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Q96BY7

- ATG2B_HUMAN

UniProt

Q96BY7 - ATG2B_HUMAN

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Protein

Autophagy-related protein 2 homolog B

Gene
ATG2B, C14orf103
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. cellular response to nitrogen starvation Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog B
Gene namesi
Name:ATG2B
Synonyms:C14orf103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20187. ATG2B.

Subcellular locationi

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet 1 Publication

GO - Cellular componenti

  1. extrinsic component of membrane Source: RefGenome
  2. lipid particle Source: UniProtKB-SubCell
  3. pre-autophagosomal structure Source: RefGenome
  4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20782078Autophagy-related protein 2 homolog BPRO_0000089909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei379 – 3791Phosphoserine By similarity
Modified residuei497 – 4971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BY7.
PaxDbiQ96BY7.
PRIDEiQ96BY7.

Expressioni

Gene expression databases

BgeeiQ96BY7.
CleanExiHS_ATG2B.
GenevestigatoriQ96BY7.

Organism-specific databases

HPAiHPA000880.
HPA001427.
HPA019665.

Interactioni

Protein-protein interaction databases

BioGridi120412. 3 interactions.
IntActiQ96BY7. 4 interactions.
STRINGi9606.ENSP00000353010.

Structurei

3D structure databases

ProteinModelPortaliQ96BY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.

Phylogenomic databases

eggNOGiNOG304940.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ96BY7.
KOiK17906.
OMAiKHGEFWL.
OrthoDBiEOG7S4X51.
PhylomeDBiQ96BY7.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BY7-1 [UniParc]FASTAAdd to Basket

« Hide

MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP     50
LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM 100
VFRPRPRPAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL 150
EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGTALEI RIERTVYCDE 200
TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPVET 250
EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ 300
NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN 350
KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS 400
SREEEVFFSM ADMDMSHSLS SLPPLGDPPN MDLELSLTST YTNTPAGSPL 450
SATVLQPTWG EFLDHHKEQP VRGSTFPSNL VHPTPLQKTS LPSRSVSVDE 500
SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA VAFFTCIEKI 550
DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST 600
DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK 650
HSENRGPQGN QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK 700
LATVEMMASH MYTSYNKHIS LHKAFTEVFL DDSHSPANCR ISVQVATPAL 750
NLSVRFPIPD LRSDQERGPW FKKSLQKEIL YLAFTDLEFK TEFIGGSTPE 800
QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS DDFDWPRIVL 850
KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP 900
FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN 950
KSFYEKLYNR IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK 1000
DSFSAFKSAV HYDEESGSEE ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS 1050
FLSVLLNINH GLIAVFTDVK QDNGDLLENK HGEFWLEFNS GSLFCVTKYE 1100
GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP HWLEPTIYSS 1150
EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL 1200
QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR 1250
PLYLPIRSLL TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI 1300
NLSRDYVRVM DMGLLELTIT AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS 1350
DSCAALMNLI QYIASYGDLQ TPNKADMKPG AFQRRSKVDS SGRSSSRGPV 1400
LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK SQIQEPCCSD 1450
LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA 1500
MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV 1550
KEVSLVWHLY GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK 1600
GRNHDFLMEI QLSKVKFQHE VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI 1650
RDRLATSQMN KFLYLYCSKE MPRKAHSNML TVKALHVCPE SGRSPQECCL 1700
RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV KKSPGADVTC 1750
SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS 1800
FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL 1850
KLKRLSYRHG LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL 1900
VQGLKDLVWL PIEQYRKDGR IVRGFQRGAA SFGTSTAMAA LELTNRMVQT 1950
IQAAAETAYD MVSPGTLSIE PKKTKRFPHH RLAHQPVDLR EGVAKAYSVV 2000
KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV KPLIVATEAT 2050
SNVLGGMRNQ IRPDVRQDES QKWRHGDD 2078
Length:2,078
Mass (Da):232,763
Last modified:October 5, 2010 - v5
Checksum:iAA573F5C64D96C36
GO

Sequence cautioni

The sequence BAA91504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC87363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1124 – 11241N → D.1 Publication
Corresponds to variant rs9323945 [ dbSNP | Ensembl ].
VAR_045956
Natural varianti1383 – 13831Q → E.2 Publications
Corresponds to variant rs3759601 [ dbSNP | Ensembl ].
VAR_021523
Natural varianti1567 – 15671I → T.2 Publications
Corresponds to variant rs2289622 [ dbSNP | Ensembl ].
VAR_023096

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti765 – 7651Q → R in BAB70872. 1 Publication
Sequence conflicti1905 – 19051K → E in BAA91504. 1 Publication
Sequence conflicti1932 – 19321F → S in BAC87363. 1 Publication
Sequence conflicti2062 – 20621R → G in BAA91504. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355102 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
AK001104 mRNA. Translation: BAA91504.1. Different initiation.
AK055200 mRNA. Translation: BAB70872.1. Sequence problems.
AK128275 mRNA. Translation: BAC87363.1. Different initiation.
BC015016 mRNA. Translation: AAH15016.3.
CCDSiCCDS9944.2.
RefSeqiNP_060506.5. NM_018036.5.
UniGeneiHs.168241.

Genome annotation databases

EnsembliENST00000359933; ENSP00000353010; ENSG00000066739.
GeneIDi55102.
KEGGihsa:55102.
UCSCiuc001yfi.3. human.

Polymorphism databases

DMDMi308153682.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355102 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
AK001104 mRNA. Translation: BAA91504.1 . Different initiation.
AK055200 mRNA. Translation: BAB70872.1 . Sequence problems.
AK128275 mRNA. Translation: BAC87363.1 . Different initiation.
BC015016 mRNA. Translation: AAH15016.3 .
CCDSi CCDS9944.2.
RefSeqi NP_060506.5. NM_018036.5.
UniGenei Hs.168241.

3D structure databases

ProteinModelPortali Q96BY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120412. 3 interactions.
IntActi Q96BY7. 4 interactions.
STRINGi 9606.ENSP00000353010.

Polymorphism databases

DMDMi 308153682.

Proteomic databases

MaxQBi Q96BY7.
PaxDbi Q96BY7.
PRIDEi Q96BY7.

Protocols and materials databases

DNASUi 55102.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359933 ; ENSP00000353010 ; ENSG00000066739 .
GeneIDi 55102.
KEGGi hsa:55102.
UCSCi uc001yfi.3. human.

Organism-specific databases

CTDi 55102.
GeneCardsi GC14M096747.
HGNCi HGNC:20187. ATG2B.
HPAi HPA000880.
HPA001427.
HPA019665.
neXtProti NX_Q96BY7.
PharmGKBi PA162377102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304940.
HOGENOMi HOG000034149.
HOVERGENi HBG079553.
InParanoidi Q96BY7.
KOi K17906.
OMAi KHGEFWL.
OrthoDBi EOG7S4X51.
PhylomeDBi Q96BY7.
TreeFami TF313482.

Miscellaneous databases

ChiTaRSi ATG2B. human.
GenomeRNAii 55102.
NextBioi 58696.
PROi Q96BY7.

Gene expression databases

Bgeei Q96BY7.
CleanExi HS_ATG2B.
Genevestigatori Q96BY7.

Family and domain databases

InterProi IPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view ]
PANTHERi PTHR13190. PTHR13190. 1 hit.
Pfami PF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124; GLU-1383 AND THR-1567.
    Tissue: Embryo and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANTS GLU-1383 AND THR-1567.
    Tissue: Skin.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
    Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
    Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATG2B_HUMAN
AccessioniPrimary (citable) accession number: Q96BY7
Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 98 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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