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Protein

Coiled-coil-helix-coiled-coil-helix domain-containing protein 1

Gene

CHCHD1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
Alternative name(s):
28S ribosomal protein S37, mitochondrial
Short name:
MRP-S37
Mitochondrial small ribosomal subunit protein mS371 Publication
Nuclear protein C2360
Gene namesi
Name:CHCHD1
Synonyms:C10orf34, MRPS37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:23518. CHCHD1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi118487.
OpenTargetsiENSG00000172586.
PharmGKBiPA134964437.

Polymorphism and mutation databases

BioMutaiCHCHD1.
DMDMi62510504.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001291581 – 118Coiled-coil-helix-coiled-coil-helix domain-containing protein 1Add BLAST118

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi45 ↔ 76PROSITE-ProRule annotation
Disulfide bondi55 ↔ 66PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiQ96BP2.
MaxQBiQ96BP2.
PaxDbiQ96BP2.
PeptideAtlasiQ96BP2.
PRIDEiQ96BP2.

PTM databases

iPTMnetiQ96BP2.
PhosphoSitePlusiQ96BP2.

Expressioni

Gene expression databases

BgeeiENSG00000172586.
CleanExiHS_CHCHD1.
ExpressionAtlasiQ96BP2. baseline and differential.
GenevisibleiQ96BP2. HS.

Organism-specific databases

HPAiHPA039046.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
revP046183EBI-5454898,EBI-6164309From Human immunodeficiency virus type 1 group M subtype B (isolate HXB2).

Protein-protein interaction databases

BioGridi125612. 9 interactors.
IntActiQ96BP2. 4 interactors.
MINTiMINT-8051738.
STRINGi9606.ENSP00000361923.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50A21-118[»]
ProteinModelPortaliQ96BP2.
SMRiQ96BP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 84CHCHPROSITE-ProRule annotationAdd BLAST43

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 55Cx9C motif 1PROSITE-ProRule annotationAdd BLAST11
Motifi66 – 76Cx9C motif 2PROSITE-ProRule annotationAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4695. Eukaryota.
ENOG410Y5R6. LUCA.
GeneTreeiENSGT00390000007683.
HOGENOMiHOG000247034.
HOVERGENiHBG050935.
InParanoidiQ96BP2.
OMAiFPNKPHL.
OrthoDBiEOG091G0YBP.
PhylomeDBiQ96BP2.
TreeFamiTF314650.

Family and domain databases

InterProiView protein in InterPro
IPR010625. CHCH.
IPR033620. CHCHD1.
IPR009069. Cys_alpha_HP_mot_SF.
PANTHERiPTHR31278. PTHR31278. 1 hit.
PfamiView protein in Pfam
PF06747. CHCH. 1 hit.
SUPFAMiSSF47072. SSF47072. 1 hit.
PROSITEiView protein in PROSITE
PS51808. CHCH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96BP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATPSLRGRL ARFGNPRKPV LKPNKPLILA NRVGERRREK GEATCITEMS
60 70 80 90 100
VMMACWKQNE FRDDACRKEI QGFLDCAARA QEARKMRSIQ ETLGESGSLL
110
PNKLNKLLQR FPNKPYLS
Length:118
Mass (Da):13,475
Last modified:December 1, 2001 - v1
Checksum:i98AA1C38045A1C7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015387 mRNA. Translation: AAH15387.1.
BC020852 mRNA. Translation: AAH20852.1.
CCDSiCCDS7334.1.
RefSeqiNP_976043.1. NM_203298.2.
UniGeneiHs.181174.

Genome annotation databases

EnsembliENST00000372833; ENSP00000361923; ENSG00000172586.
GeneIDi118487.
KEGGihsa:118487.
UCSCiuc001jvc.5. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCHCH1_HUMAN
AccessioniPrimary (citable) accession number: Q96BP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: December 1, 2001
Last modified: April 12, 2017
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families