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Q96BR5

- COA7_HUMAN

UniProt

Q96BR5 - COA7_HUMAN

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Protein

Cytochrome c oxidase assembly factor 7

Gene

COA7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Required for assembly of mitochondrial respiratory chain complex I and complex IV.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly factor 7
Alternative name(s):
Beta-lactamase hcp-like protein
Respiratory chain assembly factor 1
Sel1 repeat-containing protein 1
Gene namesi
Name:COA7
Synonyms:C1orf163, RESA1, SELRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25716. COA7.

Subcellular locationi

Mitochondrion intermembrane space 1 Publication

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 231230Cytochrome c oxidase assembly factor 7PRO_0000282364Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96BR5.
PaxDbiQ96BR5.
PeptideAtlasiQ96BR5.
PRIDEiQ96BR5.

PTM databases

PhosphoSiteiQ96BR5.

Expressioni

Gene expression databases

BgeeiQ96BR5.
CleanExiHS_C1orf163.
GenevestigatoriQ96BR5.

Organism-specific databases

HPAiHPA028154.
HPA029926.

Interactioni

Protein-protein interaction databases

BioGridi122417. 16 interactions.
IntActiQ96BR5. 2 interactions.
STRINGi9606.ENSP00000360593.

Structurei

3D structure databases

ProteinModelPortaliQ96BR5.
SMRiQ96BR5. Positions 32-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati34 – 6633Sel1-like 1Add
BLAST
Repeati68 – 10437Sel1-like 2Add
BLAST
Repeati108 – 14639Sel1-like 3Add
BLAST
Repeati147 – 18337Sel1-like 4Add
BLAST
Repeati184 – 21936Sel1-like 5Add
BLAST

Sequence similaritiesi

Belongs to the hcp beta-lactamase family.Curated
Contains 5 Sel1-like repeats.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0790.
GeneTreeiENSGT00390000004835.
HOVERGENiHBG107158.
InParanoidiQ96BR5.
KOiK18180.
OMAiKHSDSCY.
OrthoDBiEOG7VTDP0.
PhylomeDBiQ96BR5.
TreeFamiTF105805.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF08238. Sel1. 4 hits.
[Graphical view]
SMARTiSM00671. SEL1. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BR5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGMVDFQDE EQVKSFLENM EVECNYHCYH EKDPDGCYRL VDYLEGIRKN
60 70 80 90 100
FDEAAKVLKF NCEENQHSDS CYKLGAYYVT GKGGLTQDLK AAARCFLMAC
110 120 130 140 150
EKPGKKSIAA CHNVGLLAHD GQVNEDGQPD LGKARDYYTR ACDGGYTSSC
160 170 180 190 200
FNLSAMFLQG APGFPKDMDL ACKYSMKACD LGHIWACANA SRMYKLGDGV
210 220 230
DKDEAKAEVL KNRAQQLHKE QQKGVQPLTF G
Length:231
Mass (Da):25,709
Last modified:February 10, 2009 - v2
Checksum:iDB7E2BEDCC0ECE8B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771Y → H in BAB14063. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti219 – 2191K → R.2 Publications
Corresponds to variant rs443751 [ dbSNP | Ensembl ].
VAR_031401

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022501 mRNA. Translation: BAB14063.1.
AC099784 Genomic DNA. No translation available.
BC015313 mRNA. Translation: AAH15313.1.
CCDSiCCDS570.1.
RefSeqiNP_075565.2. NM_023077.2.
UniGeneiHs.349905.

Genome annotation databases

EnsembliENST00000371538; ENSP00000360593; ENSG00000162377.
GeneIDi65260.
KEGGihsa:65260.
UCSCiuc001cui.2. human.

Polymorphism databases

DMDMi223590164.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022501 mRNA. Translation: BAB14063.1 .
AC099784 Genomic DNA. No translation available.
BC015313 mRNA. Translation: AAH15313.1 .
CCDSi CCDS570.1.
RefSeqi NP_075565.2. NM_023077.2.
UniGenei Hs.349905.

3D structure databases

ProteinModelPortali Q96BR5.
SMRi Q96BR5. Positions 32-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122417. 16 interactions.
IntActi Q96BR5. 2 interactions.
STRINGi 9606.ENSP00000360593.

PTM databases

PhosphoSitei Q96BR5.

Polymorphism databases

DMDMi 223590164.

Proteomic databases

MaxQBi Q96BR5.
PaxDbi Q96BR5.
PeptideAtlasi Q96BR5.
PRIDEi Q96BR5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371538 ; ENSP00000360593 ; ENSG00000162377 .
GeneIDi 65260.
KEGGi hsa:65260.
UCSCi uc001cui.2. human.

Organism-specific databases

CTDi 65260.
GeneCardsi GC01M053154.
H-InvDB HIX0000588.
HGNCi HGNC:25716. COA7.
HPAi HPA028154.
HPA029926.
MIMi 615623. gene.
neXtProti NX_Q96BR5.
PharmGKBi PA142672414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0790.
GeneTreei ENSGT00390000004835.
HOVERGENi HBG107158.
InParanoidi Q96BR5.
KOi K18180.
OMAi KHSDSCY.
OrthoDBi EOG7VTDP0.
PhylomeDBi Q96BR5.
TreeFami TF105805.

Miscellaneous databases

GenomeRNAii 65260.
NextBioi 67382.
PROi Q96BR5.
SOURCEi Search...

Gene expression databases

Bgeei Q96BR5.
CleanExi HS_C1orf163.
Genevestigatori Q96BR5.

Family and domain databases

Gene3Di 1.25.40.10. 1 hit.
InterProi IPR006597. Sel1-like.
IPR011990. TPR-like_helical_dom.
[Graphical view ]
Pfami PF08238. Sel1. 4 hits.
[Graphical view ]
SMARTi SM00671. SEL1. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
    Tissue: Teratocarcinoma.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-219.
    Tissue: Bone marrow and Prostate.
  4. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "C1orf163/RESA1 is a novel mitochondrial intermembrane space protein connected to respiratory chain assembly."
    Kozjak-Pavlovic V., Prell F., Thiede B., Gotz M., Wosiek D., Ott C., Rudel T.
    J. Mol. Biol. 426:908-920(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCOA7_HUMAN
AccessioniPrimary (citable) accession number: Q96BR5
Secondary accession number(s): Q0P6I7, Q9H9Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3