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Protein

Protein FAM3D

Gene

FAM3D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

GO - Biological processi

  • negative regulation of insulin secretion Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM3D
Gene namesi
Name:FAM3D
ORF Names:UNQ567/PRO1130
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:18665. FAM3D.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38628.

Polymorphism and mutation databases

BioMutaiFAM3D.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 224199Protein FAM3DPRO_0000008754Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 83By similarity
Disulfide bondi61 ↔ 218By similarity
Glycosylationi107 – 1071N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96BQ1.
PRIDEiQ96BQ1.

PTM databases

iPTMnetiQ96BQ1.
PhosphoSiteiQ96BQ1.

Expressioni

Tissue specificityi

Abundantly expressed in placenta and weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiQ96BQ1.
CleanExiHS_FAM3D.
ExpressionAtlasiQ96BQ1. baseline and differential.
GenevisibleiQ96BQ1. HS.

Organism-specific databases

HPAiHPA013844.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: UniProtKB

Protein-protein interaction databases

BioGridi126274. 1 interaction.
STRINGi9606.ENSP00000351632.

Structurei

3D structure databases

ProteinModelPortaliQ96BQ1.
SMRiQ96BQ1. Positions 51-220.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IJP8. Eukaryota.
ENOG410Y9GG. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ96BQ1.
OMAiKSKSPFE.
OrthoDBiEOG79PJQG.
PhylomeDBiQ96BQ1.
TreeFamiTF353414.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVSGVLRLL ALIFAIVTTW MFIRSYMSFS MKTIRLPRWL AASPTKEIQV
60 70 80 90 100
KKYKCGLIKP CPANYFAFKI CSGAANVVGP TMCFEDRMIM SPVKNNVGRG
110 120 130 140 150
LNIALVNGTT GAVLGQKAFD MYSGDVMHLV KFLKEIPGGA LVLVASYDDP
160 170 180 190 200
GTKMNDESRK LFSDLGSSYA KQLGFRDSWV FIGAKDLRGK SPFEQFLKNS
210 220
PDTNKYEGWP ELLEMEGCMP PKPF
Length:224
Mass (Da):24,963
Last modified:December 1, 2001 - v1
Checksum:i153E81C21F193551
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601P → S.
Corresponds to variant rs17059569 [ dbSNP | Ensembl ].
VAR_053087
Natural varianti118 – 1181A → S.
Corresponds to variant rs33966924 [ dbSNP | Ensembl ].
VAR_053088

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494381 mRNA. Translation: AAM94282.1.
AY358677 mRNA. Translation: AAQ89040.1.
AK127546 mRNA. Translation: BAG54521.1.
CH471055 Genomic DNA. Translation: EAW65382.1.
BC015359 mRNA. Translation: AAH15359.1.
CCDSiCCDS2893.1.
RefSeqiNP_620160.1. NM_138805.2.
XP_005264919.1. XM_005264862.3.
XP_006713028.1. XM_006712965.2.
XP_011531653.1. XM_011533351.1.
UniGeneiHs.61265.

Genome annotation databases

EnsembliENST00000358781; ENSP00000351632; ENSG00000198643.
GeneIDi131177.
KEGGihsa:131177.
UCSCiuc003dkq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF494381 mRNA. Translation: AAM94282.1.
AY358677 mRNA. Translation: AAQ89040.1.
AK127546 mRNA. Translation: BAG54521.1.
CH471055 Genomic DNA. Translation: EAW65382.1.
BC015359 mRNA. Translation: AAH15359.1.
CCDSiCCDS2893.1.
RefSeqiNP_620160.1. NM_138805.2.
XP_005264919.1. XM_005264862.3.
XP_006713028.1. XM_006712965.2.
XP_011531653.1. XM_011533351.1.
UniGeneiHs.61265.

3D structure databases

ProteinModelPortaliQ96BQ1.
SMRiQ96BQ1. Positions 51-220.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126274. 1 interaction.
STRINGi9606.ENSP00000351632.

PTM databases

iPTMnetiQ96BQ1.
PhosphoSiteiQ96BQ1.

Polymorphism and mutation databases

BioMutaiFAM3D.

Proteomic databases

PaxDbiQ96BQ1.
PRIDEiQ96BQ1.

Protocols and materials databases

DNASUi131177.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358781; ENSP00000351632; ENSG00000198643.
GeneIDi131177.
KEGGihsa:131177.
UCSCiuc003dkq.4. human.

Organism-specific databases

CTDi131177.
GeneCardsiFAM3D.
HGNCiHGNC:18665. FAM3D.
HPAiHPA013844.
MIMi608619. gene.
neXtProtiNX_Q96BQ1.
PharmGKBiPA38628.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJP8. Eukaryota.
ENOG410Y9GG. LUCA.
GeneTreeiENSGT00530000063020.
HOGENOMiHOG000285992.
HOVERGENiHBG051544.
InParanoidiQ96BQ1.
OMAiKSKSPFE.
OrthoDBiEOG79PJQG.
PhylomeDBiQ96BQ1.
TreeFamiTF353414.

Miscellaneous databases

ChiTaRSiFAM3D. human.
GenomeRNAii131177.
NextBioi82885.
PROiQ96BQ1.
SOURCEiSearch...

Gene expression databases

BgeeiQ96BQ1.
CleanExiHS_FAM3D.
ExpressionAtlasiQ96BQ1. baseline and differential.
GenevisibleiQ96BQ1. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-107.
    Tissue: Saliva.

Entry informationi

Entry nameiFAM3D_HUMAN
AccessioniPrimary (citable) accession number: Q96BQ1
Secondary accession number(s): Q547G2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.