Q96BN8 (F105B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein FAM105B

Gene names

Name:

FAM105B

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities	Belongs to the FAM105 family.
Sequence caution	The sequence AAH07706.3 differs from that shown. Reason: Erroneous initiation. The sequence AAH15392.2 differs from that shown. Reason: Erroneous initiation. The sequence BAC03828.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Protein FAM105B		PRO_0000261637
Regions
	Coiled coil	49 – 73	25	Potential
Natural variations
	Natural variant	155	1	M → L. Corresponds to variant rs11953822 [ dbSNP | Ensembl ].		VAR_053819
	Natural variant	227	1	S → N. Corresponds to variant rs9312870 [ dbSNP | Ensembl ].		VAR_029469
	Natural variant	311	1	N → S. Corresponds to variant rs9312870 [ dbSNP | Ensembl ].		VAR_053820
Experimental info
	Sequence conflict	211	1	R → G in BAC03828. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q96BN8 [UniParc]. Last modified November 28, 2006. Version 3. Checksum: 65071FF7B427C2FA	FASTA	352	40,263
	10 20 30 40 50 60 MSRGTMPQPE AWPGASCAET PAREAAATAR DGGKAAASGQ PRPEMQCPAE HEEDMYRAAD 70 80 90 100 110 120 EIEKEKELLI HERGASEPRL SVAPEMDIMD YCKKEWRGNT QKATCMKMGY EEVSQKFTSI 130 140 150 160 170 180 RRVRGDNYCA LRATLFQAMS QAVGLPPWLQ DPELMLLPEK LISKYNWIKQ WKLGLKFDGK 190 200 210 220 230 240 NEDLVDKIKE SLTLLRKKWA GLAEMRTAEA RQIACDELFT NEAEEYSLYE AVKFLMLNRA 250 260 270 280 290 300 IELYNDKEKG KEVPFFSVLL FARDTSNDPG QLLRNHLNQV GHTGGLEQVE MFLLAYAVRH 310 320 330 340 350 TIQVYRLSKY NTEEFITVYP TDPPKDWPVV TLIAEDDRHY NIPVRVCEET SL

References

[1]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary and Prostate.
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 123-298.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH471102 Genomic DNA. Translation: EAX08038.1. CH471102 Genomic DNA. Translation: EAX08039.1. BC007706 mRNA. Translation: AAH07706.3. Different initiation. BC015392 mRNA. Translation: AAH15392.2. Different initiation. AK092203 mRNA. Translation: BAC03828.1. Different initiation.
IPI	IPI00101734.
RefSeq	NP_612357.4. NM_138348.4.
UniGene	Hs.406335.
3D structure databases
ProteinModelPortal	Q96BN8.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BN8. 1 interaction.
PTM databases
PhosphoSite	Q96BN8.
Polymorphism databases
DMDM	118572305.
Proteomic databases
PeptideAtlas	Q96BN8.
PRIDE	Q96BN8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284274; ENSP00000284274; ENSG00000154124.
GeneID	90268.
KEGG	hsa:90268.
UCSC	uc003jfk.1. human.
Organism-specific databases
CTD	90268.
GeneCards	GC05P014666.
HGNC	HGNC:25118. FAM105B.
neXtProt	NX_Q96BN8.
PharmGKB	PA142671789.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16792.
GeneTree	ENSGT00390000009802.
HOGENOM	HBG445927.
HOVERGEN	HBG104927.
InParanoid	Q96BN8.
OMA	HTGGLEQ.
Gene expression databases
ArrayExpress	Q96BN8.
Bgee	Q96BN8.
CleanEx	HS_FAM105B.
Genevestigator	Q96BN8.
GermOnline	ENSG00000154124. Homo sapiens.
Family and domain databases
InterPro	IPR023235. FAM105. IPR023237. FAM105B. [Graphical view]
PRINTS	PR02055. PROTEINF105. PR02057. PROTEINF105B.
ProtoNet	Search...
Other
NextBio	76620.

Entry information

Entry name

F105B_HUMAN

Accession

Primary (citable) accession number: Q96BN8
Secondary accession number(s): D3DTD3, Q8NAS0, Q96IA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	January 25, 2012
This is version 54 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.