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Q96BJ3

- AIDA_HUMAN

UniProt

Q96BJ3 - AIDA_HUMAN

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Protein

Axin interactor, dorsalization-associated protein

Gene
AIDA, C1orf80
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling By similarity.

GO - Biological processi

  1. dorsal/ventral pattern formation Source: UniProtKB
  2. negative regulation of JNK cascade Source: UniProtKB
  3. negative regulation of JUN kinase activity Source: MGI
  4. regulation of protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Axin interactor, dorsalization-associated protein
Alternative name(s):
Axin interaction partner and dorsalization antagonist
Gene namesi
Name:AIDA
Synonyms:C1orf80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:25761. AIDA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Axin interactor, dorsalization-associated proteinPRO_0000305277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BJ3.
PaxDbiQ96BJ3.
PRIDEiQ96BJ3.

PTM databases

PhosphoSiteiQ96BJ3.

Expressioni

Tissue specificityi

Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication

Gene expression databases

ArrayExpressiQ96BJ3.
BgeeiQ96BJ3.
CleanExiHS_AIDA.
GenevestigatoriQ96BJ3.

Organism-specific databases

HPAiHPA027935.

Interactioni

Subunit structurei

Interacts with AXIN1 By similarity.

Protein-protein interaction databases

BioGridi122326. 2 interactions.
IntActiQ96BJ3. 3 interactions.
MINTiMINT-8247588.
STRINGi9606.ENSP00000339161.

Structurei

3D structure databases

ProteinModelPortaliQ96BJ3.
SMRiQ96BJ3. Positions 3-115, 152-305.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 22168Axin-binding By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili27 – 6236 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the AIDA family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG48105.
HOGENOMiHOG000006666.
HOVERGENiHBG057354.
InParanoidiQ96BJ3.
OMAiSQHNNSE.
OrthoDBiEOG7XPZ6D.
PhylomeDBiQ96BJ3.
TreeFamiTF328541.

Family and domain databases

Gene3Di1.20.120.360. 1 hit.
InterProiIPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view]
PfamiPF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view]
SUPFAMiSSF109779. SSF109779. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q96BJ3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH    50
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN 100
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA 150
RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID 200
LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK 250
RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH 300
QTLHKE 306
Length:306
Mass (Da):35,023
Last modified:December 1, 2001 - v1
Checksum:i48E563CEEC398ECC
GO
Isoform 2 (identifier: Q96BJ3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.

Show »
Length:141
Mass (Da):16,444
Checksum:i7934104EAB68EED2
GO
Isoform 3 (identifier: Q96BJ3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-236: Missing.

Note: No experimental confirmation available.

Show »
Length:224
Mass (Da):25,914
Checksum:iFF95596B7B9C0385
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 2. VSP_028322Add
BLAST
Alternative sequencei155 – 23682Missing in isoform 3. VSP_034661Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301E → G in BAB14281. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022868 mRNA. Translation: BAB14281.1.
AK289865 mRNA. Translation: BAF82554.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73929.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73930.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40463.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40464.1.
BC015535 mRNA. Translation: AAH15535.1.
BC043142 mRNA. Translation: AAH43142.1.
BC067805 mRNA. Translation: AAH67805.1.
AL833718 mRNA. Translation: CAH56257.1.
CCDSiCCDS1533.1. [Q96BJ3-1]
RefSeqiNP_073742.2. NM_022831.2. [Q96BJ3-1]
UniGeneiHs.156625.
Hs.534965.

Genome annotation databases

EnsembliENST00000340020; ENSP00000339161; ENSG00000186063. [Q96BJ3-1]
ENST00000355727; ENSP00000347964; ENSG00000186063. [Q96BJ3-3]
GeneIDi64853.
KEGGihsa:64853.
UCSCiuc001hnn.3. human. [Q96BJ3-1]

Polymorphism databases

DMDMi74751770.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK022868 mRNA. Translation: BAB14281.1 .
AK289865 mRNA. Translation: BAF82554.1 .
AL392172 , AL592148 Genomic DNA. Translation: CAH73929.1 .
AL392172 , AL592148 Genomic DNA. Translation: CAH73930.1 .
AL592148 , AL392172 Genomic DNA. Translation: CAI40463.1 .
AL592148 , AL392172 Genomic DNA. Translation: CAI40464.1 .
BC015535 mRNA. Translation: AAH15535.1 .
BC043142 mRNA. Translation: AAH43142.1 .
BC067805 mRNA. Translation: AAH67805.1 .
AL833718 mRNA. Translation: CAH56257.1 .
CCDSi CCDS1533.1. [Q96BJ3-1 ]
RefSeqi NP_073742.2. NM_022831.2. [Q96BJ3-1 ]
UniGenei Hs.156625.
Hs.534965.

3D structure databases

ProteinModelPortali Q96BJ3.
SMRi Q96BJ3. Positions 3-115, 152-305.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 122326. 2 interactions.
IntActi Q96BJ3. 3 interactions.
MINTi MINT-8247588.
STRINGi 9606.ENSP00000339161.

PTM databases

PhosphoSitei Q96BJ3.

Polymorphism databases

DMDMi 74751770.

Proteomic databases

MaxQBi Q96BJ3.
PaxDbi Q96BJ3.
PRIDEi Q96BJ3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340020 ; ENSP00000339161 ; ENSG00000186063 . [Q96BJ3-1 ]
ENST00000355727 ; ENSP00000347964 ; ENSG00000186063 . [Q96BJ3-3 ]
GeneIDi 64853.
KEGGi hsa:64853.
UCSCi uc001hnn.3. human. [Q96BJ3-1 ]

Organism-specific databases

CTDi 64853.
GeneCardsi GC01M222841.
H-InvDB HIX0001616.
HIX0028617.
HGNCi HGNC:25761. AIDA.
HPAi HPA027935.
MIMi 612375. gene.
neXtProti NX_Q96BJ3.
PharmGKBi PA162376104.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG48105.
HOGENOMi HOG000006666.
HOVERGENi HBG057354.
InParanoidi Q96BJ3.
OMAi SQHNNSE.
OrthoDBi EOG7XPZ6D.
PhylomeDBi Q96BJ3.
TreeFami TF328541.

Miscellaneous databases

GenomeRNAii 64853.
NextBioi 66981.
PROi Q96BJ3.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q96BJ3.
Bgeei Q96BJ3.
CleanExi HS_AIDA.
Genevestigatori Q96BJ3.

Family and domain databases

Gene3Di 1.20.120.360. 1 hit.
InterProi IPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view ]
Pfami PF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view ]
SUPFAMi SSF109779. SSF109779. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Caudate nucleus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306 (ISOFORM 1).
    Tissue: Stomach.
  5. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
    Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
    Dev. Cell 13:268-282(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIDA_HUMAN
AccessioniPrimary (citable) accession number: Q96BJ3
Secondary accession number(s): A8K1F0
, Q49A81, Q5JRA4, Q658P1, Q9H9E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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