Q96BW5 (PTER_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphotriesterase-related protein
EC=3.1.-.-

Alternative name(s):
Parathion hydrolase-related protein
Short name=hPHRP

Gene names

Name:

PTER

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Cofactor	Binds 2 divalent metal cations per subunit By similarity.
Sequence similarities	Belongs to the phosphotriesterase family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	hydrolase activity, acting on ester bonds Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96BW5-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96BW5-2)

The sequence of this isoform differs from the canonical sequence as follows:
     234-280: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Phosphotriesterase-related protein		PRO_0000205364
Sites
	Metal binding	26	1	Divalent metal cation 1 By similarity
	Metal binding	28	1	Divalent metal cation 1 By similarity
	Metal binding	169	1	Divalent metal cation 1 By similarity
	Metal binding	169	1	Divalent metal cation 2 By similarity
	Metal binding	201	1	Divalent metal cation 2 By similarity
	Metal binding	230	1	Divalent metal cation 2 By similarity
	Metal binding	298	1	Divalent metal cation 1 By similarity
Natural variations
	Alternative sequence	234 – 280	47	Missing in isoform 2.		VSP_038342
	Natural variant	97	1	E → G. Corresponds to variant rs36023740 [ dbSNP | Ensembl ].		VAR_051610
Experimental info
	Sequence conflict	234	1	T → A in AAK14923. Ref.1
	Sequence conflict	259	1	E → D in AAK14923. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 76DCEA1E5C9FED46	FASTA	349	39,018
	10 20 30 40 50 60 MSSLSGKVQT VLGLVEPSKL GRTLTHEHLA MTFDCCYCPP PPCQEAISKE PIVMKNLYWI 70 80 90 100 110 120 QKNAYSHKEN LQLNQETEAI KEELLYFKAN GGGALVENTT TGISRDTQTL KRLAEETGVH 130 140 150 160 170 180 IISGAGFYVD ATHSSETRAM SVEQLTDVLM NEILHGADGT SIKCGIIGEI GCSWPLTESE 190 200 210 220 230 240 RKVLQATAHA QAQLGCPVII HPGRSSRAPF QIIRILQEAG ADISKTVMSH LDRTILDKKE 250 260 270 280 290 300 LLEFAQLGCY LEYDLFGTEL LHYQLGPDID MPDDNKRIRR VRLLVEEGCE DRILVAHDIH 310 320 330 340 TKTRLMKYGG HGYSHILTNV VPKMLLRGIT ENVLDKILIE NPKQWLTFK
	Isoform 2 [UniParc]. Checksum: 802FA46C4E3625FF	FASTA	302	33,436
	10 20 30 40 50 60 MSSLSGKVQT VLGLVEPSKL GRTLTHEHLA MTFDCCYCPP PPCQEAISKE PIVMKNLYWI 70 80 90 100 110 120 QKNAYSHKEN LQLNQETEAI KEELLYFKAN GGGALVENTT TGISRDTQTL KRLAEETGVH 130 140 150 160 170 180 IISGAGFYVD ATHSSETRAM SVEQLTDVLM NEILHGADGT SIKCGIIGEI GCSWPLTESE 190 200 210 220 230 240 RKVLQATAHA QAQLGCPVII HPGRSSRAPF QIIRILQEAG ADISKTVMSH LDRVRLLVEE 250 260 270 280 290 300 GCEDRILVAH DIHTKTRLMK YGGHGYSHIL TNVVPKMLLR GITENVLDKI LIENPKQWLT FK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel gene expressed in human liver non-tumor tissues." Li Y., Wu T., Xu S., Ren S., Chen Z., Han Z. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Liver.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Amygdala.
[3]	NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Uterus.
[7]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF212237 mRNA. Translation: AAK14923.1. AK095486 mRNA. Translation: BAG53067.1. AK314910 mRNA. Translation: BAG37422.1. EF445015 Genomic DNA. Translation: ACA06055.1. EF445015 Genomic DNA. Translation: ACA06056.1. EF445015 Genomic DNA. Translation: ACA06057.1. AL360230 Genomic DNA. Translation: CAH73146.1. CH471072 Genomic DNA. Translation: EAW86226.1. CH471072 Genomic DNA. Translation: EAW86229.1. CH471072 Genomic DNA. Translation: EAW86227.1. CH471072 Genomic DNA. Translation: EAW86228.1. CH471072 Genomic DNA. Translation: EAW86230.1. BC015092 mRNA. Translation: AAH15092.1. BC050411 mRNA. Translation: AAH50411.1.
IPI	IPI00100933. IPI00903152.
RefSeq	NP_001001484.1. NM_001001484.2. NP_001248765.1. NM_001261836.1. NP_001248766.1. NM_001261837.1. NP_001248767.1. NM_001261838.1. NP_109589.2. NM_030664.4.
UniGene	Hs.444321. Hs.741515. Hs.741924.
3D structure databases
ProteinModelPortal	Q96BW5.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000298942.
PTM databases
PhosphoSite	Q96BW5.
Polymorphism databases
DMDM	32171701.
Proteomic databases
PaxDb	Q96BW5.
PeptideAtlas	Q96BW5.
PRIDE	Q96BW5.
Protocols and materials databases
DNASU	9317.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000298942; ENSP00000298942; ENSG00000165983. ENST00000343656; ENSP00000342390; ENSG00000165983. ENST00000378000; ENSP00000367239; ENSG00000165983. ENST00000423462; ENSP00000389535; ENSG00000165983. ENST00000535784; ENSP00000439485; ENSG00000165983.
GeneID	9317.
KEGG	hsa:9317.
UCSC	uc001iog.1. human. uc009xjp.1. human.
Organism-specific databases
CTD	9317.
GeneCards	GC10P016518.
HGNC	HGNC:9590. PTER.
HPA	HPA038045.
MIM	604446. gene.
neXtProt	NX_Q96BW5.
PharmGKB	PA33944.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1735.
HOGENOM	HOG000081700.
HOVERGEN	HBG002463.
InParanoid	Q96BW5.
KO	K07048.
OMA	ETGVHII.
OrthoDB	EOG479F7B.
PhylomeDB	Q96BW5.
Gene expression databases
Bgee	Q96BW5.
CleanEx	HS_PTER.
Genevestigator	Q96BW5.
GermOnline	ENSG00000165983. Homo sapiens.
Family and domain databases
InterPro	IPR017947. AryldialkylPase_Zn-BS. IPR001559. Aryldialkylphosphatase. [Graphical view]
PANTHER	PTHR10819. PTHR10819. 1 hit.
Pfam	PF02126. PTE. 1 hit. [Graphical view]
PROSITE	PS01322. PHOSPHOTRIESTERASE_1. 1 hit. PS51347. PHOSPHOTRIESTERASE_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PTER. human.
GenomeRNAi	9317.
NextBio	34899.
SOURCE	Search...

Entry information

Entry name

PTER_HUMAN

Accession

Primary (citable) accession number: Q96BW5
Secondary accession number(s): B0YJ77 , B3KTF5, D3DRU0, Q9BY46

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.