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Q96B49

- TOM6_HUMAN

UniProt

Q96B49 - TOM6_HUMAN

Protein

Mitochondrial import receptor subunit TOM6 homolog

Gene

TOMM6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. protein targeting to mitochondrion Source: Reactome

    Keywords - Biological processi

    Protein transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_118595. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial import receptor subunit TOM6 homolog
    Alternative name(s):
    Overexpressed breast tumor protein
    Translocase of outer membrane 6 kDa subunit homolog
    Gene namesi
    Name:TOMM6
    Synonyms:OBTP, TOM6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:34528. TOMM6.

    Subcellular locationi

    Mitochondrion outer membrane 1 Publication

    GO - Cellular componenti

    1. mitochondrial outer membrane translocase complex Source: InterPro
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA164726679.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7474Mitochondrial import receptor subunit TOM6 homologPRO_0000302856Add
    BLAST

    Proteomic databases

    MaxQBiQ96B49.
    PaxDbiQ96B49.
    PRIDEiQ96B49.

    PTM databases

    PhosphoSiteiQ96B49.

    Expressioni

    Gene expression databases

    CleanExiHS_TOMM6.
    GenevestigatoriQ96B49.

    Organism-specific databases

    HPAiHPA004801.

    Interactioni

    Subunit structurei

    Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

    Protein-protein interaction databases

    STRINGi9606.ENSP00000381856.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96B49.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Tom6 family.Curated

    Phylogenomic databases

    eggNOGiNOG41605.
    HOGENOMiHOG000081508.
    HOVERGENiHBG054583.
    InParanoidiQ96B49.
    KOiK17772.
    OMAiAGWANET.
    OrthoDBiEOG7VHT0Z.
    PhylomeDBiQ96B49.
    TreeFamiTF330716.

    Family and domain databases

    InterProiIPR029182. TOMM6.
    [Graphical view]
    PANTHERiPTHR15527:SF0. PTHR15527:SF0. 1 hit.
    PfamiPF15184. TOMM6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96B49-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG   50
    LFAAGVWLAR NLSDIDLMAP QPGV 74
    Length:74
    Mass (Da):8,002
    Last modified:December 1, 2001 - v1
    Checksum:i805462C0444865FD
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti16 – 161E → K in AAF25683. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB435319 mRNA. Translation: BAG30996.1.
    AF216754 mRNA. Translation: AAF25683.1.
    AL365205 Genomic DNA. Translation: CAM16154.1.
    BC015975 mRNA. Translation: AAH15975.1.
    BC018624 mRNA. Translation: AAH18624.1.
    BC022274 mRNA. Translation: AAH22274.1.
    CCDSiCCDS47424.1.
    RefSeqiNP_001127965.1. NM_001134493.1.
    UniGeneiHs.731633.

    Genome annotation databases

    EnsembliENST00000398881; ENSP00000381856; ENSG00000214736.
    ENST00000398884; ENSP00000381859; ENSG00000214736.
    GeneIDi100188893.
    KEGGihsa:100188893.
    UCSCiuc011dug.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB435319 mRNA. Translation: BAG30996.1 .
    AF216754 mRNA. Translation: AAF25683.1 .
    AL365205 Genomic DNA. Translation: CAM16154.1 .
    BC015975 mRNA. Translation: AAH15975.1 .
    BC018624 mRNA. Translation: AAH18624.1 .
    BC022274 mRNA. Translation: AAH22274.1 .
    CCDSi CCDS47424.1.
    RefSeqi NP_001127965.1. NM_001134493.1.
    UniGenei Hs.731633.

    3D structure databases

    ProteinModelPortali Q96B49.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000381856.

    PTM databases

    PhosphoSitei Q96B49.

    Proteomic databases

    MaxQBi Q96B49.
    PaxDbi Q96B49.
    PRIDEi Q96B49.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000398881 ; ENSP00000381856 ; ENSG00000214736 .
    ENST00000398884 ; ENSP00000381859 ; ENSG00000214736 .
    GeneIDi 100188893.
    KEGGi hsa:100188893.
    UCSCi uc011dug.1. human.

    Organism-specific databases

    CTDi 100188893.
    GeneCardsi GC06P041755.
    HGNCi HGNC:34528. TOMM6.
    HPAi HPA004801.
    neXtProti NX_Q96B49.
    PharmGKBi PA164726679.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41605.
    HOGENOMi HOG000081508.
    HOVERGENi HBG054583.
    InParanoidi Q96B49.
    KOi K17772.
    OMAi AGWANET.
    OrthoDBi EOG7VHT0Z.
    PhylomeDBi Q96B49.
    TreeFami TF330716.

    Enzyme and pathway databases

    Reactomei REACT_118595. Mitochondrial protein import.

    Miscellaneous databases

    GenomeRNAii 100188893.
    NextBioi 20775091.
    PROi Q96B49.

    Gene expression databases

    CleanExi HS_TOMM6.
    Genevestigatori Q96B49.

    Family and domain databases

    InterProi IPR029182. TOMM6.
    [Graphical view ]
    PANTHERi PTHR15527:SF0. PTHR15527:SF0. 1 hit.
    Pfami PF15184. TOMM6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
      Kato H., Mihara K.
      Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, SUBCELLULAR LOCATION.
    2. "Identification of a novel human over-expressed breast tumor protein in hepatocellular carcinoma."
      Kok L.D., Au T.C., Fung K.P., Lee C.Y., Tsui S.K., Waye M.M.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver cancer.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow, Prostate and Skin.
    5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiTOM6_HUMAN
    AccessioniPrimary (citable) accession number: Q96B49
    Secondary accession number(s): B2DG15, Q9UH52
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: December 1, 2001
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3