Q96BY7 (ATG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Autophagy-related protein 2 homolog B

Gene names

Name:	ATG2B
Synonyms:	C14orf103

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2078 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Ref.5
Subcellular location	Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet Ref.5.
Sequence similarities	Belongs to the ATG2 family.
Sequence caution	The sequence BAA91504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu. The sequence BAC87363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Autophagy
Cellular component	Lipid droplet Membrane
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	autophagy Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2078	2078	Autophagy-related protein 2 homolog B		PRO_0000089909
Amino acid modifications
	Modified residue	497	1	Phosphoserine Ref.4
	Modified residue	1583	1	Phosphoserine By similarity
Natural variations
	Natural variant	1124	1	N → D. Ref.2 Corresponds to variant rs9323945 [ dbSNP | Ensembl ].		VAR_045956
	Natural variant	1383	1	Q → E. Ref.2 Ref.3 Corresponds to variant rs3759601 [ dbSNP | Ensembl ].		VAR_021523
	Natural variant	1567	1	I → T. Ref.2 Ref.3 Corresponds to variant rs2289622 [ dbSNP | Ensembl ].		VAR_023096
Experimental info
	Sequence conflict	765	1	Q → R in BAB70872. Ref.2
	Sequence conflict	1905	1	K → E in BAA91504. Ref.2
	Sequence conflict	1932	1	F → S in BAC87363. Ref.2
	Sequence conflict	2062	1	R → G in BAA91504. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96BY7 [UniParc]. Last modified October 5, 2010. Version 5. Checksum: AA573F5C64D96C36	FASTA	2,078	232,763
	10 20 30 40 50 60 MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP LDKWCLNEIL 70 80 90 100 110 120 ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM VFRPRPRPAT GSEPMYWSSF 130 140 150 160 170 180 MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL EKFAETIETV LRRVKVTFID TVLRIEHVPE 190 200 210 220 230 240 NSKTGTALEI RIERTVYCDE TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS 250 260 270 280 290 300 PVCSTAPVET EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ 310 320 330 340 350 360 NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN KDRKNRPMQQ 370 380 390 400 410 420 EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS SREEEVFFSM ADMDMSHSLS 430 440 450 460 470 480 SLPPLGDPPN MDLELSLTST YTNTPAGSPL SATVLQPTWG EFLDHHKEQP VRGSTFPSNL 490 500 510 520 530 540 VHPTPLQKTS LPSRSVSVDE SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA 550 560 570 580 590 600 VAFFTCIEKI DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST 610 620 630 640 650 660 DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK HSENRGPQGN 670 680 690 700 710 720 QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK LATVEMMASH MYTSYNKHIS 730 740 750 760 770 780 LHKAFTEVFL DDSHSPANCR ISVQVATPAL NLSVRFPIPD LRSDQERGPW FKKSLQKEIL 790 800 810 820 830 840 YLAFTDLEFK TEFIGGSTPE QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS 850 860 870 880 890 900 DDFDWPRIVL KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP 910 920 930 940 950 960 FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN KSFYEKLYNR 970 980 990 1000 1010 1020 IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK DSFSAFKSAV HYDEESGSEE 1030 1040 1050 1060 1070 1080 ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS FLSVLLNINH GLIAVFTDVK QDNGDLLENK 1090 1100 1110 1120 1130 1140 HGEFWLEFNS GSLFCVTKYE GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP 1150 1160 1170 1180 1190 1200 HWLEPTIYSS EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL 1210 1220 1230 1240 1250 1260 QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR PLYLPIRSLL 1270 1280 1290 1300 1310 1320 TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI NLSRDYVRVM DMGLLELTIT 1330 1340 1350 1360 1370 1380 AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS DSCAALMNLI QYIASYGDLQ TPNKADMKPG 1390 1400 1410 1420 1430 1440 AFQRRSKVDS SGRSSSRGPV LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK 1450 1460 1470 1480 1490 1500 SQIQEPCCSD LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA 1510 1520 1530 1540 1550 1560 MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV KEVSLVWHLY 1570 1580 1590 1600 1610 1620 GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK GRNHDFLMEI QLSKVKFQHE 1630 1640 1650 1660 1670 1680 VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI RDRLATSQMN KFLYLYCSKE MPRKAHSNML 1690 1700 1710 1720 1730 1740 TVKALHVCPE SGRSPQECCL RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV 1750 1760 1770 1780 1790 1800 KKSPGADVTC SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS 1810 1820 1830 1840 1850 1860 FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL KLKRLSYRHG 1870 1880 1890 1900 1910 1920 LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL VQGLKDLVWL PIEQYRKDGR 1930 1940 1950 1960 1970 1980 IVRGFQRGAA SFGTSTAMAA LELTNRMVQT IQAAAETAYD MVSPGTLSIE PKKTKRFPHH 1990 2000 2010 2020 2030 2040 RLAHQPVDLR EGVAKAYSVV KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV 2050 2060 2070 KPLIVATEAT SNVLGGMRNQ IRPDVRQDES QKWRHGDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124; GLU-1383 AND THR-1567. Tissue: Embryo and Thymus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANTS GLU-1383 AND THR-1567. Tissue: Skin.
[4]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[5]	"Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets." Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N. Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL355102 Genomic DNA. No translation available. AL359240 Genomic DNA. No translation available. AK001104 mRNA. Translation: BAA91504.1. Different initiation. AK055200 mRNA. Translation: BAB70872.1. Sequence problems. AK128275 mRNA. Translation: BAC87363.1. Different initiation. BC015016 mRNA. Translation: AAH15016.3.
IPI	IPI00872410.
RefSeq	NP_060506.5. NM_018036.5.
UniGene	Hs.168241.
3D structure databases
ProteinModelPortal	Q96BY7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BY7. 3 interactions.
STRING	9606.ENSP00000353010.
Polymorphism databases
DMDM	308153682.
Proteomic databases
PaxDb	Q96BY7.
PRIDE	Q96BY7.
Protocols and materials databases
DNASU	55102.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000359933; ENSP00000353010; ENSG00000066739.
GeneID	55102.
KEGG	hsa:55102.
UCSC	uc001yfi.3. human.
Organism-specific databases
CTD	55102.
GeneCards	GC14M096747.
HGNC	HGNC:20187. ATG2B.
HPA	HPA000880. HPA001427. HPA019665.
neXtProt	NX_Q96BY7.
PharmGKB	PA162377102.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG304940.
HOGENOM	HOG000034149.
HOVERGEN	HBG079553.
InParanoid	Q96BY7.
OMA	KHGEFWL.
OrthoDB	EOG49S65D.
Gene expression databases
Bgee	Q96BY7.
CleanEx	HS_ATG2B.
Genevestigator	Q96BY7.
GermOnline	ENSG00000066739. Homo sapiens.
Family and domain databases
InterPro	IPR026849. ATG2. IPR026885. ATG2_CAD_motif. IPR015412. Autophagy-rel_C. IPR026854. VPS13A_N. [Graphical view]
PANTHER	PTHR13190. PTHR13190. 1 hit.
Pfam	PF13329. ATG2_CAD. 1 hit. PF09333. ATG_C. 1 hit. PF12624. Chorein_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ATG2B. human.
GenomeRNAi	55102.
NextBio	58696.

Entry information

Entry name

ATG2B_HUMAN

Accession

Primary (citable) accession number: Q96BY7
Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2003
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 86 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.