Q96BZ8 (LENG1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Leukocyte receptor cluster member 1

Gene names

Name:

LENG1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Belongs to the leukocyte receptor cluster (LRC) present on 19q13.4.
Sequence caution	The sequence AAG01393.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Leukocyte receptor cluster member 1		PRO_0000254627
Regions
	Coiled coil	16 – 46	31	Potential
	Coiled coil	89 – 115	27	Potential
	Coiled coil	196 – 222	27	Potential
Amino acid modifications
	Modified residue	59	1	Phosphoserine Ref.5 Ref.6 Ref.7
	Modified residue	245	1	Phosphoserine Ref.4
Natural variations
	Natural variant	97	1	E → K. Corresponds to variant rs35089861 [ dbSNP | Ensembl ].		VAR_051090

Sequences

	Sequence		Length	Mass (Da)
	Q96BZ8 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 25516678771B31F7	FASTA	264	30,529
	10 20 30 40 50 60 MNILPKKSWH VRNKDNVARV RRDEAQAREE EKERERRVLL AQQEARTEFL RKKARHQNSL 70 80 90 100 110 120 PELEAAEAGA PGSGPVDLFR ELLEEGKGVI RGNKEYEEEK RQEKERQEKA LGILTYLGQS 130 140 150 160 170 180 AAEAQTQPPW YQLPPGRGGP PPGPAPDEKI KSRLDPLREM QKHLGKKRQH GGDEGSRSRK 190 200 210 220 230 240 EKEGSEKQRP KEPPSLDQLR AERLRREAAE RSRAEALLAR VQGRALQEGQ PEEDETDDRR 250 260 RRYNSQFNPQ LARRPRQQDP HLTH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[2]	"Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster." Wende H., Volz A., Ziegler A. Immunogenetics 51:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-264, IDENTIFICATION IN THE LRC. Tissue: Thymus.
[3]	Erratum Wende H., Volz A., Ziegler A. Immunogenetics 52:3-4(2001)
[4]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-245, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[7]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC014986 mRNA. Translation: AAH14986.1. AF211966 mRNA. Translation: AAG01393.1. Different initiation.
IPI	IPI00100947.
RefSeq	NP_077292.1. NM_024316.1.
UniGene	Hs.590974.
3D structure databases
ProteinModelPortal	Q96BZ8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BZ8. 1 interaction.
MINT	MINT-1397585.
STRING	9606.ENSP00000222224.
PTM databases
PhosphoSite	Q96BZ8.
Polymorphism databases
DMDM	74731296.
Proteomic databases
PaxDb	Q96BZ8.
PRIDE	Q96BZ8.
Protocols and materials databases
DNASU	79165.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000222224; ENSP00000222224; ENSG00000105617. ENST00000571795; ENSP00000460529; ENSG00000268380. ENST00000575187; ENSP00000459276; ENSG00000262168. ENST00000575918; ENSP00000461644; ENSG00000262174. ENST00000593410; ENSP00000470904; ENSG00000268202. ENST00000595771; ENSP00000471043; ENSG00000267810. ENST00000598551; ENSP00000472486; ENSG00000268039. ENST00000599651; ENSP00000472997; ENSG00000268680. ENST00000601202; ENSP00000472340; ENSG00000268228.
GeneID	79165.
KEGG	hsa:79165.
UCSC	uc002qdm.3. human.
Organism-specific databases
CTD	79165.
GeneCards	GC19M054658.
HGNC	HGNC:15502. LENG1.
HPA	HPA043541.
neXtProt	NX_Q96BZ8.
PharmGKB	PA134904804.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85993.
HOGENOM	HOG000006930.
HOVERGEN	HBG060372.
InParanoid	Q96BZ8.
OMA	DEKIKNR.
OrthoDB	EOG41ZFCF.
PhylomeDB	Q96BZ8.
Gene expression databases
ArrayExpress	Q96BZ8.
Bgee	Q96BZ8.
CleanEx	HS_LENG1.
Genevestigator	Q96BZ8.
GermOnline	ENSG00000105617. Homo sapiens.
Family and domain databases
InterPro	IPR019339. CIR_N_dom. [Graphical view]
SMART	SM01083. Cir_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	79165.
NextBio	68110.

Entry information

Entry name

LENG1_HUMAN

Accession

Primary (citable) accession number: Q96BZ8
Secondary accession number(s): Q9HCU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.