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Protein

ADP-ribosylation factor-like protein 8A

Gene

ARL8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35GTP7
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi130 – 133GTP4

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: UniProtKB
  • mitotic nuclear division Source: UniProtKB-KW
  • small GTPase mediated signal transduction Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Mitosis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143862-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8A
Alternative name(s):
ADP-ribosylation factor-like protein 10B
Novel small G protein indispensable for equal chromosome segregation 2
Gene namesi
Name:ARL8A
Synonyms:ARL10B, GIE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25192. ARL8A.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei1 – 19Note=Mediates targeting to membranesBy similarityAdd BLAST19

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • late endosome membrane Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • membrane Source: UniProtKB
  • midbody Source: UniProtKB
  • spindle midzone Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000143862.
PharmGKBiPA134905021.

Polymorphism and mutation databases

BioMutaiARL8A.
DMDMi74751775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329161 – 186ADP-ribosylation factor-like protein 8AAdd BLAST186

Proteomic databases

EPDiQ96BM9.
MaxQBiQ96BM9.
PaxDbiQ96BM9.
PeptideAtlasiQ96BM9.
PRIDEiQ96BM9.

PTM databases

iPTMnetiQ96BM9.
PhosphoSitePlusiQ96BM9.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000143862.
CleanExiHS_ARL8A.
ExpressionAtlasiQ96BM9. baseline and differential.
GenevisibleiQ96BM9. HS.

Organism-specific databases

HPAiHPA038759.
HPA040515.
HPA045924.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PUF60Q9UHX13EBI-4401082,EBI-1053259
UQCRHP079195EBI-4401082,EBI-1224427

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126084. 12 interactors.
IntActiQ96BM9. 4 interactors.
STRINGi9606.ENSP00000272217.

Structurei

Secondary structure

1186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 17Combined sources9
Beta strandi19 – 26Combined sources8
Helixi33 – 42Combined sources10
Beta strandi46 – 49Combined sources4
Beta strandi54 – 62Combined sources9
Beta strandi65 – 72Combined sources8
Helixi76 – 79Combined sources4
Helixi82 – 86Combined sources5
Beta strandi90 – 97Combined sources8
Helixi101 – 103Combined sources3
Helixi104 – 115Combined sources12
Helixi118 – 120Combined sources3
Beta strandi125 – 130Combined sources6
Helixi140 – 146Combined sources7
Helixi149 – 151Combined sources3
Beta strandi157 – 161Combined sources5
Turni164 – 166Combined sources3
Helixi170 – 179Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZD9X-ray1.70A18-186[»]
2H18X-ray1.90A9-182[»]
4ILEX-ray2.68A1-181[»]
ProteinModelPortaliQ96BM9.
SMRiQ96BM9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96BM9.

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ96BM9.
KOiK07955.
OMAiFIKDREV.
OrthoDBiEOG091G0USZ.
PhylomeDBiQ96BM9.
TreeFamiTF105470.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI
60 70 80 90 100
PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD
110 120 130 140 150
QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,416
Last modified:December 1, 2001 - v1
Checksum:iEE5141235CE0F414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118752 mRNA. Translation: BAD23993.1.
AK127138 mRNA. Translation: BAG54442.1.
AL592300 Genomic DNA. Translation: CAI13107.1.
CH471067 Genomic DNA. Translation: EAW91395.1.
BC015408 mRNA. Translation: AAH15408.1.
CCDSiCCDS1421.1.
RefSeqiNP_001243058.1. NM_001256129.1.
NP_620150.1. NM_138795.3.
UniGeneiHs.497399.
Hs.604697.

Genome annotation databases

EnsembliENST00000272217; ENSP00000272217; ENSG00000143862.
GeneIDi127829.
KEGGihsa:127829.
UCSCiuc001gxk.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118752 mRNA. Translation: BAD23993.1.
AK127138 mRNA. Translation: BAG54442.1.
AL592300 Genomic DNA. Translation: CAI13107.1.
CH471067 Genomic DNA. Translation: EAW91395.1.
BC015408 mRNA. Translation: AAH15408.1.
CCDSiCCDS1421.1.
RefSeqiNP_001243058.1. NM_001256129.1.
NP_620150.1. NM_138795.3.
UniGeneiHs.497399.
Hs.604697.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZD9X-ray1.70A18-186[»]
2H18X-ray1.90A9-182[»]
4ILEX-ray2.68A1-181[»]
ProteinModelPortaliQ96BM9.
SMRiQ96BM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126084. 12 interactors.
IntActiQ96BM9. 4 interactors.
STRINGi9606.ENSP00000272217.

PTM databases

iPTMnetiQ96BM9.
PhosphoSitePlusiQ96BM9.

Polymorphism and mutation databases

BioMutaiARL8A.
DMDMi74751775.

Proteomic databases

EPDiQ96BM9.
MaxQBiQ96BM9.
PaxDbiQ96BM9.
PeptideAtlasiQ96BM9.
PRIDEiQ96BM9.

Protocols and materials databases

DNASUi127829.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000272217; ENSP00000272217; ENSG00000143862.
GeneIDi127829.
KEGGihsa:127829.
UCSCiuc001gxk.3. human.

Organism-specific databases

CTDi127829.
GeneCardsiARL8A.
H-InvDBHIX0200127.
HGNCiHGNC:25192. ARL8A.
HPAiHPA038759.
HPA040515.
HPA045924.
MIMi616597. gene.
neXtProtiNX_Q96BM9.
OpenTargetsiENSG00000143862.
PharmGKBiPA134905021.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0075. Eukaryota.
ENOG410XNUK. LUCA.
GeneTreeiENSGT00830000128269.
HOGENOMiHOG000163692.
HOVERGENiHBG105214.
InParanoidiQ96BM9.
KOiK07955.
OMAiFIKDREV.
OrthoDBiEOG091G0USZ.
PhylomeDBiQ96BM9.
TreeFamiTF105470.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000143862-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiARL8A. human.
EvolutionaryTraceiQ96BM9.
GeneWikiiARL8A.
GenomeRNAii127829.
PROiQ96BM9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143862.
CleanExiHS_ARL8A.
ExpressionAtlasiQ96BM9. baseline and differential.
GenevisibleiQ96BM9. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR024156. Small_GTPase_ARF.
IPR006689. Small_GTPase_ARF/SAR.
[Graphical view]
PfamiPF00025. Arf. 1 hit.
[Graphical view]
PRINTSiPR00328. SAR1GTPBP.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiPS51417. ARF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARL8A_HUMAN
AccessioniPrimary (citable) accession number: Q96BM9
Secondary accession number(s): B3KXD0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.