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Protein

S100P-binding protein

Gene

S100PBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
S100P-binding protein
Alternative name(s):
S100P-binding protein Riken
Gene namesi
Name:S100PBPImported
Synonyms:S100PBPR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25768. S100PBP.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: HGNC
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64766.
OpenTargetsiENSG00000116497.
PharmGKBiPA142670958.

Polymorphism and mutation databases

BioMutaiS100PBP.
DMDMi74731274.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170511 – 408S100P-binding proteinAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BU1.
MaxQBiQ96BU1.
PaxDbiQ96BU1.
PeptideAtlasiQ96BU1.
PRIDEiQ96BU1.

PTM databases

iPTMnetiQ96BU1.
PhosphoSitePlusiQ96BU1.

Expressioni

Tissue specificityi

Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000116497.
CleanExiHS_S100PBP.
ExpressionAtlasiQ96BU1. baseline and differential.
GenevisibleiQ96BU1. HS.

Organism-specific databases

HPAiHPA024170.
HPA024220.
HPA027242.
HPA027328.

Interactioni

Subunit structurei

Interacts with S100P.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC

Protein-protein interaction databases

BioGridi122278. 2 interactors.
STRINGi9606.ENSP00000362574.

Structurei

3D structure databases

ProteinModelPortaliQ96BU1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFXP. Eukaryota.
ENOG410XUP0. LUCA.
GeneTreeiENSGT00390000007209.
HOGENOMiHOG000231089.
HOVERGENiHBG100003.
InParanoidiQ96BU1.
OMAiSLTQWVD.
OrthoDBiEOG091G04XE.
PhylomeDBiQ96BU1.
TreeFamiTF337946.

Family and domain databases

InterProiIPR026097. S100PBP.
[Graphical view]
PANTHERiPTHR14455:SF0. PTHR14455:SF0. 1 hit.
PfamiPF15427. S100PBPR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q96BU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCSRVPSEQ SSGTSLLPKD GAPFSWDSLD EDGLDDSLLE LSEGEEDDGD
60 70 80 90 100
VNYTEEEIDA LLKEDDPSYE QSSGEDDGGH VEKGERGSQI LLDTPREKNS
110 120 130 140 150
SYSLGPVAET PDLFKLPQLS TSSGHGPAHT KPLNRRSVLE KNLIKVTVAP
160 170 180 190 200
FNPTVCDALL DKDETDSSKD TEKLSSLGEE MREDGLSPNE SKLCTESEGI
210 220 230 240 250
SPNNSAWNGP QLSSSNNNFQ QTVSDKNMPD SENPTSVFSR ISDHSETPNM
260 270 280 290 300
ELSCRNGGSH KSSCEMRSLV VSTSSNKQDV LNKDSGKMKG HERRLGKVIP
310 320 330 340 350
VLQTKTRTNV PTFSQSNLEQ QKQLYLRSVI AHIEDPEDTN QGISGELCAL
360 370 380 390 400
MDQVHHMQHS KWQHPSDLTT RNYARRQKHL QRYSLTQWVD RNMRSHHRFQ

RLPDFSYS
Length:408
Mass (Da):45,582
Last modified:December 1, 2001 - v1
Checksum:iC366D258BEF3AAF5
GO
Isoform 21 Publication (identifier: Q96BU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-408: Missing.

Show »
Length:342
Mass (Da):37,452
Checksum:i3592CA7F16ADFC79
GO

Sequence cautioni

The sequence BAB14335 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti329V → L in BAB14335 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052661343 – 408Missing in isoform 2. 2 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022965 mRNA. Translation: BAB14335.1. Different initiation.
AK090711 mRNA. Translation: BAG52216.1.
BX647667 mRNA. Translation: CAI46038.1.
CH471059 Genomic DNA. Translation: EAX07503.1.
CH471059 Genomic DNA. Translation: EAX07504.1.
CH471059 Genomic DNA. Translation: EAX07505.1.
BC015175 mRNA. Translation: AAH15175.1.
CCDSiCCDS30666.1. [Q96BU1-1]
RefSeqiNP_001243050.1. NM_001256121.1. [Q96BU1-1]
NP_073590.2. NM_022753.3. [Q96BU1-1]
XP_011540263.1. XM_011541961.2. [Q96BU1-1]
XP_011540264.1. XM_011541962.2. [Q96BU1-1]
UniGeneiHs.440880.
Hs.734633.

Genome annotation databases

EnsembliENST00000373475; ENSP00000362574; ENSG00000116497. [Q96BU1-1]
ENST00000373476; ENSP00000362575; ENSG00000116497. [Q96BU1-1]
GeneIDi64766.
KEGGihsa:64766.
UCSCiuc001bvz.5. human. [Q96BU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022965 mRNA. Translation: BAB14335.1. Different initiation.
AK090711 mRNA. Translation: BAG52216.1.
BX647667 mRNA. Translation: CAI46038.1.
CH471059 Genomic DNA. Translation: EAX07503.1.
CH471059 Genomic DNA. Translation: EAX07504.1.
CH471059 Genomic DNA. Translation: EAX07505.1.
BC015175 mRNA. Translation: AAH15175.1.
CCDSiCCDS30666.1. [Q96BU1-1]
RefSeqiNP_001243050.1. NM_001256121.1. [Q96BU1-1]
NP_073590.2. NM_022753.3. [Q96BU1-1]
XP_011540263.1. XM_011541961.2. [Q96BU1-1]
XP_011540264.1. XM_011541962.2. [Q96BU1-1]
UniGeneiHs.440880.
Hs.734633.

3D structure databases

ProteinModelPortaliQ96BU1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122278. 2 interactors.
STRINGi9606.ENSP00000362574.

PTM databases

iPTMnetiQ96BU1.
PhosphoSitePlusiQ96BU1.

Polymorphism and mutation databases

BioMutaiS100PBP.
DMDMi74731274.

Proteomic databases

EPDiQ96BU1.
MaxQBiQ96BU1.
PaxDbiQ96BU1.
PeptideAtlasiQ96BU1.
PRIDEiQ96BU1.

Protocols and materials databases

DNASUi64766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373475; ENSP00000362574; ENSG00000116497. [Q96BU1-1]
ENST00000373476; ENSP00000362575; ENSG00000116497. [Q96BU1-1]
GeneIDi64766.
KEGGihsa:64766.
UCSCiuc001bvz.5. human. [Q96BU1-1]

Organism-specific databases

CTDi64766.
DisGeNETi64766.
GeneCardsiS100PBP.
HGNCiHGNC:25768. S100PBP.
HPAiHPA024170.
HPA024220.
HPA027242.
HPA027328.
MIMi611889. gene.
neXtProtiNX_Q96BU1.
OpenTargetsiENSG00000116497.
PharmGKBiPA142670958.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFXP. Eukaryota.
ENOG410XUP0. LUCA.
GeneTreeiENSGT00390000007209.
HOGENOMiHOG000231089.
HOVERGENiHBG100003.
InParanoidiQ96BU1.
OMAiSLTQWVD.
OrthoDBiEOG091G04XE.
PhylomeDBiQ96BU1.
TreeFamiTF337946.

Miscellaneous databases

GenomeRNAii64766.
PROiQ96BU1.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116497.
CleanExiHS_S100PBP.
ExpressionAtlasiQ96BU1. baseline and differential.
GenevisibleiQ96BU1. HS.

Family and domain databases

InterProiIPR026097. S100PBP.
[Graphical view]
PANTHERiPTHR14455:SF0. PTHR14455:SF0. 1 hit.
PfamiPF15427. S100PBPR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS1PBP_HUMAN
AccessioniPrimary (citable) accession number: Q96BU1
Secondary accession number(s): B3KR04
, D3DPQ5, Q5HYH3, Q9H997
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.