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Protein

Nucleus accumbens-associated protein 2

Gene

NACC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.1 Publication

GO - Molecular functioni

  • histone deacetylase activity Source: BHF-UCL
  • histone deacetylase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: BHF-UCL
  • transcription factor activity, RNA polymerase II transcription factor binding Source: BHF-UCL

GO - Biological processi

  • cellular protein-containing complex localization Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
  • posttranscriptional regulation of gene expression Source: BHF-UCL
  • protein homooligomerization Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 2
Short name:
NAC-2
Alternative name(s):
BTB/POZ domain-containing protein 14A
Repressor with BTB domain and BEN domain
Gene namesi
Name:NACC2
Synonyms:BTBD14A, NAC2, RBB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148411.7
HGNCiHGNC:23846 NACC2
MIMi615786 gene
neXtProtiNX_Q96BF6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi138151
OpenTargetsiENSG00000148411
PharmGKBiPA164723421

Polymorphism and mutation databases

BioMutaiNACC2
DMDMi74751767

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636681 – 587Nucleus accumbens-associated protein 2Add BLAST587

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki174Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki217Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki299Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki429Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki456Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ96BF6
MaxQBiQ96BF6
PaxDbiQ96BF6
PeptideAtlasiQ96BF6
PRIDEiQ96BF6

PTM databases

iPTMnetiQ96BF6
PhosphoSitePlusiQ96BF6

Expressioni

Gene expression databases

BgeeiENSG00000148411
CleanExiHS_NACC2
ExpressionAtlasiQ96BF6 baseline and differential
GenevisibleiQ96BF6 HS

Organism-specific databases

HPAiHPA047924
HPA052962

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with the NuRD complex. Interacts (via C-terminal part) with HDAC2. Interacts (via BTB domain) with MTA1, MTA2 and MTA3.1 Publication

GO - Molecular functioni

  • histone deacetylase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

Protein-protein interaction databases

BioGridi126501, 12 interactors
IntActiQ96BF6, 2 interactors
MINTiQ96BF6
STRINGi9606.ENSP00000277554

Structurei

3D structure databases

ProteinModelPortaliQ96BF6
SMRiQ96BF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 94BTBPROSITE-ProRule annotationAdd BLAST65
Domaini351 – 448BENPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231834
HOVERGENiHBG052875
InParanoidiQ96BF6
KOiK10486
OMAiSVPPACF
OrthoDBiEOG091G05RI
PhylomeDBiQ96BF6
TreeFamiTF331184

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF10523 BEN, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q96BF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQMLHIEIP NFGNTVLGCL NEQRLLGLYC DVSIVVKGQA FKAHRAVLAA
60 70 80 90 100
SSLYFRDLFS GNSKSAFELP GSVPPACFQQ ILSFCYTGRL TMTASEQLVV
110 120 130 140 150
MYTAGFLQIQ HIVERGTDLM FKVSSPHCDS QTAVIEDAGS EPQSPCNQLQ
160 170 180 190 200
PAAAAAAPYV VSPSVPIPLL TRVKHEAMEL PPAGPGLAPK RPLETGPRDG
210 220 230 240 250
VAVAAGAAVA AGTAPLKLPR VSYYGVPSLA TLIPGIQQMP YPQGERTSPG
260 270 280 290 300
ASSLPTTDSP TSYHNEEDEE DDEAYDTMVE EQYGQMYIKA SGSYAVQEKP
310 320 330 340 350
EPVPLESRSC VLIRRDLVAL PASLISQIGY RCHPKLYSEG DPGEKLELVA
360 370 380 390 400
GSGVYITRGQ LMNCHLCAGV KHKVLLRRLL ATFFDRNTLA NSCGTGIRSS
410 420 430 440 450
TSDPSRKPLD SRVLNAVKLY CQNFAPSFKE SEMNVIAADM CTNARRVRKR
460 470 480 490 500
WLPKIKSMLP EGVEMYRTVM GSAAASVPLD PEFPPAAAQV FEQRIYAERR
510 520 530 540 550
GDAATIVALR TDAVNVDLSA AANPAFDAGE EVDGAGSVIQ EVAAPEPLPA
560 570 580
DGQSPPQPFE QGGGGPSRPQ TPAAAARRPE GTYAGTL
Length:587
Mass (Da):62,837
Last modified:December 1, 2001 - v1
Checksum:iBE1EF06B210EEDBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591038 Genomic DNA No translation available.
AL355574 Genomic DNA No translation available.
BC015649 mRNA Translation: AAH15649.1
CCDSiCCDS6993.1
RefSeqiNP_653254.1, NM_144653.4
XP_011516523.1, XM_011518221.2
UniGeneiHs.112895
Hs.736561

Genome annotation databases

EnsembliENST00000277554; ENSP00000277554; ENSG00000148411
ENST00000371753; ENSP00000360818; ENSG00000148411
GeneIDi138151
KEGGihsa:138151
UCSCiuc004cgv.4 human

Similar proteinsi

Entry informationi

Entry nameiNACC2_HUMAN
AccessioniPrimary (citable) accession number: Q96BF6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: December 1, 2001
Last modified: April 25, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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