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Protein

Phospholipase D4

Gene

PLD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214PROSITE-ProRule annotation1
Active sitei216PROSITE-ProRule annotation1
Active sitei221PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1483148 Synthesis of PG
R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol
R-HSA-2029485 Role of phospholipids in phagocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D4 (EC:3.1.4.4)
Short name:
PLD 4
Alternative name(s):
Choline phosphatase 4
Phosphatidylcholine-hydrolyzing phospholipase D4
Gene namesi
Name:PLD4
Synonyms:C14orf175
ORF Names:UNQ2488/PRO5775
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000166428.12
HGNCiHGNC:23792 PLD4
neXtProtiNX_Q96BZ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi122618
OpenTargetsiENSG00000166428
PharmGKBiPA134861676

Polymorphism and mutation databases

BioMutaiPLD4
DMDMi121944492

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803331 – 506Phospholipase D4Add BLAST506

Proteomic databases

MaxQBiQ96BZ4
PaxDbiQ96BZ4
PeptideAtlasiQ96BZ4
PRIDEiQ96BZ4
ProteomicsDBi76132

PTM databases

iPTMnetiQ96BZ4
PhosphoSitePlusiQ96BZ4

Expressioni

Gene expression databases

BgeeiENSG00000166428
CleanExiHS_PLD4
ExpressionAtlasiQ96BZ4 baseline and differential
GenevisibleiQ96BZ4 HS

Organism-specific databases

HPAiHPA051512

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376372

Structurei

3D structure databases

ProteinModelPortaliQ96BZ4
SMRiQ96BZ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 236PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini423 – 449PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOVERGENiHBG052880
InParanoidiQ96BZ4
KOiK16860
PhylomeDBiQ96BZ4
TreeFamiTF313378

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF00614 PLDc, 1 hit
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 2 hits

Sequencei

Sequence statusi: Complete.

Q96BZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPLWKAAV APTWPCSMPP RRPWDREAGT LQVLGALAVL WLGSVALICL
60 70 80 90 100
LWQVPRPPTW GQVQPKDVPR SWEHGSSPAW EPLEAEARQQ RDSCQLVLVE
110 120 130 140 150
SIPQDLPSAA GSPSAQPLGQ AWLQLLDTAQ ESVHVASYYW SLTGPDIGVN
160 170 180 190 200
DSSSQLGEAL LQKLQQLLGR NISLAVATSS PTLARTSTDL QVLAARGAHV
210 220 230 240 250
RQVPMGRLTR GVLHSKFWVV DGRHIYMGSA NMDWRSLTQV KELGAVIYNC
260 270 280 290 300
SHLAQDLEKT FQTYWVLGVP KAVLPKTWPQ NFSSHFNRFQ PFHGLFDGVP
310 320 330 340 350
TTAYFSASPP ALCPQGRTRD LEALLAVMGS AQEFIYASVM EYFPTTRFSH
360 370 380 390 400
PPRYWPVLDN ALRAAAFGKG VRVRLLVGCG LNTDPTMFPY LRSLQALSNP
410 420 430 440 450
AANVSVDVKV FIVPVGNHSN IPFSRVNHSK FMVTEKAAYI GTSNWSEDYF
460 470 480 490 500
SSTAGVGLVV TQSPGAQPAG ATVQEQLRQL FERDWSSRYA VGLDGQAPGQ

DCVWQG
Length:506
Mass (Da):55,626
Last modified:May 16, 2006 - v2
Checksum:iD7F820C83131FE26
GO

Sequence cautioni

The sequence AAQ89202 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06175116C → R. Corresponds to variant dbSNP:rs894037Ensembl.1
Natural variantiVAR_03111927E → Q. Corresponds to variant dbSNP:rs2841280Ensembl.1
Natural variantiVAR_031120135V → M. Corresponds to variant dbSNP:rs3803295Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358843 mRNA Translation: AAQ89202.1 Different initiation.
BC015003 mRNA Translation: AAH15003.2
CCDSiCCDS9995.2
RefSeqiNP_620145.2, NM_138790.3
UniGeneiHs.407101

Genome annotation databases

EnsembliENST00000392593; ENSP00000376372; ENSG00000166428
GeneIDi122618
KEGGihsa:122618
UCSCiuc001ypu.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPLD4_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ4
Secondary accession number(s): Q6UWD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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