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Protein

Coiled-coil domain-containing protein 127

Gene

CCDC127

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 127
Gene namesi
Name:CCDC127
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:30520. CCDC127.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162381297.

Polymorphism and mutation databases

BioMutaiCCDC127.
DMDMi74731264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 260260Coiled-coil domain-containing protein 127PRO_0000263750Add
BLAST

Proteomic databases

EPDiQ96BQ5.
MaxQBiQ96BQ5.
PaxDbiQ96BQ5.
PeptideAtlasiQ96BQ5.
PRIDEiQ96BQ5.

PTM databases

iPTMnetiQ96BQ5.
PhosphoSiteiQ96BQ5.

Expressioni

Gene expression databases

BgeeiQ96BQ5.
CleanExiHS_CCDC127.
ExpressionAtlasiQ96BQ5. baseline and differential.
GenevisibleiQ96BQ5. HS.

Organism-specific databases

HPAiHPA045052.

Interactioni

Protein-protein interaction databases

BioGridi126379. 8 interactions.
IntActiQ96BQ5. 8 interactions.
MINTiMINT-1198594.
STRINGi9606.ENSP00000296824.

Structurei

3D structure databases

ProteinModelPortaliQ96BQ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili49 – 13587Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IE2N. Eukaryota.
ENOG410ZQ95. LUCA.
GeneTreeiENSGT00390000008818.
HOGENOMiHOG000111384.
HOVERGENiHBG054382.
InParanoidiQ96BQ5.
OMAiYLKYWEL.
OrthoDBiEOG7288S9.
PhylomeDBiQ96BQ5.
TreeFamiTF331099.

Sequencei

Sequence statusi: Complete.

Q96BQ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLNDPPNW NIRPNSRADG GDGSRWNYAL LVPMLGLAAF RWIWSRESQK
60 70 80 90 100
EVEKEREAYR RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA
110 120 130 140 150
SYREALISQG RKLVEEKKLL EQERAQVMQE KRQVQPLRSA YLSCLQREEN
160 170 180 190 200
WQRRARLLLK EFEAVLTERQ NIYCSLFLPR SKRLEIEKSL LVRASVDPVA
210 220 230 240 250
ADLEMAAGLT DIFQHDTYCG DVWNTNKRQN GRLMWLYLKY WELVVELKKF
260
KRVEEAILEK
Length:260
Mass (Da):30,834
Last modified:December 1, 2001 - v1
Checksum:i5BA395FB63A94824
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601R → H.
Corresponds to variant rs11557427 [ dbSNP | Ensembl ].
VAR_050737

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098567 mRNA. Translation: BAC05336.1.
BC015349 mRNA. Translation: AAH15349.1.
CCDSiCCDS3852.1.
RefSeqiNP_660308.1. NM_145265.2.
UniGeneiHs.294145.

Genome annotation databases

EnsembliENST00000296824; ENSP00000296824; ENSG00000164366.
GeneIDi133957.
KEGGihsa:133957.
UCSCiuc003jam.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK098567 mRNA. Translation: BAC05336.1.
BC015349 mRNA. Translation: AAH15349.1.
CCDSiCCDS3852.1.
RefSeqiNP_660308.1. NM_145265.2.
UniGeneiHs.294145.

3D structure databases

ProteinModelPortaliQ96BQ5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126379. 8 interactions.
IntActiQ96BQ5. 8 interactions.
MINTiMINT-1198594.
STRINGi9606.ENSP00000296824.

PTM databases

iPTMnetiQ96BQ5.
PhosphoSiteiQ96BQ5.

Polymorphism and mutation databases

BioMutaiCCDC127.
DMDMi74731264.

Proteomic databases

EPDiQ96BQ5.
MaxQBiQ96BQ5.
PaxDbiQ96BQ5.
PeptideAtlasiQ96BQ5.
PRIDEiQ96BQ5.

Protocols and materials databases

DNASUi133957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296824; ENSP00000296824; ENSG00000164366.
GeneIDi133957.
KEGGihsa:133957.
UCSCiuc003jam.2. human.

Organism-specific databases

CTDi133957.
GeneCardsiCCDC127.
HGNCiHGNC:30520. CCDC127.
HPAiHPA045052.
neXtProtiNX_Q96BQ5.
PharmGKBiPA162381297.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE2N. Eukaryota.
ENOG410ZQ95. LUCA.
GeneTreeiENSGT00390000008818.
HOGENOMiHOG000111384.
HOVERGENiHBG054382.
InParanoidiQ96BQ5.
OMAiYLKYWEL.
OrthoDBiEOG7288S9.
PhylomeDBiQ96BQ5.
TreeFamiTF331099.

Miscellaneous databases

GenomeRNAii133957.
PROiQ96BQ5.

Gene expression databases

BgeeiQ96BQ5.
CleanExiHS_CCDC127.
ExpressionAtlasiQ96BQ5. baseline and differential.
GenevisibleiQ96BQ5. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCC127_HUMAN
AccessioniPrimary (citable) accession number: Q96BQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.