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Protein

Mitochondrial import receptor subunit TOM6 homolog

Gene

TOMM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM6 homolog
Alternative name(s):
Overexpressed breast tumor protein
Translocase of outer membrane 6 kDa subunit homolog
Gene namesi
Name:TOMM6
Synonyms:OBTP, TOM6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:34528. TOMM6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726679.

Polymorphism and mutation databases

BioMutaiTOMM6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 7473Mitochondrial import receptor subunit TOM6 homologPRO_0000302856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ96B49.
MaxQBiQ96B49.
PaxDbiQ96B49.
PeptideAtlasiQ96B49.
PRIDEiQ96B49.
TopDownProteomicsiQ96B49.

PTM databases

iPTMnetiQ96B49.
PhosphoSiteiQ96B49.

Expressioni

Gene expression databases

CleanExiHS_TOMM6.
GenevisibleiQ96B49. HS.

Organism-specific databases

HPAiHPA004801.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

Protein-protein interaction databases

IntActiQ96B49. 1 interaction.
STRINGi9606.ENSP00000381856.

Structurei

3D structure databases

ProteinModelPortaliQ96B49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom6 family.Curated

Phylogenomic databases

eggNOGiENOG410JENH. Eukaryota.
ENOG41114XV. LUCA.
GeneTreeiENSGT00390000002376.
HOGENOMiHOG000081508.
HOVERGENiHBG054583.
InParanoidiQ96B49.
KOiK17772.
OMAiWLRGVFR.
OrthoDBiEOG091G1975.
PhylomeDBiQ96B49.
TreeFamiTF330716.

Family and domain databases

InterProiIPR029182. TOMM6.
[Graphical view]
PANTHERiPTHR15527:SF0. PTHR15527:SF0. 1 hit.
PfamiPF15184. TOM6p. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q96B49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG
60 70
LFAAGVWLAR NLSDIDLMAP QPGV
Length:74
Mass (Da):8,002
Last modified:December 1, 2001 - v1
Checksum:i805462C0444865FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → K in AAF25683 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435319 mRNA. Translation: BAG30996.1.
AF216754 mRNA. Translation: AAF25683.1.
AL365205 Genomic DNA. Translation: CAM16154.1.
BC015975 mRNA. Translation: AAH15975.1.
BC018624 mRNA. Translation: AAH18624.1.
BC022274 mRNA. Translation: AAH22274.1.
CCDSiCCDS47424.1.
RefSeqiNP_001127965.1. NM_001134493.1.
UniGeneiHs.731633.

Genome annotation databases

EnsembliENST00000398881; ENSP00000381856; ENSG00000214736.
ENST00000398884; ENSP00000381859; ENSG00000214736.
GeneIDi100188893.
KEGGihsa:100188893.
UCSCiuc011dug.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435319 mRNA. Translation: BAG30996.1.
AF216754 mRNA. Translation: AAF25683.1.
AL365205 Genomic DNA. Translation: CAM16154.1.
BC015975 mRNA. Translation: AAH15975.1.
BC018624 mRNA. Translation: AAH18624.1.
BC022274 mRNA. Translation: AAH22274.1.
CCDSiCCDS47424.1.
RefSeqiNP_001127965.1. NM_001134493.1.
UniGeneiHs.731633.

3D structure databases

ProteinModelPortaliQ96B49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ96B49. 1 interaction.
STRINGi9606.ENSP00000381856.

PTM databases

iPTMnetiQ96B49.
PhosphoSiteiQ96B49.

Polymorphism and mutation databases

BioMutaiTOMM6.

Proteomic databases

EPDiQ96B49.
MaxQBiQ96B49.
PaxDbiQ96B49.
PeptideAtlasiQ96B49.
PRIDEiQ96B49.
TopDownProteomicsiQ96B49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398881; ENSP00000381856; ENSG00000214736.
ENST00000398884; ENSP00000381859; ENSG00000214736.
GeneIDi100188893.
KEGGihsa:100188893.
UCSCiuc011dug.2. human.

Organism-specific databases

CTDi100188893.
GeneCardsiTOMM6.
HGNCiHGNC:34528. TOMM6.
HPAiHPA004801.
MIMi616168. gene.
neXtProtiNX_Q96B49.
PharmGKBiPA164726679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JENH. Eukaryota.
ENOG41114XV. LUCA.
GeneTreeiENSGT00390000002376.
HOGENOMiHOG000081508.
HOVERGENiHBG054583.
InParanoidiQ96B49.
KOiK17772.
OMAiWLRGVFR.
OrthoDBiEOG091G1975.
PhylomeDBiQ96B49.
TreeFamiTF330716.

Enzyme and pathway databases

ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.

Miscellaneous databases

GenomeRNAii100188893.
PROiQ96B49.
SOURCEiSearch...

Gene expression databases

CleanExiHS_TOMM6.
GenevisibleiQ96B49. HS.

Family and domain databases

InterProiIPR029182. TOMM6.
[Graphical view]
PANTHERiPTHR15527:SF0. PTHR15527:SF0. 1 hit.
PfamiPF15184. TOM6p. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTOM6_HUMAN
AccessioniPrimary (citable) accession number: Q96B49
Secondary accession number(s): B2DG15, Q9UH52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: September 7, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.