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Protein
Submitted name:

5'-nucleotidase

Gene

NT5E

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
5'-nucleotidaseImported
Submitted name:
5'-nucleotidase, ecto (CD73), isoform CRA_cImported
Submitted name:
NT5E proteinImported
Gene namesi
Name:NT5EImported
ORF Names:hCG_401111Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:8021. NT5E.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000135318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_500878542027 – 264Sequence analysisAdd BLAST238

Expressioni

Gene expression databases

BgeeiENSG00000135318.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000257770.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 244MetallophosInterPro annotationAdd BLAST216

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG4419. Eukaryota.
COG0737. LUCA.
GeneTreeiENSGT00530000063775.
HOGENOMiHOG000151244.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCPRAARAPA TLLLALGAVL WPAAGAWELT ILHTNDVHSR LEQTSEDSSK
60 70 80 90 100
CVNASRCMGG VARLFTKVQQ IRRAEPNVLL LDAGDQYQGT IWFTVYKGAE
110 120 130 140 150
VAHFMNALRY DAMALGNHEF DNGVEGLIEP LLKEAKFPIL SANIKAKGPL
160 170 180 190 200
ASQISGLYLP YKVLPVGDEV VGIVGYTSKE TPFLSNPGTN LVFEDEITAL
210 220 230 240 250
QPEVDKLKTL NVNKIIALGH SGFEMDKLIA QKVRGVDVVV GGHSNTFLYT
260
GNCFKRIAWA RMSR
Length:264
Mass (Da):28,841
Last modified:December 1, 2001 - v1
Checksum:iCDDD53A8C6116D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135903 Genomic DNA. No translation available.
AL589666 Genomic DNA. No translation available.
BC015940 mRNA. Translation: AAH15940.1.
CH471051 Genomic DNA. Translation: EAW48636.1.
UniGeneiHs.153952.

Genome annotation databases

EnsembliENST00000369646; ENSP00000358660; ENSG00000135318.
UCSCiuc003pkn.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL135903 Genomic DNA. No translation available.
AL589666 Genomic DNA. No translation available.
BC015940 mRNA. Translation: AAH15940.1.
CH471051 Genomic DNA. Translation: EAW48636.1.
UniGeneiHs.153952.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000257770.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369646; ENSP00000358660; ENSG00000135318.
UCSCiuc003pkn.4. human.

Organism-specific databases

HGNCiHGNC:8021. NT5E.
OpenTargetsiENSG00000135318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4419. Eukaryota.
COG0737. LUCA.
GeneTreeiENSGT00530000063775.
HOGENOMiHOG000151244.

Miscellaneous databases

ChiTaRSiNT5E. human.

Gene expression databases

BgeeiENSG00000135318.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR006146. 5'-Nucleotdase_CS.
IPR006179. 5_nucleotidase/apyrase.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PANTHERiPTHR11575. PTHR11575. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR01607. APYRASEFAMLY.
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00785. 5_NUCLEOTIDASE_1. 1 hit.
PS00786. 5_NUCLEOTIDASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ96B60_HUMAN
AccessioniPrimary (citable) accession number: Q96B60
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.