Reviewed, UniProtKB/Swiss-Prot Q96B49 (TOM6_HUMAN)

Names and origin

Protein names

Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
Alternative name(s):
    Translocase of outer membrane 6 kDa subunit homolog
    Overexpressed breast tumor protein

Gene names

Name:	TOMM6
Synonyms:	OBTP, TOM6

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	74 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Subunit structure	Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).
Subcellular location	Mitochondrion outer membrane. Ref.1
Sequence similarities	Belongs to the Tom6 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 74	74	Mitochondrial import receptor subunit TOM6 homolog		PRO_0000302856
Amino acid modifications
	Modified residue	63	1	Phosphoserine Ref.5
Experimental info
	Sequence conflict	16	1	E → K in AAF25683. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q96B49-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: 805462C0444865FD	FASTA	74	8,002
	10 20 30 40 50 60 MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG LFAAGVWLAR 70 NLSDIDLMAP QPGV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane." Kato H., Mihara K. Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed: 18331822] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, SUBCELLULAR LOCATION.
[2]	"Identification of a novel human over-expressed breast tumor protein in hepatocellular carcinoma." Kok L.D., Au T.C., Fung K.P., Lee C.Y., Tsui S.K., Waye M.M. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver cancer.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow, Prostate and Skin.
[5]	"Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC." Gevaert K., Staes A., Van Damme J., De Groot S., Hugelier K., Demol H., Martens L., Goethals M., Vandekerckhove J. Proteomics 5:3589-3599(2005) [PubMed: 16097034] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63, MASS SPECTROMETRY. Tissue: Hepatocyte.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB435319 mRNA. Translation: BAG30996.1. AF216754 mRNA. Translation: AAF25683.1. AL365205 Genomic DNA. Translation: CAM16154.1. BC015975 mRNA. Translation: AAH15975.1. BC018624 mRNA. Translation: AAH18624.1. BC022274 mRNA. Translation: AAH22274.1.
IPI	IPI00386294.
RefSeq	NP_001127965.1.
UniGene	Hs.525899
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q96B49.
Proteomic databases
PRIDE	Q96B49.
Genome annotation databases
Ensembl	ENST00000398881; ENSP00000381856; ENSG00000214736; Homo sapiens. [Genome view] ENST00000398884; ENSP00000381859; ENSG00000214736; Homo sapiens. [Genome view]
GeneID	100188893.
KEGG	hsa:100188893.
Organism-specific databases
CTD	100188893.
GeneCards	GC06P041864.
HGNC	HGNC:34528. TOMM6.
HPA	HPA004801.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q96B49.
OMA	NDFRRNL.
Gene expression databases
CleanEx	HS_TOMM6.
Genevestigator	Q96B49.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

TOM6_HUMAN

Accession

Primary (citable) accession number: Q96B49
Secondary accession number(s): B2DG15, Q9UH52

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.