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Protein

Coiled-coil-helix-coiled-coil-helix domain-containing protein 1

Gene

CHCHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172586-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Alternative name(s):
28S ribosomal protein S37, mitochondrial
Short name:
MRP-S37
Nuclear protein C2360
Gene namesi
Name:CHCHD1
Synonyms:C10orf34, MRPS37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23518. CHCHD1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi118487.
OpenTargetsiENSG00000172586.
PharmGKBiPA134964437.

Polymorphism and mutation databases

BioMutaiCHCHD1.
DMDMi62510504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291581 – 118Coiled-coil-helix-coiled-coil-helix domain-containing protein 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 76PROSITE-ProRule annotation
Disulfide bondi55 ↔ 66PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96BP2.
MaxQBiQ96BP2.
PaxDbiQ96BP2.
PeptideAtlasiQ96BP2.
PRIDEiQ96BP2.

PTM databases

iPTMnetiQ96BP2.
PhosphoSitePlusiQ96BP2.

Expressioni

Gene expression databases

BgeeiENSG00000172586.
CleanExiHS_CHCHD1.
ExpressionAtlasiQ96BP2. baseline and differential.
GenevisibleiQ96BP2. HS.

Organism-specific databases

HPAiHPA039046.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-5454898,EBI-6164309From a different organism.

Protein-protein interaction databases

BioGridi125612. 9 interactors.
IntActiQ96BP2. 3 interactors.
MINTiMINT-8051738.
STRINGi9606.ENSP00000361923.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A21-118[»]
ProteinModelPortaliQ96BP2.
SMRiQ96BP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 84CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 55Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi66 – 76Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Contains 1 CHCH (coiled coil-helix-coiled coil-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4695. Eukaryota.
ENOG410Y5R6. LUCA.
GeneTreeiENSGT00390000007683.
HOGENOMiHOG000247034.
HOVERGENiHBG050935.
InParanoidiQ96BP2.
OMAiFPNKPHL.
OrthoDBiEOG091G0YBP.
PhylomeDBiQ96BP2.
TreeFamiTF314650.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR010625. CHCH.
IPR033620. CHCHD1.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PANTHERiPTHR31278. PTHR31278. 1 hit.
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS
60 70 80 90 100
VMMACWKQNE FRDDACRKEI QGFLDCAARA QEARKMRSIQ ETLGESGSLL
110
PNKLNKLLQR FPNKPYLS
Length:118
Mass (Da):13,475
Last modified:December 1, 2001 - v1
Checksum:i98AA1C38045A1C7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015387 mRNA. Translation: AAH15387.1.
BC020852 mRNA. Translation: AAH20852.1.
CCDSiCCDS7334.1.
RefSeqiNP_976043.1. NM_203298.2.
UniGeneiHs.181174.

Genome annotation databases

EnsembliENST00000372833; ENSP00000361923; ENSG00000172586.
GeneIDi118487.
KEGGihsa:118487.
UCSCiuc001jvc.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015387 mRNA. Translation: AAH15387.1.
BC020852 mRNA. Translation: AAH20852.1.
CCDSiCCDS7334.1.
RefSeqiNP_976043.1. NM_203298.2.
UniGeneiHs.181174.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A21-118[»]
ProteinModelPortaliQ96BP2.
SMRiQ96BP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125612. 9 interactors.
IntActiQ96BP2. 3 interactors.
MINTiMINT-8051738.
STRINGi9606.ENSP00000361923.

PTM databases

iPTMnetiQ96BP2.
PhosphoSitePlusiQ96BP2.

Polymorphism and mutation databases

BioMutaiCHCHD1.
DMDMi62510504.

Proteomic databases

EPDiQ96BP2.
MaxQBiQ96BP2.
PaxDbiQ96BP2.
PeptideAtlasiQ96BP2.
PRIDEiQ96BP2.

Protocols and materials databases

DNASUi118487.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372833; ENSP00000361923; ENSG00000172586.
GeneIDi118487.
KEGGihsa:118487.
UCSCiuc001jvc.5. human.

Organism-specific databases

CTDi118487.
DisGeNETi118487.
GeneCardsiCHCHD1.
HGNCiHGNC:23518. CHCHD1.
HPAiHPA039046.
MIMi608842. gene.
neXtProtiNX_Q96BP2.
OpenTargetsiENSG00000172586.
PharmGKBiPA134964437.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4695. Eukaryota.
ENOG410Y5R6. LUCA.
GeneTreeiENSGT00390000007683.
HOGENOMiHOG000247034.
HOVERGENiHBG050935.
InParanoidiQ96BP2.
OMAiFPNKPHL.
OrthoDBiEOG091G0YBP.
PhylomeDBiQ96BP2.
TreeFamiTF314650.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172586-MONOMER.
ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

GenomeRNAii118487.
PROiQ96BP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172586.
CleanExiHS_CHCHD1.
ExpressionAtlasiQ96BP2. baseline and differential.
GenevisibleiQ96BP2. HS.

Family and domain databases

Gene3Di1.10.810.10. 1 hit.
InterProiIPR010625. CHCH.
IPR033620. CHCHD1.
IPR009069. Cys_alpha_HP_mot_SF.
[Graphical view]
PANTHERiPTHR31278. PTHR31278. 1 hit.
PfamiPF06747. CHCH. 1 hit.
[Graphical view]
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiPS51808. CHCH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHCH1_HUMAN
AccessioniPrimary (citable) accession number: Q96BP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.