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Protein

Phospholipase D4

Gene

PLD4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

A phosphatidylcholine + H2O = choline + a phosphatidate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei214 – 2141PROSITE-ProRule annotation
Active sitei216 – 2161PROSITE-ProRule annotation
Active sitei221 – 2211PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-HSA-1483148. Synthesis of PG.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipase D4 (EC:3.1.4.4)
Short name:
PLD 4
Alternative name(s):
Choline phosphatase 4
Phosphatidylcholine-hydrolyzing phospholipase D4
Gene namesi
Name:PLD4
Synonyms:C14orf175
ORF Names:UNQ2488/PRO5775
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:23792. PLD4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei31 – 5121HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134861676.

Polymorphism and mutation databases

BioMutaiPLD4.
DMDMi121944492.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 506506Phospholipase D4PRO_0000280333Add
BLAST

Proteomic databases

MaxQBiQ96BZ4.
PaxDbiQ96BZ4.
PeptideAtlasiQ96BZ4.
PRIDEiQ96BZ4.

PTM databases

iPTMnetiQ96BZ4.
PhosphoSiteiQ96BZ4.

Expressioni

Gene expression databases

BgeeiQ96BZ4.
CleanExiHS_PLD4.
ExpressionAtlasiQ96BZ4. baseline and differential.
GenevisibleiQ96BZ4. HS.

Organism-specific databases

HPAiHPA051512.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376372.

Structurei

3D structure databases

ProteinModelPortaliQ96BZ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini209 – 23628PLD phosphodiesterase 1PROSITE-ProRule annotationAdd
BLAST
Domaini423 – 44927PLD phosphodiesterase 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the phospholipase D family.Curated
Contains 2 PLD phosphodiesterase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603. Eukaryota.
ENOG410XQZ4. LUCA.
GeneTreeiENSGT00390000009798.
HOVERGENiHBG052880.
InParanoidiQ96BZ4.
KOiK16860.
PhylomeDBiQ96BZ4.
TreeFamiTF313378.

Family and domain databases

InterProiIPR032803. PLDc_3.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF00614. PLDc. 1 hit.
PF13918. PLDc_3. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BZ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKPLWKAAV APTWPCSMPP RRPWDREAGT LQVLGALAVL WLGSVALICL
60 70 80 90 100
LWQVPRPPTW GQVQPKDVPR SWEHGSSPAW EPLEAEARQQ RDSCQLVLVE
110 120 130 140 150
SIPQDLPSAA GSPSAQPLGQ AWLQLLDTAQ ESVHVASYYW SLTGPDIGVN
160 170 180 190 200
DSSSQLGEAL LQKLQQLLGR NISLAVATSS PTLARTSTDL QVLAARGAHV
210 220 230 240 250
RQVPMGRLTR GVLHSKFWVV DGRHIYMGSA NMDWRSLTQV KELGAVIYNC
260 270 280 290 300
SHLAQDLEKT FQTYWVLGVP KAVLPKTWPQ NFSSHFNRFQ PFHGLFDGVP
310 320 330 340 350
TTAYFSASPP ALCPQGRTRD LEALLAVMGS AQEFIYASVM EYFPTTRFSH
360 370 380 390 400
PPRYWPVLDN ALRAAAFGKG VRVRLLVGCG LNTDPTMFPY LRSLQALSNP
410 420 430 440 450
AANVSVDVKV FIVPVGNHSN IPFSRVNHSK FMVTEKAAYI GTSNWSEDYF
460 470 480 490 500
SSTAGVGLVV TQSPGAQPAG ATVQEQLRQL FERDWSSRYA VGLDGQAPGQ

DCVWQG
Length:506
Mass (Da):55,626
Last modified:May 16, 2006 - v2
Checksum:iD7F820C83131FE26
GO

Sequence cautioni

The sequence AAQ89202.1 differs from that shown. Reason: Erroneous initiation. Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161C → R.
Corresponds to variant rs894037 [ dbSNP | Ensembl ].
VAR_061751
Natural varianti27 – 271E → Q.
Corresponds to variant rs2841280 [ dbSNP | Ensembl ].
VAR_031119
Natural varianti135 – 1351V → M.
Corresponds to variant rs3803295 [ dbSNP | Ensembl ].
VAR_031120

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358843 mRNA. Translation: AAQ89202.1. Different initiation.
BC015003 mRNA. Translation: AAH15003.2.
CCDSiCCDS9995.2.
RefSeqiNP_620145.2. NM_138790.3.
UniGeneiHs.407101.

Genome annotation databases

EnsembliENST00000392593; ENSP00000376372; ENSG00000166428.
GeneIDi122618.
KEGGihsa:122618.
UCSCiuc001ypu.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY358843 mRNA. Translation: AAQ89202.1. Different initiation.
BC015003 mRNA. Translation: AAH15003.2.
CCDSiCCDS9995.2.
RefSeqiNP_620145.2. NM_138790.3.
UniGeneiHs.407101.

3D structure databases

ProteinModelPortaliQ96BZ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376372.

PTM databases

iPTMnetiQ96BZ4.
PhosphoSiteiQ96BZ4.

Polymorphism and mutation databases

BioMutaiPLD4.
DMDMi121944492.

Proteomic databases

MaxQBiQ96BZ4.
PaxDbiQ96BZ4.
PeptideAtlasiQ96BZ4.
PRIDEiQ96BZ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392593; ENSP00000376372; ENSG00000166428.
GeneIDi122618.
KEGGihsa:122618.
UCSCiuc001ypu.2. human.

Organism-specific databases

CTDi122618.
GeneCardsiPLD4.
HGNCiHGNC:23792. PLD4.
HPAiHPA051512.
neXtProtiNX_Q96BZ4.
PharmGKBiPA134861676.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3603. Eukaryota.
ENOG410XQZ4. LUCA.
GeneTreeiENSGT00390000009798.
HOVERGENiHBG052880.
InParanoidiQ96BZ4.
KOiK16860.
PhylomeDBiQ96BZ4.
TreeFamiTF313378.

Enzyme and pathway databases

ReactomeiR-HSA-1483148. Synthesis of PG.
R-HSA-1855204. Synthesis of IP3 and IP4 in the cytosol.
R-HSA-2029485. Role of phospholipids in phagocytosis.

Miscellaneous databases

GenomeRNAii122618.
PROiQ96BZ4.

Gene expression databases

BgeeiQ96BZ4.
CleanExiHS_PLD4.
ExpressionAtlasiQ96BZ4. baseline and differential.
GenevisibleiQ96BZ4. HS.

Family and domain databases

InterProiIPR032803. PLDc_3.
IPR001736. PLipase_D/transphosphatidylase.
[Graphical view]
PfamiPF00614. PLDc. 1 hit.
PF13918. PLDc_3. 1 hit.
[Graphical view]
SMARTiSM00155. PLDc. 2 hits.
[Graphical view]
PROSITEiPS50035. PLD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: B-cell.

Entry informationi

Entry nameiPLD4_HUMAN
AccessioniPrimary (citable) accession number: Q96BZ4
Secondary accession number(s): Q6UWD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 16, 2006
Last modified: July 6, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.