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Q96BR1

- SGK3_HUMAN

UniProt

Q96BR1 - SGK3_HUMAN

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Protein
Serine/threonine-protein kinase Sgk3
Gene
SGK3, CISK, SGKL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na+ channels: SCNN1A/ENAC and SCN5A, K+ channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes.21 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei191 – 1911ATP By similarity
Active sitei286 – 2861Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 1769ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. calcium channel regulator activity Source: UniProtKB
  3. chloride channel regulator activity Source: UniProtKB
  4. phosphatidylinositol binding Source: InterPro
  5. potassium channel regulator activity Source: UniProtKB
  6. protein binding Source: IntAct
  7. protein kinase activity Source: ProtInc
  8. protein serine/threonine kinase activity Source: ProtInc
  9. sodium channel regulator activity Source: UniProtKB

GO - Biological processi

  1. ion transmembrane transport Source: Reactome
  2. protein phosphorylation Source: ProtInc
  3. regulation of cell growth Source: UniProtKB
  4. regulation of cell migration Source: UniProtKB
  5. regulation of cell proliferation Source: UniProtKB
  6. regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  7. response to stress Source: ProtInc
  8. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_160189. Stimuli-sensing channels.
SignaLinkiQ96BR1.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Sgk3 (EC:2.7.11.1)
Alternative name(s):
Cytokine-independent survival kinase
Serum/glucocorticoid-regulated kinase 3
Serum/glucocorticoid-regulated kinase-like
Gene namesi
Name:SGK3
Synonyms:CISK, SGKL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:10812. SGK3.

Subcellular locationi

Cytoplasmic vesicle By similarity. Early endosome. Recycling endosome
Note: Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.2 Publications

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
  2. cytosol Source: Reactome
  3. early endosome Source: UniProtKB-SubCell
  4. recycling endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi90 – 901R → A: Partially localized to the membrane. 1 Publication
Mutagenesisi191 – 1911K → M: Abolishes activity. 1 Publication
Mutagenesisi486 – 4861S → D: Increased activation. 1 Publication

Organism-specific databases

PharmGKBiPA35722.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Serine/threonine-protein kinase Sgk3
PRO_0000086649Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei126 – 1261Phosphoserine By similarity
Modified residuei129 – 1291Phosphoserine By similarity
Modified residuei320 – 3201Phosphothreonine; by PDPK12 Publications
Modified residuei486 – 4861Phosphoserine2 Publications

Post-translational modificationi

Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BR1.
PaxDbiQ96BR1.
PRIDEiQ96BR1.

PTM databases

PhosphoSiteiQ96BR1.

Expressioni

Tissue specificityi

Expressed in most tissues with highest levels in pancreas, kidney liver, heart and brain and lower levels in lung, placenta and skeletal muscle. Expression is higher in ER-positive breast tumors than ER-negative breast tumors.1 Publication

Inductioni

Induced by estrogen/ER in breast cancer cells.1 Publication

Gene expression databases

ArrayExpressiQ96BR1.
BgeeiQ96BR1.
CleanExiHS_SGK2.
HS_SGK3.
GenevestigatoriQ96BR1.

Organism-specific databases

HPAiHPA027146.

Interactioni

Subunit structurei

Interacts with GSK3B and FLII. Interacts with PDPK1 in a phosphorylation-dependent manner.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ITCHQ96J025EBI-2801236,EBI-1564678

Protein-protein interaction databases

BioGridi117195. 7 interactions.
IntActiQ96BR1. 5 interactions.
MINTiMINT-2813751.
STRINGi9606.ENSP00000262211.

Structurei

3D structure databases

ProteinModelPortaliQ96BR1.
SMRiQ96BR1. Positions 11-490.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 124113PX
Add
BLAST
Domaini162 – 419258Protein kinase
Add
BLAST
Domaini420 – 49677AGC-kinase C-terminal
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi195 – 20511Nuclear localization signal By similarity
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233033.
HOVERGENiHBG108317.
InParanoidiQ96BR1.
KOiK13304.
OMAiHPELYNH.
OrthoDBiEOG7Q5HCW.
PhylomeDBiQ96BR1.
TreeFamiTF320906.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96BR1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQRDHTMDYK ESCPSVSIPS SDEHREKKKR FTVYKVLVSV GRSEWFVFRR    50
YAEFDKLYNT LKKQFPAMAL KIPAKRIFGD NFDPDFIKQR RAGLNEFIQN 100
LVRYPELYNH PDVRAFLQMD SPKHQSDPSE DEDERSSQKL HSTSQNINLG 150
PSGNPHAKPT DFDFLKVIGK GSFGKVLLAK RKLDGKFYAV KVLQKKIVLN 200
RKEQKHIMAE RNVLLKNVKH PFLVGLHYSF QTTEKLYFVL DFVNGGELFF 250
HLQRERSFPE HRARFYAAEI ASALGYLHSI KIVYRDLKPE NILLDSVGHV 300
VLTDFGLCKE GIAISDTTTT FCGTPEYLAP EVIRKQPYDN TVDWWCLGAV 350
LYEMLYGLPP FYCRDVAEMY DNILHKPLSL RPGVSLTAWS ILEELLEKDR 400
QNRLGAKEDF LEIQNHPFFE SLSWADLVQK KIPPPFNPNV AGPDDIRNFD 450
TAFTEETVPY SVCVSSDYSI VNASVLEADD AFVGFSYAPP SEDLFL 496
Length:496
Mass (Da):57,108
Last modified:December 1, 2001 - v1
Checksum:i76A6CCEB69006CF1
GO
Isoform 2 (identifier: Q96BR1-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     327-358: Missing.

Show »
Length:464
Mass (Da):53,306
Checksum:iD5028F96C651C465
GO

Sequence cautioni

The sequence AAF12758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti92 – 921A → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035636
Natural varianti355 – 3551L → P.1 Publication
VAR_041076

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei327 – 35832Missing in isoform 2.
VSP_041903Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541F → V in AAF27051. 1 Publication
Sequence conflicti127 – 1271D → G in AAF27051. 1 Publication
Sequence conflicti187 – 1871F → V in AAF27051. 1 Publication
Sequence conflicti294 – 2941L → V in AAF27051. 1 Publication
Sequence conflicti387 – 3871T → R in AAF27051. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169035 mRNA. Translation: AAF12758.1. Different initiation.
AF085233 mRNA. Translation: AAF27051.2.
AK074666 mRNA. Translation: BAG51984.1.
AK291428 mRNA. Translation: BAF84117.1.
AC011031 Genomic DNA. No translation available.
AC090154 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86919.1.
BC015326 mRNA. Translation: AAH15326.1.
CCDSiCCDS6195.1. [Q96BR1-1]
CCDS6196.1. [Q96BR1-2]
RefSeqiNP_001028750.1. NM_001033578.2. [Q96BR1-1]
NP_001191102.1. NM_001204173.1. [Q96BR1-1]
NP_037389.4. NM_013257.4. [Q96BR1-1]
NP_733827.2. NM_170709.2. [Q96BR1-2]
UniGeneiHs.613417.
Hs.733251.

Genome annotation databases

EnsembliENST00000345714; ENSP00000331816; ENSG00000104205. [Q96BR1-1]
ENST00000396596; ENSP00000379842; ENSG00000104205. [Q96BR1-1]
ENST00000520976; ENSP00000430691; ENSG00000104205. [Q96BR1-2]
ENST00000521198; ENSP00000430463; ENSG00000104205. [Q96BR1-1]
ENST00000522398; ENSP00000430256; ENSG00000104205. [Q96BR1-1]
GeneIDi100533105.
23678.
KEGGihsa:100533105.
hsa:23678.
UCSCiuc003xwp.3. human. [Q96BR1-1]
uc003xwu.3. human. [Q96BR1-2]

Polymorphism databases

DMDMi28558163.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF169035 mRNA. Translation: AAF12758.1 . Different initiation.
AF085233 mRNA. Translation: AAF27051.2 .
AK074666 mRNA. Translation: BAG51984.1 .
AK291428 mRNA. Translation: BAF84117.1 .
AC011031 Genomic DNA. No translation available.
AC090154 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW86919.1 .
BC015326 mRNA. Translation: AAH15326.1 .
CCDSi CCDS6195.1. [Q96BR1-1 ]
CCDS6196.1. [Q96BR1-2 ]
RefSeqi NP_001028750.1. NM_001033578.2. [Q96BR1-1 ]
NP_001191102.1. NM_001204173.1. [Q96BR1-1 ]
NP_037389.4. NM_013257.4. [Q96BR1-1 ]
NP_733827.2. NM_170709.2. [Q96BR1-2 ]
UniGenei Hs.613417.
Hs.733251.

3D structure databases

ProteinModelPortali Q96BR1.
SMRi Q96BR1. Positions 11-490.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117195. 7 interactions.
IntActi Q96BR1. 5 interactions.
MINTi MINT-2813751.
STRINGi 9606.ENSP00000262211.

Chemistry

BindingDBi Q96BR1.
ChEMBLi CHEMBL6186.
GuidetoPHARMACOLOGYi 1536.

PTM databases

PhosphoSitei Q96BR1.

Polymorphism databases

DMDMi 28558163.

Proteomic databases

MaxQBi Q96BR1.
PaxDbi Q96BR1.
PRIDEi Q96BR1.

Protocols and materials databases

DNASUi 23678.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000345714 ; ENSP00000331816 ; ENSG00000104205 . [Q96BR1-1 ]
ENST00000396596 ; ENSP00000379842 ; ENSG00000104205 . [Q96BR1-1 ]
ENST00000520976 ; ENSP00000430691 ; ENSG00000104205 . [Q96BR1-2 ]
ENST00000521198 ; ENSP00000430463 ; ENSG00000104205 . [Q96BR1-1 ]
ENST00000522398 ; ENSP00000430256 ; ENSG00000104205 . [Q96BR1-1 ]
GeneIDi 100533105.
23678.
KEGGi hsa:100533105.
hsa:23678.
UCSCi uc003xwp.3. human. [Q96BR1-1 ]
uc003xwu.3. human. [Q96BR1-2 ]

Organism-specific databases

CTDi 100533105.
23678.
GeneCardsi GC08P067579.
GC08P067624.
HGNCi HGNC:10812. SGK3.
HPAi HPA027146.
MIMi 607591. gene.
neXtProti NX_Q96BR1.
PharmGKBi PA35722.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233033.
HOVERGENi HBG108317.
InParanoidi Q96BR1.
KOi K13304.
OMAi HPELYNH.
OrthoDBi EOG7Q5HCW.
PhylomeDBi Q96BR1.
TreeFami TF320906.

Enzyme and pathway databases

Reactomei REACT_160189. Stimuli-sensing channels.
SignaLinki Q96BR1.

Miscellaneous databases

GeneWikii SGK3.
NextBioi 46545.
PROi Q96BR1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96BR1.
Bgeei Q96BR1.
CleanExi HS_SGK2.
HS_SGK3.
Genevestigatori Q96BR1.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR001683. Phox.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
SSF64268. SSF64268. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase."
    Kobayashi T., Deak M., Morrice N., Cohen P.
    Biochem. J. 344:189-197(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PHOSPHORYLATION AT THR-320, MUTAGENESIS OF SER-486.
  2. "Cloning and mapping of a novel human Serum/Glucocorticoid regulated kinase-like gene, SGKL, to chromosome 8q12.3-q13.1."
    Dai F., Yu L., He H., Zhao Y., Yang J., Zhang X., Zhao S.
    Genomics 62:95-97(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Zhao Y.
    Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain and Mammary gland.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Mammary gland.
  7. "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK-3beta) at serine-9 through direct interaction."
    Dai F., Yu L., He H., Chen Y., Yu J., Yang Y., Xu Y., Ling W., Zhao S.
    Biochem. Biophys. Res. Commun. 293:1191-1196(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF GSK3B, INTERACTION WITH GSK3B.
  8. "Activation of Na+/K+-ATPase by the serum and glucocorticoid-dependent kinase isoforms."
    Henke G., Setiawan I., Boehmer C., Lang F.
    Kidney Blood Press. Res. 25:370-374(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF NA(+)/K(+) ATPASE.
  9. "K(+) channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK."
    Gamper N., Fillon S., Feng Y., Friedrich B., Lang P.A., Henke G., Huber S.M., Kobayashi T., Cohen P., Lang F.
    Pflugers Arch. 445:60-66(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  10. "Serum and glucocorticoid inducible kinases in the regulation of the cardiac sodium channel SCN5A."
    Boehmer C., Wilhelm V., Palmada M., Wallisch S., Henke G., Brinkmeier H., Cohen P., Pieske B., Lang F.
    Cardiovasc. Res. 57:1079-1084(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SCN5A.
  11. "Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B."
    Boehmer C., Henke G., Schniepp R., Palmada M., Rothstein J.D., Broeer S., Lang F.
    J. Neurochem. 86:1181-1188(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC1A3/EAAT1.
  12. "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms."
    Embark H.M., Boehmer C., Vallon V., Luft F., Lang F.
    Pflugers Arch. 445:601-606(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF KCNE1 AND KCNQ1.
  13. "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC."
    Friedrich B., Feng Y., Cohen P., Risler T., Vandewalle A., Broeer S., Wang J., Pearce D., Lang F.
    Pflugers Arch. 445:693-696(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SCNN1A/ENAC.
  14. "Regulation of intestinal phosphate cotransporter NaPi IIb by ubiquitin ligase Nedd4-2 and by serum- and glucocorticoid-dependent kinase 1."
    Palmada M., Dieter M., Speil A., Boehmer C., Mack A.F., Wagner H.J., Klingel K., Kandolf R., Murer H., Biber J., Closs E.I., Lang F.
    Am. J. Physiol. 287:G143-G150(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC34A2/NAPI-2B, FUNCTION IN PHOSPHORYLATION OF NEDD4L.
  15. "Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B."
    Boehmer C., Embark H.M., Bauer A., Palmada M., Yun C.H., Weinman E.J., Endou H., Cohen P., Lahme S., Bichler K.H., Lang F.
    Biochem. Biophys. Res. Commun. 313:998-1003(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC13A2/NADC1.
  16. "Regulation of the epithelial Ca2+ channel TRPV5 by the NHE regulating factor NHERF2 and the serum and glucocorticoid inducible kinase isoforms SGK1 and SGK3 expressed in Xenopus oocytes."
    Embark H.M., Setiawan I., Poppendieck S., van de Graaf S.F., Boehmer C., Palmada M., Wieder T., Gerstberger R., Cohen P., Yun C.C., Bindels R.J., Lang F.
    Cell. Physiol. Biochem. 14:203-212(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF TRPV5.
  17. "Peroxisomal targeting as a tool for assaying protein-protein interactions in the living cell: cytokine-independent survival kinase (CISK) binds PDK-1 in vivo in a phosphorylation-dependent manner."
    Nilsen T., Slagsvold T., Skjerpen C.S., Brech A., Stenmark H., Olsnes S.
    J. Biol. Chem. 279:4794-4801(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PDPK1, PHOSPHORYLATION BY PDPK1.
  18. "Regulation of the voltage gated K+ channel Kv1.3 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid inducible kinase SGK1."
    Henke G., Maier G., Wallisch S., Boehmer C., Lang F.
    J. Cell. Physiol. 199:194-199(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF KCNA3/KV1.3.
  19. "Regulation of CLC-Ka/barttin by the ubiquitin ligase Nedd4-2 and the serum- and glucocorticoid-dependent kinases."
    Embark H.M., Boehmer C., Palmada M., Rajamanickam J., Wyatt A.W., Wallisch S., Capasso G., Waldegger P., Seyberth H.W., Waldegger S., Lang F.
    Kidney Int. 66:1918-1925(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF BSND.
  20. "The serine/threonine kinases SGK1, 3 and PKB stimulate the amino acid transporter ASCT2."
    Palmada M., Speil A., Jeyaraj S., Boehmer C., Lang F.
    Biochem. Biophys. Res. Commun. 331:272-277(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC1A5/ASCT2.
  21. "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3."
    Boehmer C., Rajamanickam J., Schniepp R., Kohler K., Wulff P., Kuhl D., Palmada M., Lang F.
    Biochem. Biophys. Res. Commun. 329:738-742(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC1A7/EAAT5.
  22. "Stimulation of the creatine transporter SLC6A8 by the protein kinases SGK1 and SGK3."
    Shojaiefard M., Christie D.L., Lang F.
    Biochem. Biophys. Res. Commun. 334:742-746(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC6A8.
  23. "Upregulation of HERG channels by the serum and glucocorticoid inducible kinase isoform SGK3."
    Maier G., Palmada M., Rajamanickam J., Shumilina E., Boehmer C., Lang F.
    Cell. Physiol. Biochem. 18:177-186(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF KCNH2/HERG.
  24. "CISK attenuates degradation of the chemokine receptor CXCR4 via the ubiquitin ligase AIP4."
    Slagsvold T., Marchese A., Brech A., Stenmark H.
    EMBO J. 25:3738-3749(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ITHC/AIP4, PHOSPHORYLATION AT SER-486.
  25. "Role of the Phox homology domain and phosphorylation in activation of serum and glucocorticoid-regulated kinase-3."
    Tessier M., Woodgett J.R.
    J. Biol. Chem. 281:23978-23989(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT THR-320 AND SER-486, MUTAGENESIS OF ARG-90 AND LYS-191.
  26. "Regulation of the epithelial calcium channel TRPV6 by the serum and glucocorticoid-inducible kinase isoforms SGK1 and SGK3."
    Boehmer C., Palmada M., Kenngott C., Lindner R., Klaus F., Laufer J., Lang F.
    FEBS Lett. 581:5586-5590(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF TRPV6.
  27. "Identification of Flightless-I as a substrate of the cytokine-independent survival kinase CISK."
    Xu J., Liao L., Qin J., Xu J., Liu D., Songyang Z.
    J. Biol. Chem. 284:14377-14385(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PHOSPHORYLATION OF FLII, INTERACTION WITH FLII.
  28. "The serum and glucocorticoid inducible kinases SGK1-3 stimulate the neutral amino acid transporter SLC6A19."
    Boehmer C., Sopjani M., Klaus F., Lindner R., Laufer J., Jeyaraj S., Lang F., Palmada M.
    Cell. Physiol. Biochem. 25:723-732(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC6A19.
  29. "Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids."
    He P., Lee S.J., Lin S., Seidler U., Lang F., Fejes-Toth G., Naray-Fejes-Toth A., Yun C.C.
    Mol. Biol. Cell 22:3812-3825(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN REGULATION OF SLC9A3/NHE3, SUBCELLULAR LOCATION.
  30. "SGK3 is an estrogen-inducible kinase promoting estrogen-mediated survival of breast cancer cells."
    Wang Y., Zhou D., Phung S., Masri S., Smith D., Chen S.
    Mol. Endocrinol. 25:72-82(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.
  31. "Sgk kinases and their role in epithelial transport."
    Loffing J., Flores S.Y., Staub O.
    Annu. Rev. Physiol. 68:461-490(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  32. Cited for: REVIEW ON FUNCTION.
  33. Cited for: VARIANT [LARGE SCALE ANALYSIS] VAL-92.
  34. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-355.

Entry informationi

Entry nameiSGK3_HUMAN
AccessioniPrimary (citable) accession number: Q96BR1
Secondary accession number(s): A8K5W3
, B3KQC2, Q9P1Q7, Q9UKG5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2003
Last sequence update: December 1, 2001
Last modified: September 3, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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