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Protein

Transmembrane protein 186

Gene

TMEM186

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 186
Gene namesi
Name:TMEM186
Synonyms:C16orf51
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24530. TMEM186.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei80 – 10021HelicalSequence analysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162406190.

Polymorphism and mutation databases

BioMutaiTMEM186.
DMDMi74731207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Transmembrane protein 186PRO_0000279439Add
BLAST

Proteomic databases

MaxQBiQ96B77.
PaxDbiQ96B77.
PRIDEiQ96B77.

PTM databases

iPTMnetiQ96B77.
PhosphoSiteiQ96B77.

Expressioni

Gene expression databases

BgeeiQ96B77.
CleanExiHS_TMEM186.
GenevisibleiQ96B77. HS.

Organism-specific databases

HPAiHPA018226.

Interactioni

Protein-protein interaction databases

BioGridi117394. 24 interactions.
IntActiQ96B77. 2 interactions.
MINTiMINT-3051082.

Structurei

3D structure databases

ProteinModelPortaliQ96B77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TMEM186 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZSW. Eukaryota.
ENOG4111SG0. LUCA.
GeneTreeiENSGT00390000000087.
HOGENOMiHOG000059619.
HOVERGENiHBG107416.
InParanoidiQ96B77.
OMAiYRFDAIR.
OrthoDBiEOG7XDBHZ.
PhylomeDBiQ96B77.
TreeFamiTF326623.

Family and domain databases

InterProiIPR026571. Tmem186.
[Graphical view]
PANTHERiPTHR13603. PTHR13603. 1 hit.

Sequencei

Sequence statusi: Complete.

Q96B77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALLRAVRR FRGKAVWERP LHGLWCCSGQ EDPKRWVGSS SPISKEKLPN
60 70 80 90 100
AETEKFWMFY RFDAIRTFGF LSRLKLAQTA LTVVALPPGY YLYSQGLLTL
110 120 130 140 150
NTVCLMSGIS GFALTMLCWM SYFLRRLVGI LYLNESGTML RVAHLNFWGW
160 170 180 190 200
RQDTYCPMAD VIPLTETKDR PQEMFVRIQR YSGKQTFYVT LRYGRILDRE
210
RFTQVFGVHQ MLK
Length:213
Mass (Da):24,893
Last modified:December 1, 2001 - v1
Checksum:iBE993F091D8FF6F0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti19 – 191R → G in CAB45703 (PubMed:11230166).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080088 mRNA. Translation: CAB45703.2.
AK314404 mRNA. Translation: BAG37027.1.
CH471112 Genomic DNA. Translation: EAW85205.1.
BC015912 mRNA. Translation: AAH15912.1.
CCDSiCCDS10535.1.
PIRiT12474.
RefSeqiNP_056236.2. NM_015421.3.
UniGeneiHs.513330.

Genome annotation databases

EnsembliENST00000333050; ENSP00000331640; ENSG00000184857.
GeneIDi25880.
KEGGihsa:25880.
UCSCiuc002cze.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080088 mRNA. Translation: CAB45703.2.
AK314404 mRNA. Translation: BAG37027.1.
CH471112 Genomic DNA. Translation: EAW85205.1.
BC015912 mRNA. Translation: AAH15912.1.
CCDSiCCDS10535.1.
PIRiT12474.
RefSeqiNP_056236.2. NM_015421.3.
UniGeneiHs.513330.

3D structure databases

ProteinModelPortaliQ96B77.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117394. 24 interactions.
IntActiQ96B77. 2 interactions.
MINTiMINT-3051082.

PTM databases

iPTMnetiQ96B77.
PhosphoSiteiQ96B77.

Polymorphism and mutation databases

BioMutaiTMEM186.
DMDMi74731207.

Proteomic databases

MaxQBiQ96B77.
PaxDbiQ96B77.
PRIDEiQ96B77.

Protocols and materials databases

DNASUi25880.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000333050; ENSP00000331640; ENSG00000184857.
GeneIDi25880.
KEGGihsa:25880.
UCSCiuc002cze.3. human.

Organism-specific databases

CTDi25880.
GeneCardsiTMEM186.
HGNCiHGNC:24530. TMEM186.
HPAiHPA018226.
neXtProtiNX_Q96B77.
PharmGKBiPA162406190.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZSW. Eukaryota.
ENOG4111SG0. LUCA.
GeneTreeiENSGT00390000000087.
HOGENOMiHOG000059619.
HOVERGENiHBG107416.
InParanoidiQ96B77.
OMAiYRFDAIR.
OrthoDBiEOG7XDBHZ.
PhylomeDBiQ96B77.
TreeFamiTF326623.

Miscellaneous databases

GenomeRNAii25880.
NextBioi47296.
PROiQ96B77.

Gene expression databases

BgeeiQ96B77.
CleanExiHS_TMEM186.
GenevisibleiQ96B77. HS.

Family and domain databases

InterProiIPR026571. Tmem186.
[Graphical view]
PANTHERiPTHR13603. PTHR13603. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.

Entry informationi

Entry nameiTM186_HUMAN
AccessioniPrimary (citable) accession number: Q96B77
Secondary accession number(s): B2RAY0, Q9Y4T4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: December 1, 2001
Last modified: April 13, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.