Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Mitochondrial import receptor subunit TOM6 homolog

Gene

TOMM6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. cellular protein metabolic process Source: Reactome
  2. protein targeting to mitochondrion Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM6 homolog
Alternative name(s):
Overexpressed breast tumor protein
Translocase of outer membrane 6 kDa subunit homolog
Gene namesi
Name:TOMM6
Synonyms:OBTP, TOM6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 6

Organism-specific databases

HGNCiHGNC:34528. TOMM6.

Subcellular locationi

Mitochondrion outer membrane 1 Publication

GO - Cellular componenti

  1. mitochondrial outer membrane translocase complex Source: InterPro
  2. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164726679.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7474Mitochondrial import receptor subunit TOM6 homologPRO_0000302856Add
BLAST

Proteomic databases

MaxQBiQ96B49.
PaxDbiQ96B49.
PRIDEiQ96B49.

PTM databases

PhosphoSiteiQ96B49.

Expressioni

Gene expression databases

CleanExiHS_TOMM6.
GenevestigatoriQ96B49.

Organism-specific databases

HPAiHPA004801.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70).1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000381856.

Structurei

3D structure databases

ProteinModelPortaliQ96B49.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom6 family.Curated

Phylogenomic databases

eggNOGiNOG41605.
GeneTreeiENSGT00390000002376.
HOGENOMiHOG000081508.
HOVERGENiHBG054583.
InParanoidiQ96B49.
KOiK17772.
OMAiWLRGVFR.
OrthoDBiEOG7VHT0Z.
PhylomeDBiQ96B49.
TreeFamiTF330716.

Family and domain databases

InterProiIPR029182. TOMM6.
[Graphical view]
PANTHERiPTHR15527:SF0. PTHR15527:SF0. 1 hit.
PfamiPF15184. TOMM6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTVPVSA AGSANETPEI PDNVGDWLRG VYRFATDRND FRRNLILNLG
60 70
LFAAGVWLAR NLSDIDLMAP QPGV
Length:74
Mass (Da):8,002
Last modified:December 1, 2001 - v1
Checksum:i805462C0444865FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161E → K in AAF25683 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435319 mRNA. Translation: BAG30996.1.
AF216754 mRNA. Translation: AAF25683.1.
AL365205 Genomic DNA. Translation: CAM16154.1.
BC015975 mRNA. Translation: AAH15975.1.
BC018624 mRNA. Translation: AAH18624.1.
BC022274 mRNA. Translation: AAH22274.1.
CCDSiCCDS47424.1.
RefSeqiNP_001127965.1. NM_001134493.1.
UniGeneiHs.731633.

Genome annotation databases

EnsembliENST00000398881; ENSP00000381856; ENSG00000214736.
ENST00000398884; ENSP00000381859; ENSG00000214736.
GeneIDi100188893.
KEGGihsa:100188893.
UCSCiuc011dug.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB435319 mRNA. Translation: BAG30996.1.
AF216754 mRNA. Translation: AAF25683.1.
AL365205 Genomic DNA. Translation: CAM16154.1.
BC015975 mRNA. Translation: AAH15975.1.
BC018624 mRNA. Translation: AAH18624.1.
BC022274 mRNA. Translation: AAH22274.1.
CCDSiCCDS47424.1.
RefSeqiNP_001127965.1. NM_001134493.1.
UniGeneiHs.731633.

3D structure databases

ProteinModelPortaliQ96B49.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000381856.

PTM databases

PhosphoSiteiQ96B49.

Proteomic databases

MaxQBiQ96B49.
PaxDbiQ96B49.
PRIDEiQ96B49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000398881; ENSP00000381856; ENSG00000214736.
ENST00000398884; ENSP00000381859; ENSG00000214736.
GeneIDi100188893.
KEGGihsa:100188893.
UCSCiuc011dug.1. human.

Organism-specific databases

CTDi100188893.
GeneCardsiGC06P041755.
HGNCiHGNC:34528. TOMM6.
HPAiHPA004801.
neXtProtiNX_Q96B49.
PharmGKBiPA164726679.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG41605.
GeneTreeiENSGT00390000002376.
HOGENOMiHOG000081508.
HOVERGENiHBG054583.
InParanoidiQ96B49.
KOiK17772.
OMAiWLRGVFR.
OrthoDBiEOG7VHT0Z.
PhylomeDBiQ96B49.
TreeFamiTF330716.

Enzyme and pathway databases

ReactomeiREACT_118595. Mitochondrial protein import.

Miscellaneous databases

GenomeRNAii100188893.
NextBioi20775091.
PROiQ96B49.

Gene expression databases

CleanExiHS_TOMM6.
GenevestigatoriQ96B49.

Family and domain databases

InterProiIPR029182. TOMM6.
[Graphical view]
PANTHERiPTHR15527:SF0. PTHR15527:SF0. 1 hit.
PfamiPF15184. TOMM6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of Tom5 and Tom6 in the preprotein translocase complex of human mitochondrial outer membrane."
    Kato H., Mihara K.
    Biochem. Biophys. Res. Commun. 369:958-963(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION IN THE TOM COMPLEX, SUBCELLULAR LOCATION.
  2. "Identification of a novel human over-expressed breast tumor protein in hepatocellular carcinoma."
    Kok L.D., Au T.C., Fung K.P., Lee C.Y., Tsui S.K., Waye M.M.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver cancer.
  3. "The DNA sequence and analysis of human chromosome 6."
    Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
    , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
    Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow, Prostate and Skin.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTOM6_HUMAN
AccessioniPrimary (citable) accession number: Q96B49
Secondary accession number(s): B2DG15, Q9UH52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: December 1, 2001
Last modified: January 7, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.