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Protein

Uncharacterized protein C18orf25

Gene

C18orf25

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C18orf25
Gene namesi
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:28172. C18orf25.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919240.

Polymorphism and mutation databases

BioMutaiC18orf25.
DMDMi209572602.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Uncharacterized protein C18orf25PRO_0000079312Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661PhosphoserineCombined sources
Modified residuei143 – 1431PhosphoserineCombined sources
Modified residuei145 – 1451PhosphoserineCombined sources
Modified residuei147 – 1471PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ96B23.
MaxQBiQ96B23.
PaxDbiQ96B23.
PRIDEiQ96B23.

PTM databases

iPTMnetiQ96B23.
PhosphoSiteiQ96B23.

Expressioni

Gene expression databases

BgeeiQ96B23.
CleanExiHS_C18orf25.
ExpressionAtlasiQ96B23. baseline and differential.
GenevisibleiQ96B23. HS.

Organism-specific databases

HPAiHPA051314.
HPA051899.

Interactioni

Protein-protein interaction databases

BioGridi127053. 38 interactions.
IntActiQ96B23. 7 interactions.
MINTiMINT-1438786.
STRINGi9606.ENSP00000282059.

Structurei

3D structure databases

ProteinModelPortaliQ96B23.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili175 – 20026Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IKCJ. Eukaryota.
ENOG410Z94Y. LUCA.
HOVERGENiHBG056975.
InParanoidiQ96B23.
PhylomeDBiQ96B23.
TreeFamiTF351299.

Family and domain databases

InterProiIPR029306. RNF111_N.
[Graphical view]
PfamiPF15303. RNF111_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q96B23-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMEEAVGKV EELIESEAPP KASEQETAKE EDGSVELESQ VQKDGVADST
60 70 80 90 100
VISSMPCLLM ELRRDSSESQ LASTESDKPT TGRVYESDSS NHCMLSPSSS
110 120 130 140 150
GHLADSDTLS SAEENEPSQA ETAVEGDPSG VSGATVGRKS RRSRSESETS
160 170 180 190 200
TMAAKKNRQS SDKQNGRVAK VKGHRSQKHK ERIRLLRQKR EAAARKKYNL
210 220 230 240 250
LQDSSTSDSD LTCDSSTSSS DDDEEVSGSS KTITAEIPDG PPVVAHYDMS
260 270 280 290 300
DTNSDPEVVN VDNLLAAAVV QEHSNSVGGQ DTGATWRTSG LLEELNAEAG
310 320 330 340 350
HLDPGFLASD KTSGNAPLNE EINIASSDSE VEIVGVQEHA RCVHPRGGVI
360 370 380 390 400
QSVSSWKHGS GTQYVSTRQT QSWTAVTPQQ TWASPAEVVD LTLDEDSRRK

YLL
Length:403
Mass (Da):43,324
Last modified:October 14, 2008 - v2
Checksum:i1843683941D4DD01
GO
Isoform 2 (identifier: Q96B23-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-299: Missing.

Show »
Length:342
Mass (Da):36,977
Checksum:iCE45696435E5ED16
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331I → V in CAD89920 (PubMed:17974005).Curated
Sequence conflicti315 – 3151N → S in CAE45812 (PubMed:17974005).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti313 – 3131S → SA.4 Publications
VAR_046670

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei239 – 29961Missing in isoform 2. 3 PublicationsVSP_014753Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289738 mRNA. Translation: BAF82427.1.
AK292981 mRNA. Translation: BAF85670.1.
AL713661 mRNA. Translation: CAD28470.1.
AL832027 mRNA. Translation: CAD89920.1.
BX640683 mRNA. Translation: CAE45812.1.
AC021763 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01473.1.
BC016149 mRNA. Translation: AAH16149.1.
BC084579 mRNA. Translation: AAH84579.1.
RefSeqiNP_001008240.1. NM_001008239.2.
NP_659492.1. NM_145055.3.
XP_011524124.1. XM_011525822.1.
UniGeneiHs.116486.

Genome annotation databases

EnsembliENST00000619301; ENSP00000480074; ENSG00000152242.
GeneIDi147339.
KEGGihsa:147339.
UCSCiuc032hdc.2. human. [Q96B23-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289738 mRNA. Translation: BAF82427.1.
AK292981 mRNA. Translation: BAF85670.1.
AL713661 mRNA. Translation: CAD28470.1.
AL832027 mRNA. Translation: CAD89920.1.
BX640683 mRNA. Translation: CAE45812.1.
AC021763 Genomic DNA. No translation available.
CH471088 Genomic DNA. Translation: EAX01473.1.
BC016149 mRNA. Translation: AAH16149.1.
BC084579 mRNA. Translation: AAH84579.1.
RefSeqiNP_001008240.1. NM_001008239.2.
NP_659492.1. NM_145055.3.
XP_011524124.1. XM_011525822.1.
UniGeneiHs.116486.

3D structure databases

ProteinModelPortaliQ96B23.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127053. 38 interactions.
IntActiQ96B23. 7 interactions.
MINTiMINT-1438786.
STRINGi9606.ENSP00000282059.

PTM databases

iPTMnetiQ96B23.
PhosphoSiteiQ96B23.

Polymorphism and mutation databases

BioMutaiC18orf25.
DMDMi209572602.

Proteomic databases

EPDiQ96B23.
MaxQBiQ96B23.
PaxDbiQ96B23.
PRIDEiQ96B23.

Protocols and materials databases

DNASUi147339.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000619301; ENSP00000480074; ENSG00000152242.
GeneIDi147339.
KEGGihsa:147339.
UCSCiuc032hdc.2. human. [Q96B23-1]

Organism-specific databases

CTDi147339.
GeneCardsiC18orf25.
H-InvDBHIX0014428.
HIX0030489.
HGNCiHGNC:28172. C18orf25.
HPAiHPA051314.
HPA051899.
neXtProtiNX_Q96B23.
PharmGKBiPA134919240.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCJ. Eukaryota.
ENOG410Z94Y. LUCA.
HOVERGENiHBG056975.
InParanoidiQ96B23.
PhylomeDBiQ96B23.
TreeFamiTF351299.

Miscellaneous databases

ChiTaRSiC18orf25. human.
GenomeRNAii147339.
NextBioi85587.
PROiQ96B23.

Gene expression databases

BgeeiQ96B23.
CleanExiHS_C18orf25.
ExpressionAtlasiQ96B23. baseline and differential.
GenevisibleiQ96B23. HS.

Family and domain databases

InterProiIPR029306. RNF111_N.
[Graphical view]
PfamiPF15303. RNF111_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-313 INS.
    Tissue: Brain and Trachea.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT ALA-313 INS.
    Tissue: Lymph node and Skeletal muscle.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-313 INS.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-313 INS.
    Tissue: Eye and Lung.
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66; SER-143 AND SER-145, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCR025_HUMAN
AccessioniPrimary (citable) accession number: Q96B23
Secondary accession number(s): A8K123
, A8KAB6, Q5XG78, Q6N058, Q86TB5, Q8TCQ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: October 14, 2008
Last modified: May 11, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.