ID   RGMA_HUMAN              Reviewed;         450 AA.
AC   Q96B86; Q0JV97; Q8NC80; Q9H0E6; Q9NPM3;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 2.
DT   07-JUL-2009, entry version 49.
DE   RecName: Full=Repulsive guidance molecule A;
DE   AltName: Full=RGM domain family member A;
DE   Flags: Precursor;
GN   Name=RGMA; Synonyms=RGM;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Testis;
RX   MEDLINE=21154917; PubMed=11230166; DOI=10.1101/gr.GR1547R;
RA   Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA   Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H.,
RA   Lauber J., Duesterhoeft A., Beyer A., Koehrer K., Strack N.,
RA   Mewes H.-W., Ottenwaelder B., Obermaier B., Tampe J., Heubner D.,
RA   Wambutt R., Korn B., Klein M., Poustka A.;
RT   "Towards a catalog of human genes and proteins: sequencing and
RT   analysis of 500 novel complete protein coding human cDNAs.";
RL   Genome Res. 11:422-435(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1) AND PARTIAL
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Retina;
RG   The European IMAGE consortium;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Uterus;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Repulsive guidance molecules (Rgm) are involved in the
CC       guidance of growth cones of the developing neurons.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q96B86-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q96B86-2; Sequence=VSP_022294;
CC         Note=Incomplete sequence. No experimental confirmation
CC         available;
CC   -!- SIMILARITY: Belongs to the repulsive guidance molecule (RGM)
CC       family.
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DR   EMBL; AL136826; CAB66760.1; -; mRNA.
DR   EMBL; AK074910; BAC11285.1; -; mRNA.
DR   EMBL; AK074966; BAC11321.1; -; mRNA.
DR   EMBL; AK074980; BAC11330.1; -; mRNA.
DR   EMBL; AL390083; CAB98207.1; -; mRNA.
DR   EMBL; BC015886; AAH15886.2; -; mRNA.
DR   IPI; IPI00015049; -.
DR   IPI; IPI00478417; -.
DR   RefSeq; NP_064596.1; -.
DR   UniGene; Hs.271277; -.
DR   IntAct; Q96B86; 2.
DR   PRIDE; Q96B86; -.
DR   Ensembl; ENSG00000182175; Homo sapiens.
DR   GeneID; 56963; -.
DR   KEGG; hsa:56963; -.
DR   GeneCards; GC15M091387; -.
DR   HGNC; HGNC:30308; RGMA.
DR   HPA; CAB012343; -.
DR   MIM; 607362; gene.
DR   PharmGKB; PA128394693; -.
DR   HOGENOM; Q96B86; -.
DR   HOVERGEN; Q96B86; -.
DR   Pathway_Interaction_DB; bmppathway; BMP receptor signaling.
DR   NextBio; 62595; -.
DR   ArrayExpress; Q96B86; -.
DR   Bgee; Q96B86; -.
DR   CleanEx; HS_RGMA; -.
DR   GermOnline; ENSG00000182175; Homo sapiens.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR009496; RGM_C.
DR   InterPro; IPR010536; RGM_N.
DR   Pfam; PF06534; RGM_C; 1.
DR   Pfam; PF06535; RGM_N; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Cell membrane; Complete proteome; Glycoprotein;
KW   GPI-anchor; Lipoprotein; Membrane; Signal.
FT   SIGNAL        1     47       Potential.
FT   PROPEP       48    168       Removed in mature form (By similarity).
FT                                /FTId=PRO_0000030385.
FT   CHAIN       169    424       Repulsive guidance molecule A.
FT                                /FTId=PRO_0000030386.
FT   PROPEP      425    450       Removed in mature form (Potential).
FT                                /FTId=PRO_0000030387.
FT   LIPID       424    424       GPI-anchor amidated alanine (Potential).
FT   CARBOHYD    114    114       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    159    159       N-linked (GlcNAc...) (Potential).
FT   CARBOHYD    389    389       N-linked (GlcNAc...) (Potential).
FT   VAR_SEQ       1      4       MQPP -> ARGRGGRSLPARCSRRRSEAALSSQRDLFSSPF
FT                                FLNSSS (in isoform 2).
FT                                /FTId=VSP_022294.
FT   CONFLICT    199    199       V -> A (in Ref. 2; BAC11285).
SQ   SEQUENCE   450 AA;  49361 MW;  E3244FA591182DCF CRC64;
     MQPPRERLVV TGRAGWMGMG RGAGRSALGF WPTLAFLLCS FPAATSPCKI LKCNSEFWSA
     TSGSHAPASD DTPEFCAALR SYALCTRRTA RTCRGDLAYH SAVHGIEDLM SQHNCSKDGP
     TSQPRLRTLP PAGDSQERSD SPEICHYEKS FHKHSATPNY THCGLFGDPH LRTFTDRFQT
     CKVQGAWPLI DNNYLNVQVT NTPVLPGSAA TATSKLTIIF KNFQECVDQK VYQAEMDELP
     AAFVDGSKNG GDKHGANSLK ITEKVSGQHV EIQAKYIGTT IVVRQVGRYL TFAVRMPEEV
     VNAVEDWDSQ GLYLCLRGCP LNQQIDFQAF HTNAEGTGAR RLAAASPAPT APETFPYETA
     VAKCKEKLPV EDLYYQACVF DLLTTGDVNF TLAAYYALED VKMLHSNKDK LHLYERTRDL
     PGRAAAGLPL APRPLLGALV PLLALLPVFC
//