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Q96BY7

- ATG2B_HUMAN

UniProt

Q96BY7 - ATG2B_HUMAN

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Protein

Autophagy-related protein 2 homolog B

Gene

ATG2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

GO - Biological processi

  1. autophagic vacuole assembly Source: RefGenome
  2. cellular response to nitrogen starvation Source: RefGenome
  3. mitochondrion degradation Source: RefGenome
  4. nucleophagy Source: RefGenome
Complete GO annotation...

Keywords - Biological processi

Autophagy

Names & Taxonomyi

Protein namesi
Recommended name:
Autophagy-related protein 2 homolog B
Gene namesi
Name:ATG2B
Synonyms:C14orf103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20187. ATG2B.

Subcellular locationi

Preautophagosomal structure membrane 1 Publication; Peripheral membrane protein 1 Publication. Lipid droplet 1 Publication

GO - Cellular componenti

  1. extrinsic component of membrane Source: RefGenome
  2. lipid particle Source: UniProtKB-KW
  3. pre-autophagosomal structure Source: RefGenome
Complete GO annotation...

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 20782078Autophagy-related protein 2 homolog BPRO_0000089909Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei379 – 3791PhosphoserineBy similarity
Modified residuei497 – 4971Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BY7.
PaxDbiQ96BY7.
PRIDEiQ96BY7.

Expressioni

Gene expression databases

BgeeiQ96BY7.
CleanExiHS_ATG2B.
GenevestigatoriQ96BY7.

Organism-specific databases

HPAiHPA000880.
HPA001427.
HPA019665.

Interactioni

Protein-protein interaction databases

BioGridi120412. 6 interactions.
IntActiQ96BY7. 4 interactions.
STRINGi9606.ENSP00000353010.

Structurei

3D structure databases

ProteinModelPortaliQ96BY7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATG2 family.Curated

Phylogenomic databases

eggNOGiNOG304940.
GeneTreeiENSGT00620000087966.
HOGENOMiHOG000034149.
HOVERGENiHBG079553.
InParanoidiQ96BY7.
KOiK17906.
OMAiKHGEFWL.
OrthoDBiEOG7S4X51.
PhylomeDBiQ96BY7.
TreeFamiTF313482.

Family and domain databases

InterProiIPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view]
PANTHERiPTHR13190. PTHR13190. 1 hit.
PfamiPF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BY7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP
60 70 80 90 100
LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM
110 120 130 140 150
VFRPRPRPAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL
160 170 180 190 200
EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGTALEI RIERTVYCDE
210 220 230 240 250
TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPVET
260 270 280 290 300
EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ
310 320 330 340 350
NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN
360 370 380 390 400
KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS
410 420 430 440 450
SREEEVFFSM ADMDMSHSLS SLPPLGDPPN MDLELSLTST YTNTPAGSPL
460 470 480 490 500
SATVLQPTWG EFLDHHKEQP VRGSTFPSNL VHPTPLQKTS LPSRSVSVDE
510 520 530 540 550
SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA VAFFTCIEKI
560 570 580 590 600
DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST
610 620 630 640 650
DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK
660 670 680 690 700
HSENRGPQGN QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK
710 720 730 740 750
LATVEMMASH MYTSYNKHIS LHKAFTEVFL DDSHSPANCR ISVQVATPAL
760 770 780 790 800
NLSVRFPIPD LRSDQERGPW FKKSLQKEIL YLAFTDLEFK TEFIGGSTPE
810 820 830 840 850
QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS DDFDWPRIVL
860 870 880 890 900
KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP
910 920 930 940 950
FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN
960 970 980 990 1000
KSFYEKLYNR IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK
1010 1020 1030 1040 1050
DSFSAFKSAV HYDEESGSEE ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS
1060 1070 1080 1090 1100
FLSVLLNINH GLIAVFTDVK QDNGDLLENK HGEFWLEFNS GSLFCVTKYE
1110 1120 1130 1140 1150
GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP HWLEPTIYSS
1160 1170 1180 1190 1200
EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL
1210 1220 1230 1240 1250
QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR
1260 1270 1280 1290 1300
PLYLPIRSLL TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI
1310 1320 1330 1340 1350
NLSRDYVRVM DMGLLELTIT AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS
1360 1370 1380 1390 1400
DSCAALMNLI QYIASYGDLQ TPNKADMKPG AFQRRSKVDS SGRSSSRGPV
1410 1420 1430 1440 1450
LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK SQIQEPCCSD
1460 1470 1480 1490 1500
LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA
1510 1520 1530 1540 1550
MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV
1560 1570 1580 1590 1600
KEVSLVWHLY GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK
1610 1620 1630 1640 1650
GRNHDFLMEI QLSKVKFQHE VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI
1660 1670 1680 1690 1700
RDRLATSQMN KFLYLYCSKE MPRKAHSNML TVKALHVCPE SGRSPQECCL
1710 1720 1730 1740 1750
RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV KKSPGADVTC
1760 1770 1780 1790 1800
SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS
1810 1820 1830 1840 1850
FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL
1860 1870 1880 1890 1900
KLKRLSYRHG LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL
1910 1920 1930 1940 1950
VQGLKDLVWL PIEQYRKDGR IVRGFQRGAA SFGTSTAMAA LELTNRMVQT
1960 1970 1980 1990 2000
IQAAAETAYD MVSPGTLSIE PKKTKRFPHH RLAHQPVDLR EGVAKAYSVV
2010 2020 2030 2040 2050
KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV KPLIVATEAT
2060 2070
SNVLGGMRNQ IRPDVRQDES QKWRHGDD
Length:2,078
Mass (Da):232,763
Last modified:October 5, 2010 - v5
Checksum:iAA573F5C64D96C36
GO

Sequence cautioni

The sequence BAA91504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAC87363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti765 – 7651Q → R in BAB70872. (PubMed:14702039)Curated
Sequence conflicti1905 – 19051K → E in BAA91504. (PubMed:14702039)Curated
Sequence conflicti1932 – 19321F → S in BAC87363. (PubMed:14702039)Curated
Sequence conflicti2062 – 20621R → G in BAA91504. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1124 – 11241N → D.1 Publication
Corresponds to variant rs9323945 [ dbSNP | Ensembl ].
VAR_045956
Natural varianti1383 – 13831Q → E.2 Publications
Corresponds to variant rs3759601 [ dbSNP | Ensembl ].
VAR_021523
Natural varianti1567 – 15671I → T.2 Publications
Corresponds to variant rs2289622 [ dbSNP | Ensembl ].
VAR_023096

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355102 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
AK001104 mRNA. Translation: BAA91504.1. Different initiation.
AK055200 mRNA. Translation: BAB70872.1. Sequence problems.
AK128275 mRNA. Translation: BAC87363.1. Different initiation.
BC015016 mRNA. Translation: AAH15016.3.
CCDSiCCDS9944.2.
RefSeqiNP_060506.5. NM_018036.5.
UniGeneiHs.168241.

Genome annotation databases

EnsembliENST00000359933; ENSP00000353010; ENSG00000066739.
GeneIDi55102.
KEGGihsa:55102.
UCSCiuc001yfi.3. human.

Polymorphism databases

DMDMi308153682.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL355102 Genomic DNA. No translation available.
AL359240 Genomic DNA. No translation available.
AK001104 mRNA. Translation: BAA91504.1 . Different initiation.
AK055200 mRNA. Translation: BAB70872.1 . Sequence problems.
AK128275 mRNA. Translation: BAC87363.1 . Different initiation.
BC015016 mRNA. Translation: AAH15016.3 .
CCDSi CCDS9944.2.
RefSeqi NP_060506.5. NM_018036.5.
UniGenei Hs.168241.

3D structure databases

ProteinModelPortali Q96BY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120412. 6 interactions.
IntActi Q96BY7. 4 interactions.
STRINGi 9606.ENSP00000353010.

Polymorphism databases

DMDMi 308153682.

Proteomic databases

MaxQBi Q96BY7.
PaxDbi Q96BY7.
PRIDEi Q96BY7.

Protocols and materials databases

DNASUi 55102.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000359933 ; ENSP00000353010 ; ENSG00000066739 .
GeneIDi 55102.
KEGGi hsa:55102.
UCSCi uc001yfi.3. human.

Organism-specific databases

CTDi 55102.
GeneCardsi GC14M096747.
HGNCi HGNC:20187. ATG2B.
HPAi HPA000880.
HPA001427.
HPA019665.
neXtProti NX_Q96BY7.
PharmGKBi PA162377102.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG304940.
GeneTreei ENSGT00620000087966.
HOGENOMi HOG000034149.
HOVERGENi HBG079553.
InParanoidi Q96BY7.
KOi K17906.
OMAi KHGEFWL.
OrthoDBi EOG7S4X51.
PhylomeDBi Q96BY7.
TreeFami TF313482.

Miscellaneous databases

ChiTaRSi ATG2B. human.
GenomeRNAii 55102.
NextBioi 58696.
PROi Q96BY7.

Gene expression databases

Bgeei Q96BY7.
CleanExi HS_ATG2B.
Genevestigatori Q96BY7.

Family and domain databases

InterProi IPR026849. ATG2.
IPR026885. ATG2_CAD_motif.
IPR015412. Autophagy-rel_C.
IPR026854. VPS13A_N.
[Graphical view ]
PANTHERi PTHR13190. PTHR13190. 1 hit.
Pfami PF13329. ATG2_CAD. 1 hit.
PF09333. ATG_C. 1 hit.
PF12624. Chorein_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124; GLU-1383 AND THR-1567.
    Tissue: Embryo and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANTS GLU-1383 AND THR-1567.
    Tissue: Skin.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
    Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
    Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiATG2B_HUMAN
AccessioniPrimary (citable) accession number: Q96BY7
Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 100 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3