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Q96BP3

- PPWD1_HUMAN

UniProt

Q96BP3 - PPWD1_HUMAN

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Protein

Peptidylprolyl isomerase domain and WD repeat-containing protein 1

Gene

PPWD1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Putative peptidylprolyl isomerase (PPIase). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. mRNA splicing, via spliceosome Source: UniProtKB
  2. protein folding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Keywords - Biological processi

mRNA processing, mRNA splicing

Enzyme and pathway databases

SignaLinkiQ96BP3.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (EC:5.2.1.8)
Alternative name(s):
Spliceosome-associated cyclophilin
Gene namesi
Name:PPWD1
Synonyms:KIAA0073
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:28954. PPWD1.

Subcellular locationi

Nucleus 1 Publication
Note: Associated with spliceosomal complexes.

GO - Cellular componenti

  1. catalytic step 2 spliceosome Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671149.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 646645Peptidylprolyl isomerase domain and WD repeat-containing protein 1PRO_0000240306Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ96BP3.
PaxDbiQ96BP3.
PeptideAtlasiQ96BP3.
PRIDEiQ96BP3.

PTM databases

PhosphoSiteiQ96BP3.

Expressioni

Gene expression databases

BgeeiQ96BP3.
CleanExiHS_PPWD1.
ExpressionAtlasiQ96BP3. baseline and differential.
GenevestigatoriQ96BP3.

Organism-specific databases

HPAiHPA019353.
HPA019360.

Interactioni

Subunit structurei

Identified in the spliceosome C complex.1 Publication

Protein-protein interaction databases

BioGridi116971. 2 interactions.
IntActiQ96BP3. 4 interactions.
MINTiMINT-2813736.
STRINGi9606.ENSP00000261308.

Structurei

Secondary structure

1
646
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi492 – 4987
Beta strandi501 – 5077
Turni509 – 5113
Helixi513 – 52412
Turni525 – 5306
Beta strandi535 – 5373
Turni538 – 5403
Beta strandi541 – 5444
Beta strandi549 – 5524
Beta strandi574 – 5807
Beta strandi592 – 5976
Helixi600 – 6023
Turni603 – 6053
Beta strandi608 – 6147
Helixi616 – 6238
Turni629 – 6313
Beta strandi634 – 6363
Beta strandi639 – 6457

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A2NX-ray1.65A/B/C473-646[»]
ProteinModelPortaliQ96BP3.
SMRiQ96BP3. Positions 88-318, 357-392, 482-646.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96BP3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati88 – 12639WD 1Add
BLAST
Repeati131 – 17040WD 2Add
BLAST
Repeati221 – 26040WD 3Add
BLAST
Repeati278 – 31942WD 4Add
BLAST
Domaini490 – 645156PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 176Poly-Arg

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation
Contains 4 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00760000119072.
HOGENOMiHOG000213214.
HOVERGENiHBG079869.
InParanoidiQ96BP3.
KOiK12736.
OMAiRFYMFTN.
OrthoDBiEOG7M98FR.
PhylomeDBiQ96BP3.
TreeFamiTF105686.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
PRINTSiPR00153. CSAPPISMRASE.
SMARTiSM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96BP3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAESGSDFQ QRRRRRRDPE EPEKTELSER ELAVAVAVSQ ENDEENEERW
60 70 80 90 100
VGPLPVEATL AKKRKVLEFE RVYLDNLPSA SMYERSYMHR DVITHVVCTK
110 120 130 140 150
TDFIITASHD GHVKFWKKIE EGIEFVKHFR SHLGVIESIA VSSEGALFCS
160 170 180 190 200
VGDDKAMKVF DVVNFDMINM LKLGYFPGQC EWIYCPGDAI SSVAASEKST
210 220 230 240 250
GKIFIYDGRG DNQPLHIFDK LHTSPLTQIR LNPVYKAVVS SDKSGMIEYW
260 270 280 290 300
TGPPHEYKFP KNVNWEYKTD TDLYEFAKCK AYPTSVCFSP DGKKIATIGS
310 320 330 340 350
DRKVRIFRFV TGKLMRVFDE SLSMFTELQQ MRQQLPDMEF GRRMAVEREL
360 370 380 390 400
EKVDAVRLIN IVFDETGHFV LYGTMLGIKV INVETNRCVR ILGKQENIRV
410 420 430 440 450
MQLALFQGIA KKHRAATTIE MKASENPVLQ NIQADPTIVC TSFKKNRFYM
460 470 480 490 500
FTKREPEDTK SADSDRDVFN EKPSKEEVMA ATQAEGPKRV SDSAIIHTSM
510 520 530 540 550
GDIHTKLFPV ECPKTVENFC VHSRNGYYNG HTFHRIIKGF MIQTGDPTGT
560 570 580 590 600
GMGGESIWGG EFEDEFHSTL RHDRPYTLSM ANAGSNTNGS QFFITVVPTP
610 620 630 640
WLDNKHTVFG RVTKGMEVVQ RISNVKVNPK TDKPYEDVSI INITVK
Length:646
Mass (Da):73,575
Last modified:December 1, 2001 - v1
Checksum:i4DEFA1C78F914430
GO
Isoform 2 (identifier: Q96BP3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-156: Missing.

Note: No experimental confirmation available.

Show »
Length:490
Mass (Da):55,700
Checksum:iD82E40743B31C263
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 156156Missing in isoform 2. 1 PublicationVSP_055266Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK301654 mRNA. Translation: BAG63131.1.
AC008560 Genomic DNA. No translation available.
BC015385 mRNA. Translation: AAH15385.1.
D38552 mRNA. Translation: BAA07555.1.
CCDSiCCDS3985.1. [Q96BP3-1]
CCDS64162.1. [Q96BP3-2]
RefSeqiNP_001265855.1. NM_001278926.1.
NP_001265856.1. NM_001278927.1.
NP_001265858.1. NM_001278929.1. [Q96BP3-2]
NP_056157.1. NM_015342.3. [Q96BP3-1]
UniGeneiHs.121432.

Genome annotation databases

EnsembliENST00000261308; ENSP00000261308; ENSG00000113593. [Q96BP3-1]
ENST00000538977; ENSP00000444496; ENSG00000113593. [Q96BP3-2]
GeneIDi23398.
KEGGihsa:23398.
UCSCiuc003jtv.5. human. [Q96BP3-1]

Polymorphism databases

DMDMi74760739.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK301654 mRNA. Translation: BAG63131.1 .
AC008560 Genomic DNA. No translation available.
BC015385 mRNA. Translation: AAH15385.1 .
D38552 mRNA. Translation: BAA07555.1 .
CCDSi CCDS3985.1. [Q96BP3-1 ]
CCDS64162.1. [Q96BP3-2 ]
RefSeqi NP_001265855.1. NM_001278926.1.
NP_001265856.1. NM_001278927.1.
NP_001265858.1. NM_001278929.1. [Q96BP3-2 ]
NP_056157.1. NM_015342.3. [Q96BP3-1 ]
UniGenei Hs.121432.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A2N X-ray 1.65 A/B/C 473-646 [» ]
ProteinModelPortali Q96BP3.
SMRi Q96BP3. Positions 88-318, 357-392, 482-646.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116971. 2 interactions.
IntActi Q96BP3. 4 interactions.
MINTi MINT-2813736.
STRINGi 9606.ENSP00000261308.

PTM databases

PhosphoSitei Q96BP3.

Polymorphism databases

DMDMi 74760739.

Proteomic databases

MaxQBi Q96BP3.
PaxDbi Q96BP3.
PeptideAtlasi Q96BP3.
PRIDEi Q96BP3.

Protocols and materials databases

DNASUi 23398.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261308 ; ENSP00000261308 ; ENSG00000113593 . [Q96BP3-1 ]
ENST00000538977 ; ENSP00000444496 ; ENSG00000113593 . [Q96BP3-2 ]
GeneIDi 23398.
KEGGi hsa:23398.
UCSCi uc003jtv.5. human. [Q96BP3-1 ]

Organism-specific databases

CTDi 23398.
GeneCardsi GC05P064859.
HGNCi HGNC:28954. PPWD1.
HPAi HPA019353.
HPA019360.
neXtProti NX_Q96BP3.
PharmGKBi PA142671149.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00760000119072.
HOGENOMi HOG000213214.
HOVERGENi HBG079869.
InParanoidi Q96BP3.
KOi K12736.
OMAi RFYMFTN.
OrthoDBi EOG7M98FR.
PhylomeDBi Q96BP3.
TreeFami TF105686.

Enzyme and pathway databases

SignaLinki Q96BP3.

Miscellaneous databases

EvolutionaryTracei Q96BP3.
GenomeRNAii 23398.
NextBioi 35475797.
PROi Q96BP3.

Gene expression databases

Bgeei Q96BP3.
CleanExi HS_PPWD1.
ExpressionAtlasi Q96BP3. baseline and differential.
Genevestigatori Q96BP3.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
2.40.100.10. 1 hit.
InterProi IPR029000. Cyclophilin-like_dom.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00160. Pro_isomerase. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
PRINTSi PR00153. CSAPPISMRASE.
SMARTi SM00320. WD40. 4 hits.
[Graphical view ]
SUPFAMi SSF50891. SSF50891. 1 hit.
SSF50978. SSF50978. 3 hits.
PROSITEi PS50072. CSA_PPIASE_2. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Esophagus.
  2. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone.
  4. "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1."
    Nomura N., Nagase T., Miyajima N., Sazuka T., Tanaka A., Sato S., Seki N., Kawarabayasi Y., Ishikawa K., Tabata S.
    DNA Res. 1:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-646 (ISOFORM 1).
    Tissue: Bone marrow.
  5. "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
    Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
    RNA 8:426-439(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPLICEOSOMAL C COMPLEX.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. "The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1)."
    Davis T.L., Walker J.R., Ouyang H., MacKenzie F., Butler-Cole C., Newman E.M., Eisenmesser E.Z., Dhe-Paganon S.
    FEBS J. 275:2283-2295(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 473-646, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPPWD1_HUMAN
AccessioniPrimary (citable) accession number: Q96BP3
Secondary accession number(s): B4DWR9, Q15002, Q7KZ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: December 1, 2001
Last modified: October 29, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3