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Protein

Transmembrane protein 18

Gene

TMEM18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell migration Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 18
Gene namesi
Name:TMEM18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:25257. TMEM18.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25Perinuclear spaceSequence analysisAdd BLAST25
Transmembranei26 – 46HelicalSequence analysisAdd BLAST21
Topological domaini47 – 52NuclearSequence analysis6
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 91Perinuclear spaceSequence analysisAdd BLAST18
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 140NuclearSequence analysisAdd BLAST28

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • nuclear membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi129787.
OpenTargetsiENSG00000151353.
PharmGKBiPA134873089.

Polymorphism and mutation databases

BioMutaiTMEM18.
DMDMi121944491.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002843691 – 140Transmembrane protein 18Add BLAST140

Proteomic databases

PaxDbiQ96B42.
PeptideAtlasiQ96B42.
PRIDEiQ96B42.

PTM databases

iPTMnetiQ96B42.
PhosphoSitePlusiQ96B42.

Expressioni

Gene expression databases

BgeeiENSG00000151353.
CleanExiHS_TMEM18.
ExpressionAtlasiQ96B42. baseline and differential.
GenevisibleiQ96B42. HS.

Organism-specific databases

HPAiHPA040233.

Interactioni

Subunit structurei

Forms homooligomers, independently of the DNA-binding domain.1 Publication

Protein-protein interaction databases

STRINGi9606.ENSP00000281017.

Structurei

3D structure databases

ProteinModelPortaliQ96B42.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni113 – 140DNA-bindingAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili116 – 140Sequence analysisAdd BLAST25

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi130 – 138Nuclear localization signal9

Sequence similaritiesi

Belongs to the TMEM18 family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IZTN. Eukaryota.
ENOG41125VK. LUCA.
GeneTreeiENSGT00390000015191.
HOGENOMiHOG000230683.
HOVERGENiHBG104687.
InParanoidiQ96B42.
OMAiAQNWSSF.
PhylomeDBiQ96B42.
TreeFamiTF324883.

Family and domain databases

InterProiIPR026721. TMEM18.
[Graphical view]
PfamiPF14770. TMEM18. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96B42-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSAFSVSSF PVSIPAVLTQ TDWTEPWLMG LATFHALCVL LTCLSSRSYR
60 70 80 90 100
LQIGHFLCLV ILVYCAEYIN EAAAMNWRLF SKYQYFDSRG MFISIVFSAP
110 120 130 140
LLVNAMIIVV MWVWKTLNVM TDLKNAQERR KEKKRRRKED
Length:140
Mass (Da):16,265
Last modified:November 8, 2005 - v2
Checksum:iFDE25DA6B7CCC2BC
GO
Isoform 2 (identifier: Q96B42-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-19: PSAFSVSSFPVSIPAVLT → LSGYL

Show »
Length:127
Mass (Da):15,011
Checksum:i25B6D00BD1183F58
GO

Sequence cautioni

The sequence CAB70668 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0244692 – 19PSAFS…PAVLT → LSGYL in isoform 2. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137269 mRNA. Translation: CAB70668.1. Different initiation.
AC092159 Genomic DNA. Translation: AAY14770.1.
CH471053 Genomic DNA. Translation: EAX01100.1.
CH471053 Genomic DNA. Translation: EAX01101.1.
BC016010 mRNA. Translation: AAH16010.2.
BC032379 mRNA. Translation: AAH32379.1.
CCDSiCCDS33141.1. [Q96B42-1]
PIRiT46342.
RefSeqiNP_690047.2. NM_152834.2. [Q96B42-1]
UniGeneiHs.43899.

Genome annotation databases

EnsembliENST00000281017; ENSP00000281017; ENSG00000151353. [Q96B42-1]
ENST00000355654; ENSP00000347874; ENSG00000151353. [Q96B42-2]
GeneIDi129787.
KEGGihsa:129787.
UCSCiuc002qwl.4. human. [Q96B42-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137269 mRNA. Translation: CAB70668.1. Different initiation.
AC092159 Genomic DNA. Translation: AAY14770.1.
CH471053 Genomic DNA. Translation: EAX01100.1.
CH471053 Genomic DNA. Translation: EAX01101.1.
BC016010 mRNA. Translation: AAH16010.2.
BC032379 mRNA. Translation: AAH32379.1.
CCDSiCCDS33141.1. [Q96B42-1]
PIRiT46342.
RefSeqiNP_690047.2. NM_152834.2. [Q96B42-1]
UniGeneiHs.43899.

3D structure databases

ProteinModelPortaliQ96B42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000281017.

PTM databases

iPTMnetiQ96B42.
PhosphoSitePlusiQ96B42.

Polymorphism and mutation databases

BioMutaiTMEM18.
DMDMi121944491.

Proteomic databases

PaxDbiQ96B42.
PeptideAtlasiQ96B42.
PRIDEiQ96B42.

Protocols and materials databases

DNASUi129787.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000281017; ENSP00000281017; ENSG00000151353. [Q96B42-1]
ENST00000355654; ENSP00000347874; ENSG00000151353. [Q96B42-2]
GeneIDi129787.
KEGGihsa:129787.
UCSCiuc002qwl.4. human. [Q96B42-1]

Organism-specific databases

CTDi129787.
DisGeNETi129787.
GeneCardsiTMEM18.
HGNCiHGNC:25257. TMEM18.
HPAiHPA040233.
MIMi613220. gene.
neXtProtiNX_Q96B42.
OpenTargetsiENSG00000151353.
PharmGKBiPA134873089.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZTN. Eukaryota.
ENOG41125VK. LUCA.
GeneTreeiENSGT00390000015191.
HOGENOMiHOG000230683.
HOVERGENiHBG104687.
InParanoidiQ96B42.
OMAiAQNWSSF.
PhylomeDBiQ96B42.
TreeFamiTF324883.

Miscellaneous databases

GeneWikiiTMEM18.
GenomeRNAii129787.
PROiQ96B42.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000151353.
CleanExiHS_TMEM18.
ExpressionAtlasiQ96B42. baseline and differential.
GenevisibleiQ96B42. HS.

Family and domain databases

InterProiIPR026721. TMEM18.
[Graphical view]
PfamiPF14770. TMEM18. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTMM18_HUMAN
AccessioniPrimary (citable) accession number: Q96B42
Secondary accession number(s): D6W4X9, Q8N5H2, Q9NTH3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: November 8, 2005
Last modified: November 2, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.