ID   CLD23_HUMAN             Reviewed;         292 AA.
AC   Q96B33; Q08AJ3;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2004, sequence version 2.
DT   24-JAN-2024, entry version 153.
DE   RecName: Full=Claudin-23;
GN   Name=CLDN23;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=12736707;
RA   Katoh M., Katoh M.;
RT   "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer,
RT   is a novel member of CLAUDIN gene family.";
RL   Int. J. Mol. Med. 11:683-689(2003).
CC   -!- FUNCTION: Plays a major role in tight junction-specific obliteration of
CC       the intercellular space, through calcium-independent cell-adhesion
CC       activity. {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q96B33; Q96L08: SUSD3; NbExp=3; IntAct=EBI-18201031, EBI-18194029;
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Cell
CC       membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in germinal center B-cells, placenta,
CC       stomach as well as in colon tumor. {ECO:0000269|PubMed:12736707}.
CC   -!- SIMILARITY: Belongs to the claudin family. {ECO:0000305}.
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DR   EMBL; BC125148; AAI25149.1; -; mRNA.
DR   EMBL; BC125149; AAI25150.1; -; mRNA.
DR   CCDS; CCDS55195.1; -.
DR   RefSeq; NP_919260.2; NM_194284.2.
DR   AlphaFoldDB; Q96B33; -.
DR   SMR; Q96B33; -.
DR   BioGRID; 126468; 4.
DR   IntAct; Q96B33; 1.
DR   STRING; 9606.ENSP00000428780; -.
DR   TCDB; 1.H.1.1.4; the claudin tight junction (claudin1) family.
DR   iPTMnet; Q96B33; -.
DR   PhosphoSitePlus; Q96B33; -.
DR   SwissPalm; Q96B33; -.
DR   BioMuta; CLDN23; -.
DR   DMDM; 47605532; -.
DR   EPD; Q96B33; -.
DR   MassIVE; Q96B33; -.
DR   PaxDb; 9606-ENSP00000428780; -.
DR   PeptideAtlas; Q96B33; -.
DR   ProteomicsDB; 76039; -.
DR   Antibodypedia; 52870; 148 antibodies from 22 providers.
DR   DNASU; 137075; -.
DR   Ensembl; ENST00000519106.2; ENSP00000428780.1; ENSG00000253958.2.
DR   Ensembl; ENST00000644143.2; ENSP00000495091.1; ENSG00000285098.2.
DR   GeneID; 137075; -.
DR   KEGG; hsa:137075; -.
DR   MANE-Select; ENST00000519106.2; ENSP00000428780.1; NM_194284.3; NP_919260.2.
DR   UCSC; uc003wsi.4; human.
DR   AGR; HGNC:17591; -.
DR   CTD; 137075; -.
DR   DisGeNET; 137075; -.
DR   GeneCards; CLDN23; -.
DR   HGNC; HGNC:17591; CLDN23.
DR   HPA; ENSG00000253958; Tissue enhanced (intestine, stomach).
DR   MIM; 609203; gene.
DR   neXtProt; NX_Q96B33; -.
DR   OpenTargets; ENSG00000253958; -.
DR   PharmGKB; PA134961253; -.
DR   VEuPathDB; HostDB:ENSG00000253958; -.
DR   eggNOG; ENOG502RYXX; Eukaryota.
DR   GeneTree; ENSGT00390000006975; -.
DR   HOGENOM; CLU_089834_0_0_1; -.
DR   InParanoid; Q96B33; -.
DR   OMA; STVYVDW; -.
DR   OrthoDB; 3951433at2759; -.
DR   PhylomeDB; Q96B33; -.
DR   TreeFam; TF331936; -.
DR   PathwayCommons; Q96B33; -.
DR   Reactome; R-HSA-420029; Tight junction interactions.
DR   SignaLink; Q96B33; -.
DR   BioGRID-ORCS; 137075; 13 hits in 1144 CRISPR screens.
DR   GenomeRNAi; 137075; -.
DR   Pharos; Q96B33; Tbio.
DR   PRO; PR:Q96B33; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; Q96B33; Protein.
DR   Bgee; ENSG00000253958; Expressed in mucosa of transverse colon and 91 other cell types or tissues.
DR   GO; GO:0005923; C:bicellular tight junction; ISS:UniProtKB.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0070830; P:bicellular tight junction assembly; IBA:GO_Central.
DR   GO; GO:0016338; P:calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; ISS:UniProtKB.
DR   GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR   Gene3D; 1.20.140.150; -; 1.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; CLAUDIN; 1.
DR   PANTHER; PTHR12002:SF3; CLAUDIN-23; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PRINTS; PR01077; CLAUDIN.
DR   PROSITE; PS01346; CLAUDIN; 1.
DR   Genevisible; Q96B33; HS.
PE   1: Evidence at protein level;
KW   Cell junction; Cell membrane; Membrane; Reference proteome; Tight junction;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..292
FT                   /note="Claudin-23"
FT                   /id="PRO_0000144787"
FT   TOPO_DOM        1..3
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        25..81
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        103..110
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        111..131
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        132..160
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        182..292
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          222..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         210
FT                   /note="V -> M (in dbSNP:rs12548737)"
FT                   /id="VAR_059219"
SQ   SEQUENCE   292 AA;  31915 MW;  D383B139905B8884 CRC64;
     MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE
     RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL GVRCWQDEPN FVLAGLSGVV
     LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS PVTVQVSYSL VLGYLGSCLL LLGGFSLALS
     FAPWCDERCR RRRKGPSAGP RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK
     PKPKVGFPMP RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL
//