Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q96BY7 (ATG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Autophagy-related protein 2 homolog B
Gene names
Name:ATG2B
Synonyms:C14orf103
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length2078 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion. Ref.5

Subcellular location

Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet Ref.5.

Sequence similarities

Belongs to the ATG2 family.

Sequence caution

The sequence BAA91504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu.

The sequence BAC87363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processAutophagy
   Cellular componentLipid droplet
Membrane
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processautophagy

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentlipid particle

Inferred from electronic annotation. Source: UniProtKB-SubCell

pre-autophagosomal structure membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20782078Autophagy-related protein 2 homolog B
PRO_0000089909

Amino acid modifications

Modified residue3791Phosphoserine By similarity
Modified residue4971Phosphoserine Ref.4

Natural variations

Natural variant11241N → D. Ref.2
Corresponds to variant rs9323945 [ dbSNP | Ensembl ].
VAR_045956
Natural variant13831Q → E. Ref.2 Ref.3
Corresponds to variant rs3759601 [ dbSNP | Ensembl ].
VAR_021523
Natural variant15671I → T. Ref.2 Ref.3
Corresponds to variant rs2289622 [ dbSNP | Ensembl ].
VAR_023096

Experimental info

Sequence conflict7651Q → R in BAB70872. Ref.2
Sequence conflict19051K → E in BAA91504. Ref.2
Sequence conflict19321F → S in BAC87363. Ref.2
Sequence conflict20621R → G in BAA91504. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q96BY7 [UniParc].

Last modified October 5, 2010. Version 5.
Checksum: AA573F5C64D96C36

FASTA2,078232,763
        10         20         30         40         50         60 
MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP LDKWCLNEIL 

        70         80         90        100        110        120 
ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM VFRPRPRPAT GSEPMYWSSF 

       130        140        150        160        170        180 
MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL EKFAETIETV LRRVKVTFID TVLRIEHVPE 

       190        200        210        220        230        240 
NSKTGTALEI RIERTVYCDE TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS 

       250        260        270        280        290        300 
PVCSTAPVET EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ 

       310        320        330        340        350        360 
NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN KDRKNRPMQQ 

       370        380        390        400        410        420 
EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS SREEEVFFSM ADMDMSHSLS 

       430        440        450        460        470        480 
SLPPLGDPPN MDLELSLTST YTNTPAGSPL SATVLQPTWG EFLDHHKEQP VRGSTFPSNL 

       490        500        510        520        530        540 
VHPTPLQKTS LPSRSVSVDE SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA 

       550        560        570        580        590        600 
VAFFTCIEKI DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST 

       610        620        630        640        650        660 
DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK HSENRGPQGN 

       670        680        690        700        710        720 
QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK LATVEMMASH MYTSYNKHIS 

       730        740        750        760        770        780 
LHKAFTEVFL DDSHSPANCR ISVQVATPAL NLSVRFPIPD LRSDQERGPW FKKSLQKEIL 

       790        800        810        820        830        840 
YLAFTDLEFK TEFIGGSTPE QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS 

       850        860        870        880        890        900 
DDFDWPRIVL KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP 

       910        920        930        940        950        960 
FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN KSFYEKLYNR 

       970        980        990       1000       1010       1020 
IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK DSFSAFKSAV HYDEESGSEE 

      1030       1040       1050       1060       1070       1080 
ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS FLSVLLNINH GLIAVFTDVK QDNGDLLENK 

      1090       1100       1110       1120       1130       1140 
HGEFWLEFNS GSLFCVTKYE GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP 

      1150       1160       1170       1180       1190       1200 
HWLEPTIYSS EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL 

      1210       1220       1230       1240       1250       1260 
QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR PLYLPIRSLL 

      1270       1280       1290       1300       1310       1320 
TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI NLSRDYVRVM DMGLLELTIT 

      1330       1340       1350       1360       1370       1380 
AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS DSCAALMNLI QYIASYGDLQ TPNKADMKPG 

      1390       1400       1410       1420       1430       1440 
AFQRRSKVDS SGRSSSRGPV LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK 

      1450       1460       1470       1480       1490       1500 
SQIQEPCCSD LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA 

      1510       1520       1530       1540       1550       1560 
MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV KEVSLVWHLY 

      1570       1580       1590       1600       1610       1620 
GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK GRNHDFLMEI QLSKVKFQHE 

      1630       1640       1650       1660       1670       1680 
VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI RDRLATSQMN KFLYLYCSKE MPRKAHSNML 

      1690       1700       1710       1720       1730       1740 
TVKALHVCPE SGRSPQECCL RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV 

      1750       1760       1770       1780       1790       1800 
KKSPGADVTC SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS 

      1810       1820       1830       1840       1850       1860 
FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL KLKRLSYRHG 

      1870       1880       1890       1900       1910       1920 
LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL VQGLKDLVWL PIEQYRKDGR 

      1930       1940       1950       1960       1970       1980 
IVRGFQRGAA SFGTSTAMAA LELTNRMVQT IQAAAETAYD MVSPGTLSIE PKKTKRFPHH 

      1990       2000       2010       2020       2030       2040 
RLAHQPVDLR EGVAKAYSVV KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV 

      2050       2060       2070 
KPLIVATEAT SNVLGGMRNQ IRPDVRQDES QKWRHGDD 

« Hide

References

« Hide 'large scale' references
[1]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124; GLU-1383 AND THR-1567.
Tissue: Embryo and Thymus.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANTS GLU-1383 AND THR-1567.
Tissue: Skin.
[4]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[5]"Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL355102 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
AK001104 mRNA. Translation: BAA91504.1. Different initiation.
AK055200 mRNA. Translation: BAB70872.1. Sequence problems.
AK128275 mRNA. Translation: BAC87363.1. Different initiation.
BC015016 mRNA. Translation: AAH15016.3.
RefSeqNP_060506.5. NM_018036.5.
UniGeneHs.168241.

3D structure databases

ProteinModelPortalQ96BY7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid120412. 3 interactions.
IntActQ96BY7. 4 interactions.
STRING9606.ENSP00000353010.

Polymorphism databases

DMDM308153682.

Proteomic databases

PaxDbQ96BY7.
PRIDEQ96BY7.

Protocols and materials databases

DNASU55102.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000359933; ENSP00000353010; ENSG00000066739.
GeneID55102.
KEGGhsa:55102.
UCSCuc001yfi.3. human.

Organism-specific databases

CTD55102.
GeneCardsGC14M096747.
HGNCHGNC:20187. ATG2B.
HPAHPA000880.
HPA001427.
HPA019665.
neXtProtNX_Q96BY7.
PharmGKBPA162377102.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG304940.
HOGENOMHOG000034149.
HOVERGENHBG079553.
InParanoidQ96BY7.
KOK17906.
OMAKHGEFWL.
OrthoDBEOG7S4X51.
PhylomeDBQ96BY7.
TreeFamTF313482.

Gene expression databases

BgeeQ96BY7.
CleanExHS_ATG2B.
GenevestigatorQ96BY7.

Family and domain databases

InterProIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERPTHR13190. PTHR13190. 1 hit.
PfamPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSATG2B. human.
GenomeRNAi55102.
NextBio58696.
PROQ96BY7.

Entry information

Entry nameATG2B_HUMAN
AccessionPrimary (citable) accession number: Q96BY7
Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 95 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM