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Protein

Phosphotriesterase-related protein

Gene

PTER

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi28Divalent metal cation 1; via tele nitrogenBy similarity1
Metal bindingi169Divalent metal cation 1By similarity1
Metal bindingi169Divalent metal cation 2By similarity1
Metal bindingi201Divalent metal cation 2; via pros nitrogenBy similarity1
Metal bindingi230Divalent metal cation 2; via tele nitrogenBy similarity1
Metal bindingi298Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

  • catabolic process Source: InterPro
  • epithelial cell differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS09313-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphotriesterase-related protein (EC:3.1.-.-)
Alternative name(s):
Parathion hydrolase-related protein
Short name:
hPHRP
Gene namesi
Name:PTER
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:9590. PTER.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi9317.
OpenTargetsiENSG00000165983.
PharmGKBiPA33944.

Polymorphism and mutation databases

BioMutaiPTER.
DMDMi32171701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002053641 – 349Phosphotriesterase-related proteinAdd BLAST349

Proteomic databases

EPDiQ96BW5.
MaxQBiQ96BW5.
PaxDbiQ96BW5.
PeptideAtlasiQ96BW5.
PRIDEiQ96BW5.

PTM databases

iPTMnetiQ96BW5.
PhosphoSitePlusiQ96BW5.

Expressioni

Gene expression databases

BgeeiENSG00000165983.
CleanExiHS_PTER.
ExpressionAtlasiQ96BW5. baseline and differential.
GenevisibleiQ96BW5. HS.

Organism-specific databases

HPAiHPA038044.
HPA038045.

Interactioni

Protein-protein interaction databases

BioGridi114728. 12 interactors.
STRINGi9606.ENSP00000298942.

Structurei

3D structure databases

ProteinModelPortaliQ96BW5.
SMRiQ96BW5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the phosphotriesterase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ96BW5.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG091G0D6G.
PhylomeDBiQ96BW5.
TreeFamiTF323205.

Family and domain databases

CDDicd00530. PTE. 1 hit.
InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PANTHERiPTHR10819. PTHR10819. 1 hit.
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96BW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLSGKVQT VLGLVEPSKL GRTLTHEHLA MTFDCCYCPP PPCQEAISKE
60 70 80 90 100
PIVMKNLYWI QKNAYSHKEN LQLNQETEAI KEELLYFKAN GGGALVENTT
110 120 130 140 150
TGISRDTQTL KRLAEETGVH IISGAGFYVD ATHSSETRAM SVEQLTDVLM
160 170 180 190 200
NEILHGADGT SIKCGIIGEI GCSWPLTESE RKVLQATAHA QAQLGCPVII
210 220 230 240 250
HPGRSSRAPF QIIRILQEAG ADISKTVMSH LDRTILDKKE LLEFAQLGCY
260 270 280 290 300
LEYDLFGTEL LHYQLGPDID MPDDNKRIRR VRLLVEEGCE DRILVAHDIH
310 320 330 340
TKTRLMKYGG HGYSHILTNV VPKMLLRGIT ENVLDKILIE NPKQWLTFK
Length:349
Mass (Da):39,018
Last modified:December 1, 2001 - v1
Checksum:i76DCEA1E5C9FED46
GO
Isoform 2 (identifier: Q96BW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     234-280: Missing.

Note: No experimental confirmation available.
Show »
Length:302
Mass (Da):33,436
Checksum:i802FA46C4E3625FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti234T → A in AAK14923 (Ref. 1) Curated1
Sequence conflicti259E → D in AAK14923 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05161097E → G.Corresponds to variant rs36023740dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038342234 – 280Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212237 mRNA. Translation: AAK14923.1.
AK095486 mRNA. Translation: BAG53067.1.
AK314910 mRNA. Translation: BAG37422.1.
EF445015 Genomic DNA. Translation: ACA06055.1.
EF445015 Genomic DNA. Translation: ACA06056.1.
EF445015 Genomic DNA. Translation: ACA06057.1.
AL360230 Genomic DNA. Translation: CAH73146.1.
CH471072 Genomic DNA. Translation: EAW86226.1.
CH471072 Genomic DNA. Translation: EAW86229.1.
CH471072 Genomic DNA. Translation: EAW86227.1.
CH471072 Genomic DNA. Translation: EAW86228.1.
CH471072 Genomic DNA. Translation: EAW86230.1.
BC015092 mRNA. Translation: AAH15092.1.
BC050411 mRNA. Translation: AAH50411.1.
CCDSiCCDS58070.1. [Q96BW5-2]
CCDS7111.1. [Q96BW5-1]
RefSeqiNP_001001484.1. NM_001001484.2. [Q96BW5-1]
NP_001248765.1. NM_001261836.1. [Q96BW5-1]
NP_001248766.1. NM_001261837.1. [Q96BW5-2]
NP_001248767.1. NM_001261838.1.
NP_109589.2. NM_030664.4. [Q96BW5-1]
XP_016872418.1. XM_017016929.1. [Q96BW5-2]
XP_016872419.1. XM_017016930.1. [Q96BW5-2]
UniGeneiHs.444321.
Hs.741924.
Hs.745101.

Genome annotation databases

EnsembliENST00000298942; ENSP00000298942; ENSG00000165983. [Q96BW5-2]
ENST00000378000; ENSP00000367239; ENSG00000165983. [Q96BW5-1]
ENST00000535784; ENSP00000439485; ENSG00000165983. [Q96BW5-1]
GeneIDi9317.
KEGGihsa:9317.
UCSCiuc001ioh.3. human. [Q96BW5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF212237 mRNA. Translation: AAK14923.1.
AK095486 mRNA. Translation: BAG53067.1.
AK314910 mRNA. Translation: BAG37422.1.
EF445015 Genomic DNA. Translation: ACA06055.1.
EF445015 Genomic DNA. Translation: ACA06056.1.
EF445015 Genomic DNA. Translation: ACA06057.1.
AL360230 Genomic DNA. Translation: CAH73146.1.
CH471072 Genomic DNA. Translation: EAW86226.1.
CH471072 Genomic DNA. Translation: EAW86229.1.
CH471072 Genomic DNA. Translation: EAW86227.1.
CH471072 Genomic DNA. Translation: EAW86228.1.
CH471072 Genomic DNA. Translation: EAW86230.1.
BC015092 mRNA. Translation: AAH15092.1.
BC050411 mRNA. Translation: AAH50411.1.
CCDSiCCDS58070.1. [Q96BW5-2]
CCDS7111.1. [Q96BW5-1]
RefSeqiNP_001001484.1. NM_001001484.2. [Q96BW5-1]
NP_001248765.1. NM_001261836.1. [Q96BW5-1]
NP_001248766.1. NM_001261837.1. [Q96BW5-2]
NP_001248767.1. NM_001261838.1.
NP_109589.2. NM_030664.4. [Q96BW5-1]
XP_016872418.1. XM_017016929.1. [Q96BW5-2]
XP_016872419.1. XM_017016930.1. [Q96BW5-2]
UniGeneiHs.444321.
Hs.741924.
Hs.745101.

3D structure databases

ProteinModelPortaliQ96BW5.
SMRiQ96BW5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114728. 12 interactors.
STRINGi9606.ENSP00000298942.

PTM databases

iPTMnetiQ96BW5.
PhosphoSitePlusiQ96BW5.

Polymorphism and mutation databases

BioMutaiPTER.
DMDMi32171701.

Proteomic databases

EPDiQ96BW5.
MaxQBiQ96BW5.
PaxDbiQ96BW5.
PeptideAtlasiQ96BW5.
PRIDEiQ96BW5.

Protocols and materials databases

DNASUi9317.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298942; ENSP00000298942; ENSG00000165983. [Q96BW5-2]
ENST00000378000; ENSP00000367239; ENSG00000165983. [Q96BW5-1]
ENST00000535784; ENSP00000439485; ENSG00000165983. [Q96BW5-1]
GeneIDi9317.
KEGGihsa:9317.
UCSCiuc001ioh.3. human. [Q96BW5-1]

Organism-specific databases

CTDi9317.
DisGeNETi9317.
GeneCardsiPTER.
HGNCiHGNC:9590. PTER.
HPAiHPA038044.
HPA038045.
MIMi604446. gene.
neXtProtiNX_Q96BW5.
OpenTargetsiENSG00000165983.
PharmGKBiPA33944.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGM3. Eukaryota.
COG1735. LUCA.
GeneTreeiENSGT00390000006960.
HOGENOMiHOG000081700.
HOVERGENiHBG002463.
InParanoidiQ96BW5.
KOiK07048.
OMAiETGVHII.
OrthoDBiEOG091G0D6G.
PhylomeDBiQ96BW5.
TreeFamiTF323205.

Enzyme and pathway databases

BioCyciZFISH:HS09313-MONOMER.

Miscellaneous databases

ChiTaRSiPTER. human.
GenomeRNAii9317.
PROiQ96BW5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165983.
CleanExiHS_PTER.
ExpressionAtlasiQ96BW5. baseline and differential.
GenevisibleiQ96BW5. HS.

Family and domain databases

CDDicd00530. PTE. 1 hit.
InterProiIPR017947. AryldialkylPase_Zn-BS.
IPR032466. Metal_Hydrolase.
IPR001559. Phosphotriesterase.
[Graphical view]
PANTHERiPTHR10819. PTHR10819. 1 hit.
PfamiPF02126. PTE. 1 hit.
[Graphical view]
SUPFAMiSSF51556. SSF51556. 2 hits.
PROSITEiPS01322. PHOSPHOTRIESTERASE_1. 1 hit.
PS51347. PHOSPHOTRIESTERASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTER_HUMAN
AccessioniPrimary (citable) accession number: Q96BW5
Secondary accession number(s): B0YJ77
, B3KTF5, D3DRU0, Q9BY46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.