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Q96BR5

- COA7_HUMAN

UniProt

Q96BR5 - COA7_HUMAN

Protein

Cytochrome c oxidase assembly factor 7

Gene

COA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Required for assembly of mitochondrial respiratory chain complex I and complex IV.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase assembly factor 7
    Alternative name(s):
    Beta-lactamase hcp-like protein
    Respiratory chain assembly factor 1
    Sel1 repeat-containing protein 1
    Gene namesi
    Name:COA7
    Synonyms:C1orf163, RESA1, SELRC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25716. COA7.

    Subcellular locationi

    Mitochondrion intermembrane space 1 Publication

    GO - Cellular componenti

    1. mitochondrial intermembrane space Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142672414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 231230Cytochrome c oxidase assembly factor 7PRO_0000282364Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ96BR5.
    PaxDbiQ96BR5.
    PeptideAtlasiQ96BR5.
    PRIDEiQ96BR5.

    PTM databases

    PhosphoSiteiQ96BR5.

    Expressioni

    Gene expression databases

    BgeeiQ96BR5.
    CleanExiHS_C1orf163.
    GenevestigatoriQ96BR5.

    Organism-specific databases

    HPAiHPA028154.
    HPA029926.

    Interactioni

    Protein-protein interaction databases

    BioGridi122417. 15 interactions.
    IntActiQ96BR5. 2 interactions.
    STRINGi9606.ENSP00000360593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BR5.
    SMRiQ96BR5. Positions 32-217.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati34 – 6633Sel1-like 1Add
    BLAST
    Repeati68 – 10437Sel1-like 2Add
    BLAST
    Repeati108 – 14639Sel1-like 3Add
    BLAST
    Repeati147 – 18337Sel1-like 4Add
    BLAST
    Repeati184 – 21936Sel1-like 5Add
    BLAST

    Sequence similaritiesi

    Belongs to the hcp beta-lactamase family.Curated
    Contains 5 Sel1-like repeats.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0790.
    HOVERGENiHBG107158.
    InParanoidiQ96BR5.
    KOiK18180.
    OMAiKHSDSCY.
    OrthoDBiEOG7VTDP0.
    PhylomeDBiQ96BR5.
    TreeFamiTF105805.

    Family and domain databases

    Gene3Di1.25.40.10. 1 hit.
    InterProiIPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PfamiPF08238. Sel1. 4 hits.
    [Graphical view]
    SMARTiSM00671. SEL1. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q96BR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAGMVDFQDE EQVKSFLENM EVECNYHCYH EKDPDGCYRL VDYLEGIRKN    50
    FDEAAKVLKF NCEENQHSDS CYKLGAYYVT GKGGLTQDLK AAARCFLMAC 100
    EKPGKKSIAA CHNVGLLAHD GQVNEDGQPD LGKARDYYTR ACDGGYTSSC 150
    FNLSAMFLQG APGFPKDMDL ACKYSMKACD LGHIWACANA SRMYKLGDGV 200
    DKDEAKAEVL KNRAQQLHKE QQKGVQPLTF G 231
    Length:231
    Mass (Da):25,709
    Last modified:February 10, 2009 - v2
    Checksum:iDB7E2BEDCC0ECE8B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771Y → H in BAB14063. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti219 – 2191K → R.2 Publications
    Corresponds to variant rs443751 [ dbSNP | Ensembl ].
    VAR_031401

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022501 mRNA. Translation: BAB14063.1.
    AC099784 Genomic DNA. No translation available.
    BC015313 mRNA. Translation: AAH15313.1.
    CCDSiCCDS570.1.
    RefSeqiNP_075565.2. NM_023077.2.
    UniGeneiHs.349905.

    Genome annotation databases

    EnsembliENST00000371538; ENSP00000360593; ENSG00000162377.
    GeneIDi65260.
    KEGGihsa:65260.
    UCSCiuc001cui.2. human.

    Polymorphism databases

    DMDMi223590164.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022501 mRNA. Translation: BAB14063.1 .
    AC099784 Genomic DNA. No translation available.
    BC015313 mRNA. Translation: AAH15313.1 .
    CCDSi CCDS570.1.
    RefSeqi NP_075565.2. NM_023077.2.
    UniGenei Hs.349905.

    3D structure databases

    ProteinModelPortali Q96BR5.
    SMRi Q96BR5. Positions 32-217.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122417. 15 interactions.
    IntActi Q96BR5. 2 interactions.
    STRINGi 9606.ENSP00000360593.

    PTM databases

    PhosphoSitei Q96BR5.

    Polymorphism databases

    DMDMi 223590164.

    Proteomic databases

    MaxQBi Q96BR5.
    PaxDbi Q96BR5.
    PeptideAtlasi Q96BR5.
    PRIDEi Q96BR5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371538 ; ENSP00000360593 ; ENSG00000162377 .
    GeneIDi 65260.
    KEGGi hsa:65260.
    UCSCi uc001cui.2. human.

    Organism-specific databases

    CTDi 65260.
    GeneCardsi GC01M053153.
    H-InvDB HIX0000588.
    HGNCi HGNC:25716. COA7.
    HPAi HPA028154.
    HPA029926.
    MIMi 615623. gene.
    neXtProti NX_Q96BR5.
    PharmGKBi PA142672414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0790.
    HOVERGENi HBG107158.
    InParanoidi Q96BR5.
    KOi K18180.
    OMAi KHSDSCY.
    OrthoDBi EOG7VTDP0.
    PhylomeDBi Q96BR5.
    TreeFami TF105805.

    Miscellaneous databases

    GenomeRNAii 65260.
    NextBioi 67382.
    PROi Q96BR5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96BR5.
    CleanExi HS_C1orf163.
    Genevestigatori Q96BR5.

    Family and domain databases

    Gene3Di 1.25.40.10. 1 hit.
    InterProi IPR006597. Sel1-like.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    Pfami PF08238. Sel1. 4 hits.
    [Graphical view ]
    SMARTi SM00671. SEL1. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
      Tissue: Teratocarcinoma.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
      Tissue: Bone marrow and Prostate.
    4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly."
      Kozjak-Pavlovic V., Prell F., Thiede B., Gotz M., Wosiek D., Ott C., Rudel T.
      J. Mol. Biol. 426:908-920(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCOA7_HUMAN
    AccessioniPrimary (citable) accession number: Q96BR5
    Secondary accession number(s): Q0P6I7, Q9H9Z9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3