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Q96BJ3

- AIDA_HUMAN

UniProt

Q96BJ3 - AIDA_HUMAN

Protein

Axin interactor, dorsalization-associated protein

Gene

AIDA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Dec 2001)
      Previous versions | rss
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    Functioni

    Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling By similarity.By similarity

    GO - Biological processi

    1. dorsal/ventral pattern formation Source: UniProtKB
    2. negative regulation of JNK cascade Source: UniProtKB
    3. negative regulation of JUN kinase activity Source: MGI
    4. regulation of protein homodimerization activity Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin interactor, dorsalization-associated protein
    Alternative name(s):
    Axin interaction partner and dorsalization antagonist
    Gene namesi
    Name:AIDA
    Synonyms:C1orf80
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:25761. AIDA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162376104.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 306306Axin interactor, dorsalization-associated proteinPRO_0000305277Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei144 – 1441Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ96BJ3.
    PaxDbiQ96BJ3.
    PRIDEiQ96BJ3.

    PTM databases

    PhosphoSiteiQ96BJ3.

    Expressioni

    Tissue specificityi

    Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ96BJ3.
    BgeeiQ96BJ3.
    CleanExiHS_AIDA.
    GenevestigatoriQ96BJ3.

    Organism-specific databases

    HPAiHPA027935.

    Interactioni

    Subunit structurei

    Interacts with AXIN1.By similarity

    Protein-protein interaction databases

    BioGridi122326. 2 interactions.
    IntActiQ96BJ3. 3 interactions.
    MINTiMINT-8247588.
    STRINGi9606.ENSP00000339161.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96BJ3.
    SMRiQ96BJ3. Positions 3-115, 152-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 22168Axin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili27 – 6236Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AIDA family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG48105.
    HOGENOMiHOG000006666.
    HOVERGENiHBG057354.
    InParanoidiQ96BJ3.
    OMAiSQHNNSE.
    OrthoDBiEOG7XPZ6D.
    PhylomeDBiQ96BJ3.
    TreeFamiTF328541.

    Family and domain databases

    Gene3Di1.20.120.360. 1 hit.
    InterProiIPR025939. Aida_C.
    IPR023421. AIDA_N.
    [Graphical view]
    PfamiPF14186. Aida_C2. 1 hit.
    PF08910. Aida_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF109779. SSF109779. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q96BJ3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH    50
    NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN 100
    ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA 150
    RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID 200
    LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK 250
    RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH 300
    QTLHKE 306
    Length:306
    Mass (Da):35,023
    Last modified:December 1, 2001 - v1
    Checksum:i48E563CEEC398ECC
    GO
    Isoform 2 (identifier: Q96BJ3-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-165: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:141
    Mass (Da):16,444
    Checksum:i7934104EAB68EED2
    GO
    Isoform 3 (identifier: Q96BJ3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         155-236: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:224
    Mass (Da):25,914
    Checksum:iFF95596B7B9C0385
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301E → G in BAB14281. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 165165Missing in isoform 2. 1 PublicationVSP_028322Add
    BLAST
    Alternative sequencei155 – 23682Missing in isoform 3. CuratedVSP_034661Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022868 mRNA. Translation: BAB14281.1.
    AK289865 mRNA. Translation: BAF82554.1.
    AL392172, AL592148 Genomic DNA. Translation: CAH73929.1.
    AL392172, AL592148 Genomic DNA. Translation: CAH73930.1.
    AL592148, AL392172 Genomic DNA. Translation: CAI40463.1.
    AL592148, AL392172 Genomic DNA. Translation: CAI40464.1.
    BC015535 mRNA. Translation: AAH15535.1.
    BC043142 mRNA. Translation: AAH43142.1.
    BC067805 mRNA. Translation: AAH67805.1.
    AL833718 mRNA. Translation: CAH56257.1.
    CCDSiCCDS1533.1. [Q96BJ3-1]
    RefSeqiNP_073742.2. NM_022831.2. [Q96BJ3-1]
    UniGeneiHs.156625.
    Hs.534965.

    Genome annotation databases

    EnsembliENST00000340020; ENSP00000339161; ENSG00000186063. [Q96BJ3-1]
    ENST00000355727; ENSP00000347964; ENSG00000186063. [Q96BJ3-3]
    GeneIDi64853.
    KEGGihsa:64853.
    UCSCiuc001hnn.3. human. [Q96BJ3-1]

    Polymorphism databases

    DMDMi74751770.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK022868 mRNA. Translation: BAB14281.1 .
    AK289865 mRNA. Translation: BAF82554.1 .
    AL392172 , AL592148 Genomic DNA. Translation: CAH73929.1 .
    AL392172 , AL592148 Genomic DNA. Translation: CAH73930.1 .
    AL592148 , AL392172 Genomic DNA. Translation: CAI40463.1 .
    AL592148 , AL392172 Genomic DNA. Translation: CAI40464.1 .
    BC015535 mRNA. Translation: AAH15535.1 .
    BC043142 mRNA. Translation: AAH43142.1 .
    BC067805 mRNA. Translation: AAH67805.1 .
    AL833718 mRNA. Translation: CAH56257.1 .
    CCDSi CCDS1533.1. [Q96BJ3-1 ]
    RefSeqi NP_073742.2. NM_022831.2. [Q96BJ3-1 ]
    UniGenei Hs.156625.
    Hs.534965.

    3D structure databases

    ProteinModelPortali Q96BJ3.
    SMRi Q96BJ3. Positions 3-115, 152-305.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 122326. 2 interactions.
    IntActi Q96BJ3. 3 interactions.
    MINTi MINT-8247588.
    STRINGi 9606.ENSP00000339161.

    PTM databases

    PhosphoSitei Q96BJ3.

    Polymorphism databases

    DMDMi 74751770.

    Proteomic databases

    MaxQBi Q96BJ3.
    PaxDbi Q96BJ3.
    PRIDEi Q96BJ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340020 ; ENSP00000339161 ; ENSG00000186063 . [Q96BJ3-1 ]
    ENST00000355727 ; ENSP00000347964 ; ENSG00000186063 . [Q96BJ3-3 ]
    GeneIDi 64853.
    KEGGi hsa:64853.
    UCSCi uc001hnn.3. human. [Q96BJ3-1 ]

    Organism-specific databases

    CTDi 64853.
    GeneCardsi GC01M222841.
    H-InvDB HIX0001616.
    HIX0028617.
    HGNCi HGNC:25761. AIDA.
    HPAi HPA027935.
    MIMi 612375. gene.
    neXtProti NX_Q96BJ3.
    PharmGKBi PA162376104.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG48105.
    HOGENOMi HOG000006666.
    HOVERGENi HBG057354.
    InParanoidi Q96BJ3.
    OMAi SQHNNSE.
    OrthoDBi EOG7XPZ6D.
    PhylomeDBi Q96BJ3.
    TreeFami TF328541.

    Miscellaneous databases

    GenomeRNAii 64853.
    NextBioi 66981.
    PROi Q96BJ3.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q96BJ3.
    Bgeei Q96BJ3.
    CleanExi HS_AIDA.
    Genevestigatori Q96BJ3.

    Family and domain databases

    Gene3Di 1.20.120.360. 1 hit.
    InterProi IPR025939. Aida_C.
    IPR023421. AIDA_N.
    [Graphical view ]
    Pfami PF14186. Aida_C2. 1 hit.
    PF08910. Aida_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF109779. SSF109779. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Caudate nucleus.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Pancreas and Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306 (ISOFORM 1).
      Tissue: Stomach.
    5. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
      Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
      Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAIDA_HUMAN
    AccessioniPrimary (citable) accession number: Q96BJ3
    Secondary accession number(s): A8K1F0
    , Q49A81, Q5JRA4, Q658P1, Q9H9E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 2, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3