Q96BD0 (SO4A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Solute carrier organic anion transporter family member 4A1
Short name=OATP4A1

Alternative name(s):
Colon organic anion transporter
Organic anion transporter polypeptide-related protein 1
Short name=OATP-RP1
Short name=OATPRP1
Short name=POAT
Organic anion-transporting polypeptide E
Short name=OATP-E
Sodium-independent organic anion transporter E
Solute carrier family 21 member 12

Gene names

Name:	SLCO4A1
Synonyms:	OATP1, OATP4A1, OATPE, SLC21A12

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	722 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Mediates the Na+-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Ubiquitous, with the exception of spleen and leukocytes.
Sequence similarities	Belongs to the organo anion transporter (TC 2.A.60) family. [View classification] Contains 1 Kazal-like domain.
Sequence caution	The sequence BAA91247.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sodium-independent organic anion transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Note: Experimental confirmation may be lacking for some isoforms.

Isoform 1 (identifier: Q96BD0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q96BD0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     250-410: TYLDENVKSS...GMSTFSPKFL → LFFAIACFLYKPLS
     686-722: CFLYKPLSES...ATDSQLQSSV → SSRAASDHRP...ELLFDLQPST

Isoform 3 (identifier: Q96BD0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     548-661: YRDCSCIPQN...QGSCLVYQNS → SGAAAYRPCP...QHPEAELCRS
     662-722: Missing.

Isoform 4 (identifier: Q96BD0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     572-603: STCQRKPLLLVFIFVVIFFTFLSSIPALTATL → TTALCAARTASCTSHCATQGALQPRRRMWTAR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 722	722	Solute carrier organic anion transporter family member 4A1		PRO_0000191067
Regions
	Topological domain	1 – 103	103	Cytoplasmic Potential
	Transmembrane	104 – 124	21	Helical; Name=1; Potential
	Topological domain	125 – 143	19	Extracellular Potential
	Transmembrane	144 – 164	21	Helical; Name=2; Potential
	Topological domain	165 – 170	6	Cytoplasmic Potential
	Transmembrane	171 – 195	25	Helical; Name=3; Potential
	Topological domain	196 – 222	27	Extracellular Potential
	Transmembrane	223 – 253	31	Helical; Name=4; Potential
	Topological domain	254 – 272	19	Cytoplasmic Potential
	Transmembrane	273 – 293	21	Helical; Name=5; Potential
	Topological domain	294 – 307	14	Extracellular Potential
	Transmembrane	308 – 332	25	Helical; Name=6; Potential
	Topological domain	333 – 378	46	Cytoplasmic Potential
	Transmembrane	379 – 400	22	Helical; Name=7; Potential
	Topological domain	401 – 420	20	Extracellular Potential
	Transmembrane	421 – 444	24	Helical; Name=8; Potential
	Topological domain	445 – 448	4	Cytoplasmic Potential
	Transmembrane	449 – 471	23	Helical; Name=9; Potential
	Topological domain	472 – 580	109	Extracellular Potential
	Transmembrane	581 – 603	23	Helical; Name=10; Potential
	Topological domain	604 – 612	9	Cytoplasmic Potential
	Transmembrane	613 – 638	26	Helical; Name=11; Potential
	Topological domain	639 – 671	33	Extracellular Potential
	Transmembrane	672 – 689	18	Helical; Name=12; Potential
	Topological domain	690 – 722	33	Cytoplasmic Potential
	Domain	498 – 555	58	Kazal-like
Amino acid modifications
	Modified residue	34	1	Phosphoserine Ref.9
	Modified residue	37	1	Phosphothreonine Ref.9
	Modified residue	40	1	Phosphoserine Ref.9 Ref.10
	Modified residue	43	1	Phosphoserine Ref.9 Ref.10
	Modified residue	46	1	Phosphoserine Ref.9 Ref.10
	Modified residue	50	1	Phosphoserine Ref.9 Ref.10
	Glycosylation	499	1	N-linked (GlcNAc...) Potential
	Glycosylation	557	1	N-linked (GlcNAc...) Potential
	Disulfide bond	504 ↔ 530		By similarity
	Disulfide bond	508 ↔ 519		By similarity
	Disulfide bond	510 ↔ 534		By similarity
Natural variations
	Alternative sequence	250 – 410	161	TYLDE…SPKFL → LFFAIACFLYKPLS in isoform 2.		VSP_006152
	Alternative sequence	548 – 661	114	YRDCS…VYQNS → SGAAAYRPCPPLDPGKGPPC LPLVIGAIVGLPRCTETVAV SLRIFPLVLAMHCREMHFNL SEKAPPSGFHIRCNFLYIPQ QHSCTNGNSTVSWGRVCACP ELSLQHPEAELCRS in isoform 3.		VSP_006153
	Alternative sequence	572 – 603	32	STCQR…LTATL → TTALCAARTASCTSHCATQG ALQPRRRMWTAR in isoform 4.		VSP_006154
	Alternative sequence	662 – 722	61	Missing in isoform 3.		VSP_006155
	Alternative sequence	686 – 722	37	CFLYK…LQSSV → SSRAASDHRPRPPGHGGHSA FPDDRTVPLGDAITRELLFD LQPST in isoform 2.		VSP_006156
	Natural variant	70	1	R → Q. Corresponds to variant rs34419428 [ dbSNP | Ensembl ].		VAR_053678
	Natural variant	78	1	V → I. Ref.5 Corresponds to variant rs1047099 [ dbSNP | Ensembl ].		VAR_053679
Experimental info
	Sequence conflict	246	1	T → M in BAB14566. Ref.5

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 10, 2003. Version 2. Checksum: DD8F0C10E4BCD255	FASTA	722	77,193
	10 20 30 40 50 60 MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 70 80 90 100 110 120 QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 130 140 150 160 170 180 NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 190 200 210 220 230 240 GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 250 260 270 280 290 300 ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 310 320 330 340 350 360 TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 370 380 390 400 410 420 SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 430 440 450 460 470 480 AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 490 500 510 520 530 540 MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 550 560 570 580 590 600 NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TSTCQRKPLL LVFIFVVIFF TFLSSIPALT 610 620 630 640 650 660 ATLRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN 670 680 690 700 710 720 SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS SV
	Isoform 2 [UniParc]. Checksum: 67342B00D99DCB31	FASTA	583	62,325
	10 20 30 40 50 60 MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 70 80 90 100 110 120 QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 130 140 150 160 170 180 NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 190 200 210 220 230 240 GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 250 260 270 280 290 300 ATPLYTLGVL FFAIACFLYK PLSESQFSLS ASEAATLFGY LVVPAGGGGT FLGGFFVNKL 310 320 330 340 350 360 RLRGSAVIKF CLFCTVVSLL GILVFSLHCP SVPMAGVTAS YGGSLLPEGH LNLTAPCNAA 370 380 390 400 410 420 CSCQPEHYSP VCGSDGLMYF SLCHAGCPAA TETNVDGQKV YRDCSCIPQN LSSGFGHATA 430 440 450 460 470 480 GKCTSTCQRK PLLLVFIFVV IFFTFLSSIP ALTATLRCVR DPQRSFALGI QWIVVRILGG 490 500 510 520 530 540 IPGPIAFGWV IDKACLLWQD QCGQQGSCLV YQNSAMSRYI LIMGLLYKVL GVLFFAIASS 550 560 570 580 RAASDHRPRP PGHGGHSAFP DDRTVPLGDA ITRELLFDLQ PST
	Isoform 3 [UniParc]. Checksum: 39E50AB1FC24B071	FASTA	661	70,454
	10 20 30 40 50 60 MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 70 80 90 100 110 120 QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 130 140 150 160 170 180 NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 190 200 210 220 230 240 GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 250 260 270 280 290 300 ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 310 320 330 340 350 360 TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 370 380 390 400 410 420 SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 430 440 450 460 470 480 AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 490 500 510 520 530 540 MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 550 560 570 580 590 600 NVDGQKVSGA AAYRPCPPLD PGKGPPCLPL VIGAIVGLPR CTETVAVSLR IFPLVLAMHC 610 620 630 640 650 660 REMHFNLSEK APPSGFHIRC NFLYIPQQHS CTNGNSTVSW GRVCACPELS LQHPEAELCR S
	Isoform 4 [UniParc]. Checksum: 8A5B9415E0B1CB63	FASTA	722	77,084
	10 20 30 40 50 60 MPLHQLGDKP LTFPSPNSAM ENGLDHTPPS RRASPGTPLS PGSLRSAAHS PLDTSKQPLC 70 80 90 100 110 120 QLWAEKHGAR GTHEVRYVSA GQSVACGWWA FAPPCLQVLN TPKGILFFLC AAAFLQGMTV 130 140 150 160 170 180 NGFINTVITS LERRYDLHSY QSGLIASSYD IAACLCLTFV SYFGGSGHKP RWLGWGVLLM 190 200 210 220 230 240 GTGSLVFALP HFTAGRYEVE LDAGVRTCPA NPGAVCADST SGLSRYQLVF MLGQFLHGVG 250 260 270 280 290 300 ATPLYTLGVT YLDENVKSSC SPVYIAIFYT AAILGPAAGY LIGGALLNIY TEMGRRTELT 310 320 330 340 350 360 TESPLWVGAW WVGFLGSGAA AFFTAVPILG YPRQLPGSQR YAVMRAAEMH QLKDSSRGEA 370 380 390 400 410 420 SNPDFGKTIR DLPLSIWLLL KNPTFILLCL AGATEATLIT GMSTFSPKFL ESQFSLSASE 430 440 450 460 470 480 AATLFGYLVV PAGGGGTFLG GFFVNKLRLR GSAVIKFCLF CTVVSLLGIL VFSLHCPSVP 490 500 510 520 530 540 MAGVTASYGG SLLPEGHLNL TAPCNAACSC QPEHYSPVCG SDGLMYFSLC HAGCPAATET 550 560 570 580 590 600 NVDGQKVYRD CSCIPQNLSS GFGHATAGKC TTTALCAART ASCTSHCATQ GALQPRRRMW 610 620 630 640 650 660 TARRCVRDPQ RSFALGIQWI VVRILGGIPG PIAFGWVIDK ACLLWQDQCG QQGSCLVYQN 670 680 690 700 710 720 SAMSRYILIM GLLYKVLGVL FFAIACFLYK PLSESSDGLE TCLPSQSSAP DSATDSQLQS SV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family." Tamai I., Nezu J., Uchino H., Sai Y., Oku A., Shimane M., Tsuji A. Biochem. Biophys. Res. Commun. 273:251-260(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Kidney.
[2]	"Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner." Fujiwara K., Adachi H., Nishio T., Unno M., Tokui T., Okabe M., Onogawa T., Suzuki T., Asano N., Tanemoto M., Seki M., Shiiba K., Suzuki M., Kondo Y., Nunoki K., Shimosegawa T., Iinuma K., Ito S., Matsuno S., Abe T. Endocrinology 142:2005-2012(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Hippocampus.
[3]	"Molecular cloning of a putative organic anion transporter, POAT." Itoh S., Coca-Prados M., Lu R., Chan B.S., Schuster V.L. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3).
[4]	"Identification and characterization of novel human OATP family members." Wu Y., Hsiang B.H., Zhu Y., Yang W.-P., Kirchgessner T.G. Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4), VARIANT ILE-78. Tissue: Ovarian carcinoma.
[6]	"The DNA sequence and comparative analysis of human chromosome 20." Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E. , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J. Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Pancreas.
[8]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-34; THR-37; SER-40; SER-43; SER-46 AND SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[10]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40; SER-43; SER-46 AND SER-50, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB031051 mRNA. Translation: BAA89288.1. AF187817 mRNA. Translation: AAG43447.1. AF104334 mRNA. Translation: AAF15545.1. AF205072 mRNA. Translation: AAG42204.1. AK023410 mRNA. Translation: BAB14566.1. AK000551 mRNA. Translation: BAA91247.1. Different initiation. AL357033 Genomic DNA. Translation: CAC14920.1. AL357033 Genomic DNA. Translation: CAC14921.1. BC015727 mRNA. Translation: AAH15727.1.
IPI	IPI00039680. IPI00100858. IPI00218821. IPI00873199.
RefSeq	NP_057438.3. NM_016354.3.
UniGene	Hs.235782.
3D structure databases
ProteinModelPortal	Q96BD0.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96BD0. 1 interaction.
STRING	9606.ENSP00000217159.
Protein family/group databases
TCDB	2.A.60.1.9. organo anion transporter (OAT) family.
PTM databases
PhosphoSite	Q96BD0.
Polymorphism databases
DMDM	27734555.
Proteomic databases
PaxDb	Q96BD0.
PRIDE	Q96BD0.
Protocols and materials databases
DNASU	28231.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000217159; ENSP00000217159; ENSG00000101187. ENST00000370507; ENSP00000359538; ENSG00000101187. ENST00000451793; ENSP00000414855; ENSG00000101187.
GeneID	28231.
KEGG	hsa:28231.
UCSC	uc002ydb.1. human.
Organism-specific databases
CTD	28231.
GeneCards	GC20P061273.
H-InvDB	HIX0015985. HIX0138058.
HGNC	HGNC:10953. SLCO4A1.
HPA	HPA030669. HPA030670.
MIM	612436. gene.
neXtProt	NX_Q96BD0.
PharmGKB	PA35838.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG320775.
HOVERGEN	HBG100565.
InParanoid	Q96BD0.
KO	K14354.
OMA	FKLRCSG.
OrthoDB	EOG41VK2S.
PhylomeDB	Q96BD0.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q96BD0.
Bgee	Q96BD0.
CleanEx	HS_SLCO4A1.
Genevestigator	Q96BD0.
GermOnline	ENSG00000101187. Homo sapiens.
Family and domain databases
InterPro	IPR002350. Kazal_dom. IPR020846. MFS_dom. IPR016196. MFS_dom_general_subst_transpt. IPR004156. OA_transporter. [Graphical view]
PANTHER	PTHR11388. PTHR11388. 1 hit.
Pfam	PF07648. Kazal_2. 1 hit. PF03137. OATP. 1 hit. [Graphical view]
SMART	SM00280. KAZAL. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00805. oat. 1 hit.
PROSITE	PS51465. KAZAL_2. 1 hit. PS50850. MFS. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SLCO4A1. human.
GenomeRNAi	28231.
NextBio	50544.
SOURCE	Search...

Entry information

Entry name

SO4A1_HUMAN

Accession

Primary (citable) accession number: Q96BD0
Secondary accession number(s): Q9H4T7 , Q9H4T8, Q9H8P2, Q9NWX8, Q9UI35, Q9UIG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2003
Last sequence update:	January 10, 2003
Last modified:	May 1, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

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Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.