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Q96BQ3 (TRI43_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripartite motif-containing protein 43
Gene names
Name:TRIM43
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the TRIM/RBCC family.

Contains 1 B box-type zinc finger.

Contains 1 B30.2/SPRY domain.

Contains 1 RING-type zinc finger.

Ontologies

Keywords
   DomainCoiled coil
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular_functionzinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Tripartite motif-containing protein 43
PRO_0000056265

Regions

Domain269 – 446178B30.2/SPRY
Zinc finger15 – 5642RING-type
Zinc finger88 – 12942B box-type
Coiled coil129 – 15830 Potential
Coiled coil190 – 22031 Potential

Sequences

Sequence LengthMass (Da)Tools
Q96BQ3 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: 805E4AA25617724A

FASTA44652,265
        10         20         30         40         50         60 
MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA NCPACREPSP 

        70         80         90        100        110        120 
KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK KMFCDMDKSL LCLLCSNSQE 

       130        140        150        160        170        180 
HGAHKHHPIE EAAEEHREKL LKQMRILWKK IQENQRNLYE EGRTAFLWRG NVVLRAQMIR 

       190        200        210        220        230        240 
NEYRKLHPVL HKEEKQHLER LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP 

       250        260        270        280        290        300 
DVELLQDLGD IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI 

       310        320        330        340        350        360 
RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA LGVCNNSWIR 

       370        380        390        400        410        420 
KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL GRVGVFLDFE SGSVSFLNVT 

       430        440 
KSSLIWSYPA GSLTFPVRPF FYTGHR 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009237 Genomic DNA. Translation: AAY14782.1.
BC015353 mRNA. Translation: AAH15353.1.
RefSeqNP_620155.1. NM_138800.1.
UniGeneHs.232026.

3D structure databases

ProteinModelPortalQ96BQ3.
SMRQ96BQ3. Positions 9-55, 91-129, 285-444.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126213. 10 interactions.
IntActQ96BQ3. 9 interactions.

Polymorphism databases

DMDM56404939.

Proteomic databases

PaxDbQ96BQ3.
PRIDEQ96BQ3.

Protocols and materials databases

DNASU129868.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000272395; ENSP00000272395; ENSG00000144015.
GeneID129868.
KEGGhsa:129868.
UCSCuc002suv.3. human.

Organism-specific databases

CTD129868.
GeneCardsGC02P096257.
HGNCHGNC:19015. TRIM43.
HPAHPA042223.
neXtProtNX_Q96BQ3.
PharmGKBPA134936799.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG260903.
HOGENOMHOG000234135.
HOVERGENHBG108727.
InParanoidQ96BQ3.
KOK12019.
OMANSCDWAL.
OrthoDBEOG7MD4Q8.
PhylomeDBQ96BQ3.
TreeFamTF338674.

Gene expression databases

BgeeQ96BQ3.
CleanExHS_TRIM43.
GenevestigatorQ96BQ3.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR008985. ConA-like_lec_gl_sf.
IPR003877. SPRY_rcpt.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF00622. SPRY. 1 hit.
[Graphical view]
PRINTSPR01407. BUTYPHLNCDUF.
SMARTSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi129868.
NextBio82658.
PROQ96BQ3.

Entry information

Entry nameTRI43_HUMAN
AccessionPrimary (citable) accession number: Q96BQ3
Secondary accession number(s): Q53TJ7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: December 1, 2001
Last modified: March 19, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM