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Protein

S100P-binding protein

Gene

S100PBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC

Names & Taxonomyi

Protein namesi
Recommended name:
S100P-binding protein
Alternative name(s):
S100P-binding protein Riken
Gene namesi
Name:S100PBPImported
Synonyms:S100PBPR1 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116497.17
HGNCiHGNC:25768 S100PBP
MIMi611889 gene
neXtProtiNX_Q96BU1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi64766
OpenTargetsiENSG00000116497
PharmGKBiPA142670958

Polymorphism and mutation databases

BioMutaiS100PBP
DMDMi74731274

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003170511 – 408S100P-binding proteinAdd BLAST408

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei187PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BU1
MaxQBiQ96BU1
PaxDbiQ96BU1
PeptideAtlasiQ96BU1
PRIDEiQ96BU1
ProteomicsDBi76116
76117 [Q96BU1-2]

PTM databases

CarbonylDBiQ96BU1
iPTMnetiQ96BU1
PhosphoSitePlusiQ96BU1

Expressioni

Tissue specificityi

Expressed in brain, spleen, and lung. Not detected in pancreas or liver. In pancreas, expressed predominantly in islet cells and to a lesser extent in acinar cells, but not expressed in ductal cells. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Detected in pancreatic ductal adenocarcinoma cells (at protein level). Not detected in non-neoplastic ductal epithelium (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000116497
CleanExiHS_S100PBP
ExpressionAtlasiQ96BU1 baseline and differential
GenevisibleiQ96BU1 HS

Organism-specific databases

HPAiHPA027242
HPA027328

Interactioni

Subunit structurei

Interacts with S100P.1 Publication

GO - Molecular functioni

  • calcium-dependent protein binding Source: HGNC

Protein-protein interaction databases

BioGridi122278, 2 interactors
STRINGi9606.ENSP00000362574

Structurei

3D structure databases

ProteinModelPortaliQ96BU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IFXP Eukaryota
ENOG410XUP0 LUCA
GeneTreeiENSGT00390000007209
HOGENOMiHOG000231089
HOVERGENiHBG100003
InParanoidiQ96BU1
OMAiRYSLTQW
OrthoDBiEOG091G04XE
PhylomeDBiQ96BU1
TreeFamiTF337946

Family and domain databases

InterProiView protein in InterPro
IPR026097 S100PBP
PANTHERiPTHR14455 PTHR14455, 1 hit
PfamiView protein in Pfam
PF15427 S100PBPR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q96BU1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMCSRVPSEQ SSGTSLLPKD GAPFSWDSLD EDGLDDSLLE LSEGEEDDGD
60 70 80 90 100
VNYTEEEIDA LLKEDDPSYE QSSGEDDGGH VEKGERGSQI LLDTPREKNS
110 120 130 140 150
SYSLGPVAET PDLFKLPQLS TSSGHGPAHT KPLNRRSVLE KNLIKVTVAP
160 170 180 190 200
FNPTVCDALL DKDETDSSKD TEKLSSLGEE MREDGLSPNE SKLCTESEGI
210 220 230 240 250
SPNNSAWNGP QLSSSNNNFQ QTVSDKNMPD SENPTSVFSR ISDHSETPNM
260 270 280 290 300
ELSCRNGGSH KSSCEMRSLV VSTSSNKQDV LNKDSGKMKG HERRLGKVIP
310 320 330 340 350
VLQTKTRTNV PTFSQSNLEQ QKQLYLRSVI AHIEDPEDTN QGISGELCAL
360 370 380 390 400
MDQVHHMQHS KWQHPSDLTT RNYARRQKHL QRYSLTQWVD RNMRSHHRFQ

RLPDFSYS
Length:408
Mass (Da):45,582
Last modified:December 1, 2001 - v1
Checksum:iC366D258BEF3AAF5
GO
Isoform 21 Publication (identifier: Q96BU1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-408: Missing.

Show »
Length:342
Mass (Da):37,452
Checksum:i3592CA7F16ADFC79
GO

Sequence cautioni

The sequence BAB14335 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti329V → L in BAB14335 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052661343 – 408Missing in isoform 2. 2 PublicationsAdd BLAST66

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022965 mRNA Translation: BAB14335.1 Different initiation.
AK090711 mRNA Translation: BAG52216.1
BX647667 mRNA Translation: CAI46038.1
CH471059 Genomic DNA Translation: EAX07503.1
CH471059 Genomic DNA Translation: EAX07504.1
CH471059 Genomic DNA Translation: EAX07505.1
BC015175 mRNA Translation: AAH15175.1
CCDSiCCDS30666.1 [Q96BU1-1]
RefSeqiNP_001243050.1, NM_001256121.1 [Q96BU1-1]
NP_073590.2, NM_022753.3 [Q96BU1-1]
XP_011540263.1, XM_011541961.2 [Q96BU1-1]
XP_011540264.1, XM_011541962.2 [Q96BU1-1]
UniGeneiHs.440880
Hs.734633

Genome annotation databases

EnsembliENST00000373475; ENSP00000362574; ENSG00000116497 [Q96BU1-1]
ENST00000373476; ENSP00000362575; ENSG00000116497 [Q96BU1-1]
GeneIDi64766
KEGGihsa:64766
UCSCiuc001bvz.5 human [Q96BU1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS1PBP_HUMAN
AccessioniPrimary (citable) accession number: Q96BU1
Secondary accession number(s): B3KR04
, D3DPQ5, Q5HYH3, Q9H997
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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