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Protein

MOB kinase activator 3A

Gene

MOB3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate the activity of kinases.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi83ZincBy similarity1
Metal bindingi88ZincBy similarity1
Metal bindingi165ZincBy similarity1
Metal bindingi170ZincBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
MOB kinase activator 3A
Alternative name(s):
MOB-LAK
Mob1 homolog 2A
Mps one binder kinase activator-like 2A
Gene namesi
Name:MOB3A
Synonyms:MOBKL2A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29802. MOB3A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000172081.
PharmGKBiPA134901591.

Polymorphism and mutation databases

BioMutaiMOB3A.
DMDMi56749352.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001935701 – 217MOB kinase activator 3AAdd BLAST217

Proteomic databases

EPDiQ96BX8.
MaxQBiQ96BX8.
PaxDbiQ96BX8.
PeptideAtlasiQ96BX8.
PRIDEiQ96BX8.

PTM databases

iPTMnetiQ96BX8.
PhosphoSitePlusiQ96BX8.

Expressioni

Gene expression databases

BgeeiENSG00000172081.
CleanExiHS_MOBKL2A.
ExpressionAtlasiQ96BX8. baseline and differential.
GenevisibleiQ96BX8. HS.

Organism-specific databases

HPAiHPA046866.

Interactioni

Protein-protein interaction databases

BioGridi125978. 9 interactors.
MINTiMINT-4714635.
STRINGi9606.ENSP00000349575.

Structurei

3D structure databases

ProteinModelPortaliQ96BX8.
SMRiQ96BX8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ96BX8.
OMAiYFVTEFG.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ96BX8.
TreeFamiTF300789.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96BX8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNPFLKQVF NKDKTFRPKR KFEPGTQRFE LHKKAQASLN AGLDLRLAVQ
60 70 80 90 100
LPPGEDLNDW VAVHVVDFFN RVNLIYGTIS DGCTEQSCPV MSGGPKYEYR
110 120 130 140 150
WQDEHKFRKP TALSAPRYMD LLMDWIEAQI NNEDLFPTNV GTPFPKNFLQ
160 170 180 190 200
TVRKILSRLF RVFVHVYIHH FDRIAQMGSE AHVNTCYKHF YYFVKEFGLI
210
DTKELEPLKE MTARMCH
Length:217
Mass (Da):25,464
Last modified:December 1, 2001 - v1
Checksum:iC60B6EC8A3C0AA30
GO

Sequence cautioni

The sequence AAC27672 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAB84554 differs from that shown. Chimera. There is an inclusion of DNA from another gene in position 141.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061793 mRNA. Translation: BAB84554.1. Sequence problems.
AJ580635 mRNA. Translation: CAE45267.1.
AK095471 mRNA. Translation: BAG53063.1.
AC005328 Genomic DNA. Translation: AAC27672.1. Sequence problems.
BC015049 mRNA. Translation: AAH15049.1.
CCDSiCCDS12081.1.
RefSeqiNP_570719.1. NM_130807.2.
XP_011525985.1. XM_011527683.2.
UniGeneiHs.744938.

Genome annotation databases

EnsembliENST00000357066; ENSP00000349575; ENSG00000172081.
ENST00000592280; ENSP00000466249; ENSG00000172081.
GeneIDi126308.
KEGGihsa:126308.
UCSCiuc002luu.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB061793 mRNA. Translation: BAB84554.1. Sequence problems.
AJ580635 mRNA. Translation: CAE45267.1.
AK095471 mRNA. Translation: BAG53063.1.
AC005328 Genomic DNA. Translation: AAC27672.1. Sequence problems.
BC015049 mRNA. Translation: AAH15049.1.
CCDSiCCDS12081.1.
RefSeqiNP_570719.1. NM_130807.2.
XP_011525985.1. XM_011527683.2.
UniGeneiHs.744938.

3D structure databases

ProteinModelPortaliQ96BX8.
SMRiQ96BX8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125978. 9 interactors.
MINTiMINT-4714635.
STRINGi9606.ENSP00000349575.

PTM databases

iPTMnetiQ96BX8.
PhosphoSitePlusiQ96BX8.

Polymorphism and mutation databases

BioMutaiMOB3A.
DMDMi56749352.

Proteomic databases

EPDiQ96BX8.
MaxQBiQ96BX8.
PaxDbiQ96BX8.
PeptideAtlasiQ96BX8.
PRIDEiQ96BX8.

Protocols and materials databases

DNASUi126308.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357066; ENSP00000349575; ENSG00000172081.
ENST00000592280; ENSP00000466249; ENSG00000172081.
GeneIDi126308.
KEGGihsa:126308.
UCSCiuc002luu.4. human.

Organism-specific databases

CTDi126308.
GeneCardsiMOB3A.
HGNCiHGNC:29802. MOB3A.
HPAiHPA046866.
neXtProtiNX_Q96BX8.
OpenTargetsiENSG00000172081.
PharmGKBiPA134901591.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1903. Eukaryota.
ENOG410XSM4. LUCA.
GeneTreeiENSGT00550000074456.
HOGENOMiHOG000164685.
HOVERGENiHBG052489.
InParanoidiQ96BX8.
OMAiYFVTEFG.
OrthoDBiEOG091G0LDA.
PhylomeDBiQ96BX8.
TreeFamiTF300789.

Miscellaneous databases

ChiTaRSiMOB3A. human.
GeneWikiiMOBKL2A.
GenomeRNAii126308.
PROiQ96BX8.

Gene expression databases

BgeeiENSG00000172081.
CleanExiHS_MOBKL2A.
ExpressionAtlasiQ96BX8. baseline and differential.
GenevisibleiQ96BX8. HS.

Family and domain databases

Gene3Di1.20.140.30. 1 hit.
InterProiIPR005301. MOB_kinase_act_fam.
[Graphical view]
PfamiPF03637. Mob1_phocein. 1 hit.
[Graphical view]
SMARTiSM01388. Mob1_phocein. 1 hit.
[Graphical view]
SUPFAMiSSF101152. SSF101152. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMOB3A_HUMAN
AccessioniPrimary (citable) accession number: Q96BX8
Secondary accession number(s): B3KTF1, O75249, Q8TF69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.