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Protein

Promethin

Gene

TMEM159

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Promethin
Alternative name(s):
Transmembrane protein 159
Gene namesi
Name:TMEM159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30136. TMEM159.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei55 – 7521HelicalSequence analysisAdd
BLAST
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145147935.

Polymorphism and mutation databases

BioMutaiTMEM159.
DMDMi313104024.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 161161PromethinPRO_0000279535Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence analysis
Glycosylationi141 – 1411N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ96B96.
MaxQBiQ96B96.
PaxDbiQ96B96.
PRIDEiQ96B96.

PTM databases

iPTMnetiQ96B96.
PhosphoSiteiQ96B96.

Expressioni

Tissue specificityi

Expressed at high levels in the heart and skeletal muscle. Expressed at low levels in kidney, small intestine, lung and liver.1 Publication

Gene expression databases

BgeeiQ96B96.
CleanExiHS_TMEM159.
ExpressionAtlasiQ96B96. baseline and differential.
GenevisibleiQ96B96. HS.

Organism-specific databases

HPAiHPA018033.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ADCK3Q8NI605EBI-7055862,EBI-745535
CACFD1Q9UGQ24EBI-7055862,EBI-8652492
GAD2Q053293EBI-7055862,EBI-9304251

Protein-protein interaction databases

BioGridi121403. 7 interactions.
IntActiQ96B96. 4 interactions.
MINTiMINT-8201794.
STRINGi9606.ENSP00000233047.

Structurei

3D structure databases

ProteinModelPortaliQ96B96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM159 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZ20. Eukaryota.
ENOG41126AQ. LUCA.
GeneTreeiENSGT00390000006420.
HOGENOMiHOG000069886.
HOVERGENiHBG094018.
InParanoidiQ96B96.
OMAiWFSPRPL.
PhylomeDBiQ96B96.
TreeFamiTF335782.

Family and domain databases

InterProiIPR029709. Promethin/TMEM159.
[Graphical view]
PANTHERiPTHR14275:SF0. PTHR14275:SF0. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96B96-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAKEEPQSIS RDLQELQKKL SLLIDSFQNN SKVVAFMKSP VGQYLDSHPF
60 70 80 90 100
LAFTLLVFIV MSAVPVGFFL LIVVLTTLAA LLGVIILEGL VISVGGFSLL
110 120 130 140 150
CILCGLGFVS LAMSGMMIAS YVVVSSLISC WFSPRPLTQQ NTSCDFLPAM
160
KSAEFEGLYQ E
Length:161
Mass (Da):17,522
Last modified:November 30, 2010 - v2
Checksum:i196B502EE203BA7E
GO
Isoform 2 (identifier: Q96B96-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     30-30: N → NSKLPQHSRISLDSDDGVSRLGSAG

Note: No experimental confirmation available.
Show »
Length:185
Mass (Da):19,987
Checksum:iEEFAD1983E8DED04
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti97 – 971F → L.
Corresponds to variant rs35345508 [ dbSNP | Ensembl ].
VAR_057765
Natural varianti107 – 1071G → S.1 Publication
Corresponds to variant rs1046480 [ dbSNP | Ensembl ].
VAR_030923
Natural varianti154 – 1541E → D.2 Publications
Corresponds to variant rs1063087 [ dbSNP | Ensembl ].
VAR_030924

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei30 – 301N → NSKLPQHSRISLDSDDGVSR LGSAG in isoform 2. 1 PublicationVSP_056078

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212918 mRNA. Translation: AAO52682.1.
AK074667 mRNA. Translation: BAC11122.1.
AK293557 mRNA. Translation: BAG57032.1.
AF001550 Genomic DNA. Translation: AAB67598.1.
AC008551 Genomic DNA. No translation available.
BC015812 mRNA. Translation: AAH15812.1.
CCDSiCCDS10595.1. [Q96B96-1]
CCDS76841.1. [Q96B96-2]
RefSeqiNP_001288698.1. NM_001301769.1. [Q96B96-1]
NP_001288700.1. NM_001301771.1. [Q96B96-1]
NP_001288702.1. NM_001301773.1.
NP_001288703.1. NM_001301774.1.
NP_001288704.1. NM_001301775.1. [Q96B96-2]
NP_065155.3. NM_020422.5. [Q96B96-1]
XP_005255496.1. XM_005255439.3. [Q96B96-2]
XP_006721129.1. XM_006721066.1. [Q96B96-2]
UniGeneiHs.258212.

Genome annotation databases

EnsembliENST00000233047; ENSP00000233047; ENSG00000011638. [Q96B96-1]
ENST00000261388; ENSP00000261388; ENSG00000011638. [Q96B96-1]
ENST00000451578; ENSP00000409879; ENSG00000011638. [Q96B96-2]
ENST00000572599; ENSP00000460687; ENSG00000011638. [Q96B96-1]
GeneIDi57146.
KEGGihsa:57146.
UCSCiuc002dif.5. human. [Q96B96-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY212918 mRNA. Translation: AAO52682.1.
AK074667 mRNA. Translation: BAC11122.1.
AK293557 mRNA. Translation: BAG57032.1.
AF001550 Genomic DNA. Translation: AAB67598.1.
AC008551 Genomic DNA. No translation available.
BC015812 mRNA. Translation: AAH15812.1.
CCDSiCCDS10595.1. [Q96B96-1]
CCDS76841.1. [Q96B96-2]
RefSeqiNP_001288698.1. NM_001301769.1. [Q96B96-1]
NP_001288700.1. NM_001301771.1. [Q96B96-1]
NP_001288702.1. NM_001301773.1.
NP_001288703.1. NM_001301774.1.
NP_001288704.1. NM_001301775.1. [Q96B96-2]
NP_065155.3. NM_020422.5. [Q96B96-1]
XP_005255496.1. XM_005255439.3. [Q96B96-2]
XP_006721129.1. XM_006721066.1. [Q96B96-2]
UniGeneiHs.258212.

3D structure databases

ProteinModelPortaliQ96B96.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121403. 7 interactions.
IntActiQ96B96. 4 interactions.
MINTiMINT-8201794.
STRINGi9606.ENSP00000233047.

PTM databases

iPTMnetiQ96B96.
PhosphoSiteiQ96B96.

Polymorphism and mutation databases

BioMutaiTMEM159.
DMDMi313104024.

Proteomic databases

EPDiQ96B96.
MaxQBiQ96B96.
PaxDbiQ96B96.
PRIDEiQ96B96.

Protocols and materials databases

DNASUi57146.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000233047; ENSP00000233047; ENSG00000011638. [Q96B96-1]
ENST00000261388; ENSP00000261388; ENSG00000011638. [Q96B96-1]
ENST00000451578; ENSP00000409879; ENSG00000011638. [Q96B96-2]
ENST00000572599; ENSP00000460687; ENSG00000011638. [Q96B96-1]
GeneIDi57146.
KEGGihsa:57146.
UCSCiuc002dif.5. human. [Q96B96-1]

Organism-specific databases

CTDi57146.
GeneCardsiTMEM159.
H-InvDBHIX0012870.
HGNCiHGNC:30136. TMEM159.
HPAiHPA018033.
MIMi611304. gene.
neXtProtiNX_Q96B96.
PharmGKBiPA145147935.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ20. Eukaryota.
ENOG41126AQ. LUCA.
GeneTreeiENSGT00390000006420.
HOGENOMiHOG000069886.
HOVERGENiHBG094018.
InParanoidiQ96B96.
OMAiWFSPRPL.
PhylomeDBiQ96B96.
TreeFamiTF335782.

Miscellaneous databases

ChiTaRSiTMEM159. human.
GenomeRNAii57146.
PROiQ96B96.
SOURCEiSearch...

Gene expression databases

BgeeiQ96B96.
CleanExiHS_TMEM159.
ExpressionAtlasiQ96B96. baseline and differential.
GenevisibleiQ96B96. HS.

Family and domain databases

InterProiIPR029709. Promethin/TMEM159.
[Graphical view]
PANTHERiPTHR14275:SF0. PTHR14275:SF0. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver."
    Yu S., Viswakarma N., Batra S.K., Sambasiva Rao M., Reddy J.K.
    Biochimie 86:743-761(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, VARIANT ASP-154.
    Tissue: Heart.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ASP-154.
    Tissue: Cerebellum and Mammary gland.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT SER-107.
    Tissue: Skin.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTM159_HUMAN
AccessioniPrimary (citable) accession number: Q96B96
Secondary accession number(s): A6NMA9, B4DEC1, O00323
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: November 30, 2010
Last modified: June 8, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.