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Q96B33 (CLD23_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 96. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Claudin-23
Gene names
Name:CLDN23
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity By similarity.

Subcellular location

Cell junctiontight junction By similarity. Cell membrane; Multi-pass membrane protein By similarity.

Tissue specificity

Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor. Ref.2

Sequence similarities

Belongs to the claudin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Claudin-23
PRO_0000144787

Regions

Topological domain1 – 33Cytoplasmic Potential
Transmembrane4 – 2421Helical; Potential
Topological domain25 – 8157Extracellular Potential
Transmembrane82 – 10221Helical; Potential
Topological domain103 – 1108Cytoplasmic Potential
Transmembrane111 – 13121Helical; Potential
Topological domain132 – 16029Extracellular Potential
Transmembrane161 – 18121Helical; Potential
Topological domain182 – 292111Cytoplasmic Potential

Natural variations

Natural variant2101V → M.
Corresponds to variant rs12548737 [ dbSNP | Ensembl ].
VAR_059219

Sequences

Sequence LengthMass (Da)Tools
Q96B33 [UniParc].

Last modified May 24, 2004. Version 2.
Checksum: D383B139905B8884

FASTA29231,915
        10         20         30         40         50         60 
MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW DMCREQSSRE 

        70         80         90        100        110        120 
RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL GVRCWQDEPN FVLAGLSGVV 

       130        140        150        160        170        180 
LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS PVTVQVSYSL VLGYLGSCLL LLGGFSLALS 

       190        200        210        220        230        240 
FAPWCDERCR RRRKGPSAGP RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK 

       250        260        270        280        290 
PKPKVGFPMP RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family."
Katoh M., Katoh M.
Int. J. Mol. Med. 11:683-689(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC125148 mRNA. Translation: AAI25149.1.
BC125149 mRNA. Translation: AAI25150.1.
RefSeqNP_919260.2. NM_194284.2.
UniGeneHs.183617.

3D structure databases

ProteinModelPortalQ96B33.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126468. 1 interaction.

Protein family/group databases

TCDB1.H.1.1.4. the claudin tight junction (claudin) family.

PTM databases

PhosphoSiteQ96B33.

Polymorphism databases

DMDM47605532.

Proteomic databases

PRIDEQ96B33.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000519106; ENSP00000428780; ENSG00000253958.
GeneID137075.
KEGGhsa:137075.
UCSCuc003wsi.3. human.

Organism-specific databases

CTD137075.
GeneCardsGC08P008562.
HGNCHGNC:17591. CLDN23.
MIM609203. gene.
neXtProtNX_Q96B33.
PharmGKBPA134961253.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000111788.
HOVERGENHBG050988.
KOK06087.
OMASTVYVDW.
OrthoDBEOG7PP57M.
PhylomeDBQ96B33.
TreeFamTF331936.

Enzyme and pathway databases

ReactomeREACT_111155. Cell-Cell communication.

Gene expression databases

BgeeQ96B33.
CleanExHS_CLDN23.
GenevestigatorQ96B33.

Family and domain databases

InterProIPR006187. Claudin.
IPR017974. Claudin_CS.
IPR004031. PMP22/EMP/MP20/Claudin.
[Graphical view]
PANTHERPTHR12002. PTHR12002. 1 hit.
PfamPF00822. PMP22_Claudin. 1 hit.
[Graphical view]
PRINTSPR01077. CLAUDIN.
PROSITEPS01346. CLAUDIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi137075.
NextBio83616.
PROQ96B33.
SOURCESearch...

Entry information

Entry nameCLD23_HUMAN
AccessionPrimary (citable) accession number: Q96B33
Secondary accession number(s): Q08AJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 16, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM