Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q96BR1

- SGK3_HUMAN

UniProt

Q96BR1 - SGK3_HUMAN

Protein

Serine/threonine-protein kinase Sgk3

Gene

SGK3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.21 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Enzyme regulationi

    Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei191 – 1911ATPPROSITE-ProRule annotation
    Active sitei286 – 2861Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi168 – 1769ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. calcium channel regulator activity Source: UniProtKB
    3. chloride channel regulator activity Source: UniProtKB
    4. phosphatidylinositol binding Source: InterPro
    5. potassium channel regulator activity Source: UniProtKB
    6. protein binding Source: IntAct
    7. protein kinase activity Source: ProtInc
    8. protein serine/threonine kinase activity Source: ProtInc
    9. sodium channel regulator activity Source: UniProtKB

    GO - Biological processi

    1. ion transmembrane transport Source: Reactome
    2. protein phosphorylation Source: ProtInc
    3. regulation of cell growth Source: UniProtKB
    4. regulation of cell migration Source: UniProtKB
    5. regulation of cell proliferation Source: UniProtKB
    6. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
    7. response to stress Source: ProtInc
    8. transmembrane transport Source: Reactome

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_160189. Stimuli-sensing channels.
    SignaLinkiQ96BR1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase Sgk3 (EC:2.7.11.1)
    Alternative name(s):
    Cytokine-independent survival kinase
    Serum/glucocorticoid-regulated kinase 3
    Serum/glucocorticoid-regulated kinase-like
    Gene namesi
    Name:SGK3
    Synonyms:CISK, SGKL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:10812. SGK3.

    Subcellular locationi

    Cytoplasmic vesicle By similarity. Early endosome. Recycling endosome
    Note: Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    2. cytosol Source: Reactome
    3. early endosome Source: UniProtKB-SubCell
    4. recycling endosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endosome

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi90 – 901R → A: Partially localized to the membrane. 1 Publication
    Mutagenesisi191 – 1911K → M: Abolishes activity. 1 Publication
    Mutagenesisi486 – 4861S → D: Increased activation. 1 Publication

    Organism-specific databases

    PharmGKBiPA35722.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 496496Serine/threonine-protein kinase Sgk3PRO_0000086649Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei126 – 1261PhosphoserineBy similarity
    Modified residuei129 – 1291PhosphoserineBy similarity
    Modified residuei320 – 3201Phosphothreonine; by PDPK13 Publications
    Modified residuei486 – 4861Phosphoserine3 Publications

    Post-translational modificationi

    Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.4 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96BR1.
    PaxDbiQ96BR1.
    PRIDEiQ96BR1.

    PTM databases

    PhosphoSiteiQ96BR1.

    Expressioni

    Tissue specificityi

    Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.1 Publication

    Inductioni

    Induced by estrogen/ER in breast cancer cells.1 Publication

    Gene expression databases

    ArrayExpressiQ96BR1.
    BgeeiQ96BR1.
    CleanExiHS_SGK2.
    HS_SGK3.
    GenevestigatoriQ96BR1.

    Organism-specific databases

    HPAiHPA027146.

    Interactioni

    Subunit structurei

    Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ITCHQ96J025EBI-2801236,EBI-1564678

    Protein-protein interaction databases

    BioGridi117195. 7 interactions.
    IntActiQ96BR1. 5 interactions.
    MINTiMINT-2813751.
    STRINGi9606.ENSP00000262211.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BR1.
    SMRiQ96BR1. Positions 11-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini12 – 124113PXPROSITE-ProRule annotationAdd
    BLAST
    Domaini162 – 419258Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini420 – 49677AGC-kinase C-terminalAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi195 – 20511Nuclear localization signalBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000233033.
    HOVERGENiHBG108317.
    InParanoidiQ96BR1.
    KOiK13304.
    OMAiHPELYNH.
    OrthoDBiEOG7Q5HCW.
    PhylomeDBiQ96BR1.
    TreeFamiTF320906.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96BR1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQRDHTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR    50
    YAEFDKLYNT LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN 100
    LVRYPELYNH PDVRAFLQMD SPKHQSDPSE DEDERSSQKL HSTSQNINLG 150
    PSGNPHAKPT DFDFLKVIGK GSFGKVLLAK RKLDGKFYAV KVLQKKIVLN 200
    RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL DFVNGGELFF 250
    HLQRERSFPE HRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSVGHV 300
    VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV 350
    LYEMLYGLPP FYCRDVAEMY DNILHKPLSL RPGVSLTAWS ILEELLEKDR 400
    QNRLGAKEDF LEIQNHPFFE SLSWADLVQK KIPPPFNPNV AGPDDIRNFD 450
    TAFTEETVPY SVCVSSDYSI VNASVLEADD AFVGFSYAPP SEDLFL 496
    Length:496
    Mass (Da):57,108
    Last modified:December 1, 2001 - v1
    Checksum:i76A6CCEB69006CF1
    GO
    Isoform 2 (identifier: Q96BR1-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         327-358: Missing.

    Show »
    Length:464
    Mass (Da):53,306
    Checksum:iD5028F96C651C465
    GO

    Sequence cautioni

    The sequence AAF12758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541F → V in AAF27051. (PubMed:10585774)Curated
    Sequence conflicti127 – 1271D → G in AAF27051. (PubMed:10585774)Curated
    Sequence conflicti187 – 1871F → V in AAF27051. (PubMed:10585774)Curated
    Sequence conflicti294 – 2941L → V in AAF27051. (PubMed:10585774)Curated
    Sequence conflicti387 – 3871T → R in AAF27051. (PubMed:10585774)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti92 – 921A → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035636
    Natural varianti355 – 3551L → P.1 Publication
    VAR_041076

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei327 – 35832Missing in isoform 2. 1 PublicationVSP_041903Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169035 mRNA. Translation: AAF12758.1. Different initiation.
    AF085233 mRNA. Translation: AAF27051.2.
    AK074666 mRNA. Translation: BAG51984.1.
    AK291428 mRNA. Translation: BAF84117.1.
    AC011031 Genomic DNA. No translation available.
    AC090154 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW86919.1.
    BC015326 mRNA. Translation: AAH15326.1.
    CCDSiCCDS6195.1. [Q96BR1-1]
    CCDS6196.1. [Q96BR1-2]
    RefSeqiNP_001028750.1. NM_001033578.2. [Q96BR1-1]
    NP_001191102.1. NM_001204173.1. [Q96BR1-1]
    NP_037389.4. NM_013257.4. [Q96BR1-1]
    NP_733827.2. NM_170709.2. [Q96BR1-2]
    UniGeneiHs.613417.
    Hs.733251.

    Genome annotation databases

    EnsembliENST00000345714; ENSP00000331816; ENSG00000104205. [Q96BR1-1]
    ENST00000396596; ENSP00000379842; ENSG00000104205. [Q96BR1-1]
    ENST00000520976; ENSP00000430691; ENSG00000104205. [Q96BR1-2]
    ENST00000521198; ENSP00000430463; ENSG00000104205. [Q96BR1-1]
    ENST00000522398; ENSP00000430256; ENSG00000104205. [Q96BR1-1]
    GeneIDi100533105.
    23678.
    KEGGihsa:100533105.
    hsa:23678.
    UCSCiuc003xwp.3. human. [Q96BR1-1]
    uc003xwu.3. human. [Q96BR1-2]

    Polymorphism databases

    DMDMi28558163.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF169035 mRNA. Translation: AAF12758.1 . Different initiation.
    AF085233 mRNA. Translation: AAF27051.2 .
    AK074666 mRNA. Translation: BAG51984.1 .
    AK291428 mRNA. Translation: BAF84117.1 .
    AC011031 Genomic DNA. No translation available.
    AC090154 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW86919.1 .
    BC015326 mRNA. Translation: AAH15326.1 .
    CCDSi CCDS6195.1. [Q96BR1-1 ]
    CCDS6196.1. [Q96BR1-2 ]
    RefSeqi NP_001028750.1. NM_001033578.2. [Q96BR1-1 ]
    NP_001191102.1. NM_001204173.1. [Q96BR1-1 ]
    NP_037389.4. NM_013257.4. [Q96BR1-1 ]
    NP_733827.2. NM_170709.2. [Q96BR1-2 ]
    UniGenei Hs.613417.
    Hs.733251.

    3D structure databases

    ProteinModelPortali Q96BR1.
    SMRi Q96BR1. Positions 11-490.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117195. 7 interactions.
    IntActi Q96BR1. 5 interactions.
    MINTi MINT-2813751.
    STRINGi 9606.ENSP00000262211.

    Chemistry

    BindingDBi Q96BR1.
    ChEMBLi CHEMBL6186.
    GuidetoPHARMACOLOGYi 1536.

    PTM databases

    PhosphoSitei Q96BR1.

    Polymorphism databases

    DMDMi 28558163.

    Proteomic databases

    MaxQBi Q96BR1.
    PaxDbi Q96BR1.
    PRIDEi Q96BR1.

    Protocols and materials databases

    DNASUi 23678.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000345714 ; ENSP00000331816 ; ENSG00000104205 . [Q96BR1-1 ]
    ENST00000396596 ; ENSP00000379842 ; ENSG00000104205 . [Q96BR1-1 ]
    ENST00000520976 ; ENSP00000430691 ; ENSG00000104205 . [Q96BR1-2 ]
    ENST00000521198 ; ENSP00000430463 ; ENSG00000104205 . [Q96BR1-1 ]
    ENST00000522398 ; ENSP00000430256 ; ENSG00000104205 . [Q96BR1-1 ]
    GeneIDi 100533105.
    23678.
    KEGGi hsa:100533105.
    hsa:23678.
    UCSCi uc003xwp.3. human. [Q96BR1-1 ]
    uc003xwu.3. human. [Q96BR1-2 ]

    Organism-specific databases

    CTDi 100533105.
    23678.
    GeneCardsi GC08P067579.
    GC08P067624.
    HGNCi HGNC:10812. SGK3.
    HPAi HPA027146.
    MIMi 607591. gene.
    neXtProti NX_Q96BR1.
    PharmGKBi PA35722.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000233033.
    HOVERGENi HBG108317.
    InParanoidi Q96BR1.
    KOi K13304.
    OMAi HPELYNH.
    OrthoDBi EOG7Q5HCW.
    PhylomeDBi Q96BR1.
    TreeFami TF320906.

    Enzyme and pathway databases

    Reactomei REACT_160189. Stimuli-sensing channels.
    SignaLinki Q96BR1.

    Miscellaneous databases

    GeneWikii SGK3.
    NextBioi 46545.
    PROi Q96BR1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96BR1.
    Bgeei Q96BR1.
    CleanExi HS_SGK2.
    HS_SGK3.
    Genevestigatori Q96BR1.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR001683. Phox.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    SSF64268. SSF64268. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase."
      Kobayashi T., Deak M., Morrice N., Cohen P.
      Biochem. J. 344:189-197(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PHOSPHORYLATION AT THR-320, MUTAGENESIS OF SER-486.
    2. "Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1."
      Dai F., Yu L., He H., Zhao Y., Yang J., Zhang X., Zhao S.
      Genomics 62:95-97(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Zhao Y.
      Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Brain and Mammary gland.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland.
    7. "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction."
      Dai F., Yu L., He H., Chen Y., Yu J., Yang Y., Xu Y., Ling W., Zhao S.
      Biochem. Biophys. Res. Commun. 293:1191-1196(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF GSK3B, INTERACTION WITH GSK3B.
    8. "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."
      Henke G., Setiawan I., Boehmer C., Lang F.
      Kidney Blood Press. Res. 25:370-374(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF NA(+)/K(+) ATPASE.
    9. "K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."
      Gamper N., Fillon S., Feng Y., Friedrich B., Lang P.A., Henke G., Huber S.M., Kobayashi T., Cohen P., Lang F.
      Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A."
      Boehmer C., Wilhelm V., Palmada M., Wallisch S., Henke G., Brinkmeier H., Cohen P., Pieske B., Lang F.
      Cardiovasc. Res. 57:1079-1084(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SCN5A.
    11. "Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B."
      Boehmer C., Henke G., Schniepp R., Palmada M., Rothstein J.D., Broeer S., Lang F.
      J. Neurochem. 86:1181-1188(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC1A3/EAAT1.
    12. "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."
      Embark H.M., Boehmer C., Vallon V., Luft F., Lang F.
      Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF KCNE1 AND KCNQ1.
    13. "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."
      Friedrich B., Feng Y., Cohen P., Risler T., Vandewalle A., Broeer S., Wang J., Pearce D., Lang F.
      Pflugers Arch. 445:693-696(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SCNN1A/ENAC.
    14. "Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1."
      Palmada M., Dieter M., Speil A., Boehmer C., Mack A.F., Wagner H.J., Klingel K., Kandolf R., Murer H., Biber J., Closs E.I., Lang F.
      Am. J. Physiol. 287:G143-G150(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC34A2/NAPI-2B, FUNCTION IN PHOSPHORYLATION OF NEDD4L.
    15. "Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B."
      Boehmer C., Embark H.M., Bauer A., Palmada M., Yun C.H., Weinman E.J., Endou H., Cohen P., Lahme S., Bichler K.H., Lang F.
      Biochem. Biophys. Res. Commun. 313:998-1003(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC13A2/NADC1.
    16. "Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes."
      Embark H.M., Setiawan I., Poppendieck S., van de Graaf S.F., Boehmer C., Palmada M., Wieder T., Gerstberger R., Cohen P., Yun C.C., Bindels R.J., Lang F.
      Cell. Physiol. Biochem. 14:203-212(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF TRPV5.
    17. "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner."
      Nilsen T., Slagsvold T., Skjerpen C.S., Brech A., Stenmark H., Olsnes S.
      J. Biol. Chem. 279:4794-4801(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PDPK1, PHOSPHORYLATION BY PDPK1.
    18. "Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."
      Henke G., Maier G., Wallisch S., Boehmer C., Lang F.
      J. Cell. Physiol. 199:194-199(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF KCNA3/KV1.3.
    19. "Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases."
      Embark H.M., Boehmer C., Palmada M., Rajamanickam J., Wyatt A.W., Wallisch S., Capasso G., Waldegger P., Seyberth H.W., Waldegger S., Lang F.
      Kidney Int. 66:1918-1925(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF BSND.
    20. "The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2."
      Palmada M., Speil A., Jeyaraj S., Boehmer C., Lang F.
      Biochem. Biophys. Res. Commun. 331:272-277(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC1A5/ASCT2.
    21. "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3."
      Boehmer C., Rajamanickam J., Schniepp R., Kohler K., Wulff P., Kuhl D., Palmada M., Lang F.
      Biochem. Biophys. Res. Commun. 329:738-742(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC1A7/EAAT5.
    22. "Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3."
      Shojaiefard M., Christie D.L., Lang F.
      Biochem. Biophys. Res. Commun. 334:742-746(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC6A8.
    23. "Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3."
      Maier G., Palmada M., Rajamanickam J., Shumilina E., Boehmer C., Lang F.
      Cell. Physiol. Biochem. 18:177-186(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF KCNH2/HERG.
    24. "CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4."
      Slagsvold T., Marchese A., Brech A., Stenmark H.
      EMBO J. 25:3738-3749(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ITHC/AIP4, PHOSPHORYLATION AT SER-486.
    25. "Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3."
      Tessier M., Woodgett J.R.
      J. Biol. Chem. 281:23978-23989(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT THR-320 AND SER-486, MUTAGENESIS OF ARG-90 AND LYS-191.
    26. "Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3."
      Boehmer C., Palmada M., Kenngott C., Lindner R., Klaus F., Laufer J., Lang F.
      FEBS Lett. 581:5586-5590(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF TRPV6.
    27. "Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK."
      Xu J., Liao L., Qin J., Xu J., Liu D., Songyang Z.
      J. Biol. Chem. 284:14377-14385(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PHOSPHORYLATION OF FLII, INTERACTION WITH FLII.
    28. "The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."
      Boehmer C., Sopjani M., Klaus F., Lindner R., Laufer J., Jeyaraj S., Lang F., Palmada M.
      Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC6A19.
    29. "Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."
      He P., Lee S.J., Lin S., Seidler U., Lang F., Fejes-Toth G., Naray-Fejes-Toth A., Yun C.C.
      Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF SLC9A3/NHE3, SUBCELLULAR LOCATION.
    30. "SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells."
      Wang Y., Zhou D., Phung S., Masri S., Smith D., Chen S.
      Mol. Endocrinol. 25:72-82(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION, TISSUE SPECIFICITY.
    31. "Sgk kinases and their role in epithelial transport."
      Loffing J., Flores S.Y., Staub O.
      Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    32. Cited for: REVIEW ON FUNCTION.
    33. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-92.
    34. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-355.

    Entry informationi

    Entry nameiSGK3_HUMAN
    AccessioniPrimary (citable) accession number: Q96BR1
    Secondary accession number(s): A8K5W3
    , B3KQC2, Q9P1Q7, Q9UKG5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 22, 2003
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3