Interferon alpha-inducible protein 27-like protein 1

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Q96BM0 (I27L1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Interferon alpha-inducible protein 27-like protein 1

Alternative name(s):
Interferon-stimulated gene 12c protein
Short name=ISG12(c)

Gene names

Name:	IFI27L1
Synonyms:	FAM14B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	104 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the IFI6/IFI27 family.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 104

104

Interferon alpha-inducible protein 27-like protein 1

PRO_0000147371

Regions

Transmembrane

14 – 34

Helical; Potential

Transmembrane

59 – 79

Helical; Potential

Transmembrane

81 – 101

Helical; Potential

Natural variations

Natural variant

G → S.
Corresponds to variant rs57677258 [ dbSNP | Ensembl ].

VAR_062245

Secondary structure

104

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q96BM0 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: C54AF9381B74A236
Show »

FASTA

104

9,549

        10         20         30         40         50         60 
MGKESGWDSG RAAVAAVVGG VVAVGTVLVA LSAMGFTSVG IAASSIAAKM MSTAAIANGG 

        70         80         90        100 
GVAAGSLVAI LQSVGAAGLS VTSKVIGGFA GTALGAWLGS PPSS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum.
[2]	"Identification of a novel gene family that includes the interferon-inducible human genes 6-16 and ISG12." Parker N., Porter A.C.G. BMC Genomics 5:8-8(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[3]	"Facile backbone structure determination of human membrane proteins by NMR spectroscopy." Klammt C., Maslennikov I., Bayrhuber M., Eichmann C., Vajpai N., Chiu E.J., Blain K.Y., Esquivies L., Kwon J.H., Balana B., Pieper U., Sali A., Slesinger P.A., Kwiatkowski W., Riek R., Choe S. Nat. Methods 9:834-839(2012) [PubMed] [Europe PMC] [Abstract] Cited for: STRUCTURE BY NMR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

BC015423 mRNA. Translation: AAH15423.1.
BN000225 mRNA. Translation: CAE00392.1.

IPI

IPI00060020.

RefSeq

NP_660292.1. NM_145249.2.
NP_996832.1. NM_206949.2.

UniGene

Hs.19414.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2LOQ	NMR	-	A	1-104	[»]

ProteinModelPortal

Q96BM0.

ModBase

Search...

Polymorphism databases

DMDM

27805467.

Proteomic databases

PRIDE

Q96BM0.

Protocols and materials databases

DNASU

122509.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000393115; ENSP00000376824; ENSG00000165948.
ENST00000555523; ENSP00000451851; ENSG00000165948.

GeneID

122509.

KEGG

hsa:122509.

UCSC

uc001yck.3. human.

Organism-specific databases

CTD

122509.

GeneCards

GC14P094547.

HGNC

HGNC:19754. IFI27L1.

MIM

611320. gene.

neXtProt

NX_Q96BM0.

PharmGKB

PA164720846.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG44362.

HOGENOM

HOG000112988.

InParanoid

Q96BM0.

OMA

KMMSASA.

OrthoDB

EOG4TF0N1.

Gene expression databases

ArrayExpress

Q96BM0.

Bgee

Q96BM0.

CleanEx

HS_IFI27L1.

Genevestigator

Q96BM0.

GermOnline

ENSG00000165948. Homo sapiens.

Family and domain databases

InterPro

IPR009311. Interferon-induced_6-16.
[Graphical view]

PANTHER

PTHR16932. PTHR16932. 1 hit.

Pfam

PF06140. Ifi-6-16. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

GenomeRNAi

122509.

NextBio

80902.

SOURCE

Search...

Entry information

Entry name

I27L1_HUMAN

Accession

Primary (citable) accession number: Q96BM0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	December 1, 2001
Last modified:	May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.