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Protein

Transcriptional adapter 1

Gene

TADA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in transcriptional regulation.

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 1
Alternative name(s):
SPT3-associated factor 42
Short name:
STAF42
Transcriptional adapter 1-like protein
Gene namesi
Name:TADA1
Synonyms:TADA1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30631. TADA1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: HPA
  • focal adhesion Source: HPA
  • nucleoplasm Source: HPA
  • STAGA complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165752724.

Polymorphism and mutation databases

BioMutaiTADA1.
DMDMi74760738.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Transcriptional adapter 1PRO_0000316015Add
BLAST

Proteomic databases

EPDiQ96BN2.
MaxQBiQ96BN2.
PaxDbiQ96BN2.
PeptideAtlasiQ96BN2.
PRIDEiQ96BN2.

PTM databases

iPTMnetiQ96BN2.
PhosphoSiteiQ96BN2.

Expressioni

Gene expression databases

BgeeiQ96BN2.
CleanExiHS_TADA1L.
GenevisibleiQ96BN2. HS.

Organism-specific databases

HPAiHPA028651.

Interactioni

Subunit structurei

Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.1 Publication

Protein-protein interaction databases

BioGridi125555. 24 interactions.
IntActiQ96BN2. 4 interactions.
STRINGi9606.ENSP00000356848.

Structurei

3D structure databases

ProteinModelPortaliQ96BN2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TADA1 family.Curated

Phylogenomic databases

eggNOGiENOG410IJ0B. Eukaryota.
ENOG4111F9I. LUCA.
GeneTreeiENSGT00390000011644.
HOGENOMiHOG000035120.
HOVERGENiHBG099848.
InParanoidiQ96BN2.
KOiK11317.
OMAiEARMMVT.
OrthoDBiEOG7H4DVH.
PhylomeDBiQ96BN2.
TreeFamiTF324330.

Family and domain databases

InterProiIPR024738. Hfi1/Tada1.
[Graphical view]
PfamiPF12767. SAGA-Tad1. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL
60 70 80 90 100
LTQDNVHSHN DFLLAILTRC QILVSTPDGA GSLPWPGGSA AKPGKPKGKK
110 120 130 140 150
KLSSVRQKFD HRFQPQNPLS GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ
160 170 180 190 200
LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE NHLKDILTSV VSRRKAYRLR
210 220 230 240 250
DGHFKYAFGS NVTPQPYLKN SVVAYNNLIE SPPAFTAPCA GQNPASHPPP
260 270 280 290 300
DDAEQQAALL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
310 320 330
IERIITKLWH PNHEELQQDK VHRQRLAAKE GLLLC
Length:335
Mass (Da):37,382
Last modified:December 1, 2001 - v1
Checksum:i1B07D4613107A584
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621F → S in BAF83653 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti198 – 1981R → Q.
Corresponds to variant rs2272792 [ dbSNP | Ensembl ].
VAR_038352

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290964 mRNA. Translation: BAF83653.1.
AK291922 mRNA. Translation: BAF84611.1.
AL009182, AL008639 Genomic DNA. Translation: CAI22772.1.
AL008639, AL009182 Genomic DNA. Translation: CAI23577.1.
CH471067 Genomic DNA. Translation: EAW90778.1.
BC015401 mRNA. Translation: AAH15401.1.
CCDSiCCDS1255.1.
RefSeqiNP_444281.1. NM_053053.3.
UniGeneiHs.435967.

Genome annotation databases

EnsembliENST00000367874; ENSP00000356848; ENSG00000152382.
GeneIDi117143.
KEGGihsa:117143.
UCSCiuc001gdw.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK290964 mRNA. Translation: BAF83653.1.
AK291922 mRNA. Translation: BAF84611.1.
AL009182, AL008639 Genomic DNA. Translation: CAI22772.1.
AL008639, AL009182 Genomic DNA. Translation: CAI23577.1.
CH471067 Genomic DNA. Translation: EAW90778.1.
BC015401 mRNA. Translation: AAH15401.1.
CCDSiCCDS1255.1.
RefSeqiNP_444281.1. NM_053053.3.
UniGeneiHs.435967.

3D structure databases

ProteinModelPortaliQ96BN2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125555. 24 interactions.
IntActiQ96BN2. 4 interactions.
STRINGi9606.ENSP00000356848.

PTM databases

iPTMnetiQ96BN2.
PhosphoSiteiQ96BN2.

Polymorphism and mutation databases

BioMutaiTADA1.
DMDMi74760738.

Proteomic databases

EPDiQ96BN2.
MaxQBiQ96BN2.
PaxDbiQ96BN2.
PeptideAtlasiQ96BN2.
PRIDEiQ96BN2.

Protocols and materials databases

DNASUi117143.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367874; ENSP00000356848; ENSG00000152382.
GeneIDi117143.
KEGGihsa:117143.
UCSCiuc001gdw.4. human.

Organism-specific databases

CTDi117143.
GeneCardsiTADA1.
HGNCiHGNC:30631. TADA1.
HPAiHPA028651.
MIMi612763. gene.
neXtProtiNX_Q96BN2.
PharmGKBiPA165752724.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJ0B. Eukaryota.
ENOG4111F9I. LUCA.
GeneTreeiENSGT00390000011644.
HOGENOMiHOG000035120.
HOVERGENiHBG099848.
InParanoidiQ96BN2.
KOiK11317.
OMAiEARMMVT.
OrthoDBiEOG7H4DVH.
PhylomeDBiQ96BN2.
TreeFamiTF324330.

Enzyme and pathway databases

ReactomeiR-HSA-3214847. HATs acetylate histones.

Miscellaneous databases

ChiTaRSiTADA1. human.
GenomeRNAii117143.
PROiQ96BN2.
SOURCEiSearch...

Gene expression databases

BgeeiQ96BN2.
CleanExiHS_TADA1L.
GenevisibleiQ96BN2. HS.

Family and domain databases

InterProiIPR024738. Hfi1/Tada1.
[Graphical view]
PfamiPF12767. SAGA-Tad1. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroepithelium.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo."
    Martinez E., Palhan V.B., Tjernberg A., Lymar E.S., Gamper A.M., Kundu T.K., Chait B.T., Roeder R.G.
    Mol. Cell. Biol. 21:6782-6795(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE STAGA COMPLEX, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiTADA1_HUMAN
AccessioniPrimary (citable) accession number: Q96BN2
Secondary accession number(s): A8K4J9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.