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Protein

Uncharacterized protein C18orf25

Gene

C18orf25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C18orf25
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000152242.10.
HGNCiHGNC:28172. C18orf25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919240.

Polymorphism and mutation databases

BioMutaiC18orf25.
DMDMi209572602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000793121 – 403Uncharacterized protein C18orf25Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei143PhosphoserineCombined sources1
Modified residuei145PhosphoserineCombined sources1
Modified residuei147PhosphoserineBy similarity1
Modified residuei346Omega-N-methylarginineCombined sources1
Cross-linki357Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ96B23.
MaxQBiQ96B23.
PaxDbiQ96B23.
PeptideAtlasiQ96B23.
PRIDEiQ96B23.

PTM databases

iPTMnetiQ96B23.
PhosphoSitePlusiQ96B23.

Expressioni

Gene expression databases

BgeeiENSG00000152242.
CleanExiHS_C18orf25.
ExpressionAtlasiQ96B23. baseline and differential.
GenevisibleiQ96B23. HS.

Organism-specific databases

HPAiHPA051314.
HPA051899.

Interactioni

Protein-protein interaction databases

BioGridi127053. 50 interactors.
IntActiQ96B23. 7 interactors.
MINTiMINT-1438786.
STRINGi9606.ENSP00000282059.

Structurei

3D structure databases

ProteinModelPortaliQ96B23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili175 – 200Sequence analysisAdd BLAST26

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKCJ. Eukaryota.
ENOG410Z94Y. LUCA.
HOVERGENiHBG056975.
InParanoidiQ96B23.
PhylomeDBiQ96B23.
TreeFamiTF351299.

Family and domain databases

InterProiView protein in InterPro
IPR029306. RNF111_N.
PfamiView protein in Pfam
PF15303. RNF111_N. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96B23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST
60 70 80 90 100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS
110 120 130 140 150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS
160 170 180 190 200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL
210 220 230 240 250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG PPVVAHYDMS
260 270 280 290 300
DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
310 320 330 340 350
HLDPGFLASD KTSGNAPLNE EINIASSDSE VEIVGVQEHA RCVHPRGGVI
360 370 380 390 400
QSVSSWKHGS GTQYVSTRQT QSWTAVTPQQ TWASPAEVVD LTLDEDSRRK

YLL
Length:403
Mass (Da):43,324
Last modified:October 14, 2008 - v2
Checksum:i1843683941D4DD01
GO
Isoform 2 (identifier: Q96B23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-299: Missing.

Show »
Length:342
Mass (Da):36,977
Checksum:iCE45696435E5ED16
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233I → V in CAD89920 (PubMed:17974005).Curated1
Sequence conflicti315N → S in CAE45812 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046670313S → SA4 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_014753239 – 299Missing in isoform 2. 3 PublicationsAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289738 mRNA. Translation: BAF82427.1.
AK292981 mRNA. Translation: BAF85670.1.
AL713661 mRNA. Translation: CAD28470.1.
AL832027 mRNA. Translation: CAD89920.1.
BX640683 mRNA. Translation: CAE45812.1.
AC021763 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01473.1.
BC016149 mRNA. Translation: AAH16149.1.
BC084579 mRNA. Translation: AAH84579.1.
RefSeqiNP_001008240.1. NM_001008239.2.
NP_659492.1. NM_145055.3.
XP_011524124.1. XM_011525822.1.
XP_016881044.1. XM_017025555.1.
UniGeneiHs.116486.

Genome annotation databases

EnsembliENST00000619301; ENSP00000480074; ENSG00000152242.
GeneIDi147339.
KEGGihsa:147339.
UCSCiuc032hdc.2. human. [Q96B23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCR025_HUMAN
AccessioniPrimary (citable) accession number: Q96B23
Secondary accession number(s): A8K123
, A8KAB6, Q5XG78, Q6N058, Q86TB5, Q8TCQ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 14, 2008
Last modified: September 27, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations