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Protein
Submitted name:

5'-nucleotidase

Gene

NT5E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
5'-nucleotidaseImported
Submitted name:
5'-nucleotidase, ecto (CD73), isoform CRA_cImported
Submitted name:
NT5E proteinImported
Gene namesi
Name:NT5EImported
ORF Names:hCG_401111Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000135318.11
HGNCiHGNC:8021 NT5E

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135318

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501458923627 – 264Sequence analysisAdd BLAST238

Expressioni

Gene expression databases

BgeeiENSG00000135318

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 244MetallophosInterPro annotationAdd BLAST216

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4419 Eukaryota
COG0737 LUCA
GeneTreeiENSGT00530000063775
HOGENOMiHOG000151244

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR006146 5'-Nucleotdase_CS
IPR006179 5_nucleotidase/apyrase
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PANTHERiPTHR11575 PTHR11575, 1 hit
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR01607 APYRASEFAMLY
PROSITEiView protein in PROSITE
PS00785 5_NUCLEOTIDASE_1, 1 hit
PS00786 5_NUCLEOTIDASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q96B60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK
60 70 80 90 100
CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE
110 120 130 140 150
VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL
160 170 180 190 200
ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL
210 220 230 240 250
QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT
260
GNCFKRIAWA RMSR
Length:264
Mass (Da):28,841
Last modified:December 1, 2001 - v1
Checksum:iCDDD53A8C6116D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135903 Genomic DNA No translation available.
AL589666 Genomic DNA No translation available.
BC015940 mRNA Translation: AAH15940.1
CH471051 Genomic DNA Translation: EAW48636.1
UniGeneiHs.153952

Genome annotation databases

EnsembliENST00000369646; ENSP00000358660; ENSG00000135318
UCSCiuc003pkn.4 human

Similar proteinsi

Entry informationi

Entry nameiQ96B60_HUMAN
AccessioniPrimary (citable) accession number: Q96B60
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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