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Q96B33

- CLD23_HUMAN

UniProt

Q96B33 - CLD23_HUMAN

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Protein

Claudin-23

Gene

CLDN23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

  1. identical protein binding Source: UniProtKB
  2. structural molecule activity Source: InterPro

GO - Biological processi

  1. calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules Source: UniProtKB
  2. cell-cell junction organization Source: Reactome
  3. cell junction assembly Source: Reactome
  4. tight junction assembly Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_19373. Tight junction interactions.

Protein family/group databases

TCDBi1.H.1.1.4. the claudin tight junction (claudin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-23
Gene namesi
Name:CLDN23
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:17591. CLDN23.

Subcellular locationi

Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 33CytoplasmicSequence Analysis
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Topological domaini25 – 8157ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221HelicalSequence AnalysisAdd
BLAST
Topological domaini103 – 1108CytoplasmicSequence Analysis
Transmembranei111 – 13121HelicalSequence AnalysisAdd
BLAST
Topological domaini132 – 16029ExtracellularSequence AnalysisAdd
BLAST
Transmembranei161 – 18121HelicalSequence AnalysisAdd
BLAST
Topological domaini182 – 292111CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. tight junction Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134961253.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Claudin-23PRO_0000144787Add
BLAST

Proteomic databases

PRIDEiQ96B33.

PTM databases

PhosphoSiteiQ96B33.

Expressioni

Tissue specificityi

Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.1 Publication

Gene expression databases

BgeeiQ96B33.
CleanExiHS_CLDN23.
GenevestigatoriQ96B33.

Interactioni

Protein-protein interaction databases

BioGridi126468. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ96B33.
SMRiQ96B33. Positions 1-182.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00390000006975.
HOGENOMiHOG000111788.
HOVERGENiHBG050988.
InParanoidiQ96B33.
KOiK06087.
OMAiATLGVRC.
OrthoDBiEOG7PP57M.
PhylomeDBiQ96B33.
TreeFamiTF331936.

Family and domain databases

InterProiIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERiPTHR12002. PTHR12002. 1 hit.
PfamiPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSiPR01077. CLAUDIN.
PROSITEiPS01346. CLAUDIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q96B33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW
60 70 80 90 100
DMCREQSSRE RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL
110 120 130 140 150
GVRCWQDEPN FVLAGLSGVV LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS
160 170 180 190 200
PVTVQVSYSL VLGYLGSCLL LLGGFSLALS FAPWCDERCR RRRKGPSAGP
210 220 230 240 250
RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK PKPKVGFPMP
260 270 280 290
RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL
Length:292
Mass (Da):31,915
Last modified:May 24, 2004 - v2
Checksum:iD383B139905B8884
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti210 – 2101V → M.
Corresponds to variant rs12548737 [ dbSNP | Ensembl ].
VAR_059219

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125148 mRNA. Translation: AAI25149.1.
BC125149 mRNA. Translation: AAI25150.1.
CCDSiCCDS55195.1.
RefSeqiNP_919260.2. NM_194284.2.
UniGeneiHs.183617.

Genome annotation databases

EnsembliENST00000519106; ENSP00000428780; ENSG00000253958.
GeneIDi137075.
KEGGihsa:137075.
UCSCiuc003wsi.3. human.

Polymorphism databases

DMDMi47605532.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC125148 mRNA. Translation: AAI25149.1 .
BC125149 mRNA. Translation: AAI25150.1 .
CCDSi CCDS55195.1.
RefSeqi NP_919260.2. NM_194284.2.
UniGenei Hs.183617.

3D structure databases

ProteinModelPortali Q96B33.
SMRi Q96B33. Positions 1-182.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 126468. 1 interaction.

Protein family/group databases

TCDBi 1.H.1.1.4. the claudin tight junction (claudin) family.

PTM databases

PhosphoSitei Q96B33.

Polymorphism databases

DMDMi 47605532.

Proteomic databases

PRIDEi Q96B33.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000519106 ; ENSP00000428780 ; ENSG00000253958 .
GeneIDi 137075.
KEGGi hsa:137075.
UCSCi uc003wsi.3. human.

Organism-specific databases

CTDi 137075.
GeneCardsi GC08P008562.
HGNCi HGNC:17591. CLDN23.
MIMi 609203. gene.
neXtProti NX_Q96B33.
PharmGKBi PA134961253.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00390000006975.
HOGENOMi HOG000111788.
HOVERGENi HBG050988.
InParanoidi Q96B33.
KOi K06087.
OMAi ATLGVRC.
OrthoDBi EOG7PP57M.
PhylomeDBi Q96B33.
TreeFami TF331936.

Enzyme and pathway databases

Reactomei REACT_19373. Tight junction interactions.

Miscellaneous databases

GenomeRNAii 137075.
NextBioi 83616.
PROi Q96B33.
SOURCEi Search...

Gene expression databases

Bgeei Q96B33.
CleanExi HS_CLDN23.
Genevestigatori Q96B33.

Family and domain databases

InterProi IPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view ]
PANTHERi PTHR12002. PTHR12002. 1 hit.
Pfami PF00822. PMP22_Claudin. 1 hit.
[Graphical view ]
PRINTSi PR01077. CLAUDIN.
PROSITEi PS01346. CLAUDIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family."
    Katoh M., Katoh M.
    Int. J. Mol. Med. 11:683-689(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiCLD23_HUMAN
AccessioniPrimary (citable) accession number: Q96B33
Secondary accession number(s): Q08AJ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: October 29, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3