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Protein

Phosphatidate cytidylyltransferase, mitochondrial

Gene

TAMM41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from phosphatidic acid (PA) in the mitochondrial inner membrane. Required for the biosynthesis of the dimeric phospholipid cardiolipin, which stabilizes supercomplexes of the mitochondrial respiratory chain in the mitochondrial inner membrane (By similarity).By similarity

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Cofactori

Mg2+By similarity

Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3), Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), Lysocardiolipin acyltransferase 1 (LCLAT1)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciZFISH:ENSG00000144559-MONOMER.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase, mitochondrial (EC:2.7.7.41)
Alternative name(s):
CDP-diacylglycerol synthase
Short name:
CDP-DAG synthase
Mitochondrial translocator assembly and maintenance protein 41 homolog
Short name:
TAM41
Gene namesi
Name:TAMM41
Synonyms:C3orf31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:25187. TAMM41.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi132001.
OpenTargetsiENSG00000144559.
PharmGKBiPA142672392.

Polymorphism and mutation databases

BioMutaiTAMM41.
DMDMi74731287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 24MitochondrionSequence analysisAdd BLAST24
ChainiPRO_000024835425 – 452Phosphatidate cytidylyltransferase, mitochondrialAdd BLAST428

Proteomic databases

EPDiQ96BW9.
MaxQBiQ96BW9.
PaxDbiQ96BW9.
PeptideAtlasiQ96BW9.
PRIDEiQ96BW9.

PTM databases

iPTMnetiQ96BW9.
PhosphoSitePlusiQ96BW9.

Expressioni

Gene expression databases

BgeeiENSG00000144559.
CleanExiHS_C3orf31.
ExpressionAtlasiQ96BW9. baseline and differential.
GenevisibleiQ96BW9. HS.

Organism-specific databases

HPAiHPA036834.
HPA044861.

Interactioni

Protein-protein interaction databases

BioGridi126303. 20 interactors.
STRINGi9606.ENSP00000273037.

Structurei

3D structure databases

ProteinModelPortaliQ96BW9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TAM41 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2986. Eukaryota.
ENOG410ZNKE. LUCA.
GeneTreeiENSGT00390000000616.
HOGENOMiHOG000205225.
HOVERGENiHBG081975.
InParanoidiQ96BW9.
KOiK17807.
OMAiRWHTANL.
OrthoDBiEOG091G0CTU.
PhylomeDBiQ96BW9.
TreeFamiTF314503.

Family and domain databases

InterProiIPR015222. Mmp37.
[Graphical view]
PANTHERiPTHR13619. PTHR13619. 1 hit.
PfamiPF09139. Mmp37. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96BW9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALQTLQSSW VTFRKILSHF PEELSLAFVY GSGVYRQAGP SSDQKNAMLD
60 70 80 90 100
FVFTVDDPVA WHSKNLKKNW SHYSFLKVLG PKIITSIQNN YGAGVYYNSL
110 120 130 140 150
IMCNGRLIKY GVISTNVLIE DLLNWNNLYI AGRLQKPVKI ISVNEDVTLR
160 170 180 190 200
SALDRNLKSA VTAAFLMLPE SFSEEDLFIE IAGLSYSGDF RMVVGEDKTK
210 220 230 240 250
VLNIVKPNIA HFRELYGSIL QENPQVVYKS QQGWLEIDKS PEGQFTQLMT
260 270 280 290 300
LPKTLQQQIN HIMDPPGKNR DVEETLFQVA HDPDCGDVVR LGLSAIVRPS
310 320 330 340 350
SIRQSTKGIF TAGKSFGNPC VTYLLTEWLP HSWLQCKALY LLGACEMLSF
360 370 380 390 400
DGHKLGYCSK VQTGITAAEP GGRTMSDHWQ CCWKLYCPSE FSETLPVCRV
410 420 430 440 450
FPSYCFIYQS YRCIGLQKQQ HLCSPSSSPS LRQLLPSVLV GYFCCYCHFS

KW
Length:452
Mass (Da):51,067
Last modified:March 19, 2014 - v2
Checksum:iD711A42567390653
GO
Isoform 2 (identifier: Q96BW9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     294-316: SAIVRPSSIRQSTKGIFTAGKSF → KKSVIYSSLKLHKMWKGWLRKTS
     317-452: Missing.

Note: No experimental confirmation available.
Show »
Length:316
Mass (Da):35,907
Checksum:i06B837C098BB584E
GO
Isoform 3 (identifier: Q96BW9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-337: KSFGNPCVTYLLTEWLPHSWLQCK → LKKSVIYSSLKLHKMWKGWLRKTS
     338-452: Missing.

Note: Gene prediction based on EST data.
Show »
Length:337
Mass (Da):38,079
Checksum:iE5AF0F9A98E2604A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027276116N → S.Corresponds to variant rs7641243dbSNPEnsembl.1
Natural variantiVAR_053649179I → V.Corresponds to variant rs11551661dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053905294 – 316SAIVR…AGKSF → KKSVIYSSLKLHKMWKGWLR KTS in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_055724314 – 337KSFGN…WLQCK → LKKSVIYSSLKLHKMWKGWL RKTS in isoform 3. CuratedAdd BLAST24
Alternative sequenceiVSP_053906317 – 452Missing in isoform 2. 1 PublicationAdd BLAST136
Alternative sequenceiVSP_055725338 – 452Missing in isoform 3. CuratedAdd BLAST115

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295839 mRNA. Translation: BAG58649.1.
AC090939 Genomic DNA. No translation available.
AC090958 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64113.1.
BC015088 mRNA. Translation: AAH15088.1.
CCDSiCCDS2607.1. [Q96BW9-2]
CCDS68345.1. [Q96BW9-3]
RefSeqiNP_001271330.1. NM_001284401.1. [Q96BW9-3]
NP_001308223.1. NM_001321294.1.
NP_001308224.1. NM_001321295.1.
NP_620162.1. NM_138807.3. [Q96BW9-2]
XP_005264930.1. XM_005264873.3. [Q96BW9-1]
UniGeneiHs.475472.

Genome annotation databases

EnsembliENST00000273037; ENSP00000273037; ENSG00000144559. [Q96BW9-2]
ENST00000444133; ENSP00000388598; ENSG00000144559. [Q96BW9-1]
ENST00000455809; ENSP00000398596; ENSG00000144559. [Q96BW9-3]
GeneIDi132001.
KEGGihsa:132001.
UCSCiuc003bwh.4. human. [Q96BW9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295839 mRNA. Translation: BAG58649.1.
AC090939 Genomic DNA. No translation available.
AC090958 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW64113.1.
BC015088 mRNA. Translation: AAH15088.1.
CCDSiCCDS2607.1. [Q96BW9-2]
CCDS68345.1. [Q96BW9-3]
RefSeqiNP_001271330.1. NM_001284401.1. [Q96BW9-3]
NP_001308223.1. NM_001321294.1.
NP_001308224.1. NM_001321295.1.
NP_620162.1. NM_138807.3. [Q96BW9-2]
XP_005264930.1. XM_005264873.3. [Q96BW9-1]
UniGeneiHs.475472.

3D structure databases

ProteinModelPortaliQ96BW9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126303. 20 interactors.
STRINGi9606.ENSP00000273037.

PTM databases

iPTMnetiQ96BW9.
PhosphoSitePlusiQ96BW9.

Polymorphism and mutation databases

BioMutaiTAMM41.
DMDMi74731287.

Proteomic databases

EPDiQ96BW9.
MaxQBiQ96BW9.
PaxDbiQ96BW9.
PeptideAtlasiQ96BW9.
PRIDEiQ96BW9.

Protocols and materials databases

DNASUi132001.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273037; ENSP00000273037; ENSG00000144559. [Q96BW9-2]
ENST00000444133; ENSP00000388598; ENSG00000144559. [Q96BW9-1]
ENST00000455809; ENSP00000398596; ENSG00000144559. [Q96BW9-3]
GeneIDi132001.
KEGGihsa:132001.
UCSCiuc003bwh.4. human. [Q96BW9-1]

Organism-specific databases

CTDi132001.
DisGeNETi132001.
GeneCardsiTAMM41.
HGNCiHGNC:25187. TAMM41.
HPAiHPA036834.
HPA044861.
MIMi614948. gene.
neXtProtiNX_Q96BW9.
OpenTargetsiENSG00000144559.
PharmGKBiPA142672392.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2986. Eukaryota.
ENOG410ZNKE. LUCA.
GeneTreeiENSGT00390000000616.
HOGENOMiHOG000205225.
HOVERGENiHBG081975.
InParanoidiQ96BW9.
KOiK17807.
OMAiRWHTANL.
OrthoDBiEOG091G0CTU.
PhylomeDBiQ96BW9.
TreeFamiTF314503.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
BioCyciZFISH:ENSG00000144559-MONOMER.

Miscellaneous databases

ChiTaRSiTAMM41. human.
GenomeRNAii132001.
PROiQ96BW9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144559.
CleanExiHS_C3orf31.
ExpressionAtlasiQ96BW9. baseline and differential.
GenevisibleiQ96BW9. HS.

Family and domain databases

InterProiIPR015222. Mmp37.
[Graphical view]
PANTHERiPTHR13619. PTHR13619. 1 hit.
PfamiPF09139. Mmp37. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTAM41_HUMAN
AccessioniPrimary (citable) accession number: Q96BW9
Secondary accession number(s): B4DIY7, C9J2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 19, 2014
Last modified: November 2, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.