Reviewed,
UniProtKB/Swiss-Prot Q96BY7 (ATG2B_HUMAN)
Last modified
November 24, 2009.
Version 55.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Autophagy-related protein 2 homolog B | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 2078 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Sequence similarities | Belongs to the ATG2 family. |
| Sequence caution | The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu. |
Ontologies
| Keywords | |
|---|---|
| Coding sequence diversity | Polymorphism |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| None. [Check GOA] | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 2078 | 2078 | Autophagy-related protein 2 homolog B | PRO_0000089909 | |||||
Amino acid modifications | |||||||||
| Modified residue | 240 | 1 | Phosphoserine | ||||||
| Modified residue | 497 | 1 | Phosphoserine Ref.4 | ||||||
| Modified residue | 1583 | 1 | Phosphoserine By similarity | ||||||
Natural variations | |||||||||
| Natural variant | 1124 | 1 | N → D: dbSNP rs9323945. Ref.2 | VAR_045956 | |||||
| Natural variant | 1383 | 1 | Q → E: dbSNP rs3759601. Ref.2 Ref.3 | VAR_021523 | |||||
| Natural variant | 1567 | 1 | T → I: dbSNP rs2289622. | VAR_023096 | |||||
Experimental info | |||||||||
| Sequence conflict | 765 | 1 | Q → R in BAB70872. Ref.2 | ||||||
| Sequence conflict | 1905 | 1 | K → E in BAA91504. Ref.2 | ||||||
| Sequence conflict | 1932 | 1 | F → S in BAC87363. Ref.2 | ||||||
| Sequence conflict | 2062 | 1 | R → G in BAA91504. Ref.2 | ||||||
Sequences
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References
| [1] | "The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. Weissenbach J.Nature 421:601-607(2003) [PubMed: 12508121] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124 AND GLU-1383. Tissue: Embryo and Thymus. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANT GLU-1383. Tissue: Skin. |
| [4] | "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, MASS SPECTROMETRY. |
| [5] | "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-240, MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AL355102 Genomic DNA. No translation available. AL359240 Genomic DNA. No translation available. AK001104 mRNA. Translation: BAA91504.1. Different initiation. AK055200 mRNA. Translation: BAB70872.1. Sequence problems. AK128275 mRNA. Translation: BAC87363.1. Different initiation. BC015016 mRNA. Translation: AAH15016.3. | |
| IPI | IPI00872410. |
| RefSeq | NP_060506.5. |
| UniGene | Hs.168241 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q96BY7. |
Genome annotation databases | |
| Ensembl | ENST00000359933; ENSP00000353010; ENSG00000066739; Homo sapiens. [Genome view] |
| GeneID | 55102. |
| KEGG | hsa:55102. |
Organism-specific databases | |
| CTD | 55102. |
| GeneCards | GC14M095817. |
| HGNC | HGNC:20187. ATG2B. |
| HPA | HPA000880. HPA001427. HPA019665. |
| PharmGKB | PA134868662. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q96BY7. |
| HOVERGEN | Q96BY7. |
Enzyme and pathway databases | |
| BioCyc | CATTLE:ENSBTAG00000012833-MON. |
Gene expression databases | |
| ArrayExpress | Q96BY7. |
| Bgee | Q96BY7. |
| CleanEx | HS_ATG2B. |
| Genevestigator | Q96BY7. |
| GermOnline | ENSG00000066739. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR015412. ATG2_C. [Graphical view] |
| Pfam | PF09333. ATG_C. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ATG2B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q96BY7 Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 14 Human chromosome 14: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| SIMILARITY comments Index of protein domains and families |

Clusters with


