Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Axin interactor, dorsalization-associated protein

Gene

AIDA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity).By similarity

GO - Biological processi

  1. dorsal/ventral pattern formation Source: UniProtKB
  2. negative regulation of JNK cascade Source: UniProtKB
  3. negative regulation of JUN kinase activity Source: MGI
  4. regulation of protein homodimerization activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Axin interactor, dorsalization-associated protein
Alternative name(s):
Axin interaction partner and dorsalization antagonist
Gene namesi
Name:AIDA
Synonyms:C1orf80
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:25761. AIDA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162376104.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306Axin interactor, dorsalization-associated proteinPRO_0000305277Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei144 – 1441Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ96BJ3.
PaxDbiQ96BJ3.
PRIDEiQ96BJ3.

PTM databases

PhosphoSiteiQ96BJ3.

Expressioni

Tissue specificityi

Widely expressed in adult tissues, with highest expression in the heart and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ96BJ3.
CleanExiHS_AIDA.
GenevestigatoriQ96BJ3.

Organism-specific databases

HPAiHPA027935.

Interactioni

Subunit structurei

Interacts with AXIN1.By similarity

Protein-protein interaction databases

BioGridi122326. 10 interactions.
IntActiQ96BJ3. 3 interactions.
MINTiMINT-8247588.
STRINGi9606.ENSP00000339161.

Structurei

3D structure databases

ProteinModelPortaliQ96BJ3.
SMRiQ96BJ3. Positions 3-115, 152-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni154 – 22168Axin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili27 – 6236Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the AIDA family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG48105.
GeneTreeiENSGT00390000016465.
HOGENOMiHOG000006666.
HOVERGENiHBG057354.
InParanoidiQ96BJ3.
OMAiATCLEMR.
OrthoDBiEOG7XPZ6D.
PhylomeDBiQ96BJ3.
TreeFamiTF328541.

Family and domain databases

Gene3Di1.20.120.360. 1 hit.
InterProiIPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view]
PfamiPF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view]
SUPFAMiSSF109779. SSF109779. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96BJ3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSEVTRSLLQ RWGASFRRGA DFDSWGQLVE AIDEYQILAR HLQKEAQAQH
60 70 80 90 100
NNSEFTEEQK KTIGKIATCL ELRSAALQST QSQEEFKLED LKKLEPILKN
110 120 130 140 150
ILTYNKEFPF DVQPVPLRRI LAPGEEENLE FEEDEEEGGA GAGSPDSFPA
160 170 180 190 200
RVPGTLLPRL PSEPGMTLLT IRIEKIGLKD AGQCIDPYIT VSVKDLNGID
210 220 230 240 250
LTPVQDTPVA SRKEDTYVHF NVDIELQKHV EKLTKGAAIF FEFKHYKPKK
260 270 280 290 300
RFTSTKCFAF MEMDEIKPGP IVIELYKKPT DFKRKKLQLL TKKPLYLHLH

QTLHKE
Length:306
Mass (Da):35,023
Last modified:December 1, 2001 - v1
Checksum:i48E563CEEC398ECC
GO
Isoform 2 (identifier: Q96BJ3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-165: Missing.

Note: No experimental confirmation available.

Show »
Length:141
Mass (Da):16,444
Checksum:i7934104EAB68EED2
GO
Isoform 3 (identifier: Q96BJ3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-236: Missing.

Note: No experimental confirmation available.

Show »
Length:224
Mass (Da):25,914
Checksum:iFF95596B7B9C0385
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301E → G in BAB14281 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 165165Missing in isoform 2. 1 PublicationVSP_028322Add
BLAST
Alternative sequencei155 – 23682Missing in isoform 3. CuratedVSP_034661Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022868 mRNA. Translation: BAB14281.1.
AK289865 mRNA. Translation: BAF82554.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73929.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73930.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40463.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40464.1.
BC015535 mRNA. Translation: AAH15535.1.
BC043142 mRNA. Translation: AAH43142.1.
BC067805 mRNA. Translation: AAH67805.1.
AL833718 mRNA. Translation: CAH56257.1.
CCDSiCCDS1533.1. [Q96BJ3-1]
RefSeqiNP_073742.2. NM_022831.2. [Q96BJ3-1]
UniGeneiHs.156625.
Hs.534965.

Genome annotation databases

EnsembliENST00000340020; ENSP00000339161; ENSG00000186063. [Q96BJ3-1]
ENST00000355727; ENSP00000347964; ENSG00000186063. [Q96BJ3-3]
GeneIDi64853.
KEGGihsa:64853.
UCSCiuc001hnn.3. human. [Q96BJ3-1]

Polymorphism databases

DMDMi74751770.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK022868 mRNA. Translation: BAB14281.1.
AK289865 mRNA. Translation: BAF82554.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73929.1.
AL392172, AL592148 Genomic DNA. Translation: CAH73930.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40463.1.
AL592148, AL392172 Genomic DNA. Translation: CAI40464.1.
BC015535 mRNA. Translation: AAH15535.1.
BC043142 mRNA. Translation: AAH43142.1.
BC067805 mRNA. Translation: AAH67805.1.
AL833718 mRNA. Translation: CAH56257.1.
CCDSiCCDS1533.1. [Q96BJ3-1]
RefSeqiNP_073742.2. NM_022831.2. [Q96BJ3-1]
UniGeneiHs.156625.
Hs.534965.

3D structure databases

ProteinModelPortaliQ96BJ3.
SMRiQ96BJ3. Positions 3-115, 152-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122326. 10 interactions.
IntActiQ96BJ3. 3 interactions.
MINTiMINT-8247588.
STRINGi9606.ENSP00000339161.

PTM databases

PhosphoSiteiQ96BJ3.

Polymorphism databases

DMDMi74751770.

Proteomic databases

MaxQBiQ96BJ3.
PaxDbiQ96BJ3.
PRIDEiQ96BJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000340020; ENSP00000339161; ENSG00000186063. [Q96BJ3-1]
ENST00000355727; ENSP00000347964; ENSG00000186063. [Q96BJ3-3]
GeneIDi64853.
KEGGihsa:64853.
UCSCiuc001hnn.3. human. [Q96BJ3-1]

Organism-specific databases

CTDi64853.
GeneCardsiGC01M222841.
H-InvDBHIX0001616.
HIX0028617.
HGNCiHGNC:25761. AIDA.
HPAiHPA027935.
MIMi612375. gene.
neXtProtiNX_Q96BJ3.
PharmGKBiPA162376104.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG48105.
GeneTreeiENSGT00390000016465.
HOGENOMiHOG000006666.
HOVERGENiHBG057354.
InParanoidiQ96BJ3.
OMAiATCLEMR.
OrthoDBiEOG7XPZ6D.
PhylomeDBiQ96BJ3.
TreeFamiTF328541.

Miscellaneous databases

GenomeRNAii64853.
NextBioi66981.
PROiQ96BJ3.
SOURCEiSearch...

Gene expression databases

BgeeiQ96BJ3.
CleanExiHS_AIDA.
GenevestigatoriQ96BJ3.

Family and domain databases

Gene3Di1.20.120.360. 1 hit.
InterProiIPR025939. Aida_C.
IPR023421. AIDA_N.
[Graphical view]
PfamiPF14186. Aida_C2. 1 hit.
PF08910. Aida_N. 1 hit.
[Graphical view]
SUPFAMiSSF109779. SSF109779. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Caudate nucleus.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Pancreas and Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-306 (ISOFORM 1).
    Tissue: Stomach.
  5. "A beta-catenin-independent dorsalization pathway activated by Axin/JNK signaling and antagonized by aida."
    Rui Y., Xu Z., Xiong B., Cao Y., Lin S., Zhang M., Chan S.-C., Luo W., Han Y., Lu Z., Ye Z., Zhou H.-M., Han J., Meng A., Lin S.-C.
    Dev. Cell 13:268-282(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-144, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAIDA_HUMAN
AccessioniPrimary (citable) accession number: Q96BJ3
Secondary accession number(s): A8K1F0
, Q49A81, Q5JRA4, Q658P1, Q9H9E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: December 1, 2001
Last modified: March 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.