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Q96BQ3

- TRI43_HUMAN

UniProt

Q96BQ3 - TRI43_HUMAN

Protein

Tripartite motif-containing protein 43

Gene

TRIM43

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tripartite motif-containing protein 43
    Gene namesi
    Name:TRIM43
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:19015. TRIM43.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134936799.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 446446Tripartite motif-containing protein 43PRO_0000056265Add
    BLAST

    Proteomic databases

    PaxDbiQ96BQ3.
    PRIDEiQ96BQ3.

    Expressioni

    Gene expression databases

    BgeeiQ96BQ3.
    CleanExiHS_TRIM43.
    GenevestigatoriQ96BQ3.

    Organism-specific databases

    HPAiHPA042223.

    Interactioni

    Protein-protein interaction databases

    BioGridi126213. 10 interactions.
    IntActiQ96BQ3. 11 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BQ3.
    SMRiQ96BQ3. Positions 9-55, 285-444.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini269 – 446178B30.2/SPRYPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili129 – 15830Sequence AnalysisAdd
    BLAST
    Coiled coili190 – 22031Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRIM/RBCC family.Curated
    Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
    Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
    Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri15 – 5642RING-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri88 – 12942B box-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Coiled coil, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG260903.
    HOGENOMiHOG000234135.
    HOVERGENiHBG108727.
    InParanoidiQ96BQ3.
    KOiK12019.
    OMAiNSCDWAL.
    OrthoDBiEOG7MD4Q8.
    PhylomeDBiQ96BQ3.
    TreeFamiTF338674.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProiIPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF00622. SPRY. 1 hit.
    [Graphical view]
    PRINTSiPR01407. BUTYPHLNCDUF.
    SMARTiSM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96BQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSDFSHAFQ KELTCVICLN YLVDPVTICC GHSFCRPCLC LSWEEAQSPA    50
    NCPACREPSP KMDFKTNILL KNLVTIARKA SLWQFLSSEK QICGTHRQTK 100
    KMFCDMDKSL LCLLCSNSQE HGAHKHHPIE EAAEEHREKL LKQMRILWKK 150
    IQENQRNLYE EGRTAFLWRG NVVLRAQMIR NEYRKLHPVL HKEEKQHLER 200
    LNKEYQEIFQ QLQRSWVKMD QKSKHLKEMY QELMEMCHKP DVELLQDLGD 250
    IVARSESVLL HMPQPVNPEL TAGPITGLVY RLNRFRVEIS FHFEVTNHNI 300
    RLFEDVRSWM FRRGPLNSDR SDYFAAWGAR VFSFGKHYWE LDVDNSCDWA 350
    LGVCNNSWIR KNSTMVNSED IFLLLCLKVD NHFNLLTTSP VFPHYIEKPL 400
    GRVGVFLDFE SGSVSFLNVT KSSLIWSYPA GSLTFPVRPF FYTGHR 446
    Length:446
    Mass (Da):52,265
    Last modified:December 1, 2001 - v1
    Checksum:i805E4AA25617724A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009237 Genomic DNA. Translation: AAY14782.1.
    BC015353 mRNA. Translation: AAH15353.1.
    CCDSiCCDS2015.1.
    RefSeqiNP_620155.1. NM_138800.1.
    XP_006712325.1. XM_006712262.1.
    UniGeneiHs.232026.

    Genome annotation databases

    EnsembliENST00000272395; ENSP00000272395; ENSG00000144015.
    GeneIDi129868.
    KEGGihsa:129868.
    UCSCiuc002suv.3. human.

    Polymorphism databases

    DMDMi56404939.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009237 Genomic DNA. Translation: AAY14782.1 .
    BC015353 mRNA. Translation: AAH15353.1 .
    CCDSi CCDS2015.1.
    RefSeqi NP_620155.1. NM_138800.1.
    XP_006712325.1. XM_006712262.1.
    UniGenei Hs.232026.

    3D structure databases

    ProteinModelPortali Q96BQ3.
    SMRi Q96BQ3. Positions 9-55, 285-444.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126213. 10 interactions.
    IntActi Q96BQ3. 11 interactions.

    Polymorphism databases

    DMDMi 56404939.

    Proteomic databases

    PaxDbi Q96BQ3.
    PRIDEi Q96BQ3.

    Protocols and materials databases

    DNASUi 129868.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000272395 ; ENSP00000272395 ; ENSG00000144015 .
    GeneIDi 129868.
    KEGGi hsa:129868.
    UCSCi uc002suv.3. human.

    Organism-specific databases

    CTDi 129868.
    GeneCardsi GC02P096257.
    HGNCi HGNC:19015. TRIM43.
    HPAi HPA042223.
    neXtProti NX_Q96BQ3.
    PharmGKBi PA134936799.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG260903.
    HOGENOMi HOG000234135.
    HOVERGENi HBG108727.
    InParanoidi Q96BQ3.
    KOi K12019.
    OMAi NSCDWAL.
    OrthoDBi EOG7MD4Q8.
    PhylomeDBi Q96BQ3.
    TreeFami TF338674.

    Miscellaneous databases

    GenomeRNAii 129868.
    NextBioi 82658.
    PROi Q96BQ3.

    Gene expression databases

    Bgeei Q96BQ3.
    CleanExi HS_TRIM43.
    Genevestigatori Q96BQ3.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    4.10.45.10. 1 hit.
    InterProi IPR001870. B30.2/SPRY.
    IPR003879. Butyrophylin.
    IPR008985. ConA-like_lec_gl_sf.
    IPR003877. SPRY_rcpt.
    IPR000315. Znf_B-box.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF00622. SPRY. 1 hit.
    [Graphical view ]
    PRINTSi PR01407. BUTYPHLNCDUF.
    SMARTi SM00336. BBOX. 1 hit.
    SM00184. RING. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS50188. B302_SPRY. 1 hit.
    PS50119. ZF_BBOX. 1 hit.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTRI43_HUMAN
    AccessioniPrimary (citable) accession number: Q96BQ3
    Secondary accession number(s): Q53TJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3