Q96B33 (CLD23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Claudin-23

Gene names

Name:

CLDN23

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.
Subcellular location	Cell junction › tight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor. Ref.2
Sequence similarities	Belongs to the claudin family.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane Tight junction
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	calcium-independent cell-cell adhesion Inferred from sequence or structural similarity. Source: UniProtKB tight junction assembly Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell tight junction Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	identical protein binding Inferred from sequence or structural similarity. Source: UniProtKB structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 292	292	Claudin-23		PRO_0000144787
Regions
	Topological domain	1 – 3	3	Cytoplasmic Potential
	Transmembrane	4 – 24	21	Helical; Potential
	Topological domain	25 – 81	57	Extracellular Potential
	Transmembrane	82 – 102	21	Helical; Potential
	Topological domain	103 – 110	8	Cytoplasmic Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Topological domain	132 – 160	29	Extracellular Potential
	Transmembrane	161 – 181	21	Helical; Potential
	Topological domain	182 – 292	111	Cytoplasmic Potential
Natural variations
	Natural variant	210	1	V → M. Corresponds to variant rs12548737 [ dbSNP | Ensembl ].		VAR_059219

Sequences

	Sequence		Length	Mass (Da)
	Q96B33 [UniParc]. Last modified May 24, 2004. Version 2. Checksum: D383B139905B8884	FASTA	292	31,915
	10 20 30 40 50 60 MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE 70 80 90 100 110 120 RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL GVRCWQDEPN FVLAGLSGVV 130 140 150 160 170 180 LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS PVTVQVSYSL VLGYLGSCLL LLGGFSLALS 190 200 210 220 230 240 FAPWCDERCR RRRKGPSAGP RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK 250 260 270 280 290 PKPKVGFPMP RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family." Katoh M., Katoh M. Int. J. Mol. Med. 11:683-689(2003) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC125148 mRNA. Translation: AAI25149.1. BC125149 mRNA. Translation: AAI25150.1.
IPI	IPI00059710.
RefSeq	NP_919260.2. NM_194284.2.
UniGene	Hs.183617.
3D structure databases
ProteinModelPortal	Q96B33.
ModBase	Search...
Protein family/group databases
TCDB	1.H.1.1.4. claudin tight junction (Claudin) family.
PTM databases
PhosphoSite	Q96B33.
Polymorphism databases
DMDM	47605532.
Proteomic databases
PRIDE	Q96B33.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000519106; ENSP00000428780; ENSG00000253958.
GeneID	137075.
KEGG	hsa:137075.
UCSC	uc003wsi.3. human.
Organism-specific databases
CTD	137075.
GeneCards	GC08P008562.
HGNC	HGNC:17591. CLDN23.
MIM	609203. gene.
neXtProt	NX_Q96B33.
PharmGKB	PA134961253.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000111788.
HOVERGEN	HBG050988.
KO	K06087.
OMA	QQGIWDI.
Enzyme and pathway databases
Reactome	REACT_111155. Cell-Cell communication.
Gene expression databases
Bgee	Q96B33.
CleanEx	HS_CLDN23.
Genevestigator	Q96B33.
Family and domain databases
InterPro	IPR006187. Claudin. IPR017974. Claudin_CS. IPR004031. PMP22/EMP/MP20/Claudin. [Graphical view]
PANTHER	PTHR12002. PTHR12002. 1 hit.
Pfam	PF00822. PMP22_Claudin. 1 hit. [Graphical view]
PRINTS	PR01077. CLAUDIN.
PROSITE	PS01346. CLAUDIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	137075.
NextBio	83616.
SOURCE	Search...

Entry information

Entry name

CLD23_HUMAN

Accession

Primary (citable) accession number: Q96B33
Secondary accession number(s): Q08AJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2004
Last sequence update:	May 24, 2004
Last modified:	March 6, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.