG4111NQR. LUCA.
HOGENOMiHOG000006930.
HOVERGENiHBG060372.
InParanoidiQ96BZ8.
OrthoDBiEOG091G0RX6.
PhylomeDBiQ96BZ8.
TreeFamiTF317830.

Family and domain databases

InterProiView protein in InterPro
IPR019339. CIR_N_dom.
PfamiView protein in Pfam
PF10197. Cir_N. 1 hit.
SMARTiView protein in SMART
SM01083. Cir_N. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96BZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL
60 70 80 90 100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK
110 120 130 140 150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI
160 170 180 190 200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR
210 220 230 240 250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ
260
LARRPRQQDP HLTH
Length:264
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:i25516678771B31F7
GO

Sequence cautioni

The sequence AAG01393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05109097E → K. Corresponds to variant dbSNP:rs35089861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA. Translation: AAH14986.1.
AF211966 mRNA. Translation: AAG01393.1. Different initiation.
CCDSiCCDS12881.1.
RefSeqiNP_077292.2. NM_024316.2.
UniGeneiHs.590974.

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617.
ENST00000610998; ENSP00000481386; ENSG00000276959.
ENST00000613622; ENSP00000478485; ENSG00000278516.
ENST00000614037; ENSP00000483164; ENSG00000276774.
ENST00000616103; ENSP00000481252; ENSG00000277808.
ENST00000616816; ENSP00000480516; ENSG00000277457.
ENST00000617592; ENSP00000481079; ENSG00000278426.
ENST00000619669; ENSP00000477607; ENSG00000276628.
ENST00000621285; ENSP00000479538; ENSG00000278257.
ENST00000621927; ENSP00000481948; ENSG00000275935.
GeneIDi79165.
KEGGihsa:79165.
UCSCiuc002qdm.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLENG1_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations