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Protein

Solute carrier organic anion transporter family member 4A1

Gene

SLCO4A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the Na+-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101187-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Protein family/group databases

MEROPSiI01.972.
TCDBi2.A.60.1.9. the organo anion transporter (oat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier organic anion transporter family member 4A1
Short name:
OATP4A1
Alternative name(s):
Colon organic anion transporter
Organic anion transporter polypeptide-related protein 1
Short name:
OATP-RP1
Short name:
OATPRP1
Short name:
POAT
Organic anion-transporting polypeptide E
Short name:
OATP-E
Sodium-independent organic anion transporter E
Solute carrier family 21 member 12
Gene namesi
Name:SLCO4A1
Synonyms:OATP1, OATP4A1, OATPE, SLC21A12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:10953. SLCO4A1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 103CytoplasmicSequence analysisAdd BLAST103
Transmembranei104 – 124Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini125 – 143ExtracellularSequence analysisAdd BLAST19
Transmembranei144 – 164Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini165 – 170CytoplasmicSequence analysis6
Transmembranei171 – 195Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini196 – 222ExtracellularSequence analysisAdd BLAST27
Transmembranei223 – 253Helical; Name=4Sequence analysisAdd BLAST31
Topological domaini254 – 272CytoplasmicSequence analysisAdd BLAST19
Transmembranei273 – 293Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini294 – 307ExtracellularSequence analysisAdd BLAST14
Transmembranei308 – 332Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini333 – 378CytoplasmicSequence analysisAdd BLAST46
Transmembranei379 – 400Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini401 – 420ExtracellularSequence analysisAdd BLAST20
Transmembranei421 – 444Helical; Name=8Sequence analysisAdd BLAST24
Topological domaini445 – 448CytoplasmicSequence analysis4
Transmembranei449 – 471Helical; Name=9Sequence analysisAdd BLAST23
Topological domaini472 – 580ExtracellularSequence analysisAdd BLAST109
Transmembranei581 – 603Helical; Name=10Sequence analysisAdd BLAST23
Topological domaini604 – 612CytoplasmicSequence analysis9
Transmembranei613 – 638Helical; Name=11Sequence analysisAdd BLAST26
Topological domaini639 – 671ExtracellularSequence analysisAdd BLAST33
Transmembranei672 – 689Helical; Name=12Sequence analysisAdd BLAST18
Topological domaini690 – 722CytoplasmicSequence analysisAdd BLAST33

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28231.
OpenTargetsiENSG00000101187.
PharmGKBiPA35838.

Chemistry databases

ChEMBLiCHEMBL2073679.
DrugBankiDB01053. Benzylpenicillin.
DB00286. Conjugated Estrogens.
DB00509. Dextrothyroxine.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00783. Estradiol.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.

Polymorphism and mutation databases

BioMutaiSLCO4A1.
DMDMi27734555.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001910671 – 722Solute carrier organic anion transporter family member 4A1Add BLAST722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei34PhosphoserineCombined sources1
Modified residuei37PhosphothreonineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei43PhosphoserineCombined sources1
Modified residuei46PhosphoserineCombined sources1
Modified residuei50PhosphoserineCombined sources1
Glycosylationi499N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi504 ↔ 530PROSITE-ProRule annotation
Disulfide bondi508 ↔ 519PROSITE-ProRule annotation
Disulfide bondi510 ↔ 534PROSITE-ProRule annotation
Glycosylationi557N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ96BD0.
PaxDbiQ96BD0.
PeptideAtlasiQ96BD0.
PRIDEiQ96BD0.

PTM databases

iPTMnetiQ96BD0.
PhosphoSitePlusiQ96BD0.
SwissPalmiQ96BD0.

Expressioni

Tissue specificityi

Ubiquitous, with the exception of spleen and leukocytes.

Gene expression databases

BgeeiENSG00000101187.
CleanExiHS_SLCO4A1.
ExpressionAtlasiQ96BD0. baseline and differential.
GenevisibleiQ96BD0. HS.

Organism-specific databases

HPAiHPA030669.
HPA030670.

Interactioni

Protein-protein interaction databases

BioGridi118180. 4 interactors.
IntActiQ96BD0. 5 interactors.
STRINGi9606.ENSP00000217159.

Structurei

3D structure databases

ProteinModelPortaliQ96BD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini498 – 555Kazal-likePROSITE-ProRule annotationAdd BLAST58

Sequence similaritiesi

Contains 1 Kazal-like domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG100565.
InParanoidiQ96BD0.
KOiK14354.
OMAiGPNSAME.
OrthoDBiEOG091G02FX.
PhylomeDBiQ96BD0.
TreeFamiTF317540.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Experimental confirmation may be lacking for some isoforms.
Isoform 1 (identifier: Q96BD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS
60 70 80 90 100
PLDTSKQPLC QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN
110 120 130 140 150
TPKGILFFLC AAAFLQGMTV NGFINTVITS LERRYDLHSY QSGLIASSYD
160 170 180 190 200
IAACLCLTFV SYFGGSGHKP RWLGWGVLLM GTGSLVFALP HFTAGRYEVE
210 220 230 240 250
LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG ATPLYTLGVT
260 270 280 290 300
YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT
310 320 330 340 350
TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH
360 370 380 390 400
QLKDSSRGEA SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT
410 420 430 440 450
GMSTFSPKFL ESQFSLSASE AATLFGYLVV PAGGGGTFLG GFFVNKLRLR
460 470 480 490 500
GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP MAGVTASYGG SLLPEGHLNL
510 520 530 540 550
TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET NVDGQKVYRD
560 570 580 590 600
CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT
610 620 630 640 650
ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG
660 670 680 690 700
QQGSCLVYQN SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE
710 720
TCLPSQSSAP DSATDSQLQS SV
Length:722
Mass (Da):77,193
Last modified:January 10, 2003 - v2
Checksum:iDD8F0C10E4BCD255
GO
Isoform 2 (identifier: Q96BD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     250-410: TYLDENVKSS...GMSTFSPKFL → LFFAIACFLYKPLS
     686-722: CFLYKPLSES...ATDSQLQSSV → SSRAASDHRP...ELLFDLQPST

Show »
Length:583
Mass (Da):62,325
Checksum:i67342B00D99DCB31
GO
Isoform 3 (identifier: Q96BD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     548-661: YRDCSCIPQN...QGSCLVYQNS → SGAAAYRPCP...QHPEAELCRS
     662-722: Missing.

Show »
Length:661
Mass (Da):70,454
Checksum:i39E50AB1FC24B071
GO
Isoform 4 (identifier: Q96BD0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     572-603: STCQRKPLLLVFIFVVIFFTFLSSIPALTATL → TTALCAARTASCTSHCATQGALQPRRRMWTAR

Show »
Length:722
Mass (Da):77,084
Checksum:i8A5B9415E0B1CB63
GO

Sequence cautioni

The sequence BAA91247 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti246T → M in BAB14566 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05367870R → Q.Corresponds to variant rs34419428dbSNPEnsembl.1
Natural variantiVAR_05367978V → I.1 PublicationCorresponds to variant rs1047099dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006152250 – 410TYLDE…SPKFL → LFFAIACFLYKPLS in isoform 2. 1 PublicationAdd BLAST161
Alternative sequenceiVSP_006153548 – 661YRDCS…VYQNS → SGAAAYRPCPPLDPGKGPPC LPLVIGAIVGLPRCTETVAV SLRIFPLVLAMHCREMHFNL SEKAPPSGFHIRCNFLYIPQ QHSCTNGNSTVSWGRVCACP ELSLQHPEAELCRS in isoform 3. CuratedAdd BLAST114
Alternative sequenceiVSP_006154572 – 603STCQR…LTATL → TTALCAARTASCTSHCATQG ALQPRRRMWTAR in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_006155662 – 722Missing in isoform 3. CuratedAdd BLAST61
Alternative sequenceiVSP_006156686 – 722CFLYK…LQSSV → SSRAASDHRPRPPGHGGHSA FPDDRTVPLGDAITRELLFD LQPST in isoform 2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031051 mRNA. Translation: BAA89288.1.
AF187817 mRNA. Translation: AAG43447.1.
AF104334 mRNA. Translation: AAF15545.1.
AF205072 mRNA. Translation: AAG42204.1.
AK023410 mRNA. Translation: BAB14566.1.
AK000551 mRNA. Translation: BAA91247.1. Different initiation.
AL357033 Genomic DNA. Translation: CAC14920.1.
AL357033 Genomic DNA. Translation: CAC14921.1.
BC015727 mRNA. Translation: AAH15727.1.
CCDSiCCDS13501.1. [Q96BD0-1]
RefSeqiNP_057438.3. NM_016354.3. [Q96BD0-1]
UniGeneiHs.235782.

Genome annotation databases

EnsembliENST00000217159; ENSP00000217159; ENSG00000101187. [Q96BD0-1]
ENST00000370507; ENSP00000359538; ENSG00000101187. [Q96BD0-1]
GeneIDi28231.
KEGGihsa:28231.
UCSCiuc002ydb.1. human. [Q96BD0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB031051 mRNA. Translation: BAA89288.1.
AF187817 mRNA. Translation: AAG43447.1.
AF104334 mRNA. Translation: AAF15545.1.
AF205072 mRNA. Translation: AAG42204.1.
AK023410 mRNA. Translation: BAB14566.1.
AK000551 mRNA. Translation: BAA91247.1. Different initiation.
AL357033 Genomic DNA. Translation: CAC14920.1.
AL357033 Genomic DNA. Translation: CAC14921.1.
BC015727 mRNA. Translation: AAH15727.1.
CCDSiCCDS13501.1. [Q96BD0-1]
RefSeqiNP_057438.3. NM_016354.3. [Q96BD0-1]
UniGeneiHs.235782.

3D structure databases

ProteinModelPortaliQ96BD0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118180. 4 interactors.
IntActiQ96BD0. 5 interactors.
STRINGi9606.ENSP00000217159.

Chemistry databases

ChEMBLiCHEMBL2073679.
DrugBankiDB01053. Benzylpenicillin.
DB00286. Conjugated Estrogens.
DB00509. Dextrothyroxine.
DB00390. Digoxin.
DB00917. Dinoprostone.
DB00783. Estradiol.
DB00451. Levothyroxine.
DB00279. Liothyronine.
DB01583. Liotrix.

Protein family/group databases

MEROPSiI01.972.
TCDBi2.A.60.1.9. the organo anion transporter (oat) family.

PTM databases

iPTMnetiQ96BD0.
PhosphoSitePlusiQ96BD0.
SwissPalmiQ96BD0.

Polymorphism and mutation databases

BioMutaiSLCO4A1.
DMDMi27734555.

Proteomic databases

MaxQBiQ96BD0.
PaxDbiQ96BD0.
PeptideAtlasiQ96BD0.
PRIDEiQ96BD0.

Protocols and materials databases

DNASUi28231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217159; ENSP00000217159; ENSG00000101187. [Q96BD0-1]
ENST00000370507; ENSP00000359538; ENSG00000101187. [Q96BD0-1]
GeneIDi28231.
KEGGihsa:28231.
UCSCiuc002ydb.1. human. [Q96BD0-1]

Organism-specific databases

CTDi28231.
DisGeNETi28231.
GeneCardsiSLCO4A1.
H-InvDBHIX0015985.
HIX0138058.
HGNCiHGNC:10953. SLCO4A1.
HPAiHPA030669.
HPA030670.
MIMi612436. gene.
neXtProtiNX_Q96BD0.
OpenTargetsiENSG00000101187.
PharmGKBiPA35838.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3626. Eukaryota.
ENOG410XRSF. LUCA.
GeneTreeiENSGT00760000119014.
HOVERGENiHBG100565.
InParanoidiQ96BD0.
KOiK14354.
OMAiGPNSAME.
OrthoDBiEOG091G02FX.
PhylomeDBiQ96BD0.
TreeFamiTF317540.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101187-MONOMER.
ReactomeiR-HSA-879518. Transport of organic anions.

Miscellaneous databases

ChiTaRSiSLCO4A1. human.
GeneWikiiSLCO4A1.
GenomeRNAii28231.
PROiQ96BD0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101187.
CleanExiHS_SLCO4A1.
ExpressionAtlasiQ96BD0. baseline and differential.
GenevisibleiQ96BD0. HS.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002350. Kazal_dom.
IPR020846. MFS_dom.
IPR004156. OA_transporter.
[Graphical view]
PANTHERiPTHR11388. PTHR11388. 1 hit.
PfamiPF07648. Kazal_2. 1 hit.
PF03137. OATP. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 3 hits.
TIGRFAMsiTIGR00805. oat. 1 hit.
PROSITEiPS51465. KAZAL_2. 1 hit.
PS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSO4A1_HUMAN
AccessioniPrimary (citable) accession number: Q96BD0
Secondary accession number(s): Q9H4T7
, Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 10, 2003
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.