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Protein

Epididymal sperm-binding protein 1

Gene

ELSPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to spermatozoa upon ejaculation and may play a role in sperm capacitation. Has phosphorylcholine-binding activity (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Epididymal sperm-binding protein 1
Alternative name(s):
Epididymal secretory protein 12
Short name:
hE12
Gene namesi
Name:ELSPBP1
Synonyms:E12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000169393.8.
HGNCiHGNC:14417. ELSPBP1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi64100.
OpenTargetsiENSG00000169393.
PharmGKBiPA27765.

Polymorphism and mutation databases

BioMutaiELSPBP1.
DMDMi296434494.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000030824925 – 223Epididymal sperm-binding protein 1Add BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi74 ↔ 100PROSITE-ProRule annotation
Disulfide bondi88 ↔ 115PROSITE-ProRule annotation
Disulfide bondi129 ↔ 153PROSITE-ProRule annotation
Disulfide bondi143 ↔ 168PROSITE-ProRule annotation
Disulfide bondi182 ↔ 208PROSITE-ProRule annotation
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 223PROSITE-ProRule annotation

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ96BH3.
PeptideAtlasiQ96BH3.
PRIDEiQ96BH3.

PTM databases

iPTMnetiQ96BH3.
PhosphoSitePlusiQ96BH3.

Expressioni

Tissue specificityi

Detected in cauda epididymidal fluid and on sperm membrane (at protein level).2 Publications

Gene expression databases

BgeeiENSG00000169393.
CleanExiHS_ELSPBP1.
ExpressionAtlasiQ96BH3. baseline and differential.
GenevisibleiQ96BH3. HS.

Organism-specific databases

HPAiHPA044256.
HPA050341.

Interactioni

Protein-protein interaction databases

BioGridi122060. 12 interactors.
STRINGi9606.ENSP00000340660.

Structurei

3D structure databases

ProteinModelPortaliQ96BH3.
SMRiQ96BH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 68Fibronectin type-II 1PROSITE-ProRule annotationAdd BLAST44
Domaini69 – 117Fibronectin type-II 2PROSITE-ProRule annotationAdd BLAST49
Domaini124 – 170Fibronectin type-II 3PROSITE-ProRule annotationAdd BLAST47
Domaini177 – 223Fibronectin type-II 4PROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Belongs to the seminal plasma protein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
GeneTreeiENSGT00900000141047.
HOGENOMiHOG000168399.
HOVERGENiHBG098408.
InParanoidiQ96BH3.
OMAiCETNEYG.
OrthoDBiEOG091G116D.
PhylomeDBiQ96BH3.
TreeFamiTF343543.

Family and domain databases

CDDicd00062. FN2. 3 hits.
Gene3Di2.10.10.10. 4 hits.
InterProiView protein in InterPro
IPR000562. FN_type2_dom.
IPR036943. FN_type2_sf.
IPR013806. Kringle-like.
PfamiView protein in Pfam
PF00040. fn2. 4 hits.
SMARTiView protein in SMART
SM00059. FN2. 4 hits.
SUPFAMiSSF57440. SSF57440. 4 hits.
PROSITEiView protein in PROSITE
PS00023. FN2_1. 1 hit.
PS51092. FN2_2. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96BH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRWSSYLLG WTTFLLYSYE SSGGMHEECV FPFTYKGSVY FTCTHIHSLS
60 70 80 90 100
PWCATRAVYN GQWKYCQSED YPRCIFPFIY RGKAYNSCIS QGSFLGSLWC
110 120 130 140 150
SVTSVFDEKQ QWKFCETNEY GGNSLRKPCI FPSIYRNNVV SDCMEDESNK
160 170 180 190 200
LWCPTTENMD KDGKWSFCAD TRISALVPGF PCHFPFNYKN KNYFNCTNEG
210 220
SKENLVWCAT SYNYDQDHTW VYC
Length:223
Mass (Da):26,106
Last modified:May 18, 2010 - v2
Checksum:iFC7C215BA3E5CE51
GO

Sequence cautioni

The sequence CAC14267 differs from that shown. Reason: Frameshift at position 9.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2T → N in CAC14267 (PubMed:11144225).Curated1
Sequence conflicti221V → A in AAK69481 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_036760100C → W. Corresponds to variant dbSNP:rs3745751Ensembl.1
Natural variantiVAR_036761170D → N. Corresponds to variant dbSNP:rs35362679Ensembl.1
Natural variantiVAR_036762199E → K3 PublicationsCorresponds to variant dbSNP:rs2303690Ensembl.1
Natural variantiVAR_036763215D → N. Corresponds to variant dbSNP:rs6509358Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278478 mRNA. Translation: CAC14267.1. Frameshift.
AF279147 mRNA. Translation: AAK69481.1.
AC010330 Genomic DNA. No translation available.
BC015598 mRNA. Translation: AAH15598.1.
CCDSiCCDS12708.1.
RefSeqiNP_071425.3. NM_022142.4.
UniGeneiHs.104894.

Genome annotation databases

EnsembliENST00000339841; ENSP00000340660; ENSG00000169393.
GeneIDi64100.
KEGGihsa:64100.
UCSCiuc002pht.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiESPB1_HUMAN
AccessioniPrimary (citable) accession number: Q96BH3
Secondary accession number(s): Q96RT0, Q9H4C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: May 18, 2010
Last modified: October 25, 2017
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families