Q96BQ3 (TRI43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Tripartite motif-containing protein 43

Gene names

Name:

TRIM43

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	446 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family. Contains 1 B box-type zinc finger. Contains 1 B30.2/SPRY domain. Contains 1 RING-type zinc finger.

Ontologies

Keywords
Domain	Coiled coil Zinc-finger
Ligand	Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular_function	zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 446	446	Tripartite motif-containing protein 43		PRO_0000056265
Regions
	Domain	269 – 446	178	B30.2/SPRY
	Zinc finger	15 – 56	42	RING-type
	Zinc finger	88 – 129	42	B box-type
	Coiled coil	129 – 158	30	Potential
	Coiled coil	190 – 220	31	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q96BQ3 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 805E4AA25617724A	FASTA	446	52,265
	10 20 30 40 50 60 MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP 70 80 90 100 110 120 KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE 130 140 150 160 170 180 HGAHKHHPIE EAAEEHREKL LKQMRILWKK IQENQRNLYE EGRTAFLWRG NVVLRAQMIR 190 200 210 220 230 240 NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP 250 260 270 280 290 300 DVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI 310 320 330 340 350 360 RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR 370 380 390 400 410 420 KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT 430 440 KSSLIWSYPA GSLTFPVRPF FYTGHR

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009237 Genomic DNA. Translation: AAY14782.1. BC015353 mRNA. Translation: AAH15353.1.
IPI	IPI00334320.
RefSeq	NP_620155.1. NM_138800.1.
UniGene	Hs.232026.
3D structure databases
ProteinModelPortal	Q96BQ3.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BQ3. 9 interactions.
Polymorphism databases
DMDM	56404939.
Proteomic databases
PaxDb	Q96BQ3.
PRIDE	Q96BQ3.
Protocols and materials databases
DNASU	129868.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000272395; ENSP00000272395; ENSG00000144015.
GeneID	129868.
KEGG	hsa:129868.
UCSC	uc002suv.3. human.
Organism-specific databases
CTD	129868.
GeneCards	GC02P096257.
HGNC	HGNC:19015. TRIM43.
HPA	HPA042223.
neXtProt	NX_Q96BQ3.
PharmGKB	PA134936799.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG260903.
HOGENOM	HOG000234135.
HOVERGEN	HBG108727.
InParanoid	Q96BQ3.
KO	K12019.
OMA	WSYPAGS.
PhylomeDB	Q96BQ3.
Gene expression databases
Bgee	Q96BQ3.
CleanEx	HS_TRIM43.
Genevestigator	Q96BQ3.
GermOnline	ENSG00000144015. Homo sapiens.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR001870. B30.2/SPRY. IPR003879. Butyrophylin. IPR008985. ConA-like_lec_gl_sf. IPR003877. SPRY_rcpt. IPR000315. Znf_B-box. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF00622. SPRY. 1 hit. [Graphical view]
PRINTS	PR01407. BUTYPHLNCDUF.
SMART	SM00336. BBOX. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS50188. B302_SPRY. 1 hit. PS50119. ZF_BBOX. 1 hit. PS00518. ZF_RING_1. 1 hit. PS50089. ZF_RING_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	129868.
NextBio	82658.

Entry information

Entry name

TRI43_HUMAN

Accession

Primary (citable) accession number: Q96BQ3
Secondary accession number(s): Q53TJ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 7, 2004
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.