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Protein

Leukocyte receptor cluster member 1

Gene

LENG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.

Names & Taxonomyi

Protein namesi
Recommended name:
Leukocyte receptor cluster member 1
Gene namesi
Name:LENG1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105617.3
HGNCiHGNC:15502 LENG1
neXtProtiNX_Q96BZ8

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904804

Polymorphism and mutation databases

BioMutaiLENG1
DMDMi74731296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546271 – 264Leukocyte receptor cluster member 1Add BLAST264

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei59PhosphoserineCombined sources1
Modified residuei245PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BZ8
MaxQBiQ96BZ8
PaxDbiQ96BZ8
PeptideAtlasiQ96BZ8
PRIDEiQ96BZ8

PTM databases

iPTMnetiQ96BZ8
PhosphoSitePlusiQ96BZ8

Expressioni

Gene expression databases

BgeeiENSG00000105617
CleanExiHS_LENG1
GenevisibleiQ96BZ8 HS

Organism-specific databases

HPAiHPA043541

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi122582, 52 interactors
IntActiQ96BZ8, 71 interactors
MINTiQ96BZ8
STRINGi9606.ENSP00000222224

Structurei

3D structure databases

ProteinModelPortaliQ96BZ8
SMRiQ96BZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili16 – 46Sequence analysisAdd BLAST31
Coiled coili89 – 115Sequence analysisAdd BLAST27
Coiled coili196 – 222Sequence analysisAdd BLAST27

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J0Q4 Eukaryota
ENOG4111NQR LUCA
HOGENOMiHOG000006930
HOVERGENiHBG060372
InParanoidiQ96BZ8
OrthoDBiEOG091G0RX6
PhylomeDBiQ96BZ8
TreeFamiTF317830

Family and domain databases

InterProiView protein in InterPro
IPR019339 CIR_N_dom
PfamiView protein in Pfam
PF10197 Cir_N, 1 hit
SMARTiView protein in SMART
SM01083 Cir_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q96BZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL
60 70 80 90 100
RKKARHQNSL PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK
110 120 130 140 150
RQEKERQEKA LGILTYLGQS AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI
160 170 180 190 200
KSRLDPLREM QKHLGKKRQH GGDEGSRSRK EKEGSEKQRP KEPPSLDQLR
210 220 230 240 250
AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR RRYNSQFNPQ
260
LARRPRQQDP HLTH
Length:264
Mass (Da):30,529
Last modified:December 1, 2001 - v1
Checksum:i25516678771B31F7
GO

Sequence cautioni

The sequence AAG01393 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05109097E → K. Corresponds to variant dbSNP:rs35089861Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC014986 mRNA Translation: AAH14986.1
AF211966 mRNA Translation: AAG01393.1 Different initiation.
CCDSiCCDS12881.1
RefSeqiNP_077292.2, NM_024316.2
UniGeneiHs.590974

Genome annotation databases

EnsembliENST00000222224; ENSP00000222224; ENSG00000105617
ENST00000610998; ENSP00000481386; ENSG00000276959
ENST00000613622; ENSP00000478485; ENSG00000278516
ENST00000614037; ENSP00000483164; ENSG00000276774
ENST00000616103; ENSP00000481252; ENSG00000277808
ENST00000616816; ENSP00000480516; ENSG00000277457
ENST00000617592; ENSP00000481079; ENSG00000278426
ENST00000619669; ENSP00000477607; ENSG00000276628
ENST00000621285; ENSP00000479538; ENSG00000278257
ENST00000621927; ENSP00000481948; ENSG00000275935
GeneIDi79165
KEGGihsa:79165
UCSCiuc002qdm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiLENG1_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

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