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Q96BY7

- ATG2B_HUMAN

UniProt

Q96BY7 - ATG2B_HUMAN

Protein

Autophagy-related protein 2 homolog B

Gene

ATG2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 5 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.1 Publication

    GO - Biological processi

    1. autophagic vacuole assembly Source: RefGenome
    2. cellular response to nitrogen starvation Source: RefGenome
    3. mitochondrion degradation Source: RefGenome
    4. nucleophagy Source: RefGenome

    Keywords - Biological processi

    Autophagy

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Autophagy-related protein 2 homolog B
    Gene namesi
    Name:ATG2B
    Synonyms:C14orf103
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20187. ATG2B.

    Subcellular locationi

    Preautophagosomal structure membrane 1 Publication; Peripheral membrane protein 1 Publication. Lipid droplet 1 Publication

    GO - Cellular componenti

    1. extrinsic component of membrane Source: RefGenome
    2. lipid particle Source: UniProtKB-SubCell
    3. pre-autophagosomal structure Source: RefGenome
    4. pre-autophagosomal structure membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lipid droplet, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162377102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20782078Autophagy-related protein 2 homolog BPRO_0000089909Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei379 – 3791PhosphoserineBy similarity
    Modified residuei497 – 4971Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96BY7.
    PaxDbiQ96BY7.
    PRIDEiQ96BY7.

    Expressioni

    Gene expression databases

    BgeeiQ96BY7.
    CleanExiHS_ATG2B.
    GenevestigatoriQ96BY7.

    Organism-specific databases

    HPAiHPA000880.
    HPA001427.
    HPA019665.

    Interactioni

    Protein-protein interaction databases

    BioGridi120412. 3 interactions.
    IntActiQ96BY7. 4 interactions.
    STRINGi9606.ENSP00000353010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BY7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATG2 family.Curated

    Phylogenomic databases

    eggNOGiNOG304940.
    HOGENOMiHOG000034149.
    HOVERGENiHBG079553.
    InParanoidiQ96BY7.
    KOiK17906.
    OMAiKHGEFWL.
    OrthoDBiEOG7S4X51.
    PhylomeDBiQ96BY7.
    TreeFamiTF313482.

    Family and domain databases

    InterProiIPR026849. ATG2.
    IPR026885. ATG2_CAD_motif.
    IPR015412. Autophagy-rel_C.
    IPR026854. VPS13A_N.
    [Graphical view]
    PANTHERiPTHR13190. PTHR13190. 1 hit.
    PfamiPF13329. ATG2_CAD. 1 hit.
    PF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96BY7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPWPFSESIK KRACRYLLQR YLGHFLQEKL SLEQLSLDLY QGTGSLAQVP     50
    LDKWCLNEIL ESADAPLEVT EGFIQSISLS VPWGSLLQDN CALEVRGLEM 100
    VFRPRPRPAT GSEPMYWSSF MTSSMQLAKE CLSQKLTDEQ GEGSQPFEGL 150
    EKFAETIETV LRRVKVTFID TVLRIEHVPE NSKTGTALEI RIERTVYCDE 200
    TADESSGINV HQPTAFAHKL LQLSGVSLFW DEFSASAKSS PVCSTAPVET 250
    EPKLSPSWNP KIIYEPHPQL TRNLPEIAPS DPVQIGRLIG RLELSLTLKQ 300
    NEVLPGAKLD VDGQIDSIHL LLSPRQVHLL LDMLAAIAGP ENSSKIGLAN 350
    KDRKNRPMQQ EDEYRIQMEL NRYYLRKDSL SVGVSSEQSF YETETARTPS 400
    SREEEVFFSM ADMDMSHSLS SLPPLGDPPN MDLELSLTST YTNTPAGSPL 450
    SATVLQPTWG EFLDHHKEQP VRGSTFPSNL VHPTPLQKTS LPSRSVSVDE 500
    SRPELIFRLA VGTFSISVLH IDPLSPPETS QNLNPLTPMA VAFFTCIEKI 550
    DPARFSTEDF KSFRAVFAEA CSHDHLRFIG TGIKVSYEQR QRSASRYFST 600
    DMSIGQMEFL ECLFPTDFHS VPPHYTELLT FHSKEETGSH SPVCLQLHYK 650
    HSENRGPQGN QARLSSVPHK AELQIKLNPV CCELDISIVD RLNSLLQPQK 700
    LATVEMMASH MYTSYNKHIS LHKAFTEVFL DDSHSPANCR ISVQVATPAL 750
    NLSVRFPIPD LRSDQERGPW FKKSLQKEIL YLAFTDLEFK TEFIGGSTPE 800
    QIKLELTFRE LIGSFQEEKG DPSIKFFHVS SGVDGDTTSS DDFDWPRIVL 850
    KINPPAMHSI LERIAAEEEE ENDGHYQEEE EGGAHSLKDV CDLRRPAPSP 900
    FSSRRVMFEN EQMVMPGDPV EMTEFQDKAI SNSHYVLELT LPNIYVTLPN 950
    KSFYEKLYNR IFNDLLLWEP TAPSPVETFE NISYGIGLSV ASQLINTFNK 1000
    DSFSAFKSAV HYDEESGSEE ETLQYFSTVD PNYRSRRKKK LDSQNKNSQS 1050
    FLSVLLNINH GLIAVFTDVK QDNGDLLENK HGEFWLEFNS GSLFCVTKYE 1100
    GFDDKHYICL HSSSFSLYHK GIVNGVILPT ETRLPSSTRP HWLEPTIYSS 1150
    EEDGLSKTSS DGVGGDSLNM LSVAVKILSD KSESNTKEFL IAVGLKGATL 1200
    QHRMLPSGLS WHEQILYFLN IADEPVLGYN PPTSFTTFHV HLWSCALDYR 1250
    PLYLPIRSLL TVETFSVSSS VALDKSSSTL RIILDEAALH LSDKCNTVTI 1300
    NLSRDYVRVM DMGLLELTIT AVKSDSDGEQ TEPRFELHCS SDVVHIRTCS 1350
    DSCAALMNLI QYIASYGDLQ TPNKADMKPG AFQRRSKVDS SGRSSSRGPV 1400
    LPEADQQMLR DLMSDAMEEI DMQQGTSSVK PQANGVLDEK SQIQEPCCSD 1450
    LFLFPDESGN VSQESGPTYA SFSHHFISDA MTGVPTENDD FCILFAPKAA 1500
    MQEKEEEPVI KIMVDDAIVI RDNYFSLPVN KTDTSKAPLH FPIPVIRYVV 1550
    KEVSLVWHLY GGKDFGIVPP TSPAKSYISP HSSPSHTPTR HGRNTVCGGK 1600
    GRNHDFLMEI QLSKVKFQHE VYPPCKPDCD SSLSEHPVSR QVFIVQDLEI 1650
    RDRLATSQMN KFLYLYCSKE MPRKAHSNML TVKALHVCPE SGRSPQECCL 1700
    RVSLMPLRLN IDQDALFFLK DFFTSLSAEV ELQMTPDPEV KKSPGADVTC 1750
    SLPRHLSTSK EPNLVISFSG PKQPSQNDSA NSVEVVNGME EKNFSAEEAS 1800
    FRDQPVFFRE FRFTSEVPIR LDYHGKHVSM DQGTLAGILI GLAQLNCSEL 1850
    KLKRLSYRHG LLGVDKLFSY AITEWLNDIK KNQLPGILGG VGPMHSLVQL 1900
    VQGLKDLVWL PIEQYRKDGR IVRGFQRGAA SFGTSTAMAA LELTNRMVQT 1950
    IQAAAETAYD MVSPGTLSIE PKKTKRFPHH RLAHQPVDLR EGVAKAYSVV 2000
    KEGITDTAQT IYETAAREHE SRGVTGAVGE VLRQIPPAVV KPLIVATEAT 2050
    SNVLGGMRNQ IRPDVRQDES QKWRHGDD 2078
    Length:2,078
    Mass (Da):232,763
    Last modified:October 5, 2010 - v5
    Checksum:iAA573F5C64D96C36
    GO

    Sequence cautioni

    The sequence BAA91504.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAC87363.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence BAB70872.1 differs from that shown. Reason: Erroneous termination at position 800. Translated as Glu.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti765 – 7651Q → R in BAB70872. (PubMed:14702039)Curated
    Sequence conflicti1905 – 19051K → E in BAA91504. (PubMed:14702039)Curated
    Sequence conflicti1932 – 19321F → S in BAC87363. (PubMed:14702039)Curated
    Sequence conflicti2062 – 20621R → G in BAA91504. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1124 – 11241N → D.1 Publication
    Corresponds to variant rs9323945 [ dbSNP | Ensembl ].
    VAR_045956
    Natural varianti1383 – 13831Q → E.2 Publications
    Corresponds to variant rs3759601 [ dbSNP | Ensembl ].
    VAR_021523
    Natural varianti1567 – 15671I → T.2 Publications
    Corresponds to variant rs2289622 [ dbSNP | Ensembl ].
    VAR_023096

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355102 Genomic DNA. No translation available.
    AL359240 Genomic DNA. No translation available.
    AK001104 mRNA. Translation: BAA91504.1. Different initiation.
    AK055200 mRNA. Translation: BAB70872.1. Sequence problems.
    AK128275 mRNA. Translation: BAC87363.1. Different initiation.
    BC015016 mRNA. Translation: AAH15016.3.
    CCDSiCCDS9944.2.
    RefSeqiNP_060506.5. NM_018036.5.
    UniGeneiHs.168241.

    Genome annotation databases

    EnsembliENST00000359933; ENSP00000353010; ENSG00000066739.
    GeneIDi55102.
    KEGGihsa:55102.
    UCSCiuc001yfi.3. human.

    Polymorphism databases

    DMDMi308153682.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL355102 Genomic DNA. No translation available.
    AL359240 Genomic DNA. No translation available.
    AK001104 mRNA. Translation: BAA91504.1 . Different initiation.
    AK055200 mRNA. Translation: BAB70872.1 . Sequence problems.
    AK128275 mRNA. Translation: BAC87363.1 . Different initiation.
    BC015016 mRNA. Translation: AAH15016.3 .
    CCDSi CCDS9944.2.
    RefSeqi NP_060506.5. NM_018036.5.
    UniGenei Hs.168241.

    3D structure databases

    ProteinModelPortali Q96BY7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120412. 3 interactions.
    IntActi Q96BY7. 4 interactions.
    STRINGi 9606.ENSP00000353010.

    Polymorphism databases

    DMDMi 308153682.

    Proteomic databases

    MaxQBi Q96BY7.
    PaxDbi Q96BY7.
    PRIDEi Q96BY7.

    Protocols and materials databases

    DNASUi 55102.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000359933 ; ENSP00000353010 ; ENSG00000066739 .
    GeneIDi 55102.
    KEGGi hsa:55102.
    UCSCi uc001yfi.3. human.

    Organism-specific databases

    CTDi 55102.
    GeneCardsi GC14M096747.
    HGNCi HGNC:20187. ATG2B.
    HPAi HPA000880.
    HPA001427.
    HPA019665.
    neXtProti NX_Q96BY7.
    PharmGKBi PA162377102.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG304940.
    HOGENOMi HOG000034149.
    HOVERGENi HBG079553.
    InParanoidi Q96BY7.
    KOi K17906.
    OMAi KHGEFWL.
    OrthoDBi EOG7S4X51.
    PhylomeDBi Q96BY7.
    TreeFami TF313482.

    Miscellaneous databases

    ChiTaRSi ATG2B. human.
    GenomeRNAii 55102.
    NextBioi 58696.
    PROi Q96BY7.

    Gene expression databases

    Bgeei Q96BY7.
    CleanExi HS_ATG2B.
    Genevestigatori Q96BY7.

    Family and domain databases

    InterProi IPR026849. ATG2.
    IPR026885. ATG2_CAD_motif.
    IPR015412. Autophagy-rel_C.
    IPR026854. VPS13A_N.
    [Graphical view ]
    PANTHERi PTHR13190. PTHR13190. 1 hit.
    Pfami PF13329. ATG2_CAD. 1 hit.
    PF09333. ATG_C. 1 hit.
    PF12624. Chorein_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-800 AND 1065-2078, VARIANTS ASP-1124; GLU-1383 AND THR-1567.
      Tissue: Embryo and Thymus.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1304-2078, VARIANTS GLU-1383 AND THR-1567.
      Tissue: Skin.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-497, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    5. "Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets."
      Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N.
      Mol. Biol. Cell 23:896-909(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiATG2B_HUMAN
    AccessioniPrimary (citable) accession number: Q96BY7
    Secondary accession number(s): Q6ZRE7, Q96DQ3, Q9NW80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2003
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 99 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3