Q96BJ3 (AIDA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Axin interactor, dorsalization-associated protein

Alternative name(s):
Axin interaction partner and dorsalization antagonist

Gene names

Name:	AIDA
Synonyms:	C1orf80

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling By similarity.
Subunit structure	Interacts with AXIN1 By similarity.
Tissue specificity	Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle. Ref.5
Sequence similarities	Belongs to the AIDA family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Coiled coil
Molecular function	Developmental protein
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dorsal/ventral pattern formation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of JNK cascade Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of JUN kinase activity Inferred from direct assay Ref.5. Source: MGI regulation of protein homodimerization activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q96BJ3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96BJ3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q96BJ3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     155-236: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Axin interactor, dorsalization-associated protein		PRO_0000305277
Regions
	Region	154 – 221	68	Axin-binding By similarity
	Coiled coil	27 – 62	36	Potential
Amino acid modifications
	Modified residue	144	1	Phosphoserine Ref.6 Ref.7
Natural variations
	Alternative sequence	1 – 165	165	Missing in isoform 2.		VSP_028322
	Alternative sequence	155 – 236	82	Missing in isoform 3.		VSP_034661
Experimental info
	Sequence conflict	130	1	E → G in BAB14281. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 48E563CEEC398ECC	FASTA	306	35,023
	10 20 30 40 50 60 MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH NNSEFTEEQK 70 80 90 100 110 120 KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN ILTYNKEFPF DVQPVPLRRI 130 140 150 160 170 180 LAPGEEENLE FEEDEEEGGA GAGSPDSFPA RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD 190 200 210 220 230 240 AGQCIDPYIT VSVKDLNGID LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF 250 260 270 280 290 300 FEFKHYKPKK RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH QTLHKE
	Isoform 2 [UniParc]. Checksum: 7934104EAB68EED2	FASTA	141	16,444
	10 20 30 40 50 60 MTLLTIRIEK IGLKDAGQCI DPYITVSVKD LNGIDLTPVQ DTPVASRKED TYVHFNVDIE 70 80 90 100 110 120 LQKHVEKLTK GAAIFFEFKH YKPKKRFTST KCFAFMEMDE IKPGPIVIEL YKKPTDFKRK 130 140 KLQLLTKKPL YLHLHQTLHK E
	Isoform 3 [UniParc]. Checksum: FF95596B7B9C0385	FASTA	224	25,914
	10 20 30 40 50 60 MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH NNSEFTEEQK 70 80 90 100 110 120 KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN ILTYNKEFPF DVQPVPLRRI 130 140 150 160 170 180 LAPGEEENLE FEEDEEEGGA GAGSPDSFPA RVPGAAIFFE FKHYKPKKRF TSTKCFAFME 190 200 210 220 MDEIKPGPIV IELYKKPTDF KRKKLQLLTK KPLYLHLHQT LHKE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Caudate nucleus.
[2]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Pancreas and Testis.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306 (ISOFORM 1). Tissue: Stomach.
[5]	"A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida." Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C. Dev. Cell 13:268-282(2007) [PubMed: 17681137] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed: 19690332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK022868 mRNA. Translation: BAB14281.1. AK289865 mRNA. Translation: BAF82554.1. AL392172, AL592148 Genomic DNA. Translation: CAH73929.1. AL392172, AL592148 Genomic DNA. Translation: CAH73930.1. AL592148, AL392172 Genomic DNA. Translation: CAI40463.1. AL592148, AL392172 Genomic DNA. Translation: CAI40464.1. BC015535 mRNA. Translation: AAH15535.1. BC043142 mRNA. Translation: AAH43142.1. BC067805 mRNA. Translation: AAH67805.1. AL833718 mRNA. Translation: CAH56257.1.
IPI	IPI00303602. IPI00480020. IPI00867514.
RefSeq	NP_073742.2. NM_022831.2.
UniGene	Hs.156625. Hs.534965.
3D structure databases
ProteinModelPortal	Q96BJ3.
SMR	Q96BJ3. Positions 3-115, 152-305.
ModBase	Search...
Protein-protein interaction databases
STRING	Q96BJ3.
PTM databases
PhosphoSite	Q96BJ3.
Polymorphism databases
DMDM	74751770.
Proteomic databases
PRIDE	Q96BJ3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340020; ENSP00000339161; ENSG00000186063.
GeneID	64853.
KEGG	hsa:64853.
UCSC	uc001hnn.1. human.
Organism-specific databases
CTD	64853.
GeneCards	GC01M222841.
HGNC	HGNC:25761. AIDA.
HPA	HPA027935.
MIM	612375. gene.
neXtProt	NX_Q96BJ3.
PharmGKB	PA162376104.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG15973.
GeneTree	ENSGT00390000016465.
HOGENOM	HBG410400.
HOVERGEN	HBG057354.
InParanoid	Q96BJ3.
OMA	EAQSQHN.
OrthoDB	EOG4640CJ.
PhylomeDB	Q96BJ3.
Gene expression databases
ArrayExpress	Q96BJ3.
Bgee	Q96BJ3.
CleanEx	HS_AIDA.
Genevestigator	Q96BJ3.
Family and domain databases
InterPro	IPR015006. AIDA. IPR023421. AIDA_N. [Graphical view]
Gene3D	G3DSA:1.20.120.360. G3DSA:1.20.120.360. 1 hit.
Pfam	PF08910. DUF1855. 1 hit. [Graphical view]
SUPFAM	SSF109779. SSF109779. 1 hit.
ProtoNet	Search...
Other
NextBio	66981.
SOURCE	Search...

Entry information

Entry name

AIDA_HUMAN

Accession

Primary (citable) accession number: Q96BJ3
Secondary accession number(s): A8K1F0 , Q49A81, Q5JRA4, Q658P1, Q9H9E8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.