Q96BY6 (DOC10_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dedicator of cytokinesis protein 10

Alternative name(s):
Zizimin-3

Gene names

Name:	DOCK10
Synonyms:	KIAA0694, ZIZ3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	2186 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
Tissue specificity	Expressed at low level in brain and lung. Ref.1
Domain	The DHR-2 domain may mediate some GEF activity By similarity.
Sequence similarities	Belongs to the DOCK family. Contains 1 DHR-1 domain. Contains 1 DHR-2 domain. Contains 1 PH domain.
Sequence caution	The sequence AAH15018.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA31669.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence BAA91022.1 differs from that shown. Reason: Frameshift at position 2133. The sequence BAA91583.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Molecular function	Guanine-nucleotide releasing factor
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	small GTPase mediated signal transduction Inferred from electronic annotation. Source: InterPro
Molecular_function	Rho guanyl-nucleotide exchange factor activity Inferred from electronic annotation. Source: Compara phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96BY6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Note: No experimental confirmation available.

Isoform 2 (identifier: Q96BY6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     565-593: FKDNQGNVDRDSRFSPLFRQESSKISTED → DSCSQQTRNTFNGGIGSFSFERFCVAYYF
     594-2186: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2186	2186	Dedicator of cytokinesis protein 10		PRO_0000190002
Regions
	Domain	181 – 290	110	PH
	Domain	672 – 850	179	DHR-1
	Domain	1690 – 2150	461	DHR-2
Amino acid modifications
	Modified residue	834	1	N6-acetyllysine Ref.10
	Modified residue	1232	1	Phosphoserine Ref.9
	Modified residue	1292	1	Phosphoserine Ref.7 Ref.8 Ref.9
	Modified residue	1295	1	Phosphoserine Ref.7 Ref.8 Ref.9
	Modified residue	1318	1	Phosphoserine Ref.7 Ref.9
	Modified residue	1440	1	Phosphothreonine Ref.9
Natural variations
	Alternative sequence	565 – 593	29	FKDNQ…ISTED → DSCSQQTRNTFNGGIGSFSF ERFCVAYYF in isoform 2.		VSP_007716
	Alternative sequence	594 – 2186	1593	Missing in isoform 2.		VSP_007717
Experimental info
	Sequence conflict	563	1	S → Y in BAA31669. Ref.1
	Sequence conflict	1833	1	N → D in BAA91583. Ref.5
	Sequence conflict	1966	1	T → S in BAA91022. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 3, 2011. Version 3. Checksum: 955ABC03DE2270AF	FASTA	2,186	249,531
	10 20 30 40 50 60 MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL 70 80 90 100 110 120 EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW 130 140 150 160 170 180 HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT 190 200 210 220 230 240 GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF 250 260 270 280 290 300 LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR 310 320 330 340 350 360 RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF 370 380 390 400 410 420 SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI 430 440 450 460 470 480 EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI 490 500 510 520 530 540 KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL 550 560 570 580 590 600 KSNRQFCSKL GKYRMPFAWA VRSVFKDNQG NVDRDSRFSP LFRQESSKIS TEDLVKLVSD 610 620 630 640 650 660 YRRADRISKM QTIPGSLDIA VDNVPLEHPN CVTSSFIPVK PFNMMAQTEP TVEVEEFVYD 670 680 690 700 710 720 STKYCRPYRV YKNQIYIYPK HLKYDSQKCF NKARNITVCI EFKNSDEESA KPLKCIYGKP 730 740 750 760 770 780 GGPLFTSAAY TAVLHHSQNP DFSDEVKIEL PTQLHEKHHI LFSFYHVTCD INAKANAKKK 790 800 810 820 830 840 EALETSVGYA WLPLMKHDQI ASQEYNIPIA TSLPPNYLSF QDSASGKHGG SDIKWVDGGK 850 860 870 880 890 900 PLFKVSTFVV STVNTQDPHV NAFFQECQKR EKDMSQSPTS NFIRSCKNLL NVEKIHAIMS 910 920 930 940 950 960 FLPIILNQLF KVLVQNEEDE ITTTVTRVLT DIVAKCHEEQ LDHSVQSYIK FVFKTRACKE 970 980 990 1000 1010 1020 RTVHEELAKN VTGLLKSNDS TTVKHVLKHS WFFFAIILKS MAQHLIDTNK IQLPRPQRFP 1030 1040 1050 1060 1070 1080 ESYQNELDNL VMVLSDHVIW KYKDALEETR RANHSVARFL KRCFTFMDRG YVFKMVNNYI 1090 1100 1110 1120 1130 1140 SMFSSGDLKT LCQYKFDFLQ EVCQHEHFIP LCLPIRSANI PDPLTPSEST QELHASDMPE 1150 1160 1170 1180 1190 1200 YSVTNEFCRK HFLIGILLRE VGFALQEDQD VRHLALAVLK NLMAKHSFDD RYREPRKQAQ 1210 1220 1230 1240 1250 1260 IASLYMPLYG MLLDNMPRIY LKDLYPFTVN TSNQGSRDDL STNGGFQSQT AIKHANSVDT 1270 1280 1290 1300 1310 1320 SFSKDVLNSI AAFSSIAIST VNHADSRASL ASLDSNPSTN EKSSEKTDNC EKIPRPLSLI 1330 1340 1350 1360 1370 1380 GSTLRFDKLD QAETRSLLMC FLHIMKTISY ETLIAYWQRA PSPEVSDFFS ILDVCLQNFR 1390 1400 1410 1420 1430 1440 YLGKRNIIRK IAAAFKFVQS TQNNGTLKGS NPSCQTSGLL SQWMHSTSSH EGHKQHRSQT 1450 1460 1470 1480 1490 1500 LPIIRGKNAL SNPKLLQMLD NTMTSNSNEI DIVHHVDTEA NIATEVCLTI LDLLSLFTQT 1510 1520 1530 1540 1550 1560 HQRQLQQCDC QNSLMKRVFD TYMLFFQVNQ SATALKHVFA SLRLFVCKFP SAFFQGPADL 1570 1580 1590 1600 1610 1620 CGSFCYEVLK CCNHRSRSTQ TEASALLYFF MRKNFEFNKQ KSIVRSHLQL IKAVSQLIAD 1630 1640 1650 1660 1670 1680 AGIGGSRFQH SLAITNNFAN GDKQMKNSNF PAEVKDLTKR IRTVLMATAQ MKEHEKDPEM 1690 1700 1710 1720 1730 1740 LVDLQYSLAN SYASTPELRR TWLESMAKIH ARNGDLSEAA MCYIHIAALI AEYLKRKGYW 1750 1760 1770 1780 1790 1800 KVEKICTASL LSEDTHPCDS NSLLTTPSGG SMFSMGWPAF LSITPNIKEE GAMKEDSGMQ 1810 1820 1830 1840 1850 1860 DTPYNENILV EQLYMCVEFL WKSERYELIA DVNKPIIAVF EKQRDFKKLS DLYYDIHRSY 1870 1880 1890 1900 1910 1920 LKVAEVVNSE KRLFGRYYRV AFYGQGFFEE EEGKEYIYKE PKLTGLSEIS QRLLKLYADK 1930 1940 1950 1960 1970 1980 FGADNVKIIQ DSNKVNPKDL DPKYAYIQVT YVTPFFEEKE IEDRKTDFEM HHNINRFVFE 1990 2000 2010 2020 2030 2040 TPFTLSGKKH GGVAEQCKRR TILTTSHLFP YVKKRIQVIS QSSTELNPIE VAIDEMSKKV 2050 2060 2070 2080 2090 2100 SELNQLCTME EVDMIRLQLK LQGSVSVKVN AGPMAYARAF LEETNAKKYP DNQVKLLKEI 2110 2120 2130 2140 2150 2160 FRQFADACGQ ALDVNERLIK EDQLEYQEEL RSHYKDMLSE LSTVMNEQIT GRDDLSKRGV 2170 2180 DQTCTRVISK ATPALPTVSI SSSAEV
	Isoform 2 [UniParc]. Checksum: 4C41C48C2162ADB0	FASTA	593	67,378
	10 20 30 40 50 60 MAGERTRRFT RSLLRPGQAA ELRHSAASAA AVAVSSRQQQ RQEKPRLLEP LDYETVIEEL 70 80 90 100 110 120 EKTYRNDPLQ DLLFFPSDDF SAATVSWDIR TLYSTVPEDA EHKAENLLVK EACKFYSSQW 130 140 150 160 170 180 HVVNYKYEQY SGDIRQLPRA EYKPEKLPSH SFEIDHEDAD KDEDTTSHSS SKGGGGAGGT 190 200 210 220 230 240 GVFKSGWLYK GNFNSTVNNT VTVRSFKKRY FQLTQLPDNS YIMNFYKDEK ISKEPKGCIF 250 260 270 280 290 300 LDSCTGVVQN NRLRKYAFEL KMNDLTYFVL AAETESDMDE WIHTLNRILQ ISPEGPLQGR 310 320 330 340 350 360 RSTELTDLGL DSLDNSVTCE CTPEETDSSE NNLHADFAKY LTETEDTVKT TRNMERLNLF 370 380 390 400 410 420 SLDPDIDTLK LQKKDLLEPE SVIKPFEEKA AKRIMIICKA LNSNLQGCVT ENENDPITNI 430 440 450 460 470 480 EPFFVSVALY DLRDSRKISA DFHVDLNHAA VRQMLLGASV ALENGNIDTI TPRQSEEPHI 490 500 510 520 530 540 KGLPEEWLKF PKQAVFSVSN PHSEIVLVAK IEKVLMGNIA SGAEPYIKNP DSNKYAQKIL 550 560 570 580 590 KSNRQFCSKL GKYRMPFAWA VRSVDSCSQQ TRNTFNGGIG SFSFERFCVA YYF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Ishikawa K., Nagase T., Suyama M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Brain.
[2]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[3]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1599-2186 (ISOFORM 1). Tissue: Skin.
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1599-2186 (ISOFORM 1). Tissue: Colon mucosa and Teratocarcinoma.
[6]	"Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity." Cote J.-F., Vuori K. J. Cell Sci. 115:4901-4913(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NOMENCLATURE.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292; SER-1295 AND SER-1318, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1292 AND SER-1295, MASS SPECTROMETRY. Tissue: Platelet.
[9]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1232; SER-1292; SER-1295; SER-1318 AND THR-1440, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[10]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-834, MASS SPECTROMETRY.
[11]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB014594 mRNA. Translation: BAA31669.2. Different initiation. AC011739 Genomic DNA. No translation available. AC017095 Genomic DNA. No translation available. AC093806 Genomic DNA. No translation available. BC015018 mRNA. Translation: AAH15018.1. Different initiation. AK000227 mRNA. Translation: BAA91022.1. Frameshift. AK001253 mRNA. Translation: BAA91583.1. Different initiation.
IPI	IPI00333770. IPI00375113.
RefSeq	NP_055504.2. NM_014689.2.
UniGene	Hs.46578.
3D structure databases
ProteinModelPortal	Q96BY6.
SMR	Q96BY6. Positions 181-302, 1694-2149.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BY6. 1 interaction.
STRING	9606.ENSP00000258390.
PTM databases
PhosphoSite	Q96BY6.
Polymorphism databases
DMDM	32469767.
Proteomic databases
PaxDb	Q96BY6.
PRIDE	Q96BY6.
Protocols and materials databases
DNASU	55619.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000258390; ENSP00000258390; ENSG00000135905.
GeneID	55619.
KEGG	hsa:55619.
UCSC	uc002vod.1. human. uc010fwz.1. human.
Organism-specific databases
CTD	55619.
GeneCards	GC02M225593.
H-InvDB	HIX0002889.
HGNC	HGNC:23479. DOCK10.
HPA	HPA035749.
MIM	611518. gene.
neXtProt	NX_Q96BY6.
PharmGKB	PA134983197.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG242127.
HOGENOM	HOG000231373.
HOVERGEN	HBG107819.
OMA	CQYKFDF.
OrthoDB	EOG461432.
PhylomeDB	Q96BY6.
Enzyme and pathway databases
Reactome	REACT_604. Hemostasis.
Gene expression databases
ArrayExpress	Q96BY6.
Bgee	Q96BY6.
CleanEx	HS_DOCK10.
Genevestigator	Q96BY6.
GermOnline	ENSG00000135905. Homo sapiens.
Family and domain databases
Gene3D	2.30.29.30. 1 hit.
InterPro	IPR027007. DHR-1_domain. IPR027357. DHR-2. IPR026791. DOCK. IPR010703. DOCK_C. IPR021816. DOCK_C/D_N. IPR026796. DOCK_D. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. [Graphical view]
PANTHER	PTHR23317. PTHR23317. 1 hit. PTHR23317:SF26. PTHR23317:SF26. 1 hit.
Pfam	PF06920. Ded_cyto. 1 hit. PF14429. DOCK-C2. 1 hit. PF11878. DUF3398. 1 hit. PF00169. PH. 1 hit. [Graphical view]
SMART	SM00233. PH. 1 hit. [Graphical view]
PROSITE	PS51650. DHR_1. 1 hit. PS51651. DHR_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	DOCK10. human.
GenomeRNAi	55619.
NextBio	60216.
SOURCE	Search...

Entry information

Entry name

DOC10_HUMAN

Accession

Primary (citable) accession number: Q96BY6
Secondary accession number(s): O75178, Q9NW06, Q9NXI8

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	May 3, 2011
Last modified:	May 1, 2013
This is version 109 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.