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Protein

Zinc finger protein 775

Gene

ZNF775

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 129C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri135 – 157C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 775
Gene namesi
Name:ZNF775
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:28501. ZNF775.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196456.
PharmGKBiPA162410371.

Polymorphism and mutation databases

BioMutaiZNF775.
DMDMi74760747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002804411 – 537Zinc finger protein 775Add BLAST537

Proteomic databases

EPDiQ96BV0.
PaxDbiQ96BV0.
PeptideAtlasiQ96BV0.
PRIDEiQ96BV0.

PTM databases

iPTMnetiQ96BV0.
PhosphoSitePlusiQ96BV0.

Expressioni

Gene expression databases

BgeeiENSG00000196456.
CleanExiHS_ZNF775.
ExpressionAtlasiQ96BV0. baseline and differential.
GenevisibleiQ96BV0. HS.

Interactioni

Protein-protein interaction databases

BioGridi130261. 7 interactors.
IntActiQ96BV0. 16 interactors.
MINTiMINT-8247455.
STRINGi9606.ENSP00000330838.

Structurei

3D structure databases

ProteinModelPortaliQ96BV0.
SMRiQ96BV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 129C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri135 – 157C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri163 – 185C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri191 – 213C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri281 – 303C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri309 – 331C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri337 – 359C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri366 – 388C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri502 – 524C2H2-type 11PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129964.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ96BV0.
OMAiEWAWLGL.
OrthoDBiEOG091G02KC.
PhylomeDBiQ96BV0.
TreeFamiTF350922.

Family and domain databases

InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 11 hits.
SUPFAMiSSF57667. SSF57667. 7 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 11 hits.

Sequencei

Sequence statusi: Complete.

Q96BV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESGLAGNGT GAGLVMKVKQ EKPERLLQTL APQAMLVEKD KENIFQQHRG
60 70 80 90 100
LPPRQTMGRP RALGGQEESG SPRWAPPTEQ DAGLAGRAPG SASGPLSPSL
110 120 130 140 150
SSGEGHFVCL DCGKRFSWWS SLKIHQRTHT GEKPYLCGKC GKSFSQKPNL
160 170 180 190 200
ARHQRHHTGE RPFCCPECAR RFSQKQHLLK HQKTHSRPAT HSCPECERCF
210 220 230 240 250
RHQVGLRIHQ RAHARDRQGS RAGLHELIQD AAARRACRLQ PGPPRGRPEW
260 270 280 290 300
AWLGLCQGWW GQPGARAAVS GPEGPGEPRQ FICNECGKSF TWWSSLNIHQ
310 320 330 340 350
RIHTGERPYA CPECGRRFSQ KPNLTRHLRN HTGERPHPCP HCGRGFRQKQ
360 370 380 390 400
HLLKHLRTHL PGAQAAPCPS CGKSCRSRAA LRAHQRAHAV AEPAVPAGEP
410 420 430 440 450
GDQPQAEAIP GLAARPRSSQ RSPGARDTLW GRGQAGLAGP GEPRQFICNE
460 470 480 490 500
CGKSFSWWSA LTIHQRIHTG ERPYPCPECG RRFSQKPNLT RHRRNHTGER
510 520 530
PYLCPACGRG FSQKQHLLKH QRVHRAAPAC SPKEEAR
Length:537
Mass (Da):59,752
Last modified:March 1, 2004 - v2
Checksum:iBC34D5E1E3ED0BB5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059937428T → A. Corresponds to variant dbSNP:rs13225910Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015152 mRNA. Translation: AAH15152.2.
CCDSiCCDS43678.1.
RefSeqiNP_775951.2. NM_173680.3.
UniGeneiHs.655734.

Genome annotation databases

EnsembliENST00000329630; ENSP00000330838; ENSG00000196456.
GeneIDi285971.
KEGGihsa:285971.
UCSCiuc003whf.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZN775_HUMAN
AccessioniPrimary (citable) accession number: Q96BV0
Secondary accession number(s): Q8IY24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: March 1, 2004
Last modified: June 7, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families