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Protein

Axin interactor, dorsalization-associated protein

Gene

AIDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Axin interactor, dorsalization-associated protein
Alternative name(s):
Axin interaction partner and dorsalization antagonist
Gene namesi
Name:AIDA
Synonyms:C1orf80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000186063.12
HGNCiHGNC:25761 AIDA
MIMi612375 gene
neXtProtiNX_Q96BJ3

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi64853
OpenTargetsiENSG00000186063
PharmGKBiPA162376104

Polymorphism and mutation databases

BioMutaiAIDA
DMDMi74751770

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003052771 – 306Axin interactor, dorsalization-associated proteinAdd BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei144PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96BJ3
MaxQBiQ96BJ3
PaxDbiQ96BJ3
PeptideAtlasiQ96BJ3
PRIDEiQ96BJ3

PTM databases

iPTMnetiQ96BJ3
PhosphoSitePlusiQ96BJ3
SwissPalmiQ96BJ3

Expressioni

Tissue specificityi

Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSG00000186063
CleanExiHS_AIDA
GenevisibleiQ96BJ3 HS

Organism-specific databases

HPAiHPA027935

Interactioni

Subunit structurei

Interacts with AXIN1.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi122326, 14 interactors
IntActiQ96BJ3, 12 interactors
MINTiQ96BJ3
STRINGi9606.ENSP00000339161

Structurei

3D structure databases

ProteinModelPortaliQ96BJ3
SMRiQ96BJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni154 – 221Axin-bindingBy similarityAdd BLAST68

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 62Sequence analysisAdd BLAST36

Sequence similaritiesi

Belongs to the AIDA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJ07 Eukaryota
ENOG410YXX7 LUCA
GeneTreeiENSGT00390000016465
HOGENOMiHOG000006666
HOVERGENiHBG057354
InParanoidiQ96BJ3
OMAiATCLEMR
OrthoDBiEOG091G0GXU
PhylomeDBiQ96BJ3
TreeFamiTF328541

Family and domain databases

Gene3Di1.20.120.360, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR025939 Aida_C
IPR023421 AIDA_N
IPR036818 AIDA_N_sf
IPR035892 C2_domain_sf
PfamiView protein in Pfam
PF14186 Aida_C2, 1 hit
PF08910 Aida_N, 1 hit
SUPFAMiSSF109779 SSF109779, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96BJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH
60 70 80 90 100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN
110 120 130 140 150
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA
160 170 180 190 200
RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID
210 220 230 240 250
LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK
260 270 280 290 300
RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH

QTLHKE
Length:306
Mass (Da):35,023
Last modified:December 1, 2001 - v1
Checksum:i48E563CEEC398ECC
GO
Isoform 2 (identifier: Q96BJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.
Show »
Length:141
Mass (Da):16,444
Checksum:i7934104EAB68EED2
GO
Isoform 3 (identifier: Q96BJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-236: Missing.

Note: No experimental confirmation available.
Show »
Length:224
Mass (Da):25,914
Checksum:iFF95596B7B9C0385
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130E → G in BAB14281 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0283221 – 165Missing in isoform 2. 1 PublicationAdd BLAST165
Alternative sequenceiVSP_034661155 – 236Missing in isoform 3. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022868 mRNA Translation: BAB14281.1
AK289865 mRNA Translation: BAF82554.1
AL392172 Genomic DNA No translation available.
AL592148 Genomic DNA No translation available.
BC015535 mRNA Translation: AAH15535.1
BC043142 mRNA Translation: AAH43142.1
BC067805 mRNA Translation: AAH67805.1
AL833718 mRNA Translation: CAH56257.1
CCDSiCCDS1533.1 [Q96BJ3-1]
RefSeqiNP_073742.2, NM_022831.2 [Q96BJ3-1]
UniGeneiHs.156625
Hs.534965

Genome annotation databases

EnsembliENST00000340020; ENSP00000339161; ENSG00000186063 [Q96BJ3-1]
ENST00000355727; ENSP00000347964; ENSG00000186063 [Q96BJ3-3]
GeneIDi64853
KEGGihsa:64853
UCSCiuc001hnn.4 human [Q96BJ3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAIDA_HUMAN
AccessioniPrimary (citable) accession number: Q96BJ3
Secondary accession number(s): A8K1F0
, Q49A81, Q5JRA4, Q658P1, Q9H9E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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