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Protein

ADP-ribosylation factor-like protein 8A

Gene

ARL8A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in lysosomes motility. Alternatively, may play a role in chromosome segregation (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35GTP7
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi130 – 133GTP4

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: UniProtKB
  • neutrophil degranulation Source: Reactome

Keywordsi

Biological processCell cycle, Cell division, Chromosome partition, Mitosis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
ADP-ribosylation factor-like protein 8A
Alternative name(s):
ADP-ribosylation factor-like protein 10B
Novel small G protein indispensable for equal chromosome segregation 2
Gene namesi
Name:ARL8A
Synonyms:ARL10B, GIE2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143862.7
HGNCiHGNC:25192 ARL8A
MIMi616597 gene
neXtProtiNX_Q96BM9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Intramembranei1 – 19Note=Mediates targeting to membranesBy similarityAdd BLAST19

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi127829
OpenTargetsiENSG00000143862
PharmGKBiPA134905021

Polymorphism and mutation databases

BioMutaiARL8A
DMDMi74751775

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002329161 – 186ADP-ribosylation factor-like protein 8AAdd BLAST186

Proteomic databases

EPDiQ96BM9
MaxQBiQ96BM9
PaxDbiQ96BM9
PeptideAtlasiQ96BM9
PRIDEiQ96BM9

PTM databases

iPTMnetiQ96BM9
PhosphoSitePlusiQ96BM9

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000143862
CleanExiHS_ARL8A
ExpressionAtlasiQ96BM9 baseline and differential
GenevisibleiQ96BM9 HS

Organism-specific databases

HPAiHPA038759
HPA040515
HPA045924

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • alpha-tubulin binding Source: UniProtKB
  • beta-tubulin binding Source: UniProtKB

Protein-protein interaction databases

BioGridi126084, 22 interactors
IntActiQ96BM9, 4 interactors
MINTiQ96BM9
STRINGi9606.ENSP00000272217

Structurei

Secondary structure

1186
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi9 – 17Combined sources9
Beta strandi19 – 26Combined sources8
Helixi33 – 42Combined sources10
Beta strandi46 – 49Combined sources4
Beta strandi54 – 62Combined sources9
Beta strandi65 – 72Combined sources8
Helixi76 – 79Combined sources4
Helixi82 – 86Combined sources5
Beta strandi90 – 97Combined sources8
Helixi101 – 103Combined sources3
Helixi104 – 115Combined sources12
Helixi118 – 120Combined sources3
Beta strandi125 – 130Combined sources6
Helixi140 – 146Combined sources7
Helixi149 – 151Combined sources3
Beta strandi157 – 161Combined sources5
Turni164 – 166Combined sources3
Helixi170 – 179Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZD9X-ray1.70A18-186[»]
2H18X-ray1.90A9-182[»]
4ILEX-ray2.68A1-181[»]
ProteinModelPortaliQ96BM9
SMRiQ96BM9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ96BM9

Family & Domainsi

Sequence similaritiesi

Belongs to the small GTPase superfamily. Arf family.Curated

Phylogenomic databases

eggNOGiKOG0075 Eukaryota
ENOG410XNUK LUCA
GeneTreeiENSGT00910000144027
HOGENOMiHOG000163692
HOVERGENiHBG105214
InParanoidiQ96BM9
KOiK07955
OMAiFIKDREV
OrthoDBiEOG091G0USZ
PhylomeDBiQ96BM9
TreeFamiTF105470

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR024156 Small_GTPase_ARF
IPR006689 Small_GTPase_ARF/SAR
PfamiView protein in Pfam
PF00025 Arf, 1 hit
PRINTSiPR00328 SAR1GTPBP
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51417 ARF, 1 hit

Sequencei

Sequence statusi: Complete.

Q96BM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI
60 70 80 90 100
PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD
110 120 130 140 150
QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS
160 170 180
AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Length:186
Mass (Da):21,416
Last modified:December 1, 2001 - v1
Checksum:iEE5141235CE0F414
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB118752 mRNA Translation: BAD23993.1
AK127138 mRNA Translation: BAG54442.1
AL592300 Genomic DNA No translation available.
CH471067 Genomic DNA Translation: EAW91395.1
BC015408 mRNA Translation: AAH15408.1
CCDSiCCDS1421.1
RefSeqiNP_001243058.1, NM_001256129.1
NP_620150.1, NM_138795.3
UniGeneiHs.497399
Hs.604697

Genome annotation databases

EnsembliENST00000272217; ENSP00000272217; ENSG00000143862
GeneIDi127829
KEGGihsa:127829
UCSCiuc001gxk.3 human

Similar proteinsi

Entry informationi

Entry nameiARL8A_HUMAN
AccessioniPrimary (citable) accession number: Q96BM9
Secondary accession number(s): B3KXD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: December 1, 2001
Last modified: March 28, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health