Q96B67 (ARRD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Arrestin domain-containing protein 3

Alternative name(s):
TBP-2-like inducible membrane protein
Short name=TLIMP

Gene names

Name:	ARRDC3
Synonyms:	KIAA1376

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	414 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Does not bind TXN (thioredoxin).
Subcellular location	Cytoplasm. Note: Associated with plasma membrane, as well as with endodomes and lysosomes during endocytosis. Ref.4
Tissue specificity	Highly expressed in skeletal muscle, placenta, kidney, adrenal gland, lymph node, mammary gland, thyroid, and trachea. Very low levels in colon, thymus, spleen, small intestine, bladder and bone marrow. Strong expression in differentiated adipocytes compared to preadipocytes. Ref.4
Induction	By troglitazone and pioglitazone (selective PPARG agonists), by prostaglandin J2 (PGJ2) and by L165,041 (a PPARD ligand), by vitamin D3 and, to a lesser extent, by phorbol myristate acetate (PMA) in the promyelocytic leukemia HL-60 cells. No induction by retinoic acid, nor by clofibrate (a specific PPARA agonist). Ref.4
Sequence similarities	Belongs to the arrestin family.
Sequence caution	The sequence BAA92614.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	signal transduction Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ITGB4	P16144	3	EBI-2875665,EBI-948678

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 414	414	Arrestin domain-containing protein 3		PRO_0000244349
Experimental info
	Sequence conflict	12	1	S → G in BAF84442. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96B67 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 9B02190E1BA90B1D	FASTA	414	46,395
	10 20 30 40 50 60 MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT 70 80 90 100 110 120 ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ 130 140 150 160 170 180 TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT 190 200 210 220 230 240 LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM 250 260 270 280 290 300 KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD 310 320 330 340 350 360 LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN 370 380 390 400 410 NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O. DNA Res. 7:65-73(2000) [PubMed: 10718198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[4]	"Thioredoxin-binding protein-2-like inducible membrane protein is a novel vitamin D3 and peroxisome proliferator-activated receptor (PPAR)gamma ligand target protein that regulates PPARgamma signaling." Oka S., Masutani H., Liu W., Horita H., Wang D., Kizaka-Kondoh S., Yodoi J. Endocrinology 147:733-743(2006) [PubMed: 16269462] [Abstract] Cited for: SUBCELLULAR LOCATION, LACK OF INTERACTION WITH TXN, TISSUE SPECIFICITY, INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB037797 mRNA. Translation: BAA92614.1. Different initiation. AK291753 mRNA. Translation: BAF84442.1. BC015928 mRNA. Translation: AAH15928.1. BC053619 mRNA. Translation: AAH53619.1.
IPI	IPI00002205.
RefSeq	NP_065852.1. NM_020801.2.
UniGene	Hs.726262.
3D structure databases
ProteinModelPortal	Q96B67.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q96B67. 4 interactions.
STRING	Q96B67.
PTM databases
PhosphoSite	Q96B67.
Polymorphism databases
DMDM	74731205.
Proteomic databases
PRIDE	Q96B67.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000265138; ENSP00000265138; ENSG00000113369.
GeneID	57561.
KEGG	hsa:57561.
UCSC	uc003kjz.1. human.
Organism-specific databases
CTD	57561.
GeneCards	GC05M090700.
H-InvDB	HIX0005031.
HGNC	HGNC:29263. ARRDC3.
MIM	612464. gene.
neXtProt	NX_Q96B67.
PharmGKB	PA134925765.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05537.
GeneTree	ENSGT00550000074356.
HOGENOM	HBG714698.
HOVERGEN	HBG066469.
InParanoid	Q96B67.
OMA	DNSEEGL.
OrthoDB	EOG4WDDBS.
PhylomeDB	Q96B67.
Gene expression databases
ArrayExpress	Q96B67.
Bgee	Q96B67.
CleanEx	HS_ARRDC3.
Genevestigator	Q96B67.
GermOnline	ENSG00000113369. Homo sapiens.
Family and domain databases
InterPro	IPR011021. Arrestin-like_N. IPR014752. Arrestin_C. IPR011022. Arrestin_C-like. IPR014756. Ig_E-set. [Graphical view]
Gene3D	G3DSA:2.60.40.640. Arrestin_C. 1 hit.
Pfam	PF02752. Arrestin_C. 1 hit. PF00339. Arrestin_N. 1 hit. [Graphical view]
SMART	SM01017. Arrestin_C. 1 hit. [Graphical view]
SUPFAM	SSF81296. Ig_E-set. 2 hits.
ProtoNet	Search...
Other
NextBio	64062.
SOURCE	Search...

Entry information

Entry name

ARRD3_HUMAN

Accession

Primary (citable) accession number: Q96B67
Secondary accession number(s): A8K6T8, Q9P2H1

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 27, 2006
Last sequence update:	December 1, 2001
Last modified:	January 25, 2012
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.