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Protein

Tripartite motif-containing protein 43

Gene

TRIM43

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 43
Gene namesi
Name:TRIM43
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:19015. TRIM43.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134936799.

Polymorphism and mutation databases

BioMutaiTRIM43.
DMDMi56404939.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446Tripartite motif-containing protein 43PRO_0000056265Add
BLAST

Proteomic databases

PaxDbiQ96BQ3.
PRIDEiQ96BQ3.

Expressioni

Gene expression databases

BgeeiQ96BQ3.
CleanExiHS_TRIM43.
GenevisibleiQ96BQ3. HS.

Organism-specific databases

HPAiHPA042223.
HPA042772.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ENOX1Q8TC923EBI-2129899,EBI-713221

Protein-protein interaction databases

BioGridi126213. 10 interactions.
IntActiQ96BQ3. 12 interactions.
STRINGi9606.ENSP00000272395.

Structurei

3D structure databases

ProteinModelPortaliQ96BQ3.
SMRiQ96BQ3. Positions 9-55, 93-260, 285-444.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini269 – 446178B30.2/SPRYPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili129 – 15830Sequence AnalysisAdd
BLAST
Coiled coili190 – 22031Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiNOG260903.
GeneTreeiENSGT00790000122982.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiQ96BQ3.
KOiK12019.
OMAiNSCDWAL.
OrthoDBiEOG7MD4Q8.
PhylomeDBiQ96BQ3.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA
60 70 80 90 100
NCPACREPSP KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK
110 120 130 140 150
KMFCDMDKSL LCLLCSNSQE HGAHKHHPIE EAAEEHREKL LKQMRILWKK
160 170 180 190 200
IQENQRNLYE EGRTAFLWRG NVVLRAQMIR NEYRKLHPVL HKEEKQHLER
210 220 230 240 250
LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP DVELLQDLGD
260 270 280 290 300
IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI
310 320 330 340 350
RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA
360 370 380 390 400
LGVCNNSWIR KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL
410 420 430 440
GRVGVFLDFE SGSVSFLNVT KSSLIWSYPA GSLTFPVRPF FYTGHR
Length:446
Mass (Da):52,265
Last modified:December 1, 2001 - v1
Checksum:i805E4AA25617724A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009237 Genomic DNA. Translation: AAY14782.1.
BC015353 mRNA. Translation: AAH15353.1.
CCDSiCCDS2015.1.
RefSeqiNP_620155.1. NM_138800.1.
XP_006712325.1. XM_006712262.1.
XP_011508890.1. XM_011510588.1.
UniGeneiHs.232026.

Genome annotation databases

EnsembliENST00000272395; ENSP00000272395; ENSG00000144015.
GeneIDi129868.
KEGGihsa:129868.
UCSCiuc002suv.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009237 Genomic DNA. Translation: AAY14782.1.
BC015353 mRNA. Translation: AAH15353.1.
CCDSiCCDS2015.1.
RefSeqiNP_620155.1. NM_138800.1.
XP_006712325.1. XM_006712262.1.
XP_011508890.1. XM_011510588.1.
UniGeneiHs.232026.

3D structure databases

ProteinModelPortaliQ96BQ3.
SMRiQ96BQ3. Positions 9-55, 93-260, 285-444.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126213. 10 interactions.
IntActiQ96BQ3. 12 interactions.
STRINGi9606.ENSP00000272395.

Polymorphism and mutation databases

BioMutaiTRIM43.
DMDMi56404939.

Proteomic databases

PaxDbiQ96BQ3.
PRIDEiQ96BQ3.

Protocols and materials databases

DNASUi129868.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272395; ENSP00000272395; ENSG00000144015.
GeneIDi129868.
KEGGihsa:129868.
UCSCiuc002suv.3. human.

Organism-specific databases

CTDi129868.
GeneCardsiGC02P096257.
HGNCiHGNC:19015. TRIM43.
HPAiHPA042223.
HPA042772.
neXtProtiNX_Q96BQ3.
PharmGKBiPA134936799.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG260903.
GeneTreeiENSGT00790000122982.
HOGENOMiHOG000234135.
HOVERGENiHBG108727.
InParanoidiQ96BQ3.
KOiK12019.
OMAiNSCDWAL.
OrthoDBiEOG7MD4Q8.
PhylomeDBiQ96BQ3.
TreeFamiTF338674.

Miscellaneous databases

ChiTaRSiTRIM43. human.
GenomeRNAii129868.
NextBioi82658.
PROiQ96BQ3.

Gene expression databases

BgeeiQ96BQ3.
CleanExiHS_TRIM43.
GenevisibleiQ96BQ3. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTRI43_HUMAN
AccessioniPrimary (citable) accession number: Q96BQ3
Secondary accession number(s): Q53TJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: July 22, 2015
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.