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Q96B33

- CLD23_HUMAN

UniProt

Q96B33 - CLD23_HUMAN

Protein

Claudin-23

Gene

CLDN23

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 2 (24 May 2004)
      Previous versions | rss
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    Functioni

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

    GO - Molecular functioni

    1. identical protein binding Source: UniProtKB
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. calcium-independent cell-cell adhesion Source: UniProtKB
    2. cell-cell junction organization Source: Reactome
    3. cell junction assembly Source: Reactome
    4. tight junction assembly Source: Reactome

    Enzyme and pathway databases

    ReactomeiREACT_19373. Tight junction interactions.

    Protein family/group databases

    TCDBi1.H.1.1.4. the claudin tight junction (claudin) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Claudin-23
    Gene namesi
    Name:CLDN23
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:17591. CLDN23.

    Subcellular locationi

    Cell junctiontight junction By similarity. Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134961253.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Claudin-23PRO_0000144787Add
    BLAST

    Proteomic databases

    PRIDEiQ96B33.

    PTM databases

    PhosphoSiteiQ96B33.

    Expressioni

    Tissue specificityi

    Expressed in germinal center B-cells, placenta, stomach as well as in colon tumor.1 Publication

    Gene expression databases

    BgeeiQ96B33.
    CleanExiHS_CLDN23.
    GenevestigatoriQ96B33.

    Interactioni

    Protein-protein interaction databases

    BioGridi126468. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ96B33.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 33CytoplasmicSequence Analysis
    Topological domaini25 – 8157ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1108CytoplasmicSequence Analysis
    Topological domaini132 – 16029ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini182 – 292111CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 2421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei111 – 13121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei161 – 18121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the claudin family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOGENOMiHOG000111788.
    HOVERGENiHBG050988.
    KOiK06087.
    OMAiATLGVRC.
    OrthoDBiEOG7PP57M.
    PhylomeDBiQ96B33.
    TreeFamiTF331936.

    Family and domain databases

    InterProiIPR006187. Claudin.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view]
    PANTHERiPTHR12002. PTHR12002. 1 hit.
    PfamiPF00822. PMP22_Claudin. 1 hit.
    [Graphical view]
    PRINTSiPR01077. CLAUDIN.
    PROSITEiPS01346. CLAUDIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q96B33-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTPVVMTLG MVLAPCGLLL NLTGTLAPGW RLVKGFLNQP VDVELYQGLW    50
    DMCREQSSRE RECGQTDQWG YFEAQPVLVA RALMVTSLAA TVLGLLLASL 100
    GVRCWQDEPN FVLAGLSGVV LFVAGLLGLI PVSWYNHFLG DRDVLPAPAS 150
    PVTVQVSYSL VLGYLGSCLL LLGGFSLALS FAPWCDERCR RRRKGPSAGP 200
    RRSSVSTIQV EWPEPDLAPA IKYYSDGQHR PPPAQHRKPK PKPKVGFPMP 250
    RPRPKAYTNS VDVLDGEGWE SQDAPSCSTH PCDSSLPCDS DL 292
    Length:292
    Mass (Da):31,915
    Last modified:May 24, 2004 - v2
    Checksum:iD383B139905B8884
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti210 – 2101V → M.
    Corresponds to variant rs12548737 [ dbSNP | Ensembl ].
    VAR_059219

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC125148 mRNA. Translation: AAI25149.1.
    BC125149 mRNA. Translation: AAI25150.1.
    CCDSiCCDS55195.1.
    RefSeqiNP_919260.2. NM_194284.2.
    UniGeneiHs.183617.

    Genome annotation databases

    EnsembliENST00000519106; ENSP00000428780; ENSG00000253958.
    GeneIDi137075.
    KEGGihsa:137075.
    UCSCiuc003wsi.3. human.

    Polymorphism databases

    DMDMi47605532.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC125148 mRNA. Translation: AAI25149.1 .
    BC125149 mRNA. Translation: AAI25150.1 .
    CCDSi CCDS55195.1.
    RefSeqi NP_919260.2. NM_194284.2.
    UniGenei Hs.183617.

    3D structure databases

    ProteinModelPortali Q96B33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126468. 1 interaction.

    Protein family/group databases

    TCDBi 1.H.1.1.4. the claudin tight junction (claudin) family.

    PTM databases

    PhosphoSitei Q96B33.

    Polymorphism databases

    DMDMi 47605532.

    Proteomic databases

    PRIDEi Q96B33.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000519106 ; ENSP00000428780 ; ENSG00000253958 .
    GeneIDi 137075.
    KEGGi hsa:137075.
    UCSCi uc003wsi.3. human.

    Organism-specific databases

    CTDi 137075.
    GeneCardsi GC08P008562.
    HGNCi HGNC:17591. CLDN23.
    MIMi 609203. gene.
    neXtProti NX_Q96B33.
    PharmGKBi PA134961253.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000111788.
    HOVERGENi HBG050988.
    KOi K06087.
    OMAi ATLGVRC.
    OrthoDBi EOG7PP57M.
    PhylomeDBi Q96B33.
    TreeFami TF331936.

    Enzyme and pathway databases

    Reactomei REACT_19373. Tight junction interactions.

    Miscellaneous databases

    GenomeRNAii 137075.
    NextBioi 83616.
    PROi Q96B33.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q96B33.
    CleanExi HS_CLDN23.
    Genevestigatori Q96B33.

    Family and domain databases

    InterProi IPR006187. Claudin.
    IPR017974. Claudin_CS.
    IPR004031. PMP22/EMP/MP20/Claudin.
    [Graphical view ]
    PANTHERi PTHR12002. PTHR12002. 1 hit.
    Pfami PF00822. PMP22_Claudin. 1 hit.
    [Graphical view ]
    PRINTSi PR01077. CLAUDIN.
    PROSITEi PS01346. CLAUDIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family."
      Katoh M., Katoh M.
      Int. J. Mol. Med. 11:683-689(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCLD23_HUMAN
    AccessioniPrimary (citable) accession number: Q96B33
    Secondary accession number(s): Q08AJ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: May 24, 2004
    Last modified: October 1, 2014
    This is version 100 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3