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Protein

Zinc finger protein 428

Gene

ZNF428

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 428
Alternative name(s):
Enzyme-like protein PIT13
Gene namesi
Name:ZNF428
Synonyms:C19orf37
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:20804. ZNF428.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142672216.

Polymorphism and mutation databases

BioMutaiZNF428.
DMDMi74760720.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 188188Zinc finger protein 428PRO_0000312346Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei108 – 1081PhosphothreonineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96B54.
MaxQBiQ96B54.
PaxDbiQ96B54.
PeptideAtlasiQ96B54.
PRIDEiQ96B54.

PTM databases

iPTMnetiQ96B54.
PhosphoSiteiQ96B54.

Expressioni

Gene expression databases

BgeeiQ96B54.
CleanExiHS_ZNF428.
ExpressionAtlasiQ96B54. baseline and differential.
GenevisibleiQ96B54. HS.

Organism-specific databases

HPAiHPA042596.
HPA048072.

Interactioni

Protein-protein interaction databases

BioGridi125976. 17 interactions.
IntActiQ96B54. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96B54.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi3 – 167165Glu-richAdd
BLAST

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri161 – 18323C2H2-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J37N. Eukaryota.
ENOG4111CN2. LUCA.
GeneTreeiENSGT00390000006595.
HOGENOMiHOG000155795.
HOVERGENiHBG069038.
InParanoidiQ96B54.
OrthoDBiEOG75TMFB.
PhylomeDBiQ96B54.
TreeFamiTF337528.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTETREPAET GGYASLEEDD EDLSPGPEHS SDSEYTLSEP DSEEEEDEEE
60 70 80 90 100
EEEETTDDPE YDPGYKVKQR LGGGRGGPSR RAPRAAQPPA QPCQLCGRSP
110 120 130 140 150
LGEAPPGTPP CRLCCPATAP QEAPAPEGRA LGEEEEEPPR AGEGRPAGRE
160 170 180
EEEEEEEEGT YHCTECEDSF DNLGELHGHF MLHARGEV
Length:188
Mass (Da):20,481
Last modified:March 1, 2004 - v2
Checksum:i31681A8EFE3876F2
GO

Sequence cautioni

The sequence AAC99795.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence AAP87382.1 differs from that shown.Intron retention at the C-terminus.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006276 Genomic DNA. Translation: AAC99795.1. Sequence problems.
CH471126 Genomic DNA. Translation: EAW57210.1.
BC015950 mRNA. Translation: AAH15950.2.
AY257197 mRNA. Translation: AAP87382.1. Sequence problems.
CCDSiCCDS12626.1.
RefSeqiNP_872304.2. NM_182498.3.
XP_005258574.1. XM_005258517.2.
UniGeneiHs.99093.

Genome annotation databases

EnsembliENST00000300811; ENSP00000300811; ENSG00000131116.
GeneIDi126299.
KEGGihsa:126299.
UCSCiuc002oxa.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006276 Genomic DNA. Translation: AAC99795.1. Sequence problems.
CH471126 Genomic DNA. Translation: EAW57210.1.
BC015950 mRNA. Translation: AAH15950.2.
AY257197 mRNA. Translation: AAP87382.1. Sequence problems.
CCDSiCCDS12626.1.
RefSeqiNP_872304.2. NM_182498.3.
XP_005258574.1. XM_005258517.2.
UniGeneiHs.99093.

3D structure databases

ProteinModelPortaliQ96B54.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125976. 17 interactions.
IntActiQ96B54. 1 interaction.

PTM databases

iPTMnetiQ96B54.
PhosphoSiteiQ96B54.

Polymorphism and mutation databases

BioMutaiZNF428.
DMDMi74760720.

Proteomic databases

EPDiQ96B54.
MaxQBiQ96B54.
PaxDbiQ96B54.
PeptideAtlasiQ96B54.
PRIDEiQ96B54.

Protocols and materials databases

DNASUi126299.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300811; ENSP00000300811; ENSG00000131116.
GeneIDi126299.
KEGGihsa:126299.
UCSCiuc002oxa.4. human.

Organism-specific databases

CTDi126299.
GeneCardsiZNF428.
HGNCiHGNC:20804. ZNF428.
HPAiHPA042596.
HPA048072.
neXtProtiNX_Q96B54.
PharmGKBiPA142672216.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J37N. Eukaryota.
ENOG4111CN2. LUCA.
GeneTreeiENSGT00390000006595.
HOGENOMiHOG000155795.
HOVERGENiHBG069038.
InParanoidiQ96B54.
OrthoDBiEOG75TMFB.
PhylomeDBiQ96B54.
TreeFamiTF337528.

Miscellaneous databases

GenomeRNAii126299.
PROiQ96B54.

Gene expression databases

BgeeiQ96B54.
CleanExiHS_ZNF428.
ExpressionAtlasiQ96B54. baseline and differential.
GenevisibleiQ96B54. HS.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  4. "Cloning and mapping of a novel human gene."
    Hu Q.-D., Huo K., Yuan H., Lu H., Li Y.-Y.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-109.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Toward a comprehensive characterization of a human cancer cell phosphoproteome."
    Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., Mohammed S.
    J. Proteome Res. 12:260-271(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-108, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Erythroleukemia.

Entry informationi

Entry nameiZN428_HUMAN
AccessioniPrimary (citable) accession number: Q96B54
Secondary accession number(s): O95054, Q6X3Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2004
Last modified: July 6, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.