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Protein

Cytochrome c oxidase assembly factor 7

Gene

COA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for assembly of mitochondrial respiratory chain complex I and complex IV.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 7
Alternative name(s):
Beta-lactamase hcp-like protein
Respiratory chain assembly factor 1
Sel1 repeat-containing protein 1
Gene namesi
Name:COA7
Synonyms:C1orf163, RESA1, SELRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25716. COA7.

Subcellular locationi

Mitochondrion intermembrane space 1 Publication

GO - Cellular componenti

  1. mitochondrial intermembrane space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 231230Cytochrome c oxidase assembly factor 7PRO_0000282364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96BR5.
PaxDbiQ96BR5.
PeptideAtlasiQ96BR5.
PRIDEiQ96BR5.

PTM databases

PhosphoSiteiQ96BR5.

Expressioni

Gene expression databases

BgeeiQ96BR5.
CleanExiHS_C1orf163.
GenevestigatoriQ96BR5.

Organism-specific databases

HPAiHPA028154.
HPA029926.

Interactioni

Protein-protein interaction databases

BioGridi122417. 16 interactions.
IntActiQ96BR5. 2 interactions.
STRINGi9606.ENSP00000360593.

Structurei

3D structure databases

ProteinModelPortaliQ96BR5.
SMRiQ96BR5. Positions 32-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 6633Sel1-like 1Add
BLAST
Repeati68 – 10437Sel1-like 2Add
BLAST
Repeati108 – 14639Sel1-like 3Add
BLAST
Repeati147 – 18337Sel1-like 4Add
BLAST
Repeati184 – 21936Sel1-like 5Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 5 Sel1-like repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0790.
GeneTreeiENSGT00390000004835.
HOVERGENiHBG107158.
InParanoidiQ96BR5.
KOiK18180.
OMAiKHSDSCY.
OrthoDBiEOG7VTDP0.
PhylomeDBiQ96BR5.
TreeFamiTF105805.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 4 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BR5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGMVDFQDE EQVKSFLENM EVECNYHCYH EKDPDGCYRL VDYLEGIRKN
60 70 80 90 100
FDEAAKVLKF NCEENQHSDS CYKLGAYYVT GKGGLTQDLK AAARCFLMAC
110 120 130 140 150
EKPGKKSIAA CHNVGLLAHD GQVNEDGQPD LGKARDYYTR ACDGGYTSSC
160 170 180 190 200
FNLSAMFLQG APGFPKDMDL ACKYSMKACD LGHIWACANA SRMYKLGDGV
210 220 230
DKDEAKAEVL KNRAQQLHKE QQKGVQPLTF G
Length:231
Mass (Da):25,709
Last modified:February 10, 2009 - v2
Checksum:iDB7E2BEDCC0ECE8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771Y → H in BAB14063 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191K → R.2 Publications
Corresponds to variant rs443751 [ dbSNP | Ensembl ].
VAR_031401

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022501 mRNA. Translation: BAB14063.1.
AC099784 Genomic DNA. No translation available.
BC015313 mRNA. Translation: AAH15313.1.
CCDSiCCDS570.1.
RefSeqiNP_075565.2. NM_023077.2.
UniGeneiHs.349905.

Genome annotation databases

EnsembliENST00000371538; ENSP00000360593; ENSG00000162377.
GeneIDi65260.
KEGGihsa:65260.
UCSCiuc001cui.2. human.

Polymorphism databases

DMDMi223590164.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022501 mRNA. Translation: BAB14063.1.
AC099784 Genomic DNA. No translation available.
BC015313 mRNA. Translation: AAH15313.1.
CCDSiCCDS570.1.
RefSeqiNP_075565.2. NM_023077.2.
UniGeneiHs.349905.

3D structure databases

ProteinModelPortaliQ96BR5.
SMRiQ96BR5. Positions 32-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122417. 16 interactions.
IntActiQ96BR5. 2 interactions.
STRINGi9606.ENSP00000360593.

PTM databases

PhosphoSiteiQ96BR5.

Polymorphism databases

DMDMi223590164.

Proteomic databases

MaxQBiQ96BR5.
PaxDbiQ96BR5.
PeptideAtlasiQ96BR5.
PRIDEiQ96BR5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371538; ENSP00000360593; ENSG00000162377.
GeneIDi65260.
KEGGihsa:65260.
UCSCiuc001cui.2. human.

Organism-specific databases

CTDi65260.
GeneCardsiGC01M053154.
H-InvDBHIX0000588.
HGNCiHGNC:25716. COA7.
HPAiHPA028154.
HPA029926.
MIMi615623. gene.
neXtProtiNX_Q96BR5.
PharmGKBiPA142672414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0790.
GeneTreeiENSGT00390000004835.
HOVERGENiHBG107158.
InParanoidiQ96BR5.
KOiK18180.
OMAiKHSDSCY.
OrthoDBiEOG7VTDP0.
PhylomeDBiQ96BR5.
TreeFamiTF105805.

Miscellaneous databases

GenomeRNAii65260.
NextBioi67382.
PROiQ96BR5.
SOURCEiSearch...

Gene expression databases

BgeeiQ96BR5.
CleanExiHS_C1orf163.
GenevestigatoriQ96BR5.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 4 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
    Tissue: Bone marrow and Prostate.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly."
    Kozjak-Pavlovic V., Prell F., Thiede B., Gotz M., Wosiek D., Ott C., Rudel T.
    J. Mol. Biol. 426:908-920(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q96BR5
Secondary accession number(s): Q0P6I7, Q9H9Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.