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Protein

Nucleus accumbens-associated protein 2

Gene

NACC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.1 Publication

GO - Molecular functioni

  • histone deacetylase activity Source: BHF-UCL
  • histone deacetylase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: BHF-UCL
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: BHF-UCL
  • transcription factor activity, RNA polymerase II transcription factor binding Source: BHF-UCL

GO - Biological processi

  • cellular protein complex localization Source: BHF-UCL
  • histone deacetylation Source: GOC
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  • posttranscriptional regulation of gene expression Source: BHF-UCL
  • protein homooligomerization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 2
Short name:
NAC-2
Alternative name(s):
BTB/POZ domain-containing protein 14A
Repressor with BTB domain and BEN domain
Gene namesi
Name:NACC2
Synonyms:BTBD14A, NAC2, RBB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:23846. NACC2.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Predominantly associated with chromatin.

GO - Cellular componenti

  • nuclear body Source: UniProtKB
  • nuclear chromatin Source: BHF-UCL
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164723421.

Polymorphism and mutation databases

BioMutaiNACC2.
DMDMi74751767.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Nucleus accumbens-associated protein 2PRO_0000263668Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki299 – 299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96BF6.
MaxQBiQ96BF6.
PaxDbiQ96BF6.
PRIDEiQ96BF6.

PTM databases

iPTMnetiQ96BF6.
PhosphoSiteiQ96BF6.

Expressioni

Gene expression databases

BgeeiQ96BF6.
CleanExiHS_NACC2.
ExpressionAtlasiQ96BF6. baseline and differential.
GenevisibleiQ96BF6. HS.

Organism-specific databases

HPAiHPA047924.
HPA052962.

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi126501. 10 interactions.
IntActiQ96BF6. 2 interactions.
STRINGi9606.ENSP00000277554.

Structurei

3D structure databases

ProteinModelPortaliQ96BF6.
SMRiQ96BF6. Positions 3-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9465BTBPROSITE-ProRule annotationAdd
BLAST
Domaini351 – 44898BENPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BEN domain.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ96BF6.
KOiK10486.
OMAiNSKNAFE.
OrthoDBiEOG7XH6PC.
PhylomeDBiQ96BF6.
TreeFamiTF331184.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96BF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA
60 70 80 90 100
SSLYFRDLFS GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV
110 120 130 140 150
MYTAGFLQIQ HIVERGTDLM FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ
160 170 180 190 200
PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL PPAGPGLAPK RPLETGPRDG
210 220 230 240 250
VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP YPQGERTSPG
260 270 280 290 300
ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP
310 320 330 340 350
EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA
360 370 380 390 400
GSGVYITRGQ LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS
410 420 430 440 450
TSDPSRKPLD SRVLNAVKLY CQNFAPSFKE SEMNVIAADM CTNARRVRKR
460 470 480 490 500
WLPKIKSMLP EGVEMYRTVM GSAAASVPLD PEFPPAAAQV FEQRIYAERR
510 520 530 540 550
GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ EVAAPEPLPA
560 570 580
DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTL
Length:587
Mass (Da):62,837
Last modified:December 1, 2001 - v1
Checksum:iBE1EF06B210EEDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591038, AL355574 Genomic DNA. Translation: CAI11059.1.
AL355574, AL591038 Genomic DNA. Translation: CAI14117.1.
BC015649 mRNA. Translation: AAH15649.1.
CCDSiCCDS6993.1.
RefSeqiNP_653254.1. NM_144653.4.
XP_011516523.1. XM_011518221.1.
UniGeneiHs.112895.
Hs.736561.

Genome annotation databases

EnsembliENST00000277554; ENSP00000277554; ENSG00000148411.
ENST00000371753; ENSP00000360818; ENSG00000148411.
GeneIDi138151.
KEGGihsa:138151.
UCSCiuc004cgv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591038, AL355574 Genomic DNA. Translation: CAI11059.1.
AL355574, AL591038 Genomic DNA. Translation: CAI14117.1.
BC015649 mRNA. Translation: AAH15649.1.
CCDSiCCDS6993.1.
RefSeqiNP_653254.1. NM_144653.4.
XP_011516523.1. XM_011518221.1.
UniGeneiHs.112895.
Hs.736561.

3D structure databases

ProteinModelPortaliQ96BF6.
SMRiQ96BF6. Positions 3-115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126501. 10 interactions.
IntActiQ96BF6. 2 interactions.
STRINGi9606.ENSP00000277554.

PTM databases

iPTMnetiQ96BF6.
PhosphoSiteiQ96BF6.

Polymorphism and mutation databases

BioMutaiNACC2.
DMDMi74751767.

Proteomic databases

EPDiQ96BF6.
MaxQBiQ96BF6.
PaxDbiQ96BF6.
PRIDEiQ96BF6.

Protocols and materials databases

DNASUi138151.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000277554; ENSP00000277554; ENSG00000148411.
ENST00000371753; ENSP00000360818; ENSG00000148411.
GeneIDi138151.
KEGGihsa:138151.
UCSCiuc004cgv.4. human.

Organism-specific databases

CTDi138151.
GeneCardsiNACC2.
HGNCiHGNC:23846. NACC2.
HPAiHPA047924.
HPA052962.
MIMi615786. gene.
neXtProtiNX_Q96BF6.
PharmGKBiPA164723421.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ96BF6.
KOiK10486.
OMAiNSKNAFE.
OrthoDBiEOG7XH6PC.
PhylomeDBiQ96BF6.
TreeFamiTF331184.

Miscellaneous databases

ChiTaRSiNACC2. human.
GenomeRNAii138151.
NextBioi83747.
PROiQ96BF6.
SOURCEiSearch...

Gene expression databases

BgeeiQ96BF6.
CleanExiHS_NACC2.
ExpressionAtlasiQ96BF6. baseline and differential.
GenevisibleiQ96BF6. HS.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  3. "RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene."
    Xuan C., Wang Q., Han X., Duan Y., Li L., Shi L., Wang Y., Shan L., Yao Z., Shang Y.
    Oncogene 32:3711-3721(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, SUBUNIT, FUNCTION, INTERACTION WITH MTA1; MTA2; MTA3 AND HDAC2, ASSOCIATION WITH THE NURD RP COMPLEX.
  4. "System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability."
    Xiao Z., Chang J.G., Hendriks I.A., Sigurdsson J.O., Olsen J.V., Vertegaal A.C.
    Mol. Cell. Proteomics 14:1419-1434(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-299, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiNACC2_HUMAN
AccessioniPrimary (citable) accession number: Q96BF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: March 16, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.