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Q96BK5

- PINX1_HUMAN

UniProt

Q96BK5 - PINX1_HUMAN

Protein

PIN2/TERF1-interacting telomerase inhibitor 1

Gene

PINX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.6 Publications

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. telomerase inhibitor activity Source: UniProtKB
    3. telomeric RNA binding Source: UniProtKB

    GO - Biological processi

    1. mitotic metaphase plate congression Source: UniProtKB
    2. negative regulation of cell proliferation Source: UniProtKB
    3. negative regulation of telomerase activity Source: GOC
    4. regulation of telomerase activity Source: UniProtKB
    5. telomere maintenance via telomerase Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PIN2/TERF1-interacting telomerase inhibitor 1
    Alternative name(s):
    Liver-related putative tumor suppressor
    Pin2-interacting protein X1
    Protein 67-11-3
    TRF1-interacting protein 1
    Gene namesi
    Name:PINX1
    Synonyms:LPTL, LPTS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:30046. PINX1.

    Subcellular locationi

    Nucleus. Nucleusnucleolus. Chromosometelomere. Chromosomecentromerekinetochore
    Note: Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

    GO - Cellular componenti

    1. chromosome, telomeric region Source: UniProtKB-SubCell
    2. condensed chromosome kinetochore Source: UniProtKB-SubCell
    3. kinetochore Source: UniProtKB
    4. nuclear chromosome Source: UniProtKB
    5. nucleolus Source: UniProtKB
    6. spindle Source: UniProtKB

    Keywords - Cellular componenti

    Centromere, Chromosome, Kinetochore, Nucleus, Telomere

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi291 – 2911L → A: Abolishes interaction with TERF1. 1 Publication
    Mutagenesisi293 – 2931P → A: Does not affect interaction with TERF1. 1 Publication

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    PharmGKBiPA165585852.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328PIN2/TERF1-interacting telomerase inhibitor 1PRO_0000058443Add
    BLAST

    Proteomic databases

    MaxQBiQ96BK5.
    PaxDbiQ96BK5.
    PRIDEiQ96BK5.

    PTM databases

    PhosphoSiteiQ96BK5.

    Expressioni

    Tissue specificityi

    Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

    Gene expression databases

    ArrayExpressiQ96BK5.
    BgeeiQ96BK5.
    GenevestigatoriQ96BK5.

    Organism-specific databases

    HPAiHPA023139.

    Interactioni

    Subunit structurei

    Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AHCYP235261EBI-721782,EBI-1053240
    CALM1P621581EBI-721782,EBI-397435
    CAPRIN1Q144441EBI-721782,EBI-1047080
    GTPBP4Q9BZE41EBI-721782,EBI-1056249
    HRNRQ86YZ31EBI-721782,EBI-1047017
    PABPC1P119401EBI-721782,EBI-81531
    PABPC4Q133101EBI-721782,EBI-372844
    PLEKHJ1Q9NW611EBI-721782,EBI-1057560
    RPL23AP627501EBI-721782,EBI-353254
    RPL31P628991EBI-721782,EBI-1053664
    RPS10P467831EBI-721782,EBI-354442
    RPS16P622491EBI-721782,EBI-352480
    RPS19P390191EBI-721782,EBI-354451
    RPS28P628571EBI-721782,EBI-353027
    RPS3AP612471EBI-721782,EBI-352378
    TXNP105991EBI-721782,EBI-594644

    Protein-protein interaction databases

    BioGridi120319. 26 interactions.
    IntActiQ96BK5. 9 interactions.
    MINTiMINT-221403.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 7247G-patchPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni254 – 32875Telomerase inhibitory domain (TID)Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi287 – 29711TBMAdd
    BLAST

    Domaini

    The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity.1 Publication
    The TBM domain mediates interaction with TERF1.1 Publication

    Sequence similaritiesi

    Belongs to the PINX1 family.Curated
    Contains 1 G-patch domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG242943.
    HOVERGENiHBG061365.
    InParanoidiQ96BK5.
    KOiK11135.
    OMAiEDCVWPP.
    OrthoDBiEOG789CCG.
    PhylomeDBiQ96BK5.
    TreeFamiTF321918.

    Family and domain databases

    InterProiIPR000467. G_patch_dom.
    [Graphical view]
    PfamiPF01585. G-patch. 1 hit.
    [Graphical view]
    SMARTiSM00443. G_patch. 1 hit.
    [Graphical view]
    PROSITEiPS50174. G_PATCH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96BK5-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEQ    50
    GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT 100
    DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR 150
    QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS 200
    DISETQVERK RGKKRNKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA 250
    KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK 300
    KLQKPVEIAE DATLEETLVK KKKKKDSK 328
    Length:328
    Mass (Da):37,035
    Last modified:June 20, 2002 - v2
    Checksum:iA298B31AEA6D18E1
    GO
    Isoform 2 (identifier: Q96BK5-2) [UniParc]FASTAAdd to Basket

    Also known as: PINY1

    The sequence of this isoform differs from the canonical sequence as follows:
         133-174: KDLSSRSKTD...PEENETTTTS → RCQSLHSRGE...EQAPGSSSRV
         175-328: Missing.

    Show »
    Length:174
    Mass (Da):19,714
    Checksum:iC569D5959A04362C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501Q → H in AAH15479. (PubMed:15489334)Curated
    Sequence conflicti185 – 1862RM → PV in AAK31790. (PubMed:11701125)Curated
    Sequence conflicti204 – 2041E → V in CAC51436. 1 PublicationCurated
    Sequence conflicti205 – 2051T → A in AAS19507. 1 PublicationCurated
    Sequence conflicti259 – 2591E → K in AAK31790. (PubMed:11701125)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti206 – 2061Q → H.
    Corresponds to variant rs35530857 [ dbSNP | Ensembl ].
    VAR_054024
    Natural varianti215 – 2151R → I.1 Publication
    Corresponds to variant rs17855458 [ dbSNP | Ensembl ].
    VAR_054025
    Natural varianti220 – 2201T → A.
    Corresponds to variant rs17711777 [ dbSNP | Ensembl ].
    VAR_054026
    Natural varianti254 – 2541S → C.1 Publication
    Corresponds to variant rs1078543 [ dbSNP | Ensembl ].
    VAR_054027
    Natural varianti315 – 3151E → A.
    Corresponds to variant rs34656824 [ dbSNP | Ensembl ].
    VAR_054028

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei133 – 17442KDLSS…TTTTS → RCQSLHSRGERNHDNQRLHH PGVLCQADGSTEEQAPGSSS RV in isoform 2. 2 PublicationsVSP_003945Add
    BLAST
    Alternative sequencei175 – 328154Missing in isoform 2. 2 PublicationsVSP_003946Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205718 mRNA. Translation: AAG18009.1.
    AY029161 mRNA. Translation: AAK31790.1.
    AJ344104 mRNA. Translation: CAC51436.1.
    AF418553 mRNA. Translation: AAN31333.1.
    AY238941 mRNA. Translation: AAP37006.1.
    AY523566 mRNA. Translation: AAS19507.1.
    AK000572 mRNA. Translation: BAA91263.1.
    AK313715 mRNA. Translation: BAG36458.1.
    CH471157 Genomic DNA. Translation: EAW65596.1.
    BC015479 mRNA. Translation: AAH15479.1.
    BC093762 mRNA. Translation: AAH93762.1.
    CCDSiCCDS47801.1. [Q96BK5-1]
    CCDS64825.1. [Q96BK5-2]
    RefSeqiNP_001271285.1. NM_001284356.1. [Q96BK5-2]
    NP_060354.4. NM_017884.5. [Q96BK5-1]
    UniGeneiHs.490991.
    Hs.583894.

    Genome annotation databases

    EnsembliENST00000314787; ENSP00000318966; ENSG00000254093. [Q96BK5-1]
    ENST00000519088; ENSP00000428853; ENSG00000254093. [Q96BK5-2]
    GeneIDi54984.
    KEGGihsa:54984.
    UCSCiuc003wth.2. human. [Q96BK5-1]
    uc003wti.2. human. [Q96BK5-2]

    Polymorphism databases

    DMDMi21542178.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205718 mRNA. Translation: AAG18009.1 .
    AY029161 mRNA. Translation: AAK31790.1 .
    AJ344104 mRNA. Translation: CAC51436.1 .
    AF418553 mRNA. Translation: AAN31333.1 .
    AY238941 mRNA. Translation: AAP37006.1 .
    AY523566 mRNA. Translation: AAS19507.1 .
    AK000572 mRNA. Translation: BAA91263.1 .
    AK313715 mRNA. Translation: BAG36458.1 .
    CH471157 Genomic DNA. Translation: EAW65596.1 .
    BC015479 mRNA. Translation: AAH15479.1 .
    BC093762 mRNA. Translation: AAH93762.1 .
    CCDSi CCDS47801.1. [Q96BK5-1 ]
    CCDS64825.1. [Q96BK5-2 ]
    RefSeqi NP_001271285.1. NM_001284356.1. [Q96BK5-2 ]
    NP_060354.4. NM_017884.5. [Q96BK5-1 ]
    UniGenei Hs.490991.
    Hs.583894.

    3D structure databases

    ProteinModelPortali Q96BK5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 120319. 26 interactions.
    IntActi Q96BK5. 9 interactions.
    MINTi MINT-221403.

    PTM databases

    PhosphoSitei Q96BK5.

    Polymorphism databases

    DMDMi 21542178.

    Proteomic databases

    MaxQBi Q96BK5.
    PaxDbi Q96BK5.
    PRIDEi Q96BK5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314787 ; ENSP00000318966 ; ENSG00000254093 . [Q96BK5-1 ]
    ENST00000519088 ; ENSP00000428853 ; ENSG00000254093 . [Q96BK5-2 ]
    GeneIDi 54984.
    KEGGi hsa:54984.
    UCSCi uc003wth.2. human. [Q96BK5-1 ]
    uc003wti.2. human. [Q96BK5-2 ]

    Organism-specific databases

    CTDi 54984.
    GeneCardsi GC08M010659.
    HGNCi HGNC:30046. PINX1.
    HPAi HPA023139.
    MIMi 606505. gene.
    neXtProti NX_Q96BK5.
    PharmGKBi PA165585852.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG242943.
    HOVERGENi HBG061365.
    InParanoidi Q96BK5.
    KOi K11135.
    OMAi EDCVWPP.
    OrthoDBi EOG789CCG.
    PhylomeDBi Q96BK5.
    TreeFami TF321918.

    Miscellaneous databases

    GeneWikii PINX1.
    GenomeRNAii 54984.
    NextBioi 58258.
    PROi Q96BK5.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96BK5.
    Bgeei Q96BK5.
    Genevestigatori Q96BK5.

    Family and domain databases

    InterProi IPR000467. G_patch_dom.
    [Graphical view ]
    Pfami PF01585. G-patch. 1 hit.
    [Graphical view ]
    SMARTi SM00443. G_patch. 1 hit.
    [Graphical view ]
    PROSITEi PS50174. G_PATCH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human hepatocellular carcinoma."
      Liao C., Zhao M., Song H., Uchida K., Yokoyama K.K., Li T.P.
      Hepatology 32:721-727(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Liver.
    2. "The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor."
      Zhou X.Z., Lu K.P.
      Cell 107:347-359(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT CYS-254.
      Tissue: Cervix carcinoma.
    3. Schmidt T.
      Thesis (2001), University of Goettingen, Germany
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    4. "Identification of the gene LPTL, encoding for a new isoform of human putative tumor suppressor LPTS."
      Liao C., Zhao M., Li T.P.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    5. Qiang F.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    6. Fu Q., Cao Y., Zuo A., Liang D., Zhang Y., Wang B., Huang H., Wu Y., Zhu L., Wang P., Guo S., Guo G., Zhang J., Wang X.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    7. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ILE-215.
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    10. "Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length."
      Song H., Li Y., Chen G., Xing Z., Zhao J., Yokoyama K.K., Li T., Zhao M.
      Biochem. Biophys. Res. Commun. 316:1116-1123(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MCRS1.
    11. "Characterization of interactions between PinX1 and human telomerase subunits hTERT and hTR."
      Banik S.S.R., Counter C.M.
      J. Biol. Chem. 279:51745-51748(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH TERT AND THE TELOMERASE RNA.
    12. "Characterization of a novel effect of hPinX1 on hTERT nucleolar localization."
      Lin J., Jin R., Zhang B., Yang P.X., Chen H., Bai Y.X., Xie Y., Huang C., Huang J.
      Biochem. Biophys. Res. Commun. 353:946-952(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins."
      Chen Y., Yang Y., van Overbeek M., Donigian J.R., Baciu P., de Lange T., Lei M.
      Science 319:1092-1096(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TERF1, DOMAIN TBM, MUTAGENESIS OF LEU-291 AND PRO-293.
    15. "PinX1 is recruited to the mitotic chromosome periphery by nucleolin and facilitates chromosome congression."
      Li N., Yuan K., Yan F., Huo Y., Zhu T., Liu X., Guo Z., Yao X.
      Biochem. Biophys. Res. Commun. 384:76-81(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH NCL/NUCLEOLIN.
    16. "Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells."
      Zhang B., Bai Y.X., Ma H.H., Feng F., Jin R., Wang Z.L., Lin J., Sun S.P., Yang P., Wang X.X., Huang P.T., Huang C.F., Peng Y., Chen Y.C., Kung H.F., Huang J.J.
      Cancer Res. 69:75-83(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "PinX1 is a novel microtubule-binding protein essential for accurate chromosome segregation."
      Yuan K., Li N., Jiang K., Zhu T., Huo Y., Wang C., Lu J., Shaw A., Thomas K., Zhang J., Mann D., Liao J., Jin C., Yao X.
      J. Biol. Chem. 284:23072-23082(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    18. "Human PinX1 mediates TRF1 accumulation in nucleolus and enhances TRF1 binding to telomeres."
      Yoo J.E., Oh B.-K., Park Y.N.
      J. Mol. Biol. 388:928-940(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION.
    19. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    20. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPINX1_HUMAN
    AccessioniPrimary (citable) accession number: Q96BK5
    Secondary accession number(s): B2R9B1
    , Q548A5, Q6QWG9, Q7Z7J8, Q96QD7, Q9HBU7, Q9NWW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3