Q96BR5 (SELR1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sel1 repeat-containing protein 1

Alternative name(s):
Beta-lactamase hcp-like protein

Gene names

Name:	SELRC1
Synonyms:	C1orf163

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the hcp beta-lactamase family. Contains 5 Sel1-like repeats.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Sel1 repeat-containing protein 1		PRO_0000282364
Regions
	Repeat	34 – 66	33	Sel1-like 1
	Repeat	68 – 104	37	Sel1-like 2
	Repeat	108 – 146	39	Sel1-like 3
	Repeat	147 – 183	37	Sel1-like 4
	Repeat	184 – 219	36	Sel1-like 5
Natural variations
	Natural variant	219	1	K → R. Ref.1 Ref.3 Corresponds to variant rs443751 [ dbSNP | Ensembl ].		VAR_031401
Experimental info
	Sequence conflict	77	1	Y → H in BAB14063. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q96BR5 [UniParc]. Last modified February 10, 2009. Version 2. Checksum: DB7E2BEDCC0ECE8B	FASTA	231	25,709
	10 20 30 40 50 60 MAGMVDFQDE EQVKSFLENM EVECNYHCYH EKDPDGCYRL VDYLEGIRKN FDEAAKVLKF 70 80 90 100 110 120 NCEENQHSDS CYKLGAYYVT GKGGLTQDLK AAARCFLMAC EKPGKKSIAA CHNVGLLAHD 130 140 150 160 170 180 GQVNEDGQPD LGKARDYYTR ACDGGYTSSC FNLSAMFLQG APGFPKDMDL ACKYSMKACD 190 200 210 220 230 LGHIWACANA SRMYKLGDGV DKDEAKAEVL KNRAQQLHKE QQKGVQPLTF G

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219. Tissue: Teratocarcinoma.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219. Tissue: Bone marrow and Prostate.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022501 mRNA. Translation: BAB14063.1. AC099784 Genomic DNA. No translation available. BC015313 mRNA. Translation: AAH15313.1.
IPI	IPI00303753.
RefSeq	NP_075565.2. NM_023077.2.
UniGene	Hs.349905.
3D structure databases
HSSP	HSSP built from PDB template 1OUV based on UniProtKB O25728.
ProteinModelPortal	Q96BR5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BR5. 1 interaction.
STRING	9606.ENSP00000360593.
PTM databases
PhosphoSite	Q96BR5.
Polymorphism databases
DMDM	223590164.
Proteomic databases
PaxDb	Q96BR5.
PeptideAtlas	Q96BR5.
PRIDE	Q96BR5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371538; ENSP00000360593; ENSG00000162377.
GeneID	65260.
KEGG	hsa:65260.
UCSC	uc001cui.2. human.
Organism-specific databases
CTD	65260.
GeneCards	GC01M053153.
H-InvDB	HIX0000588.
HGNC	HGNC:25716. SELRC1.
HPA	HPA028154. HPA029926.
neXtProt	NX_Q96BR5.
PharmGKB	PA142672414.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0790.
HOVERGEN	HBG107158.
InParanoid	Q96BR5.
OMA	KHSDSCY.
OrthoDB	EOG4D52ZH.
PhylomeDB	Q96BR5.
Gene expression databases
Bgee	Q96BR5.
CleanEx	HS_C1orf163.
Genevestigator	Q96BR5.
Family and domain databases
Gene3D	1.25.40.10. 1 hit.
InterPro	IPR006597. Sel1-like. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF08238. Sel1. 4 hits. [Graphical view]
SMART	SM00671. SEL1. 5 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	65260.
NextBio	67382.

Entry information

Entry name

SELR1_HUMAN

Accession

Primary (citable) accession number: Q96BR5
Secondary accession number(s): Q0P6I7, Q9H9Z9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 79 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.